The focus of our research is the biosynthesis of natural products in actinomycetes. We are particularly interested in polyketide and aminoglycoside pathways and the development of molecular tools for their engineering in order to improve the product yields and generate new bioactive derivatives.

• Polyketide engineering: Implementation of trans-acyltransferases (trans-ATs) as valuable tool for “bioderivatization” of natural products
• Aminoglycoside biosynthesis and producer strain optimization by pathway engineering