Forum Scientiarum

Identification of the Human Receptor for the Staphylococcus aureus lipoprotein-like (Lpl) Protein and Its Role in Cellular Invasion

Staphylococcus aureus is a Gram-positive commensal and opportunistic human pathogenic bacterial species that causes serious community acquired and nosocomial infections. Treatment of these infections has become difficult because of the emergence of antibiotic-resistant strains. S. aureus has the ability to invade and persist within non-professional phagocytic cells (NPPCs) such as epithelial, endothelial, osteoblast, fibroblast, or kidney cells. Most S. aureus strains contain a pathogenicity island, νSaα, which encodes a set of lipoprotein like gene cluster called lpl. Particularly in highly epidemic strains, the lpl cluster comprises up to 10 homologous tandemly arranged lpl genes. This gene cluster contributes to internalization into NPPCs and increases invasion in murine skin and bacterial burden in a murine kidney abscess. The human receptor for this important virulence factor is still unknown. My project is focus in the identification of the human receptor for the Lpl protein from S.aureus and its role in infection and cell invasion.