Aim of the study
In my bachelor-thesis, I will investigate the influence of different pH-values on the uptake of lidocaine (a painkiller which is used for local anaesthetic) and fenofibric acid (a lipid-lowering drug) in fish. Both substances can be found in wastewater and, due to the insufficiency of conventional sewage treatment plants to remove all substances during cleansing processes, also in surface water. Furthermore, both substances are ionisable. To examine the toxicity of lidocaine and fenofibric acid, I will use the fish embryo test which will be carried out with the model organism Danio rerio. The collected data will be part of the pHION-project, which aims to create a model of the bioavailability of many more substances due to varying pH-values and, therefore, enable a better and more reliable risk assessment.