Center for Plant Molecular Biology

Job Opportunities


Stellenangebote der Universität Tübingen

Assistant Professors / Research Group Leaders (Forschungsgruppenleiter)

 

 

 


--Sorry, no open positions available


Postdoctoral scientists (Postdoktoranden)

11.12.19

2 Postdoctoral Positions on the ERC Funded Project: “Knowledge Based Design of Complex Synthetic Microbial Communities”

 

Located at the Tübingen Research Campus, we are an interdisciplinary group that bridges between microbiology, plant sciences and ecology, with a strong focus on computational biology. Therefore, we are part of the Center for Plant Molecular Biology (ZMBP) and the Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT). Our main focus is to understand fundamental mechanisms that shape microbial communities from a stochastic input to a well-defined host-associated microbial community that protects its host from harmful intruders. Our main expertise’s are in microbiology, molecular biology and bioinformatics.

Background / Objectives

Complex microbial communities (“microbiota”) that populate surfaces of higher organisms critically impact health of their hosts: They contribute to host fitness through nutrient acquisition, stress tolerance or pathogen resistance but at the same time, can promote pathogenesis and can be reservoirs for pathogens. Mechanisms for how communities shift from a beneficial to a detrimental state are largely unknown.  
In order to cure detrimental microbiota, that were damaged through stress factors including previous diseases, decoding the complex processes governing microbiota dynamics is a key challenge. To develop durable probiotics, communal stability or the ability of a community to return to a steady state following perturbation is a key factor.
Our lab has broad expertise in studying microbial communities through lab experiments and analysing factors that shape the microbiota of Arabidopsis thaliana plants under natural conditions and common garden experiments. We have discovered a hierarchical order in microbial community networks with hub microbes as key elements. A breakthrough was the discovery of microbial taxa that persist throughout the life of A. thaliana plants and their importance in network stability. In this project we use this expertise to identify key stability factors and drivers of communal dynamics to reconstitute synthetic communities. How to seed microbial communities that develop into functional probiotics is a key challenge. We will use knowledge based assembly of complex communities to seed protective microbiota. We will challenge those through pathogens and abiotic factors to refine and test the predictive power of our analyses.

The selected candidates  will use a combination of molecular biology, microbiology, genetics and computational biology. The candidates will be involved in high throughput sequencing and computational data analyses, as well as microbial reconstitution assays. Methods will be adapted and developed according to needs for rigorously testing inferred hypotheses.

Requirements

The ideal applicant will have a doctoral degree, background in bioinformatics, molecular biology / microbiology and microbial ecology. A background in plant-microbial interactions is welcomed but not required. We seek highly motivated applicants that have extensive experience in at least one of these fields and basic knowledge in the others. Candidates with knowledge of a scripting language, experience in R and statistics background are preferred. A lab technician will be supporting these roles.

Payment / Position

All positions will be immediately available (for 36 months, renewable after evaluation). Salary and benefits are commensurate with public service organisation rules (E 13 TV-L). The University of Tübingen is an equal opportunity employer. The University seeks to raise the number of women in research and teaching and therefore urges qualified women academics to apply for these positions. Equally qualified applicants with disabilities will be given preference. The employment will be carried out by the central administration of the University of Tübingen.

Application

For questions concerning the projects please contact Prof. Eric Kemen (eric.kemenspam prevention@uni-tuebingen.de)

Please provide an application letter clearly stating which position you are applying for, including curriculum vitae, list of publications, a statement of research interests, and arrange for minimum two academic letters of recommendation to be sent by email no later than January 10th, 2020 to:
Angela Gürtel
Universität Tübingen
ZMBP / Microbial Interactions
Auf der Morgenstelle 32
D-72076 Tübingen / Germany
Phone: +49-(0)7071/29-76605
angela.guertelspam prevention@zmbp.uni-tuebingen.de

 

 

6.12.19

Am Zentrum für Molekularbiologie der Pflanzen (ZMBP) der Universität Tübingen ist zum 1.1.2020 die 100 %-Stelle eines

Wissenschaftlers (Postdoc) w/m/d in der Abt. Mikroskopie

zu besetzen. Die Stelle ist bis 31.12.2021 befristet.

Das Aufgabengebiet umfasst vor allem die Betreuung der Konfokalen Mikroskope des ZMBP. Das beinhaltet die Durchführung von Servicemessungen, die Wartung der Geräte, die projektnahe Einweisung und Unterstützung von Nutzern sowie die selbständige Bearbeitung von mikroskopisch orientierten Forschungsprojekten. Des Weiteren sind die Weiterentwicklung spektromikroskopischer Methoden sowie die Interaktion mit der Superresolutionmikroskopie-Facility des SFB 1101 wünschenswert.

Für diese Tätigkeit suchen wir eine flexible, aufgeschlossene und hilfsbereite Person mit einem entsprechenden wissenschaftlichen Hochschulabschluss (Promotion) in Biologie oder Biochemie, sowie eingehender Erfahrungen in Konfokaler Mikroskopie von Pflanzen mit den Geräten Leica TCS SP8 (inklusive FLIM, FRET) und Zeiss LSM 880 Airyscan.

Sehr gute deutsche und englische Sprachkenntnisse auch in der Lehre im Fachgebiet Mikroskopie werden erwartet.

Die Vergütung erfolgt nach E 13 TV-L. Schwerbehinderte werden bei gleicher Eignung bevorzugt berücksichtigt.

Für Rückfragen und nähere Informationen steht Ihnen Frau Dr. Sandra Richter (Tel.: 07071/29-76662) gerne zur Verfügung.

Bitte senden Sie Ihre Bewerbung mit den üblichen Unterlagen bis zum 13.12.2019 elektronisch in einer pdf-Datei an silvia.roeckerspam prevention@zmbp.uni-tuebingen.de

Die Einstellung erfolgt durch die Zentrale Verwaltung der Universität.

 

26.11.19

Am Zentrum für Molekularbiologie der Pflanzen (ZMBP) der Universität Tübingen ist zum nächstmöglichen Zeitpunkt die 50 %-Stelle eines

Wissenschaftlers (Post Doc) w-m-d

Leitung der Unit „Bi-Molekulare Interaktionen“

unbefristet zu besetzen.

Die Aufgaben umfassen die Verantwortung und Betreuung der Unit „Bi-Molekulare Interaktionen“ des ZMBP einschließlich der Bedienung und Instandhaltung der Geräte (Biacore, Thermophorese, Kalorimetrie). Weiter wird die Unterstützung der Arbeitsgruppen bei der Nutzung der Geräte sowie der Auswertung und Interpretation der gemessenen Daten erwartet. Zusätzlich erfordert die Tätigkeit die Unterstützung aller Mitarbeiter des ZMBP in Fragen der Proteinexpression und Proteinaufreinigung. Daneben muss in diesen Aufgabenfeldern gelehrt werden.

Dafür suchen wir eine dynamische, aufgeschlossene und serviceorientierte Person mit eingehenden Erfahrungen in den Bereichen Biacore, Thermophorese, Kalorimetrie sowie Proteinexpression und Proteinaufreinigung. Erfahrungen im Pflanzenbereich sind wünschenswert, jedoch nicht zwingende Voraussetzung.

Sehr gute englische Sprachkenntnisse werden vorausgesetzt.

Die Vergütung erfolgt nach E 13 TV-L. Schwerbehinderte werden bei gleicher Eignung bevorzugt berücksichtigt.

Für Rückfragen und nähere Informationen steht Ihnen Herr Dr. Mark Stahl
(Tel. 07071/29-74240) gerne zur Verfügung.

Bitte senden Sie Ihre Bewerbung mit den üblichen Unterlagen bis zum 31.12.2019 elektronisch in einer pdf-Datei an liane.schoenspam prevention@zmbp.uni-tuebingen.de.

Die Einstellung erfolgt durch die Zentrale Verwaltung der Universität.

 

 

 

 

Postdoctoral Researcher (f/m) in Plant Cell Biology

We have an opening for a post-doctoral researcher in our group at the Center for Plant Molecular Biology at the University of Tübingen, Germany. If you are interested in plant cytoskeleton and its role in division plane establishment and maintenance in plants, come and join our team. Information on our research and publications is available at the ZMBP website – Developmental Genetics/Research group Müller.

We are looking for a motivated individual with expertise in cell and molecular biology. Experience with advanced confocal imaging and image analysis is an advantage. The ZMBP is a multi-national Institution and therefore English communication skills are a requirement. You will contribute to ongoing projects pertaining to division zone maintenance and phragmoplast guidance by kinesin-12 motor proteins and thus teamwork abilities are expected.

The University of Tübingen is an equal opportunity employer and particularly welcomes applications from qualified women and individuals with disabilities. Formal employment procedures will be carried out by the central administration of the University of Tübingen. Salary and benefits are according to TV-L E13 in agreement with guidelines of the University of Tübingen. Funding is secured until December 2020 and the position may be extended pending on available funding.

Please send your application, including a letter of motivation, curriculum vitae and contact information for two referees directly to
Dr. Sabine Müller: sabine.muellerspam prevention@zmbp.uni-tuebingen.de.

Screening of applications will start 30.04.2019 and will continue until the position is filled.

 

 

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Sorry, no open positions available


Graduate students (Doktoranden)

26.11.19

PhD Position in Plant-microbe interaction and cell biology

Research: Our group at the ZMBP Tübingen is interested in the role of the proteasome and autophagy during plant immunity. Recently, we have identified that Pseudomonas activates autophagy for proteasome degradation and enhanced pathogenicity (Üstün et al., 2018). On the contrary, another bacterial pathogen, Xanthomonas campestris pv. vesicatoria, which infects tomato plants, is using a bacterial effector protein to perturb autophagy.

In this project we aim to investigate:

  • Bacterial effectors from Xanthomonas and their impact on autophagy
  • the autophagy pathway in tomato using CRISPR/Cas9 technology
  • Bacterial effectors and their effect on endocytic degradation and vacuolar trafficking

Requirements/Qualifications:

We are looking for a talented PhD student (f,m,d) with proven expertise in cell and molecular biology. Prior experiences with methods to study plant-microbe interactions and advanced confocal microscopy are highly advantageous but not required. Excellent English communication skills as well as teamwork abilities are expected. A master’s degree in molecular biology, biochemistry or corresponding is required. We offer an innovative and scientifically stimulating environment and use a combination of state-of-the-art techniques. The work will include cell biological (confocal microscopy), biochemical (Co-IP, protein purification, protein-protein interactions), genetic and transcriptomic approaches using tomato, tobacco, Arabidopsis and Xanthomonas as model organisms.

More information can be found on our lab homepage: http://theustunlab.com/

References:

Üstün S., et al. (2018) Bacteria exploit autophagy for proteasome degradation and enhanced virulence in plants. The Plant Cell

Üstün S. et al. (2017). Autophagy as a mediator of life and death in plants. Curr Opin Plant Biol

Üstün S. and Börnke F (2014) Interactions of Xanthomonas type-III effector proteins with the plant ubiquitin and ubiquitin-like pathways. Frontiers Plant Science

The position is available immediately. Reviewing of applications will begin immediately and the position will remain open until a suitable candidate is found. Please send your application as a composite pdf-file in English (letter of motivation stating your research interests, CV, name and addresses of at least two referees) via email: suayib.uestuenspam prevention@zmbp.uni-tuebingen.de

The ZMBP is a worldclass center for Plant Biology research and is situated in a brand-new and well-equipped building in the University of Tübingen science campus. The University of Tübingen is an equal opportunity employer and particularly welcomes applications from qualified women and individuals with disabilities. Formal employment procedures will be carried out by the central administration of the University of Tübingen.

 

 

13.8.19

PhD position in Molecular Biology and Biophysic

General interest: Most biological processes involve changes in molecular and cell shapes, and such deformations, in essence, involve a mechanical component. But how a mechanical stress is perceived and how this signal is transduced into the cell to exert these effects is still poorly understood, and remains challenging questions in both the plant and animal community.
Among the structural components of plant cells (cell wall, cytoskeleton…), the plasma membrane has received very little attention. Our group at the ZMBP Tübingen investigates the role of membrane lipids at the nexus between plant morphogenesis and mechanics using Arabidopsis as a model. For more information, visit our website "Stanislas Lab ZMBP“.

PhD project: In order to understand at the molecular level, the role of the lipid composition of the PM for mechano-sensing, it is needed to simplify the system. This will allow to test a wide range of hypothesis and to clearly make a link between a mechanical stimulus and a molecular response.
The selected PhD candidate will have to develop a microfluidic device to induce and quantify of mechanical signals at the cell level.

References:
A phosphoinositide map at the shoot apical meristem in Arabidopsis thaliana, Stanislas T, Platre M, Liu M, Rambaud L, Jaillais Y, Hamant H, BMC Biology, 16:20 (2018)
In-vivo analysis of morphogenesis in plants Stanislas T, Hamant O, Traas J, Methods in Cell Biology, 139:203-223 (2017)
A PtdIns(4)P-driven electrostatic field controls cell membrane identity and signalling in plants. Simon ML, Platre MP, Marques Bueno MM, Armengot L, Stanislas T, Bayle V, Caillaud MC, Jaillais Y, Nature Plant, 20, 2, 16089 (2016)


Requirements/Qualifications: We are looking for highly motivated candidates with a master degree in biology, engineering sciences, nanotechnology, biophysics or equivalent. Specific skills in microfluidics is highly advantageous. Prior experience with confocal microscopy is a plus but not required. Good English communication skills as well as excellent teamwork abilities are expected.
The position is available immediately. Application will be accepted until the position is filled. Please send your application in English as a composite pdf-file (letter of motivation stating your research interests, CV, name and addresses of at least two referees) to thomas.stanislasspam prevention@zmbp.uni-tuebingen.de

The ZMBP is a world‐class center for Plant Biology research and is situated in a brand-new and well-equipped building in the University of Tübingen science campus. The University of Tübingen is an equal opportunity employer and particularly welcomes applications from qualified women and individuals with disabilities. Formal employment procedures will be carried out by the central administration of the University of Tübingen.

 

 

13.12.18

PhD position available in plant three-dimensional genomics

A PhD position is available from 1st April 2019 in the laboratory of Dr. Chang Liu
at Zentrum für Molekularbiologie der Pflanzen (ZMBP) in University of Tübingen. This
position remains open until it is filled; the contract is for 3 years (including an initial 6-
month probation period) with a possibility to extend. The salary and benefits are based
on the German public service TV-L pay scale and are commensurate with training and
experience.

Our team works on investigating 3D-chromatin structures in plants, and we aim to
understand the interplay between 3D-chromatin organization and transcriptional
regulation in response to developmental cues and environmental changes. From a
structural point of view, by combining high throughput sequencing, computing, and
modern molecular biology approaches, much of our work has been focused on
integrative genome-wide analysis on chromatin folding, transcriptome, and epigenetic
marks.

You will be working on a project about perinuclear chromatin anchoring in plants. This
project is closely related to our recent findings showing preferential perinuclear
localization of repressed chromatin in Arabidopsis thaliana (PMID: 28385710). You will
be using various molecular and bioinformatic tools to unveil the mechanisms by which
specific chromatin regions are tethered to the nuclear periphery.

To apply, you should have a Master or equivalent degree in Biology or Bioinformatics
(or related areas). Please send your application materials as a single pdf file containing
a detailed curriculum vitae, a motivation letter, and contact details of at least two
referees to: chang.liuspam prevention@zmbp.uni-tuebingen.de

The University of Tübingen is an equal opportunity employer. Disabled candidates will
be given preference over other equally qualified applicants. The University seeks to
raise the number of women in research and teaching and therefore urges qualified
women to apply. The appointment is facilitated by the central administration.
The working language in ZMBP is English, for more details about ZMBP and its
graduate program, please visit:
http://www.zmbp.uni-tuebingen.de/zmbp.html

 

Permanent advertisement

Am Zentrum für Molekularbiologie der Pflanzen (ZMBP), Abt. Entwicklungsgenetik, werden hochmotivierte

Doktorand(inn)en

Bachelor

für DFG-finanzierte Projekte zu den Themen Zellpolarität, Zellkommunikation, Cytokinese gesucht.

Weitere Information in: Weijers et al., 2006, Dev. Cell 10, 265; Geldner et al., 2003, Cell 112, 219; Richter et al., 2007, Nature 448, 488; Reichardt et al., 2007, Curr. Biol. (in press).

Erfahrungen in Genetik, Molekularbiologie, Proteinbiochemie oder Zellbiologie sowie gute Englisch-Kenntnisse sind erwünscht. Bitte senden Sie Ihre Bewerbung mit der Angabe von 3 möglichen Referenzen per email an:

Prof. Dr. Gerd Jürgens, ZMBP-Entwicklungsgenetik, Universität Tübingen,

Auf der Morgenstelle 32, 72076 Tübingen, Tel. 07071/29 78887,

e-mail: gerd.juergens(at)zmbp.uni-tuebingen.de

Permanent advertisement

The Center for Molecular Biology of Plants, Developmental Genetics, is seeking highly qualified

PhD students

Bachelor or MSc students

in the areas of cell polarity, cell-cell communication, cytokinesis (DFG-funded projects). For more information, see Weijers et al., 2006, Dev. Cell 10, 265; Geldner et al., 2003, Cell 112, 219; Richter et al., 2007, Nature 448, 488; Reichardt et al., 2007, Curr. Biol. (in press).

The successful candidates are highly motivated, proficient in English and experienced in genetics, molecular biology, cell biology or biochemistry. Please send your application including names of 3 potential referees by e-mail to:

Prof. Dr. Gerd Jürgens, ZMBP-Entwicklungsgenetik, Universität Tübingen,

Auf der Morgenstelle 32, 72076 Tübingen, Tel. 07071/29 78887,

e-mail: gerd.juergens(at)zmbp.uni-tuebingen.de


Undergraduate students (Bachelor, Master)

9.12.19

The Timmermans research group has an opening for a Masters Thesis project:

High-throughput CRISPR-CAS screening for small RNA mobility factors

During this project, you will learn how to:

  • set up and manage a reverse genetic screen.
  • use gateway cloning, and create genetically stable plant lines.
  • use genome editing by the CRISPR-CAS system.
  • take advantage of high-throughput amplicon sequencing for mutant identification.
  • use proximity labeling of proteins using TurboID.
  • write a master thesis in the style of a research journal article and to present your results to the scientific community.

MicroRNAs (miRNAs) are a class of non-coding small RNAs involved in a wide range of biological processes. Plants use miRNAs as signaling molecules to control developmental processes similar to morphogens in animals. Despite their central importance, it is still unknown how miRNAs move from one cell to another. We recently showed that miRNA mobility is regulated at individual cell-cell interfaces1. However, the molecular mechanism of this regulation is not understood. Solving this question will be the focus of the master project.
We are an international research group located in the ZMBP. During your stay, you will interact with experienced researchers who will provide supervision and ensure a productive training period. You will gain experience with cutting-edge technologies and, after an initial training period, will be able to work independently. Of course, help is always at hand. The project is set up and a preferable starting period is the beginning of 2020. If you are interested, please send your CV and brief introduction outlining your goals and interests to Simon Klesen.
1Skopelitis, Damianos S., et al. "Gating of miRNA movement at defined cell-cell interfaces governs their impact as positional signals." Nature communications 9.1 (2018): 3107.
Timmermans research group: https://uni-tuebingen.de/de/63353
Contact person: simon.klesenspam prevention@uni-tuebingen.de

 

6.11.18
 

Master Thesis Project

“Design and Characterization of a Nanosensor for In Vivo Turgor Measurements in Plant Cells”

The turgor of plant cells is crucial for plant stability and survival. Environmental cues such as drought or altered osmotic pressure lead to the change in turgor pressure having many functional consequences for the plant cell.

Therefore, the monitoring of the turgor pressure in the living plant cell is of great interest However, there is presently no technique to follow turgor changes in real time in living plant cells at cellular resolution.

Based on molecular, biochemical and biophysical considerations we, the research groups of Erik Schäffer and Klaus Harter, developed a concept and strategy for the making of a Förster Resonance Energy Transfer (FRET)-based, genetically encoded nanosensor that should facilitate the measurement of dynamic changes in the plant cell´s turgor.

The thesis work is mainly about

  • Cloning of the nanosensor gene on the basis of already available DNA fragments using the Golden Gate technology
  • Transformation of the nanosensor construct into plant cells and analysis of its expression and intracellular localization by (confocal) light microscopy
  • Determination of the nanosensor´s FRET efficiency under dynamic osmotic stress conditions using spectro-microscopical approaches (e.g. Fluorescence Lifetime Imaging: FLIM)

In addition to biology students with molecular background, the work might also be of interest for master students in Nano-Science and Biochemistry.

We offer an innovative and scientifically stimulating environment, and cutting-edge techniques. The position is available immediately.

For further information, please contact:

Prof. Dr. Klaus Harter
ZMBP/Plant Physiology

3. Etage, room 3R19

Auf der Morgenstelle 32

72076 Tübingen, Germany

+49 (0)7071 2972605

klaus.harterspam prevention@zmbp.uni-tuebingen.de

 

 

 

14.8.18

Master and or Bachelor Thesis in Plant Pathogen Interactions (RG El Kasmi)

Our research group in the Department for Plant Physiology at the Center for Plant Molecular Biology (ZMBP), University of Tübingen, is offering the possibility for a highly motivated Master and or Bachelor (of Biology, Biochemistry or Cellular Nanoscience) student to do her/his thesis project in our lab.

We are currently working on the characterization of interactors of a plant immune receptor of the NLR family. We would like to validate the preliminary results (interactions observed in yeast-2-hybrid screen) and to further cell biologically, genetically and biochemically characterize the function of the identified proteins during (NLR-mediated) immunity.
The project will include the following methods:
•    Molecular analysis (cloning, bacterial transformation, etc.)
•    In planta Protein-protein interaction studies (co-immunoprecipitation, BiFC and FRET interaction assays)
•    Genetic studies (crosses, genotyping, etc.)
•    Plant infection assays
We offer an innovative and scientifically stimulating environment, a well-equipped lab as well as an international and cooperative research team.
For applying, please send an email with a short motivation statement to Dr. Farid El Kasmi at farid.el-kasmispam prevention@zmbp.uni-tuebingen.de
For more details about the ZMBP and our research, please visit:
http://uni-tuebingen.de/fakultaeten/mathematisch-naturwissenschaftliche-fakultaet/fachbereiche/zentren/zmbp/res/plant-physiology/research-groups/elkasmi/

 

Permanent advertisement

Master and/or Bachelor Thesis in Plant Biochemistry

Our research group in the Department for Plant Biochemistry at the Center for Plant Molecular Biology (ZMBP), University of Tübingen, is seeking highly motivated Master and Bachelor students.

Our department is working on the characterization of plant immunity receptors and their regulators, as well as downstream signaling pathways.

Projects generally include the following methods:

  • Generation of plant mutants and their characterization
  • Recombinant protein expression and purification
  • In vitro and in vivo phosphorylation experiments
  • Protein-protein interaction studies (co-immunoprecipitation, yeast two-hybrid and FRET-FLIM interaction assays)
  • Molecular and physiological studies (cloning, real time-PCR, etc.)
  • Plant infection assays

We offer an innovative and scientifically stimulating environment, a well-equipped lab as well as an international and cooperative research team. You should apply if you are a biology or biochemistry student who is enthusiastic about science and keen on learning new techniques.

For applying, please send an email with a short motivation statement (attachments as pdf-files only) to andrea.gustspam prevention@zmbp.uni-tuebingen.de

For more details about the ZMBP, please visit:

http://www.zmbp.uni-tuebingen.de/zmbp.html

 



Sorry, no open positions available


Technical staff (Technische Angestellte)

 

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Student lab assistants (Wissenschaftliche Hilfskräfte)

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Administration staff (Verwaltungskräfte)

 

 

 

- Sorry, no open positions available
 

 

 


Gardeners and Technical Support staff (Gärtnerei- und Werkstattpersonal, Hausmeisterei)

 

 

 

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Sorry, no open positions available