Interfaculty Institute of Biochemistry (IFIB)

Selected publications

Vera Hagmann, Stefanie Sommer, Patrick Fabian, Jan Bierlmeier, Nadine van Treel, Henning D. Mootz, Dirk Schwarzer, Jorge E. Azevedo & Gabriele Dodt (2018). Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery. 
Scientific Reports  8:16014. DOI:10.1038/s41598-018-34200-5

Ana G. Pedrosa, Tânia Francisco, Diana Bicho, Ana F. Dias, Aurora Barros-Barbosa, Vera Hagmann, Gabriele Dodt, Tony A. Rodrigues, and Jorge E. Azevedo. (2018). Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.  J. Biol. Chem. 293:11553. doi:10.1074/jbc.RA118.003669

Giannopoulou EA, Emmanouilidis L, Sattler M , Dodt G, Wilmanns, M. 2015. Towards the molecular mechanism of the integration of peroxisomal membrane proteins.
Biochim. Biophys. Acta,

Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M. 2014. PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox-Sensitive Protein.
Traffic,15(1):94-103. Epub 2013 Oct 31. Abstract

Dietrich D, Seiler F, Essmann F, Dodt G. 2013. Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells.
Biochim. Biophys. Acta, 1833(12):3013-24. Epub 2013 Aug 13. Abstract

Schmidt F, Dietrich D, Eylenstein R, Groemping Y, Stehle T, Dodt G. 2012. The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis.
Traffic, 13(9):1244-60. Epub 2012 Jun 19. Abstract

Pergola C, Rogge A, Dodt G, Northoff H, Weinigel C, Barz D, Rådmark O, Sautebin L, Werz O. 2011. Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes.
FASEB J., 25(10):3377-87. Epub 2011 Jun 21. Abstract

Delille HK, Dodt G, Schrader M. 2011. Pex11pβ-mediated maturation of peroxisomes.
Commun. Integr. Biol., 4(1):51-4. 2011 Jan. Abstract

Schmidt F, Treiber N, Zocher G, Bjelic S, Steinmetz MO, Kalbacher H, Stehle T, Dodt G. 2010. Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19.
J Biol Chem., 285(33):25410-7. Epub 2010 Jun 16. Abstract

Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, Hoffmann M, Hoernig C, Fischer L, Steinhilber D, Franke L, Schneider G, Rådmark O, Sautebin L, Werz O. 2009. Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
Cell Mol Life Sci. , 66(16):2759-71. Epub 2009 Jul 5. Abstract

Pergola C, Dodt G, Rossi A, Neunhoeffer E, Lawrenz B, Northoff H, Samuelsson B, Rådmark O, Sautebin L, Werz O. 2008. ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma.
Proc Natl Acad Sci U S A., 105(50):19881-6. Epub 2008 Dec 8. Abstract

Albert D, Pergola C, Koeberle A, Dodt G, Steinhilber D, Werz O. 2008. The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes.
J Leukoc Biol., 83(4):1019-27. Epub 2008 Jan 24. Abstract

Fischer L, Hornig M, Pergola C, Meindl N, Franke L, Tanrikulu Y, Dodt G, Schneider G, Steinhilber D, Werz O. 2007. The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.
Br J Pharmacol., 152(4):471-80. Epub 2007 Aug 20. Abstract

Qutob D, Kemmerling B, Brunner F, Kufner I, Engelhardt S, Gust AA, Luberacki B, Seitz HU, Stahl D, Rauhut T, Glawischnig E, Schween G, Lacombe B, Watanabe N, Lam E, Schlichting R, Scheel D, Nau K, Dodt G, Hubert D, Gijzen M and T Nurnberger. 2006. Phytotoxicity and Innate Immune Responses Induced by Nep1-Like Proteins.
Plant Cell, 18(12):3721-44. Epub 2006 Dec 28. Abstract

Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, and HW Moser. 2006. Peroxisome biogenesis disorders.
Biochim Biophys Acta. 1763(12):1733-1748. Abstract

Frommer KW, Reichenmiller K, Schutt BS, Hoeflich A, Ranke MB, Dodt G, and MW Elmlinger. 2006. IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T.
J Mol Endocrinol 37(1):13-23. Abstract

Muntau, A.C., A.A. Roscher, W.H. Kunau, and G. Dodt. 2003.
The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis.
Eur J Cell Biol 82(7):333-342. Abstract

Thieringer H, Moellers B, Dodt G, Kunau WH, and M Driscoll. 2003. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans.
J Cell Sci 116:1797-804 Abstract

Muntau, A.C., A.A. Roscher, W.H. Kunau, and G. Dodt. 2003. Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).
Adv Exp Med Biol 544:221-224. Abstract

Dodt, G., and C. Walter. 2003. Study of mutant proteins with folding defects in cultured patient cells.
Methods Mol Biol 232:165-173. Abstract

Walter, C., J. Gootjes, P.A. Mooijer, H. Portsteffen, C. Klein, H.R. Waterham, P.G. Barth, J.T. Epplen, W.H. Kunau, R.J. Wanders, and G. Dodt. 2001. Disorders of peroxisome biogenesis due to mutations in PEX1: phenotypes and PEX1 protein levels.
Am J Hum Genet 69(1):35-48. Abstract

Dodt, G., D. Warren, E. Becker, P. Rehling, and S.J. Gould. 2001. Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p.
J Biol Chem 276(45):41769-41781. Abstract

Dodt, G., D.G. Kim, S.A. Reimann, B.E. Reuber, K. McCabe, S.J. Gould, and S.J. Mihalik. 2000. L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases.
Biochem J 345 Pt 3:487-494. Abstract

Dodt, G., D. Kim, S. Reimann, K. McCabe, S.J. Gould, and S.J. Mihalik. 2000. The human L-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than D-amino acid oxidases.
Cell Biochem Biophys 32 Spring:313-316. Abstract

Soukupova, M., C. Sprenger, K. Gorgas, W.H. Kunau, and G. Dodt. 1999. Identification and characterization of the human peroxin PEX3.
Eur J Cell Biol 78(6):357-374. Abstract

Reuber, B.E., C. Karl, S.A. Reimann, S.J. Mihalik, and G. Dodt. 1997. Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase.
J Biol Chem 272(10):6766-6776. Abstract

Portsteffen, H., A. Beyer, E. Becker, C. Epplen, A. Pawlak, W.H. Kunau, and G. Dodt. 1997. Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders.
Nat Genet 17(4):449-452. Abstract

Dodt, G., and S.J. Gould. 1996. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor.
J Cell Biol 135(6 Pt 2):1763-1774. Abstract

Dodt, G., N. Braverman, D. Valle, and S.J. Gould. 1996. From expressed sequence tags to peroxisome biogenesis disorder genes.
Ann N Y Acad Sci 804:516-523. Abstract

Distel, B., R. Erdmann, S.J. Gould, G. Blobel, D.I. Crane, J.M. Cregg, G. Dodt, Y. Fujiki, J.M. Goodman, W.W. Just, J.A. Kiel, W.H. Kunau, P.B. Lazarow, G.P. Mannaerts, H.W. Moser, T. Osumi, R.A. Rachubinski, A. Roscher, S. Subramani, H.F. Tabak, T. Tsukamoto, D. Valle, I. van der Klei, P.P. van Veldhoven, and M. Veenhuis. 1996. A unified nomenclature for peroxisome biogenesis factors.
J Cell Biol 135(1):1-3. Abstract

Dodt, G., N. Braverman, C. Wong, A. Moser, H.W. Moser, P. Watkins, D. Valle, and S.J. Gould. 1995. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders.
Nat Genet 9(2):115-125. Abstract