Interfaculty Institute of Microbiology and Infection Medicine

List of Publications


Dr. Christopher Weidenmaier


  1. Wanner S. , Schade J., Keinhörster D., Weller N., Kull L., Bauer J., Schade J. ,Grau T.,Winstel V. , Kretschmer D.,Kolata J.Wolz, C. Bröker B., Weidenmaier C. Wall teichoic acids mediate increased virulence in Staphylococcus aureus. Nature Microbiology 13;2:17048.
  2. Zipperer A, Konnerth C, Laux C, Berscheid A , Janek D, Weidenmaier C, Burian M, Schilling N, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Birgit Schittek, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B 2016. Human commensals producing a novel antibiotic impair pathogen colonization. Nature 535:511-6.
  3. Schade J, Weidenmaier C 2016. Cell wall glycopolymers of Firmicutes and their role as non-protein adhesins. FEBS Letters epub ahead of print.
  4. Prax M, Mechler L, Weidenmaier C and Bertram R. 2016. Glucose Augments Killing Efficiency of Daptomycin Challenged Staphylococcus aureus Persisters. PLoS One 9;11(3):e0150907.
  5. Sheikh S, Sturzu A, Kalbacher H, Nägele T, Weidenmaier C, Horger M, Schwentner C, Ernemann U, Heckl S. Fluorescein-labeled Bacitracin and Daptomycin Conjugates: Synthesis, Fluorescence Imaging and Evaluation. Med Chem epub ahead of print.
  6. Weidenmaier C, Lee JC. 2016. Structure and Function of Surface Polysaccharides of Staphylococcus aureus. Curr Top Microbiol Immunol epub ahead of print.
  7. Sturzu A, Sheikh S, Echner H, Deeg M, Nägele T, Weidenmaier C, Schwentner C, Horger M, Ernemann U, Heckl S.2015. Chemosensitization of prostate carcinoma cells with a receptor-directed Smac conjugate. Med Chem epub ahead of print.
  8. Wistel V., Kühner P., Salomon F., Larsen J., Skov R., Hoffmann W., Peschel A., Weidenmaier C. 2015. Wall teichoic acid glycosylation governs Staphylococcus aureus nasal colonization. mBio 6:e00632.
  9. Willmann, M., M. El-Hadidi, D. H. Huson, M. Schutz, C. Weidenmaier, I. B. Autenrieth, and S. Peter. 2015. Antibiotic selection pressure determination through sequence-based metagenomics. Antimicrob Agents Chemother. epub ahead of print
  10. Geroge S., Nguyen T., Geiger T., Weidenmaier C., Lee JC, Liese J and Christiane Wolz. 2015. Phenotypic Heterogeneity and Temporal Expression of the Capsular Polysaccharide Only Partially Depends on Quorum Sensing in Staphylococcus aureus. Mol Microbiol. epub ahead of print
  11. Kolata, J., Kuhbandner, I., Link, C., Normann, N., Hai Vu, C., Steil, L., Weidenmaier, C., and Broeker, B.M. 2015. The fall of a dogma? Unexpected high T cell memory response to S. aureus in humans. J Infect Dis 212:830-8.
  12. Willmann M, Bezdan D, Zapata L, Susak H, Vogel w, Schröppel K, Liese J, Weidenmaier C, Autenrieth I, Ossowski S, Peter S. 2014. Analysis of a long-term outbreak of extensively drug-resistant Pseudomonas aeruginosa: a molecular epidemiological study. J Antimicrob Chemother 70:1322-30
  13. Mishra NN, Bayer AS, Weidenmaier C, Grau T, Wanner S, Stefanie S, Cafiso V, Bertuccio T, Yeaman MR, Nast CC, Yang SJ. 2014. Phenotypic and Genotypic Characterization of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Strains: Relative Roles of mprF and dlt Operons. PLoS One 16:e107426
  14. Sheikh S, Sturzu A, Kalbacher H, Nagele T, Weidenmaier C, Horger M, Ernemann U, Heckl S. 2014. Fluorescence imaging of human cells with a novel conjugate of the antifungal nystatin. Med Chem 10:348-354.
  15. Krismer B, Liebeke M, Janek D, Nega M, Rautenberg M, Hornig G, Unger C, Weidenmaier C, Lalk M, Peschel A. 2014. Nutrient limitation governs Staphylococcus aureus metabolism and niche adaptation in the human nose. PLoS Pathog 10:e1003862.
  16. Baur S, Rautenberg M, Faulstich M, Grau T, Severin Y, Unger C, Hoffmann WH, Rudl T, Autenrieth IB, Weidenmaier C. 2014. A Nasal Epithelial Receptor for Staphylococcus aureus WTA Governs Adhesion to Epithelial Cells and Modulates Nasal Colonization. PLoS Pathog 10:e1004089.
  17. Bertsche, U., S. J. Yang, D. Kuehner, S. Wanner, N. N. Mishra, T. Roth, M. Nega, A. Schneider, C. Mayer, T. Grau, A. S. Bayer, and C. Weidenmaier. 2013. Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. PLoS One 8:e67398.
  18. Pappelbaum, K. I., C. Gorzelanny, S. Grassle, J. Suckau, M. W. Laschke, M. Bischoff, C. Bauer, M. Schorpp-Kistner, C. Weidenmaier, R. Schneppenheim, T. Obser, B. Sinha, and S. W. Schneider. 2013. Ultralarge von Willebrand factor fibers mediate luminal Staphylococcus aureus adhesion to an intact endothelial cell layer under shear stress. Circulation 128:50-9.
  19. Simanski, M., R. Glaser, B. Koten, U. Meyer-Hoffert, S. Wanner, C. Weidenmaier, A. Peschel, and J. Harder. 2013. Staphylococcus aureus subverts cutaneous defense by d-alanylation of teichoic acids. Exp Dermatol 22:294-6.
  20. Weidenmaier, C., C. Goerke, and C. Wolz. 2012. Staphylococcus aureus determinants for nasal colonization. Trends Microbiol 20:243-50.
  21. Bertsche, U*., C. Weidenmaier*,1, D. Kuehner, S. J. Yang, S. Baur, S. Wanner, P. Francois, J. Schrenzel, M. R. Yeaman, and A. S. Bayer. 2011. Correlation of daptomycin resistance in a clinical Staphylococcus aureus strain with increased cell wall teichoic acid production and D-alanylation. Antimicrob Agents Chemother 55:3922-8. *contributed equally, 1corresponding author
  22. Park, S., K. A. Kelley, E. Vinogradov, R. Solinga, C. Weidenmaier, Y. Misawa, and J. C. Lee. 2010. Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus. J Bacteriol 192:4618-26.
  23. Weidenmaier, C., R. M. McLoughlin, and J. C. Lee. 2010. The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism. PLoS One 5:e13227.
  24. Kohler, T., C. Weidenmaier, and A. Peschel. 2009. Wall teichoic acid protects Staphylococcus aureus against antimicrobial fatty acids from human skin. J Bacteriol 191:4482-4.
  25. Koprivnjak, T., C. Weidenmaier, A. Peschel, and J. P. Weiss. 2008. Wall teichoic acid deficiency in Staphylococcus aureus confers selective resistance to mammalian group IIA phospholipase A(2) and human beta-defensin 3. Infect Immun 76:2169-76.
  26. Weidenmaier, C., and A. Peschel. 2008. Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions. Nat Rev Microbiol 6:276-87.
  27. Weidenmaier, C., J. F. Kokai-Kun, E. Kulauzovic, T. Kohler, G. Thumm, H. Stoll, F. Gotz, and A. Peschel. 2008. Differential roles of sortase-anchored surface proteins and wall teichoic acid in Staphylococcus aureus nasal colonization. Int J Med Microbiol 298:505-13.
  28. Bera, A., R. Biswas, S. Herbert, E. Kulauzovic, C. Weidenmaier, A. Peschel, and F. Gotz. 2007. Influence of wall teichoic acid on lysozyme resistance in Staphylococcus aureus. J Bacteriol 189:280-3.
  29. Kristian, S. A., V. Datta, C. Weidenmaier, R. Kansal, I. Fedtke, A. Peschel, R. L. Gallo, and V. Nizet. 2005. D-alanylation of teichoic acids promotes group a streptococcus antimicrobial peptide resistance, neutrophil survival, and epithelial cell invasion. J Bacteriol 187:6719-25.
  30. Weidenmaier, C., A. Peschel, V. A. Kempf, N. Lucindo, M. R. Yeaman, and A. S. Bayer. 2005. DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model. Infect Immun 73:8033-8.
  31. Weidenmaier, C., A. Peschel, Y. Q. Xiong, S. A. Kristian, K. Dietz, M. R. Yeaman, and A. S. Bayer. 2005. Lack of wall teichoic acids in Staphylococcus aureus leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditis. J Infect Dis 191:1771-7.
  32. Weidenmaier, C., J. F. Kokai-Kun, S. A. Kristian, T. Chanturiya, H. Kalbacher, M. Gross, G. Nicholson, B. Neumeister, J. J. Mond, and A. Peschel. 2004. Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections. Nat Med 10:243-5.
  33. Weidenmaier, C., S. A. Kristian, and A. Peschel. 2003. Bacterial resistance to antimicrobial host defenses-an emerging target for novel antiinfective strategies? Curr Drug Targets 4:643-9.
  34. Collins, L. V., S. A. Kristian, C. Weidenmaier, M. Faigle, K. P. Van Kessel, J. A. Van Strijp, F. Gotz, B. Neumeister, and A. Peschel. 2002. Staphylococcus aureus strains lacking D-alanine modifications of teichoic acids are highly susceptible to human neutrophil killing and are virulence attenuated in mice. J Infect Dis 186:214-9.

Additional Publications: Conference abstracts, book chapters, comments etc.

  1. Weidenmaier, C., Janek, D., Kokai-kun, J. Peschel A. Crucial role of MPRF-mediated defensin resistance in Staphylococcus aureus nasal colonization. 2014. Old Herborn University Seminar Monograph 28: 43-47
  2. Weidenmaier, C., S. Wanner, M. Rautenberg, S. Baur, and L. Kull. 2011. Structure-function relationship of zwitterionic cell wall polymer dependent immune modulatory mechanisms. International Journal of Medical Microbiology 301:91-91.
  3. Kohler, T., C. Weidenmaier, and A. Peschel. 2008. An easy prey for the innate immunity: The influence of wall teichoic acid in resistance against antimicrobial fatty acids. International Journal of Medical Microbiology 298:86-86.
  4. Kohler, T., E. Kulauzovic, C. Weidenmaier, and A. Peschel. 2007. Nasal colonization, the major source of Staphylococcus aureus infections, is a multifactorial process involving surface protein and wall teichoic acid-mediated interactions. International Journal of Medical Microbiology 297:127-127.
  5. Kohler, T., C. Weidenmaier, J. Kokai-Kun, E. Kulauzovic, G. Thumm, F. Gotz, J. Mond, and A. Peschel. 2006. Surface anchored proteins and wall teichoic acids are required for nasal colonization by Staphylococcus aureus. International Journal of Medical Microbiology 296:145-146.
  6. Weidenmaier, C., 2006. Wandteichonsäure von Staphylococcus aureus: Schlüsselmolekül für Kolonisation and Infektion. Biospektrum 12: 446
  7. Fedtke, I., C. Weidenmaier, G. Nicholson, F. Gotz, and A. Peschel. 2004. Lipoteichoic acids (LTA): Cell wall polymers with key roles in Staphylococcus aureus virulence. International Journal of Medical Microbiology 294:87-87.
  8. Weidenmaier, C., J. F. Kokai-Kun, and A. Peschel. 2004. Nasal colonization by Staphylococcus aureus - Reply. Nature Medicine 10:447-447.

Patent(s):

Wall teichoic acid as a target for anti-staphylococcal therapies and vaccines

USPTO Applicaton #: #20040247605 - Class: 424184100 (USPTO)