Novel Targets - Mode of Action Studies - Antibacterial Drug Discovery
Since the 1940s we have experienced the impressive potential of antibiotics in reducing morbidity and mortality. However, this achievement is severely threatened by bacterial resistance development. Worse, the number of antibiotic drug approvals is constantly declining.
There is an urgent need to evaluate novel antimicrobial agents with new modes of action that are devoid of cross-resistances to current therapeutics (...more). Considering the strong ability of bacteria to respond to any antibiotic treatment by genetic as well as physiological adaptations, it is important to study and develop successful antibacterial mechanisms with reduced potential for resistance development (...more).