Interfaculty Institute of Microbiology and Infection Medicine

Publications

   
28. Pan S, Malik IT, Thomy D, Henrichfreise B, Sass P. The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci. Sci Rep. 9(1):14129. doi: 10.1038/s41598-019-50505-5 (2019). 
27. Tribelli PM, Luqman A, Nguyen MT, Madlung J, Fan SH, Macek B, Sass P, Bitschar K, Schittek B, Kretschmer D, Götz F. Staphylococcus aureus Lpl protein triggers human host cell invasion via activation of Hsp90 receptor. Cell Microbiol. e13111. doi: 10.1111/cmi.13111 (2019). 
26.

Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P, Brötz-Oesterhelt H. The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor. Appl. Environ. Microbiol. doi:10.1128/AEM.01292-19 (2019).

25. Mayer C, Sass P*, Brötz-Oesterhelt H*. Consequences of dosing and timing on the antibacterial effects of ADEP antibiotics. Int J Med Microbiol. 151329. doi: 10.1016/j.ijmm.2019.151329 (2019). 
24. Luqman A, Ebner P, Reichert S, Sass P, Kabagema-Bilan C, Heilmann C, Ruth P, Götz F. A new host cell internalisation pathway for SadA-expressing staphylococci triggered by excreted neurochemicals. Cell Microbiol. e13044. doi: 10.1111/cmi.13044 (2019). 
23.

Sass P. Molekulare Antibiotikaforschung: neue Wirkprinzipien gegen multiresistente Keime. Biospektrum 25: 463. https://doi.org/10.1007/s12268-019-1076-0 (2019). 

22.

Wang H, Kraus F, Popella P, Baykal A, Guttroff C, François P, Sass P, Plietker B, Götz F. The polycyclic polyprenylated acylphloroglucinol antibiotic PPAP 23 targets the membrane and iron metabolism in Staphylococcus aureus. Front Microbiol doi: 10.3389/fmicb.2019.00014 (2019).

21.

Reichert S, Ebner P, Bonetti EJ, Luqman A, Nega M, Schrenzel J, Spröer C, Bunk B, Overmann J, Sass P, François P, Götz F. Genetic adaptation of a mevalonate pathway deficient mutant in Staphylococcus aureus. Front Microbiol doi: 10.3389/fmicb.2018.01539 (2018).

20. Perez R, Wörmer LP, Sass P, Maldener, I. 2017. A highly asynchronous developmental program triggered during germination of dormant akinetes of the filamentous diazotrophic cyanobacteria. FEMS Microbiol Ecol. 94(1). doi: 10.1093/femsec/fix131 (2018).
19. Sass P. 2017. Antibiotics: Precious Goods in Changing Times. Methods Mol Biol. 2017;1520:3-22.
18.

Sass P. 2017. Antibiotics: Methods and Protocols, Methods in Molecular Biology, vol. 1520, Peter Sass (ed.), DOI 10.1007/978-1-4939-6634-9_1, © Springer Science+Business Media New York 2017

17.

Hardt P, Engels I, Rausch M, Gajdiss M, Ulm H, Sass P, Ohlsen K, Sahl HG, Bierbaum G, Schneider T, Grein F. 2017. The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus. Int. J. Med. Microbiol. 307(1):1-10. doi: 10.1016/j.ijmm.2016.12.001.

16.

Famulla, K., P. Sass, I. Malik, T. Akopian, O. Kandror, M. Alber, B. Hinzen, H. Ruebsamen-Schaeff, R. Kalscheuer, A.L. Goldberg, H. Brötz-Oesterhelt. 2016. „Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.” Mol Microbiol. (2016) 101(2):194-209.

15.

Gersch, M., K. Famulla, M. Dahmen, C. Göbl, I. Malik, K. Richter, V.S. Korotkov, P. Sass, H. Rübsamen-Schaeff, T. Madl, H. Brötz-Oesterhelt, S.A. Sieber. 2015. „AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.” Nature Commun. (2015), 6:6320.

14.

Brötz-Oesterhelt, H., and P. Sass. 2014. “Bacterial caseinolytic proteases as novel targets for antibacterial treatment.” Int J Med Microbiol. (2014); 304(1):23-30. doi: 10.1016/j.ijmm.2013.09.001.

13.

Berscheid, A., P. François, A. Strittmatter, G. Gottschalk, J. Schrenzel, P. Sass*, G. Bierbaum*. 2014. „Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS.” J Antimicrob Chemother. (2014), 69(12):3190-8.

12.

Sass, P., and H. Brötz-Oesterhelt, H. 2013. “Bacterial cell division as a target for new antibiotics.” Curr. Opin. Microbiol. (2013); 16(5):522-30. doi: 10.1016/j.mib.2013.07.006.

11.

Bara, R., I. Zerfass, A.H. Aly, H. Goldbach-Gecke, V. Raghavan, P. Sass, A. Mándi, V. Wray, P.L. Polavarapu, A. Pretsch, W. Lin, T. Kurtán, A. Debbab, H. Brötz-Oesterhelt, and P. Proksch. 2013. “Atropisomeric dihydro-anthracenones as inhibitors of multiresistant Staphylococcus aureus” J. Med. Chem. (2013), 56(8):3257-72.

10.

Brötz-Oesterhelt, H., and P. Sass. 2013. “Bacterial cell stress protein ClpP: A novel antibiotic target.” In: B. Henderson (ed.), “Moonlighting Cell Stress Proteins in Microbial Infections” in the series Heat Shock Proteins 7:375-385. Springer Netherlands, DOI 10.1007/978-94-007-6787-4_24, Print ISBN 978-94-007-6786-7, Online ISBN 978-94-007-6787-4.

9.

Sass, P., and H. Brötz-Oesterhelt. 2012. “Bacterial stress responses to antimicrobial agents.” In: H.C. Wong (ed.), Stress responses in foodborne microorganisms. Nova Science Publishers, Inc., ISBN: 978-1-61122-810-6.

8.

Sass, P.*, A. Berscheid*, A. Jansen, M. Oedenkoven, C. Szekat, A. Strittmatter, G. Gottschalk, and G. Bierbaum. 2012. “Genome sequence of Staphylococcus aureus VC40, a vancomycin and daptomycin resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics.” J. Bacteriol. (2012), 194(8):2107-08.

7.

Berscheid, A.*, P. Sass*, K. Weber-Lasalle, A.L. Cheung, and G. Bierbaum. 2012. “Revisiting the genomes of the Staphylococcus aureus strains NCTC 8325 and RN4220.” Int J Med Microbiol. (2012), 302(2):84-87.

6.

Sass, P, M. Josten, K. Famulla, G. Schiffer, H.-G. Sahl, L. Hamoen, and H. Brötz-Oesterhelt. 2011. „Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ.“ Proc Natl Acad Sci U S A. (2011), 108(42):17474-9.

5.

Brötz-Oesterhelt, H., and P. Sass. 2011. Molekulare Antibiotikaforschung – Neue Leitstrukturen und Wirkmechanismen gegen multiresistente Bakterien. Annual reports of the Heinrich Heine University of Düsseldorf.

4.

Brötz-Oesterhelt, H., and P. Sass. 2010. “Post-genomic strategies in antibacterial drug discovery.” Future Microbiology (2010); 5(10): 1553-1579.

3.

Sass, P., and G. Bierbaum. 2009. “Native graS mutation supports the susceptibility of Staphylococcus aureus strain SG511 to antimicrobial peptides.” Int J Med Microbiol. (2009); 299(5):313-22.

2.

Sass, P., A. Jansen, C. Szekat, V. Sass, H.-G. Sahl, and G. Bierbaum. 2008. „The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus.” BMC Microbiol. (2008); 8:186.

1.

Sass, P., and G. Bierbaum. 2007. “Lytic activity of recombinant bacteriophage ɸ11 and ɸ12 endolysins on whole cells and biofilms of Staphylococcus aureus.” Appl Environ Microbiol. (2007); 73(1):347-52.

*equal contribution