Interfaculty Institute of Biochemistry (IFIB)



Tashackori H, Sharifi M, Ahmadian Chashmi N, Fuss E, Behmanesh M, Safaie N (2018) RNAi-mediated silencing of pinoresinol lariciresinol reductase in Linum album hairy roots alters the phenolic accumulation in response to fungal elicitor. Journal of Plant Physiology 232, 115–126


Corbin C, Drouet S, Mateljak I, Markulin L, Decortil C, Renouard S, Lopez T, Doussot J, Lamblin F, Auguin D, Laine E, Fuss E, Hano C (2017) Functional characterization of the pinoresiol-lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response. Planta 246, 405-420


Raatz B, Eicker A, Schmitz G, Fuss E, Müller D, Rossmann S, Theres K (2011) Specific expression of LATERAL SUPPRESSOR is controlled by an evolutionary conserved 3` enhancer. The Plant Journal 68, 400-412


Hemmati S, von Heimendahl CBI, Klaes M, Alfermann AW, Schmidt TJ, Fuss E (2010) Pinoresinol-lariciresinol reductases with opposite enatiospecificity determine the enantiomeric composition of lignans in Linum usitatissimum L.. Planta Medica 76, 928-934

Schmidt TJ, Hemmati S, Klaes M, Konuklugil B, Mohagheghzadeh A, Ionkova I, Fuss E, Alfermann AW (2010) Lignans in flowering aerial parts of Linum species - Chemodiversity in the lights of systematics and phylogeny. Phytochemistry 71, 1714-1728

Ionkova I, Antonova I, Momekov G, Fuss E (2010) Production of podophyllotoxin in Linum linearifolium in vitro cultures. Pharmacognosy Magazine 6, 180-185


Ionkova I, Fuss E (2009) Influence of different strains of Agrobacterium rhizogenes on induction of hairy roots and lignan production in Linum tauricum ssp. tauricum. Pharmacognosy Magazine 4, 14-18


Schmidt T, Alfermann AW, Fuss E (2008) HPLC-MS identification of dibenzylbutyrolactone-type lignans: Insights into ESI-MS/MS fragmentation of lign-7-eno-9, 9'-lactones and application to the lignans of Linum usitatissimum L. (common flax) Rapid Communications in Mass Spectrometry 22, 3642-3650

Ionkova I, Goermova BP, Vasilev NP, Fuss E (2008) Lignan production in cell cultures of Linum tauricum ssp. tauricum. Phytologia Balcanica (im Druck)

Bayindir Ü, Alfermann AW, Fuss E (2008) Hinokinin biosynthesis in Linum strictum ssp. corymbulosum. The Plant Journal 55, 810-820

Ahmad Saufi, Alfermann AW, Fuss E (2008) The enantiomeric composition of lignans in Phaleria macrocarpa (Schef.) Boerl.. Zeitschrift für Naturforschung C 63c, 13-16

Vasilev N, Ebel R, Edrada RA, Fuss E, Alfermann AW, Ionkova I, Petrova A, Repplinger M, Schmidt TJ (2008) Metabolic profiling of lignan variability in Linum species of Section Syllinum native to Bulgaria. Planta Medica 74, 273-280


Konuklugil B, Ionkova I, Vasilev N, Schmidt TJ, Windhövel J, Fuss E, Alfermann AW (2007): Lignans from Linum species of sections Syllinum and Linum. Natural Product Research 21, 1-6

Hemmati S, Schmidt TJ, Fuss E (2007) (+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B. FEBS Letters 581, 603-610

Federolf K, Alfermann AW, Fuss E (2007) Aryltetralin formation in two different cell suspension cultures of Linum album: Deoxypodophyllotoxin 6-hydroxylase, a key-enzyme in the formation of 6-methoxypodophyllotoxin? Phytochemistry 68, 1397-1408

Ionkova I, Antonova I, Momekov G, Fuss E (2007) Cytotoxic activity of Bulgarian Linum species. Pharmacognosy Magazine 3, 192-195

Hemmati S, Federolf K, Alfermann AW, Fuss E (2007) Justicidin B 7-hydroxylase, a cytochrome P450 monoxygenase from cell cultures of L. perenne involved in the biosynthesis of diphyllin. Phytochemistry 68, 2736-2743


Mohagheghzadeh A, Schmidt TJ, Bayindir Ü, Fuss E, Mehregan I, Alfermann AW (2006): Diaryl­butyrolactone lignans from Linum corymbulosum in vitro cultures. Planta Medica 72, 1165-1167

Fuss E (2006): Gentechnische Experimente zur Beeinflussung der Lignanbiosynthese. Journal für Verbraucherschutz und Lebensmittelsicherheit Supplement 1, 131

Schmidt TJ, Hemmati S, Fuss E, Alfermann AW (2006): A combined HPLC-UV and HPLC/MS-MS method for the identification of lignans and its application to the lignans of Linum usitatissimum L. and Linum bienne L.. Phytochemical Analysis 17, 299-311


Van Fürden B, Humburg A, Fuss E (2005): Influence of methyl jasmonate on podophyllotoxin and 6-methoxypodophyllotoxin accumulation in cell suspension cultures of Linum album. Plant Cell Reports 24, 312-317

von Heimendahl CBI, Schäfer K, Eklund P, Sjöholm R, Schmidt TJ, Fuss E (2005): Pinoresinol-lariciresinol reductases with different stereospecificity Linum album and Linum usitatissimum. Phytochemistry 66, 1254-1263

Wink M, Alfermann AW, Franke R, Wetterauer B, Distl M, Windhövel J, Fuss E, Garden H, Mohagheghzadeh A, Wildi E, Ripplinger P (2005): Sustainable bioproduction of phytochemicals by plant in-vitro cultures: Anticancer agents. Plant Genetic Resources: characterization and utilization 3 (2), 90-100

Konuklugil B, Fuss E, Alfermann AW (2005): Isolation of the lignan 6-methoxy­podophyllotoxin from Linum boissieri and biosynthesis of lignans in this species. Pharmaceutical Biology 43, 737-739


Gidoni D, Fuss E, Burbidge A, Speckmann GJ, James S, Nijkamp D, Mett A, Feiler J, Smoker M, de Vroomen MJ, Leader D, Liharska T, Groenendijk J, Coppoolse E, Smit JJM, Levin I, de Both M, Schuch W, Jones JDG, Taylor IB, Theres K, van Haaren MJJ (2003): Multi-functional T-DNA/Ds tomato lines designed for gene cloning and molecular and physical dissection of the tomato genome. Plant Molecular Biology 51: 83-98


Petersen M, Szabo E, Meinhard J, Karwatzki B, Gertlowski C, Kempin B, Fuss E (1995): Biosynthesis and accumulation of rosmarinic acid in suspension cultures of Coleus blumei. Plant Cell Tissue Organ Culture 43: 89-93


Fuss E (2003): Lignans in plant cell and organ cultures: An overview. Phytochemistry Reviews 2, 307-320


Fuss E (2008) Stereochemistry in lignan biosynthesis. Planta Medica 74, 924

Fuhrmann HG, Boland W, Alfermann AW, Fuss E (2008) Influence of elicitation on the lignin biosynthesis in cell cultures of Linum album L.. Planta Medica 74, 1163

Hemmati S, Schneider B, Schmidt TJ, Federolf K, Alfermann AW, Fuss E (2008) Biosynthesis of justicidin B and diphyllin in cell cultures of Linum perenne L. Himmelszelt. Planta Medica 74, 1168

Bayindir Ü, Mohagheghzadeh A, Alfermann AW, Fuss E (2008) Hinokinin biosynthesis in Linum corymbulosum Reichenb.. Planta Medica 74, 1169


Windhövel J, Fuss E, Alfermann AW (2001): Die Biosynthese von cytotoxischen Lignanen in Linum album: Cinnamoyl-CoA: NADP Oxidoreduktase. Dtsch. Ges. Qualitätsforsch. (Pflanzl. Nahrungsmittel), Proc. XXXVI. Vortragstagung, S.159 - 164

Garden H, Fuss E, Alfermann AW (2001): Einfluss der Sauerstoffversorgung auf die Produktion von Podophyllotoxin durch pflanzliche Zellkulturen im Schlaufenreaktor. Dtsch. Ges. Qualitätsforsch. (Pflanzl. Nahrungsmittel), Proc. XXXVI. Vortragstagung, S. 165 - 170

Alfermann AW, Petersen M, Fuss E (2002) Production of natural products by plant cell biotechnology: results, problems and perspectives. In Laimer M and Rücker W (Eds.) Plant tissue culture, 100 years since Gottlieb Haberlandt. Springer Wien New York, S. 153 - 166

Fuss E, Windhövel J, Mohagheghzadeh M, Immeln D, Sommer S, Alfermann AW (2006) Genetic Manipulation of the lignan biosynthesis in hairy roots of Linum album Ky.. In Daayf F, El Hadrami A, Adam L, Balance GM (Eds.) Polyphenols Communications 2006, S. 69-70