Interfaculty Institute of Microbiology and Infection Medicine

Cellular and Molecular Microbiology

Section Head: Prof. Samuel Wagner, PhD

The Section of Cellular and Molecular Microbiology of the Institute of Medical Microbiology and Hygiene is headed by Samuel Wagner. Research in the section deals with assembly, structure, and function of bacterial virulence-associated secretion systems, in particular with type III secretion systems of Salmonella Typhimurium and the type IV secretion system of Legionella pneumophila.

News

27/08/2018 — Lea Krampens work on the secretion of membrane proteins through type III and type IVB secretion systems was published in Nature Communications.

09/08/2018 — A review article on bacterial type III secretion systems was published in FEMS Microbiology Letters.

09/7/2018 — An article on the regulation of (p)ppGpp synthetase und hydrolase that was co-authored by our group was published in PLoS Genetics.

02/7/2018 — An article on the structure of the core export apparatus of bacterial type III secretion systems that was co-authored by our group was published in Nature Structural and Molecular Biology.

06/02/2018 — Tobias Dietsche was awarded the DZIF-DGHM Promotionspreis 2018. The award ceremony is held at the DGHM annual meeting 2018 in Bochum (19-21/02/2018).

05/02/2018 — The BW Foundation selected our proposal on the development of a pathogenicity blocker against Salmonella for funding. Collaboration partners on this project are Prof. Antti Poso, UK Tübingen, Dr. Marcus Hartmann, MPI Tübingen and Prof. Mark Brönstrup, HZI Braunschweig.

17/01/2018 — An article on the structure of the core export apparatus of bacterial type III secretion sytems that was co-authored by our group was published as pre-print on bioRxiv.

07/12/2017 — Tobias Dietsche defends his PhD thesis entitled: New insights into organization, assembly and function of the export apparatus of bacterial type III secretion systems.

20/07/2017 — Susann Zilkenat defends her PhD thesis entitled: Elucidating the architecture of the type III secretion system export apparatus.

30/06/2017 — Two articles on the assembly of the export apparatus of bacterial flagella that were co-authored by our group were accepted for publication in PLoS Biology.

29/06/2017 — Our article ‘Structural and functional characterization of the bacterial type III secretion export apparatus’ has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Arne Rietsch.

18/04/2017 — Lea Krampen defended her PhD thesis entitled: Discrimination between membrane protein targeting pathways in Salmonella Typhimurium.

20/02/2017 — Description of a novel E. coli protein production strain developed by Samuel Wagner was accepted for publication in Scientific Reports (Isolation and characterization of the E. colimembrane protein production strain Mutant56(DE3)).

06/02/2017 — Samuel Wagner was awarded the DGHM Förderpreis 2017. The award ceremony is held at the joint DGHM/VAAM annual meeting 2017 in Würzburg (5-8/3/2017).

29/11/2016 — Iwan Grin wins a Best Poster Prize at the DZIF Annual Meeting 2016 for his work "C26 - a novel compound inhibiting the expression of T3SS-1 of S. Typhimurium".

17/11/2016 — Research article on the "Structural and functional characterization of the bacterial type III secretion export apparatus" accepted for publication in PLoS Pathogens.

20/09/2016 — Review on "Stoichiometry determination of macromolecular membrane protein complexes" accepted for publication in Biological Chemistry.

14/09/2016 — Detailed description of blue native PAGE for the analysis of bacterial secretion systems in press in Methods in Molecular Biology.

02/05/2016 — Susann Zilkenat's paper selected as "Highlight" of the May issue of Molecular and Cellular Proteomics.

05/04/2016 — Lea Krampen achieves a second place in the Best Poster competition of the Typ III Secretion Systems 2016 meeting for her work "Fine-tuning of hydrophobicity facilitates membrane protein secretion through bacterial T3SSs".