Aim of the study
My bachelor thesis is part of the pHION project aiming to develop a model that allows the extrapolation of the toxicity of ionisable substances at different pH-values. In this context, I investigate the pH-dependent toxicity of two different pesticides (pentachlorophenol (PCP) and 2,4-dichlorophenoxyacetic acid (2,4-D)) in zebrafish (Danio rerio) embryos. PCP is an organochloride and belongs to the group of aromatic hydrocarbons. Due to the fungicidal effect it is often used as a wood preservative. The second substance, 2,4-D, is a common herbicide against dicotyledonous plants and can be absorbed through the skin after exposure. As a result of human use, both substances can be detected in surface waters and may pose a risk to non-target organisms exposed.