Institute of Organic Chemistry

Dr. Nadine Schilling

Curriculum Vitae

 

08/2014

Finished diploma study in chemistry

  • Diploma thesis: Identification and charakterisation citrullinated peptides and proteines with glyoxal-containing reagents

03/2015

Started dissertation with the group of Prof. Dr. Grond

  • Dissertation thesis: Peptide synthesis, SAR-studies and structural optimization of the novel antibiotic peptide lugdunin
07/2018 Commencement of an innovation grant as PostDoc

Main Focus of studies

  • LCMS-Analytics
  • Solid-phase-peptide-synthesis
  • Peptide-derivatisation (SAR-Studies)
  • Structure elucidation of natural products

 

Publication

  • Zipperer, A., Konnerth, M. C., Laux, C., Berscheid, A., Janek, D., Weidenmaier, C., Burian, M., Schilling, N. A., Slavetinsky, C., Marschal, M., Willmann, M., Kalbacher, H., Schittek, B., Brötz-Oesterhelt, H., Grond, S., Peschel, A. & Krismer, B. Human commensals producing a novel antibiotic impair pathogen colonization. Nature 535, 511-516, doi:10.1038/nature18634 (2016).

  • Fuchs, K., Cardona Gloria, Y., Wolz, O. O., Herster, F., Sharma, L., Dillen, C. A., Täumer, C., Dickhöfer, S., Bittner, Z., Dang, T. M., Singh, A., Haischer, D., Schlöffel, M. A., Koymans, K. J., Sanmuganantham, T., Krach, M., Roger, T., Le Roy, D., Schilling, N. A., Frauhammer, F., Miller, L. S., Nürnberger, T., LeibundGut‐Landmann, S., Gust, A. A., Macek, B., Frank, M., Gouttefangeas, C., Dela Cruz, C. S., Hartl, D. & Weber, A. N. The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size. EMBO reports, doi:10.15252/embr.201846065 %J EMBO reports (2018).

  • Krismer, B., Peschel, A., Grond, S., Zipperer, A., Konnerth, M. C., Janek, D., Kalbacher, H. & Schilling, N. A. Novel anti-infective compound. (2018).

  • Schilling, N. A., Berscheid, A., Schumacher, J., Saur, J. S., Konnerth, M. C., Wirtz, S. N., Beltrán-Beleña, J. M., Zipperer, A., Krismer, B., Peschel, A., Kalbacher, H., Brötz-Oesterhelt, H., Steinem, C. & Grond, S. Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability. Angew. Chem. Int. Ed., doi:10.1002/anie.201901589.

  • Schilling, N. A., Berscheid, A., Schumacher, J., Saur, J. S., Konnerth, M. C., Wirtz, S. N., Beltrán-Beleña, J. M., Zipperer, A., Krismer, B., Peschel, A., Kalbacher, H., Brötz-Oesterhelt, H., Steinem, C. & Grond, S. Synthetische Analoga zeigen die essentiellen Strukturmotive von Lugdunin und seinen Protonentransport. Angew. Chem., doi:10.1002/ange.201901589.

  • Bitschar, K., Sauer, B., Focken, J., Dehmer, H., Moos, S., Konnerth, M., Schilling, N. A., Grond, S., Kalbacher, H., Kurschus, F. C., Götz, F., Krismer, B., Peschel, A. & Schittek, B. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat. Commun. 10, 2730, doi:10.1038/s41467-019-10646-7 (2019)

  • Alexander, S., Sumbla, S., Hubert, K., Thomas, N., Christopher, W., Bettina, M. W.-B., Nadine, S., Ulrike, E. & Stefan, H. Synthesis of a novel curcumin derivative as potential imaging probe in Alzheimer’s disease imaging. Current Alzheimer Research 16, 1-1, doi:http://dx.doi.org/10.2174/1567205016666190816130516 (2019)

  • Z. A. Bittner, X. Liu, S. Dickhoefer, H. Kalbacher, K. Bosch, L. Andreeva, A. Marcu, S. Stevanovic, M. Mangan, P. Duewell, M. Lovotti, F. Herster, M. W. Loeffler, S. Shankar, A. Tapia-Abellan, O. O. Wolz, N. A. Shilling, J. Kuemmerle-Deschner, S. Wagner, A. Delor, B. Grimbacher, H. Wu, E. Latz, A. N. Weber. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. bioRxiv 2019, 864702.