Ecotoxicological effects and risk evaluation of pollutants

In the collaborative project within the Water Network Baden-Württemberg we investigate the complex interaction (networks) for selected trace organic compounds (antidiabetic and neuroactive drugs, artificial sweeteners) with the aim to reduce effects. The network results from compound occurrence in the environment, biological effects, use pattern and measures to control the use and consumption. In this context our focus is on the identification and occurrence of transformation products in the environment and in ecotoxicological test systems and organisms used. Electrochemical and lab-scale experiments are used in combination with nontarget and target screening approaches. 

Effect-Net: A multi-scale effect network for hazard identification and risk evaluation of high consumption chemicals in aquatic ecosystems -  Effect network in water research (Ministry for Science, Research and Art, Baden-Wuerttemberg (Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg; Wassernetzwerk; 2015 - 2020)


Rita Triebskorn, Carolin Huhn (Univ. Tübingen), Günther Proll (Biametrics, Tübingen), Thomas Braunbeck, Jale Tosun, Ursula Kummer (Univ. Heidelberg), Thomas Dickmeis, Gerald Brenner-Weiss, Thomas Schwartz (KIT, Karlsruhe), Jutta Schneider-Rapp (Ökoconsult, Stuttgart)


  • Jacob, S., Knoll, S., Huhn, C., Köhler, H.-R., Tisler, S., Zwiener, C. and Triebskorn, R. (2019) Effects of guanylurea, the transformation product of the antidiabetic drug metformin, on the health of brown trout (Salmo trutta f. fario). PeerJ 7, e7289.
  • Jacob, S., Köhler, H.-R., Tisler, S., Zwiener, C. and Triebskorn, R. (2019) Impact of the Antidiabetic Drug Metformin and Its Transformation Product Guanylurea on the Health of the Big Ramshorn Snail (Planorbarius corneus). Frontiers in Environmental Science 7(45).
  • Tisler, S., Zindler, F., Freeling, F., Nödler, K., Toelgyesi, L., Braunbeck, T. and Zwiener, C. (2019) Transformation Products of Fluoxetine Formed by Photodegradation in Water and Biodegradation in Zebrafish Embryos (Danio rerio). Environmental Science & Technology 53, 7400-7409.
  • Tisler, S. and Zwiener, C. (2019) Aerobic and anaerobic formation and biodegradation of guanyl urea and other transformation products of metformin. Water Research 149, 130-135.
  • Jacob, S., Dötsch, A., Knoll, S., Köhler, H.-R., Rogall, E., Stoll, D., Tisler, S., Huhn, C., Schwartz, T., Zwiener, C. and Triebskorn, R. (2018) Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)? Environmental Sciences Europe 30(1), 48.   10.1186/s12302-018-0179-4
  • Tisler, S. and Zwiener, C. (2018) Formation and occurrence of transformation products of metformin in wastewater and surface water. Science of the Total Environment 628–629, 1121-1129.