15.03.2022

New GEM of Finegoldia magna ATCC 29328

A new genome-scale metabolic model of Finegoldia magna was constructed by Josua Carl as a bachelor's thesis project.

Finegoldia magna, a Gram-positive, anaerobic coccus (GPAC), is a bacterium of clinical interest due to multiple possible infection sites in the human body and its variety of virulence factors. Moreover, it has belongs to the most pathogenic species among the GPACs. The bacterium is often the cause of dangerous infections because it acts as a commensal bacterium on the human skin and mucous membranes. In the hope of expanding the comprehension of F. magna, particularly in the nasal environment, a genome-scale metabolic model (GEM) was drafted, curated, and evaluated by Josua Carl in his bachelor's thesis. To this end, Josua Carl applied various software tools and self-implemented methods, which he made available on github.com/JosuaCarl/Script_Assisted_Modeling. He used the resulting model to simulate growth on the synthetic nasal medium three (SNM3) and in the minimal media to understand the required environment better.