16.11.2021

New genome-scale reconstruction of Corynebacterium simulans PES1

In his bachelor thesis, Jan-Philipp Leusch reconstructed a new model.

Corynebacterium simulans is a Gram-positive aerobic bacterium belonging to the Actinobacteria group. It was first described in 2000. C. simulans is part of the typical human bacterial flora and can be found, for example, in the nose. Due to its close relationship to the pathogenic bacterium Corynebacterium striatum, it is sometimes misclassified as Corynebacterium striatum in the case of infection and can cause an incorrect therapeutic approach. C. simulans can act opportunely as a pathogen itself, but the mechanisms and conditions for this are largely unknown. For this reason, Jan-Philipp Leusch developed and reconstructed a genome-scale model of C. simulans PES1 in his bachelor thesis. Such a computer model can be used in the future to determine and further investigate the role of C. simulans and the interaction with other organisms in infections.