News
10.09.2019
Updated model of the pathogen H. influenzae
Niklas Henle expanded a genome-scale model of Haemophilus influenzae toward the human nose microbiome in his bachelor thesis.
As a result of his bachelor thesis, Niklas Henle updated the model of the pathogen Haemophilus influenzae, 20 years after Schilling et al. created the original model. The updated model now contains significantly more metabolic pathways and is available in the current version of the systems biology file format SBML.
Moreover, Mr. Henle thus fine-tuned the new version of the model to predict cell growth on the synthetic nasal fluid SNM3, which Krismer et al. experimentally defined in Tübingen. This medium provides all requirements of growth for a variety of different nasal bacteria. Mr. Henle's research can pave the way toward a comprehensive model of the nasal microbiome.