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10.09.2019

Updated model of the pathogen H. influenzae

Niklas Henle expanded a genome-scale model of Haemophilus influenzae toward the human nose microbiome in his bachelor thesis.

This image shows a snapshot of the central metabolic pathways of the new H. influenzae model. Red and blue pathways indicate non-active or active reactions of the model on SNM3, respectively.

As a result of his bachelor thesis, ​​Niklas Henle updated the model of the pathogen Haemophilus influenzae, 20 years after Schilling et al. created the  original model. The updated model now contains significantly more metabolic pathways and is available in the current version of the systems biology file format SBML.

Moreover, Mr. Henle thus fine-tuned the new version of the model to predict cell growth on the synthetic nasal fluid SNM3, which Krismer et al. experimentally defined in Tübingen. This medium provides all requirements of growth for a variety of different nasal bacteria. Mr. Henle's research can pave the way toward a comprehensive model of the nasal microbiome.

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