Project A7 - Capsule and cell wall proteins: Heterogenous expression and localisation in vitro and during colonisation
PD Dr. Christiane Wolz
Eberhard Karls Universität Tübingen
Universitätsklinikum
IMIT - Interfakultäres Institut für Mikrobiologie und Infektionsmedizin
Elfriede-Aulhorn-Str. 6
72076 Tübinge
Tel.: 07071/29-80187
Fax: 07071/29-5165
E-mail: christiane.wolz@med.uni-tuebingen.de
Staff (Direct dial)
PhD Students: Elisabeth Shilpa George Tel. 29-84662; shilpa.george@med.uni-tuebingen.de
Daniela Keinehörster Tel. 29-84662; daniela.keinhoerster@med.uni-tuebingen.de
Summary
We will follow the hypothesis that the regulatory RNAIII of the quorum sensing system agr functions as a master regulator for heterogeneous cell surface antigen expression in S. aureus. Single-cell assays for the detection of transcripts as well a gene products will be applied to characterise surface properties of S. aureus populations grown in vitro and in S. aureus containing specimens from humans and infected animals.
Zusammenfassung