Fišarová L, Botka T, Du X, Mašlaňová I, Bárdy P, Pantůček R, Benešík M, Roudnický P, Winstel V, Larsen J, Rosenstein R, Peschel A, Doškař J. Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands. mSphere. 6: e00223-21. doi:

Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Höhne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, García-Beccaria M, Gabernet G, Nahnsen S, Mallm JP, Vogel M, Schoonjans K, Lautwein T, Köhrer K, Häussinger D, Luedde T, Heikenwalder M, Keitel V. Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. J Hepatol. Apr 16:1–42. doi: 10.1016/j.jhep.2021.03.029. Online ahead of print.

Walter A, Friz S, Mayer C. Chitin, Chitin Oligosaccharide, and Chitin Disaccharide Metabolism of Escherichia coli Revisited: Reassignment of the Roles of ChiA, ChbR, ChbF, and ChbG. Microb Physiol. Apr 1:1–17. ( 2021) doi: 10.1159/000515178. Online ahead of print.

Rapp J, Rath P, Kilian J, Brilisauer K, Grond S, Forchhammer K. A bioactive molecule made by unusual salvage of radical SAM enzyme by-product 5-deoxyadenosine blurs the boundary of primary and secondary metabolism. J Biol Chem. Mar 31:100621. (2021) doi: 10.1016/j.jbc.2021.100621. Online ahead of print.

Zimmermann M, Patil KR, Typas A, Maier L. Towards a mechanistic understanding of reciprocal drug-microbiome interactions. Mol Syst Biol. 17:e10116. (2021) doi: 10.15252/msb.202010116.

Huergo LF, Selim KA, Conzentino MS, Gerhardt ECM, Santos ARS, Wagner B, Alford JT, Deobald N, Pedrosa FO, de Souza EM, Nogueira MB, Raboni SM, Souto D, Rego FGM, Zanette DL, Aoki MN, Nardin JM, Fornazari B, Morales HMP, Borges VA, Nelde A, Walz JS, Becker M, Schneiderhan-Marra N, Rothbauer U, Reis RA, Forchhammer K. Magnetic Bead-Based Immunoassay Allows Rapid, Inexpensive, and Quantitative Detection of Human SARS-CoV-2 Antibodies. ACS Sens. Mar 26;6(3):703-708. (2021) doi: 10.1021/acssensors.0c02544.

Hörömpöli D, Ciglia C, Glüsenkamp KH, Haustedt LO, Falkenstein-Paul H, Bendas G, Berscheid A, Brötz-Oesterhelt H. The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes. Antimicrob Agents Chemother. 65:e00986-20. (2021) doi: 10.1128/AAC.00986-20.

Müller M, Calvert M, Hottmann I, Kluj RM, Teufel T, Balbuchta K, Engelbrecht A, Selim KA, Xu Q, Borisova M, Titz A, Mayer C. The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases. J Biol Chem. Mar 5:100519. (2021) doi: 10.1016/j.jbc.2021.100519. Online ahead of print.

Silber N, Mayer C, Matos de Opitz CL, Sass P. Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool. Commun Biol. 4(1):270. (2021) doi: 10.1038/s42003-021-01789-9.

Renz A, Widerspick L, Dräger A. First Genome-Scale Metabolic Model of Dolosigranulum pigrum Confirms Multiple Auxotrophies. Metabolites. 11(4):232. (2021) doi: 10.3390/metabo11040232.

Mohammad M, Na M, Hu Z, Nguyen MT, Kopparapu PK, Jarneborn A, Karlsson A, Ali A, Pullerits R, Götz F, Jin T. Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing. Commun Biol. 4(1):432. (2021) doi: 10.1038/s42003-021-01947-z.

Ortiz A, Vega NM, Ratzke C, Gore J. Interspecies bacterial competition regulates community assembly in the C. elegans intestine. ISME J. Feb 15. (2021) doi: 10.1038/s41396-021-00910-4. Online ahead of print.

Doello S, Burkhardt M, Forchhammer K. The essential role of sodium bioenergetics and ATP homeostasis in the developmental transitions of a cyanobacterium.Curr Biol. 31, 1-10. (2021) doi: 10.1016/j.cub.2021.01.065. Online ahead of print.

Michaelis L, Treß M, Löw HC, Klees J, Klameth C, Lange A, Grießhammer A, Schäfer A, Menz S, Steimle A, Schulze-Osthoff K, Frick JS. Gut Commensal-Induced IκBζ Expression in Dendritic Cells Influences the Th17 Response.  Front Immunol. Jan 19;11:612336. (2021) doi: 10.3389/fimmu.2020.612336.

Saur J S, Wirtz S N, Schilling N A, Krismer B, Peschel A, Grond S. Distinct Lugdunins from a New Efficient Synthesis and BroadExploitation of Its MRSA-Antimicrobial Structure. J Med Chem (2021) doi: 10.1021/acs.jmedchem.0c02170.

Wex K W, Saur J S, Handel F, Ortlieb N, Mokeev V, Kulik A, Niedermeyer T H J, Mast Y, Grond S, Berscheid A, Brötz-Oesterhelt H.
Bioreporters for direct mode of action-informed screening of antibiotic producer strains. CellChemBio (2021) doi: 10.1016/j.chembiol.2021.02.022.

Koeninger L, Osbelt L, Berscheid A, Wendler J, Berger J, Hipp K, Lesker TR, Pils MC, Malek NP, Jensen BAH, Brötz-Oesterhelt H, Strowig T, Wehkamp J. Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota. Commun Biol. 4(1):47. (2021) doi: 10.1038/s42003-020-01582-0.


Belikova D, Jochim A, Power J, Holden MTG, Heilbronner S. "Gene accordions" cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus. Nat Commun. Jul 14;11(1):3526. (2020) doi: 10.1038/s41467-020-17277-3.

Ehmann D, Koeninger L, Wendler J, Malek NP, Stange EF, Wehkamp J, Jensen BAH. Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria. Front. Microbiol. (2020)

Maier L, Goemans CV, Pruteanu M, Wirbel J, Kuhn M, Cacace E, Banerjee T, Anderson EE, Milanese A, Löber U, Forslund SK, Patil KR, Zeller G, Bork P, Typas A. Dissecting the collateral damage of antibiotics on gut microbes.

van Dalen R, Peschel A, van Sorge NM. Wall Teichoic Acid in Staphylococcus aureus Host Interaction. Trends Microbiol. (2020) doi:10.1016/j.tim.2020.05.017.

Jochim A, Adolf L, Belikova D, Schilling NA, Setyawati I, Chin D, Meyers S, Verhamme P, Heinrichs DE, Slotboom DJ, Heilbronner S. An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis. Elife

9 (2020) doi:

Luqman A, Muttaqin MZ, Yulaipi S, Ebner P, Matsuo M, Zabel S, Tribelli PM, Nieselt K, Hidayati D, Götz F. Trace amines produced by skin bacteria accelerate wound healing in mice. Commun Biol 3, 277 (2020) doi:

Klask CM, Kliem-Kuster N, Molitor B, Angenent L. Nitrate Feed Improves Growth and Ethanol Production of Clostridium ljungdahlii With CO2 and H2, but Results in Stochastic Inhibition Events. Front. Microbiol. (2020) doi:

Walter A, Unsleber S, Rismondo J, Jorge AM, Peschel A, Gründling A, Mayer C. Phosphoglycerol-type wall and lipoteichoic acids are enantiomeric polymers differentiated by the stereospecific glycerophosphodiesterase GlpQ. J Biol Chem

. 295(12):4024-4034 (2020) doi:

Wagner S, Diepold A. A Unified Nomenclature for Injectisome-Type Type III Secretion Systems. Curr Top Microbiol Immunol

. 10.1007/82 (2020) doi:

Lieven C, Beber ME, Olivier BG, Bergmann FT, Ataman M, Babaei P, Bartell JA, Blank LM, Chauhan S, Correia K, Diener C, Dräger A, et al. MEMOTE for standardized genome-scale metabolic model testing. Nat Biotechnol 38,

272–276 (2020) doi:

Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, Garcia MU, Di Tommaso P, Nahnsen S. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol 38,

276–278 (2020) doi:

Bafna JA, Sans-Serramitjana E, Acosta-Gutiérrez S, Bodrenko I, Hörömpöli D, Berscheid A, Brötz-Oesterhelt H, Winterhalter M, Ceccarelli M. Kanamycin Uptake into E. Coli Is Facilitated by OmpF and OmpC Porin Channels Located in the Outer Membrane. ACS Infect Dis. (2020) doi:


Bittner Z, Liu X, Shankar S, Tapia-Abellán A, Kalbacher H, Andreeva L, Mangan M, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Löffler MW, Wolz OO, Schilling N, Kümmerle-Deschner J, Wagner S, Delor A, Grimbacher B, Wu H, Latz E, Weber ANR. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.

Xia PF, Casini I, Schulz S, Klask CM, Angenent LT, Molitor B. Reprogramming acetogenic bacteria with CRISPR-targeted base editing via deamination. ACS Synth. Biol.

Malik IT, Pereira R, Vielberg MT, Mayer C, Straetener J, Thomy D, Famulla K, Castro H, Sass P, Groll M, Brötz‐Oesterhelt H. Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes. ChemBioChem 21 (2020)


Renz A, Widerspick L, Dräger A

. FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2. Zenodo (2020) doi:


Maier L. Komplexe Wechselwirkungen zwischen Arzneimitteln und dem Mikrobiom. Biospektrum 25, 707–710 (2019) doi:

Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond SC. Synthetic lugdunin analogues reveal essential structural motifs for antimicrobial action and proton translocation capability. Angew Chem Int Ed Engl.

(2019) May 6 doi:

George SE, Hrubesch J, Breuing I, Vetter N, Korn N, Hennemann K, Bleul L, Willmann M, Ebner P, Götz F, Wolz C. Oxidative stress drives the selection of quorum sensing mutants in the Staphylococcus aureus population