Which bacterial molecules govern the specific interactions of bacterial cells with other microorganisms and host cells?
Bacterial fitness and microbial interactions are shaped by multiple factors, including the ability to secrete antimicrobial compounds and to colonize specific niches. Scientists in Research Area A will join forces to identify and isolate from the human microbiome new bacterial strains that produce antimicrobials. The mode of action of these molecules will then be dissected and their ecological role clarified.
In parallel, using a combination of computational, genetic, cellular and biochemical approaches, gene clusters potentially involved in glycopolymer biosynthesis will be identified and their involvement in bacterial adhesion in cooperation with adhesins further characterized in culture systems as well as animal models. The long term goal of Research Area A is to identify microbial effectors that can be targeted or exploited for therapeutic interventions.
Prof. Dr. Heike Brötz-Oesterhelt
University of Tübingen
Interfaculty Institute of Microbiology and Infection Medicine
Microbial Bioactive Compounds