- MSc candidate
|send a mail||janne.burmester[at]student.uni-tuebingen.de|
Aim of the study
My master thesis is part of the joint research project MiWa – Microplastics in the Water Cycle funded by the BMBF – Federal Ministry of Education and Research. The aim of my research is to assess the impact of microplastics (< 5 mm) in combination with a commonly found antidepressant drug (amitriptylin) in freshwater ecosystems. By exposing brown trout larvae (Salmo trutta f. fario) to different microplastics concentrations with and without amytriptyline, I expect to see a certain degree of neurotoxicity resulting in an inhibition of the enzyme acetylcholinesterase. In one part of my thesis, I determine the reduced activity of acetylcholinesterase in the muscular body parts of the trout larvae using a biochemical analysis assay, whereas a second goal of the study targets the histology of the brain of the larvae, in order to make structural alterations in neural tissue visible. The focus of the study is to show possible enhanced or weakened impacts of pharmaceuticals adsorbed to microplastics since our freshwater ecosystems face these challenges lately.