Our Research Projects
Boehringer Ingelheim AI & Data Science Fellowship Program
Common Action against HIV/TB/HCV across the Regions of Europe (CARE) aims at analysing and addressing the human immunodeficiency virus (HIV), tuberculosis (TB) and hepatitis C (HCV) epidemics across Europe and Russia, by establishing new networks and consolidating previous cooperative actions between the European Union and the Russian Federation. The project generates novel research findings based on existing biological material and data already collected by the participating partners, as well as on new samples and data gathered during the project.
The Else Kröner Medical Scientist School’s ClinBrAIn: Artificial Intelligence for Clinical Brain Research projects work at the interface of clinical brain research and artificial intelligence. The joint initiative of clinical groups from the University Hospital and the Hertie Institute for Clinical Brain Research and AI research groups (the Cluster of Excellence: Machine Learning, New Perspectives for Science, the Tübingen AI Center and the Bernstein Center for Computational Neuroscience) will address various diseases of the nervous system and use approaches from robust, explainable and probabilistic machine learning.
The Horizon Europe funded European Cohorts of Patients and Schools to Advance Response to Epidemics (EuCARE) project contributes to SARS-CoV-2/COVID-19 research across Europe, Kenya, Mexico, Russia and Vietnam. We aim to deliver recommendations for optimized clinical management and treatment with the support of strong immuno-virological and Artificial Intelligence (AI) components.
Extension of deep kernel approaches
The project Extending deep kernel approaches for better prediction and understanding of ADME phenotypes and related drug response is funded by the innovation funds program of the Cluster of Excellence Machine Learning: New Perspectives for Science. The goal of this project is to extend the methodology of deep kernel networks. Furthermore, the project aims to improve the prediction of ADME phenotypes and the related drug response as well as providing new insights into the underlying mechanisms.
PRIMO (Personalized medicine for tailored cancer therapies) has the goal to improve personalized treatment concepts for cancer patients with advanced molecular and computational analysis methods. This joint project of the FZI Research Center for Information Technology, NMI Natural and Medical Sciences Institute at the University of Tübingen and Hahn-Schickard is funded by the Ministry of Economic Affairs, Labour and Housing of Baden-Württemberg (WM BW). Aiming at improving the efficacy in breast cancer treatment by advanced individualization and digitization, a workflow for multi-view data integration is established and a prototype of a personalized breast cancer treatment decision support system is developed. With additional molecular patient data like advanced protein profiling and ex-vivo tumor cell models that are developed in this project, an integrative multi-omic precision oncology analysis based on Machine Learning methods is developed to gain further insights on patient-specific cancer subtyping and to assist clinical treatment decisions.
Privacy preserving machine learning
Privacy preserving machine learning is one of the research topics that our group is interested in. We are not only developing machine learning methods for precision medicine, but we also aim to address the privacy concerns occurring during the application of these methods in real life scenarios. We try to protect the privacy of the data of patients involved in the training/testing of machine learning methods without sacrificing the performance. More specifically, we develop frameworks for collaborative training of kernel-based machine learning methods. In order to show the efficacy of our frameworks, we utilize them on precision medicine problems, such as predicting the coreceptor usage of HIV based on V3-loop sequences.
Privacy-Preserving Analytics in Medicine (PrivateAIM) develops the next-generation federated machine learning (ML) and data analytics platform for the Medical Informatics Initiative (MII), where analyses come to the data instead of data coming to the analyses.
Methods with innovative privacy models for multimodal data will be integrated into a distributed infrastructure, which can easily be adopted by the Data Integration Centers (DICs). A thorough consideration of challenges on the intersection of technology and law, the development of concepts and documents for operation by hospital IT departments in coordination with ethics committees, information security and data protection officers will facilitate translation into practice, as well as ensure availability and sustainability.
Safe ML Systems in Healthcare
Our project Certifications and Foundations of Safe Machine Learning Systems in Healthcare is funded by Carl Zeiss Stiftung.
TTU Hepatitis / HCV Treatment Optimization
The TTU Hepatitis project funded by the German Center for Infection Research (DZIF) aims to optimize the use of new directly acting antiviral (DAA) based therapies for chronic hepatitis C by defining algorithms that arrive at individualized treatment regimens.
XplOit is a project funded within the i:DSem initiative of BMBF and aims to develop a software plattform to support data integration, model development and model validation with medical data using semantic tools. As an application scenario XplOit collects and annotates data from patients who underwent hematopoietic stem cell transplantation in the University Hospitals Homburg and Essen. Our part of the project is to use this data to develop models predicting critical events after transplantation, for example CMV infection / reactivation, graft-versus-host disease or overall survival. Ideally, these predictive models have the potential to warn physicians early and improve clinical care.
The Centre of Innovative Care (Zentrum für Innovative Versorgung) is a joint project of university hospitals in the German Federal State of Baden-Württemberg: Freiburg, Heidelberg, Mannheim, Tübingen and Ulm. Our project goal is to enhance patient care through the use of new, innovative digital medicine technologies like mobile health apps. We aim to further include the patient into the treatment process, to streamline the work of clinicians and caregivers and empower scientific use of the collected data. The multimodal integration of processes and data will allow us to better understand diseases and to develop new therapy and prevention concepts in the context of given structures and institutes across Baden-Württemberg.