IFIB – Interfakultäres Institut für Biochemie

Dr. Uris Lianne Ros Quincoces


Postdoctoral Researcher

Research Areas

Membrane biophysics, biochemistry and cell biology, regulated cell death

Fields of Interest

Necroptosis regulation, biological role of MLKL, pore-forming proteins and toxins, cellular process activated upon membrane damage, advanced microscopy methods.

CV Synopsis


Post-doc at Membrane Biophysics lab, IFIB, Tübingen, Germany


Associate professor, Faculty of Biology, Havana University, Cuba


PhD, Biological Sciences, Havana University, Cuba.


Master in Science, Biochemistry, Havana, Cuba.


Biochemistry Degree, Havana University, Cuba.

Fellowships and award


Long-term fellowship from the Alexander von Humboldt Foundation (Georg Forster) for a postdoctoral position, IFIB, Tübingen, Germany.


Short-term fellowship from the Max Plank society, IFIB, Tübingen University.


Short-term fellowship from the International Union of Biochemistry and Molecular Biology (IUBMB), IFIB, Tübingen University.


Short-term fellowship from the European Molecular Biology Organization (EMBO), Membrane Biophysics lab, Bioquant Institute, Heidelberg, Germany.


Short-term fellowship from the German Academic Exchange Service (DAAD), Membrane Biophysics lab, Heidelberg, Germany.


Short-term fellowship from the Emerging Leaders in America (ELAP) scholarship from the Canadian government, Membrane Biophysics lab, Health Science Institute, McMaster University, Hamilton, Canada.


International Foundation for Science (IFS) Projects.


United Nations Universities for Biotechnology in Latin-america and Caribbean (UNU-Biolac) scholarship to visit the Spectroscopic lab in the Chemical Institute, São Paulo University, Brazil.


Scholarship from the Network of Latin-American and Caribbean Macrouniversities scholarship to visit the Spectroscopic lab in the Chemical Institute, São Paulo University, Brazil.

Publication List


Alvarez C., Ros U., Valle A, Pedrera L., Soto C., Hervis Y.P., Cabezas S., Valiente P.A., Pazos F., Lanio M.E. (2017). Biophysical and biochemical strategies to understand membrane binding and pore formation by sticholysins, pore-forming proteins from a sea anemone. Biophys Rev. 9(5):529-544.

Soto C., del Valle A., Valiente P.A., Ros U., Lanio M.E, Alvarez, C. (2017). Differential binding and activity of the pore-forming toxin sticholysin II in model membranes containing diverse ceramide-derived lipids. Biochimie 138: 20-31.

Ros U.*, Peña-Blanco A., Hänggi K., Kunzendorf U., Krautwald S., Wong W.W-L. and García-Sáez A.J. (2017). Necroptosis execution is mediated by plasma membrane nanopores independent of calcium. Cell Reports 19 (1): 175-187. *Corresponding authors.

Cabezas S., Ho S., Ros U., Lanio M.E., Alvarez C. and van der Goot FG. Damage of eukaryotic cells by the pore-forming toxin sticholysin II: Consequences of the potassium efflux. (2017). Biochimica et Biophysica Acta- Biomembranes 1859(5): 982-992.

Mesa-Galloso H., Delgado-Magnero K.H., Cabezas S., López-Castilla A., Hernández-González J.E., Pedrera L., Alvarez C., Tieleman D.P., García-Saez A.J., Lanio M.E., Ros U.*, Valiente P.A*. (2017). Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity. Protein Sci. 26(3): 550-565. *Corresponding authors.


Cosentino, K., Ros, U. and García-Sáez A.J. (2016). Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes. Biochimica et Biophysica Acta-Biomembranes 1858(3):457-466.


Pedrera, L., Gomide, A., Sánchez, R., Ros., U., Wilke, N., Pazos, F., Lanio, M.E., Itri, R., Fanani, M. and Alvarez, C. (2015): The presence of sterols favors St I-membrane association and pore formation regardless of their ability to form laterally segregated domains. Langmuir 31(36): 9911-9923.

Ros, U., Rodríguez-Vera, W., Pedrera, L., Valiente, P.A., Cabezas-Falcón, S., Lanio, M.E., García-Saez, A.J. and Alvarez, C. (2015). Differences in activity of actinoporins are related with the hydrophobicity of their N-terminus. Biochimie 116:70-78.

Ros, U. and García-Sáez A. (2015): More than a pore: the interplay of pore-forming proteins and lipid membranes. Journal of Membrane Biology 248(3):545-561.

Subburaj, Y., Ros, U., Hermann, E., Tong, R. and García-Sáez, A.J. (2015): Toxicity of an α-pore-forming toxin depends on the assembly mechanism on the target membrane as revealed by single molecule imaging. Journal of Biological Chemistry 290 (8): 4856-4865.


Pedrera, L., Fanani, M.L., Ros, U., Lanio, M.E., Maggio, B., Alvarez, C. (2014): Sticholysin I membrane interaction: an interplay between the presence of sphingomyelin and membrane fluidity. Biochimica et Biophysica Acta- Biomembranes 1838 (7): 1752-1759.


Ros, U., Edwards, M.A, Epand, R.F., Lanio, M.E., Schreier, S., Yip, C.M., Alvarez, C., Epand, R.M. (2013): The sticholysin family of pore-forming toxins induce the mixing of lipids in membrane domains. Biochimica et Biophysica Acta- Biomembranes 1828: 2757–2762.

Ros, U., Souto, A.L., de Oliveira, F.L, Crusca, E.J., Pazos, F., Cilli, E.M., Lanio, M.E., Schreier, S., Alvarez, C. (2013): Functional and topological studies with Trp-containing analogs of the peptide StII1-30 derived from the N-terminus of the pore forming toxin sticholysin II: contribution to understand its orientation in membrane. Biopolymers (Peptide Science) 100 (4): 337-346.


Ros, U., Pedrera, L., Diaz, D., de Karam, J.C., Sundbrack, T.P, Valiente, P.A., Martínez, D., Cilli, E.M., Pazos, F., Itri, R., Lanio, M.E., Schreier, S., Alvarez, C. (2011): The membranotropic activity of N-terminal peptides from the pore-forming proteins sticholysin I and II is modulated by hydrophobic and electrostatic interactions as well as lipid composition. Journal of Biosciences 36(5): 781-791.


Cilli, E.M., Pigossi, F.T., Crusca, E.Jr, Ros U., Martinez, D., Lanio, M.E., Alvarez, C., Schreier, S. (2007): Correlations between differences in amino terminal sequences and different hemolytic activity of sticholysins. Toxicon 50(8): 1201-1204.

15) Lanio, M.E., Alvarez, C., Ochoa, C., Ros, U., Pazos, F., Martínez, D., Tejuca, M., Eugenio, L.M., Casallanovo, F., Schreier, S., Lissi, E. (2007): Enhanced activity and conformational changes of sticholysins I and II resulting from their interaction with cationic micelles. Toxicon 50: 731-739.


Casallanovo, F., de Oliveira F.J., de Souza, F.C., Ros, U., Martinez, Y., Pentón, D., Tejuca, M., Martínez, D., Pazos, F., Pertinhez, T.A., Spisni, A., Cilli, E.M., Lanio, M.E., Alvarez, C., Schreier, S. (2006): Model peptides mimic the structure and function of the N-terminus of the pore-forming toxin sticholysin II. Biopolymers (Peptide Science) 84(2): 169-180.