We are fascinated by Proteins. They are the workhorses in almost all cellular processes and come with an amazing diversity of functions and interactions. To manage their daily tasks and social behavior, they must be able to interact properly with their environment. Proteins must specifically recognize other biomolecules, which may be substrates for catalysis or partner proteins to form larger macromolecular complexes. We seek to understand the architecture, mechanisms and evolution of macromolecular complexes and machines, by combining methods of structural biology with computational approaches and biochemical assay development. We have a strong focus on molecular recognition processes and exploit our findings for drug development in collaboration with medicinal chemists.
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