IFIB – Interfakultäres Institut für Biochemie

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994

2014

Lehle S, Hildebrand DG, Merz B, Malak PN, Becker MS, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O. LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis. Nucleic Acids Res, in press (2014).

Seidl MD, Nunes F, Fels B, Hildebrandt I, Schmitz W, Schulze-Osthoff K, Müller FU. A novel intronic promoter of the Crem gene induces small ICER (smICER) isoforms. FASEB J 28, 143-52 (2014).

Weiland T, Lampe J, Essmann F, Venturelli S, Berger A, Bossow S, Berchtold S, Schulze-Osthoff K, Lauer UM, Bitzer M. Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses. Int J Cancer 134, 235-43 (2014).

Bantel H, John K, Schulze-Osthoff K. Robust Detection of Liver Steatosis and Staging of NAFLD by an Improved ELISA for Serum Cytokeratin-18 Fragments. Am J Gastroenterol 109, 140-1 (2014).

2013

Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J. Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle 12, 3421-32 (2013).

John K, Wielgosz S, Schulze-Osthoff K, Bantel H, Hass R. Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome. Cell Death Dis 4:e886 (2013).

Venturelli S, Berger A, Weiland T, Essmann F, Waibel M, Nuebling T, Häcker S, Schenk M, Schulze-Osthoff K, Salih HR, Fulda S, Sipos B, Johnstone RW, Lauer UM, Bitzer M. Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells. Mol Cancer Ther 12, 2226-36 (2013).

Bareiss PM, Paczulla A, Wang H, Schairer R, Wiehr S, Kohlhofer U, Rothfuss OC, Fischer A, Perner S, Staebler A, Wallwiener D, Fend F, Fehm T, Pichler B, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C. SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res 73, 5544-55 (2013).

Alexander E, Hildebrand DG, Kriebs A, Obermayer K, Manz M, Rothfuss O, Schulze-Osthoff K, Essmann F. IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence. J Cell Sci 126, 3738-45 (2013).

Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RP, Albrecht C. Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner. PLoS One 8, e65704 (2013).

Hildebrand DG, Lehle S, Borst A, Haferkamp S, Essmann F, Schulze-Osthoff K. α-Fucosidase as a novel convenient biomarker for cellular senescence. Cell Cycle 12, 1922-7 (2013).

Hildebrand DG, Alexander E, Hörber S, Lehle S, Obermayer K, Münck NA, Rothfuss O, Frick JS, Morimatsu M, Schmitz I, Roth J, Ehrchen JM, Essmann F, Schulze-Osthoff K. IκBζ is a transcriptional key regulator of CCL2/MCP-1. J Immunol 190, 4812-20 (2013).

Braumüller H, Wieder T, Brenner E, Aßmann S, Hahn M, Alkhaled M, Schilbach K, Essmann F, Kneilling M, Griessinger C, Ranta F, Ullrich S, Mocikat R, Braungart K, Mehra T, Fehrenbacher B, Berdel J, Niessner H, Meier F, van den Broek M, Häring HU, Handgretinger R, Quintanilla-Martinez L, Fend F, Pesic M, Bauer J, Zender L, Schaller M, Schulze-Osthoff K, Röcken M. T-helper-1-cell cytokines drive cancer into senescence. Nature 494, 361-5 (2013).



Keil E, Höcker R, Schuster M, Essmann F, Ueffing N, Hoffman B, Liebermann DA, Pfeffer K, Schulze-Osthoff K, Schmitz I. Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy. Cell Death Differ 20, 321-32 (2013).



Wahl K, Siegemund M, Lehner F, Vondran F, Nüssler A, Länger F, Krech T, Kontermann R, Manns MP, Schulze-Osthoff K, Pfizenmaier K, Bantel H. Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology 57, 625-36 (2013).



Bantel H, Schulze-Osthoff K. TNF antagonists in IBD: Novel antiinflammatory mechanisms beyond cytokine inhibition. Inflamm Bowel Dis 19, E51-2 (2013).

Konantz M, André MC, Ebinger M, Grauer M, Wang H, Grzywna S, Rothfuss OC, Lehle S, Kustikova OS, Salih HR, Handgretinger R, Fend F, Baum C, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C. EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia. Leukemia 27, 56-65 (2013).

2012

Schuster M, Glauben R, Plaza-Sirvent C, Schreiber L, Annemann M, Floess S, Kühl AA, Clayton LK, Sparwasser T, Schulze-Osthoff K, Pfeffer K, Huehn J, Siegmund B, Schmitz I. IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 37, 998-1008 (2012).

Wahl K, Rosenberg W, Vaske B, Manns MP, Schulze-Osthoff K, Bahr MJ, Bantel H. Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography. PLoS One 7, e51906 (2012).

Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K. Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance. J Immunol 189, 5722-8 (2012).

Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K. Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1. Autoimmunity 45, 568-73 (2012).

Bantel H, Schulze-Osthoff K. Mechanisms of cell death in acute liver failure. Front Physiol 3:79 (2012).

Lafont E, Dupont R, Andrieu-Abadie N, Okazaki T, Schulze-Osthoff K, Levade T, Benoist H, Ségui B. Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis. Biochim Biophys Acta 1821, 684-93 (2012).

Wilhelmi V, Fischer U, van Berlo D, Schulze-Osthoff K, Schins RP, Albrecht C. Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicol In Vitro 26, 323-34 (2012).

Bantel H, Schulze-Osthoff K. Can cell death biomarkers predict the outcome of acute liver failure? Liver Int 32, 346 (2012).

Joka D, Wahl K, Moeller S, Schlue J, Vaske B, Bahr MJ, Manns MP, Schulze-Osthoff K, Bantel H. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology 55, 455-64 (2012).

Ruiz-Magaña MJ, Rodríguez-Vargas JM, Morales JC, Saldivia MA, Schulze-Osthoff K, Ruiz-Ruiz C. The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. Int J Cancer 130, 1195-207 (2012).

Essmann F, Schulze-Osthoff K. Translational approaches targeting the p53 pathway for anti-cancer therapy. Br J Pharmacol165, 328-44 (2012).

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2011

Ghoreschi K, Brück J, Kellerer C, Deng C, Peng H, Rothfuss O, Hussain RZ, Gocke AR, Respa A, Glocova I, Valtcheva N, Alexander E, Feil S, Feil R, Schulze-Osthoff K, Rupec RA, Lovett-Racke AE, Dringen R, Racke MK, Röcken M. Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208, 2291-303 (2011).

Ranta F, Leveringhaus J, Theilig D, Schulz-Raffelt G, Hennige AM, Hildebrand DG, Handrick R, Jendrossek V, Bosch F, Schulze-Osthoff K, Häring HU, Ullrich S. Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. PLoS One 6, e28828 (2011).

Cappuccini F, Eldh T, Bruder D, Gereke M, Jastrow H, Schulze-Osthoff K, Fischer U, Köhler D, Stuschke M, Jendrossek V. New insights into the molecular pathology of radiation-induced pneumopathy. Radiother Oncol 101, 86-92 (2011).

Niyazi M, Zehentmayr F, Niemöller OM, Eigenbrod S, Kretzschmar H, Schulze-Osthoff K, Tonn JC, Atkinson M, Mörtl S, Belka C. MiRNA expression patterns predict survival in glioblastoma. Radiat Oncol 6, 153 (2011).

Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber K, Dieterle A, Alers S, Iftner T, Schulze-Osthoff K, Stork B, Wesselborg S. Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1. FASEB J 25, 3250-61 (2011).

Veltkamp C, Anstaett M, Wahl K, Möller S, Gangl S, Bachmann O, Hardtke-Wolenski M, Länger F, Stremmel W, Manns MP, Schulze-Osthoff K, Bantel H. Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF{alpha} treatment. Gut 60, 1345-53 (2011).

Schulze-Osthoff K, Bantel H. Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity. Hepatology 53, 1070 (2011).

Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Essmann F. Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death Differ 18, 1130-9 (2011).

Guderian G, Peter C, Wiesner J, Sickmann A, Schulze-Osthoff K, Fischer U, Grimmler M. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. J Biol Chem 286, 1976-86 (2011).

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2010

Schmidt S, Essmann F, Cirtea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle 9, 4469-73 (2010).

Singh KK, Erkelenz S, Rattay S, Dehof AK, Hildebrandt A, Schulze-Osthoff K, Schaal H, Schwerk C. Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. RNA 16, 2442-54 (2010).

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29, 6184-92 (2010).

Brandt D, Volkmann X, Anstätt M, Länger F, Manns MP, Schulze-Osthoff K, Bantel H. Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. Eur J Cancer 46, 1464-73 (2010).

Lafont E, Milhas D, Carpentier S, Garcia V, Jin ZX, Umehara H, Okazaki T, Schulze-Osthoff K, Levade T, Benoist H, Ségui B. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell Death Differ 17, 642-54 (2010).

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2009

Blume KE, Soeroes S, Waibel M, Keppeler H, Wesselborg S, Herrmann M, Schulze-Osthoff K, Lauber K. Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis. Immunol 183, 8138-47 (2009).

Janssen K, Horn S, Niemann MT, Daniel PT, Schulze-Osthoff K, Fischer U. Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci 122, 4481-91 (2009).

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO. Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. Nucleic Acids Res 37, 6414-28 (2009).

Bantel H, Schulze-Osthoff K. Cell death in sepsis: a matter of how, when, and where. Crit Care 13, 173 (2009).

Bantel H, Bahr MJ, Schulze-Osthoff K. An apoptosis biomarker for prediction of nonalcoholic steatohepatitis. Hepatology 50, 991 (2009).

Los M, Schulze-Osthoff K. Catching chromatin relaxation in act by flow cytometry. Cell Cycle 8, 2140-1 (2009).

Lindenblatt C, Schulze-Osthoff K, Totzke G. IkappaBzeta expression is regulated by miR-124a. Cell Cycle 8, 2019-23 (2009).

Hofer S, Rosenhagen C, Nakamura H, Yodoi J, Bopp C, Zimmermann JB, Goebel M, Schemmer P, Hoffmann K, Schulze-Osthoff K, Breitkreutz R, Weigand MA. Thioredoxin in human and experimental sepsis. Crit Care Med 37, 2155-9 (2009).

Ueffing N, Singh KK, Christians A, Thorns C, Feller AC, Nagl F, Fend F, Heikaus S, Marx A, Zotz RB, Brade J, Schulz WA, Schulze-Osthoff K, Schmitz I, Schwerk C. A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein. Blood 114, 572-9 (2009).

Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ, Cohen GM. Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ 16, 1030-9 (2009).

Los M, Panigrahi S, Rashedi I, Mandal S, Stetefeld J, Essmann F, Schulze-Osthoff K. Apoptin, a tumor-selective killer. Biochim Biophys Acta 1793, 1335-42 (2009).

Los M, Maddika S, Erb B, Schulze-Osthoff K. Switching Akt: from survival signaling to deadly response. Bioessays 31, 492-5 (2009).

Graupner V, Schulze-Osthoff K, Essmann F, Jänicke RU. Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53. Cell Cycle 8, 1238-48 (2009).

Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke RU. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ 16, 869-78 (2009).

Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M. Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol 29, 1235-48 (2009).

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2008

Rudy A, López-Antón N, Barth N, Pettit GR, Dirsch VM, Schulze-Osthoff K, Rehm M, Prehn JH, Vogler M, Fulda S, Vollmar AM. Role of Smac in cephalostatin-induced cell death. Cell Death Differ 15, 1930-40 (2008).

Klonisch T, Wiechec E, Hombach-Klonisch S, Ande SR, Wesselborg S, Schulze-Osthoff K, Los M. Cancer stem cell markers in common cancers - therapeutic implications. Trends Mol Med 14, 450-60 (2008).

Hombach-Klonisch S, Panigrahi S, Rashedi I, Seifert A, Alberti E, Pocar P, Kurpisz M, Schulze-Osthoff K, Mackiewicz A, Los M. Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med 86, 1301-14 (2008).

Hombach-Klonisch S, Paranjothy T, Wiechec E, Pocar P, Mustafa T, Seifert A, Zahl C, Gerlach KL, Biermann K, Steger K, Hoang-Vu C, Schulze-Osthoff K, Los M. Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp (Warsz) 56, 165-80 (2008).

Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood 112, 690-8 (2008).

Stampfuss JJ, Censarek P, Fischer JW, Kaber G, Rauch BH, Freidel K, Fischer U, Schulze-Osthoff K, Grosser T, Grandoch M, Schrör K, Weber AA. Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis. Arterioscler Thromb Vasc Biol 28, 1375-8 (2008).

Hassan M, Alaoui A, Feyen O, Mirmohammadsadegh A, Essmann F, Tannapfel A, Gulbins E, Schulze-Osthoff K, Hengge UR. The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. Oncogene 27, 4557-68 (2008).

Volkmann X, Anstaett M, Hadem J, Stiefel P, Bahr MJ, Lehner F, Manns MP, Schulze-Osthoff K, Bantel H. Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology 47, 1624-33 (2008).

Jänicke RU, Sohn D, Schulze-Osthoff K. The dark side of a tumor suppressor: anti-apoptotic p53. Cell Death Differ 15, 959-76 (2008).

Ueffing N, Keil E, Freund C, Kühne R, Schulze-Osthoff K, Schmitz I. Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death Differ 15, 773-82 (2008).

Knobloch J, Schmitz I, Götz K, Schulze-Osthoff K, Rüther U. Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death. Mol Cell Biol 28, 529-38 (2008).

Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem 283, 5296-305 (2008).

Ghavami S, Kerkhoff C, Chazin WJ, Kadkhoda K, Xiao W, Zuse A, Hashemi M, Eshraghi M, Schulze-Osthoff K, Klonisch T, Los M. S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta 1783, 297-311 (2008).

Maddika S, Wiechec E, Ande SR, Poon IK, Fischer U, Wesselborg S, Jans DA, Schulze-Osthoff K, Los M. Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin. Oncogene 27, 3060-5 (2008).

Tretiakova I, Blaesius D, Maxia L, Wesselborg S, Schulze-Osthoff K, Cinatl J Jr, Michaelis M, Werz O. Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9. Apoptosis 13, 119-31 (2008).

Frelin C, Imbert V, Bottero V, Gonthier N, Samraj AK, Schulze-Osthoff K, Auberger P, Courtois G, Peyron JF. Inhibition of the NF-kappaB survival pathway via caspase-dependent cleavage of the IKK complex scaffold protein and NF-kappaB essential modulator NEMO. Cell Death Differ 15, 152-60 (2008).

Neise D, Graupner V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Jänicke RU, Essmann F. Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak. Oncogene 27, 1387-96 (2008).

Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Schulze-Osthoff K, Nürnberg B, Piekorz RP. TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27, 116-25 (2008).

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2007

Fischer U, Janssen K, Schulze-Osthoff K. Does caspase inhibition promote clonogenic tumor growth? Cell Cycle 15, 3048-53 (2007).

Fischer U, Janssen K, Schulze-Osthoff K. Cutting-edge apoptosis-based therapeutics: a panacea for cancer? BioDrugs 21, 273-97 (2007).

Schulze-Osthoff K, Häussinger D. Apoptosis in the liver: a matter of ion fluxes and oxidative stress: Third International Conference of the Collaborative Research Center 'Experimental Hepatology' (SFB-575), Düsseldorf, Germany, 13-14 October 2006. Liver Int 27, 1039-44 (2007).

Volkmann X, Fischer U, Bahr MJ, Ott M, Lehner F, Macfarlane M, Cohen GM, Manns MP, Schulze-Osthoff K, Bantel H. Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 46, 1498-508 (2007).

Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J Biol Chem 282, 29273-83 (2007).

Janssen K, Pohlmann S, Jänicke RU, Schulze-Osthoff K, Fischer U. Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood 110, 3662-72 (2007).

Werdehausen R, Braun S, Essmann F, Schulze-Osthoff K, Walczak H, Lipfert P, Stevens MF. Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology 107, 136-43 (2007).

Troeger A, Schmitz I, Siepermann M, Glouchkova L, Gerdemann U, Janka-Schaub GE, Schulze-Osthoff K, Dilloo D. Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL. Blood 110, 384-7 (2007).

Jänicke RU, Sohn D, Essmann F, Schulze-Osthoff K. The multiple battles fought by anti-apoptotic p21. Cell Cycle 6, 407-13 (2007).

Vutova P, Wirth M, Hippe D, Gross U, Schulze-Osthoff K, Schmitz I, Lüder CG. Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8. Cell Microbiol 9, 1556-70 (2007).

Waibel M, Kramer S, Lauber K, Lupescu A, Manns J, Schulze-Osthoff K, Lang F, Wesselborg S. Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis. Apoptosis 12, 623-30 (2007).

Viemann D, Barczyk K, Vogl T, Fischer U, Sunderkötter C, Schulze-Osthoff K, Roth J. MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program. Blood 109, 2453-60 (2007).


Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell 18, 84-93 (2007).

Janssen K, Hofmann TG, Jans DA, Hay RT, Schulze-Osthoff K, Fischer U. Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Oncogene 26, 1557-66 (2007).

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2006

Sohn D, Essmann F, Schulze-Osthoff K, Jänicke RU. p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res 66, 11254-62 (2006).

López-Antón N, Rudy A, Barth N, Schmitz ML, Pettit GR, Schulze-Osthoff K, Dirsch VM, Vollmar AM. The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. Biol Chem 281, 33078-86 (2006).

Berg CP, Stein GM, Klein R, Pascu M, Berg T, Kammer W, Priemer M, Nordheim A, Schulze-Osthoff K, Gregor M, Wesselborg S, Berg PA. Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients. Liver Int 26, 846-55 (2006).

Samraj AK, Keil E, Ueffing N, Schulze-Osthoff K, Schmitz I. Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis. J Biol Chem 281, 29652-9 (2006).

Haslinger-Löffler B, Wagner B, Brück M, Strangfeld K, Grundmeier M, Fischer U, Völker W, Peters G, Schulze-Osthoff K, Sinha B. Staphylococcus aureus induces caspase-independent cell death in human peritoneal mesothelial cells. Kidney Int 70, 1089-98 (2006).

Jänicke RU, Sohn D, Totzke G, Schulze-Osthoff K. Caspase-10 in mouse or not? Science 312, 1874 (2006).

Schmitz I, Meyer C, Schulze-Osthoff K. CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma. Oncogene 25, 7587-96 (2006).

Volkmann X, Cornberg M, Wedemeyer H, Lehner F, Manns MP, Schulze-Osthoff K, Bantel H. Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection. Hepatology 43, 1311-6 (2006).

Sohn D, Totzke G, Schulze-Osthoff K, Jänicke RU. Friend or foe? The proteasome in combined cancer therapy. Cell Cycle 5, 841-5 (2006).

Zacharowski K, Zacharowski PA, Koch A, Baban A, Tran N, Berkels R, Papewalis C, Schulze-Osthoff K, Knuefermann P, Zähringer U, Schumann RR, Rettori V, McCann SM, Bornstein SR. Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci USA 103, 6392-7 (2006).

Stoldt VR, Schnorr O, Schulze-Osthoff K, Scharf RE. Transforming growth factor-beta1 enhances the antifibrinolytic and prothrombotic state of growing endothelial cells in a cell cycle-specific manner. FASEB J 20, 965-6 (2006).

Joselin AP, Schulze-Osthoff K, Schwerk C. Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. J Biol Chem 281, 12475-84 (2006).

Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Jänicke RU, Schulze-Osthoff K. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J Biol Chem 281, 12645-54 (2006).

Wolf SC, Schultze M, Risler T, Rieg T, Lang F, Schulze-Osthoff K, Brehm BR. Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1. Biochem Pharmacol 71, 1175-83 (2006).

Sohn D, Totzke G, Essmann F, Schulze-Osthoff K, Levkau B, Jänicke RU. The proteasome is required for rapid initiation of death receptor-induced apoptosis. Mol Cell Biol 26, 1967-78 (2006).

Wendt J, Radetzki S, von Haefen C, Hemmati PG, Güner D, Schulze-Osthoff K, Dörken B, Daniel PT. Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells. Oncogene 25, 972-80 (2006).

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2005

Viemann D, Schulze-Osthoff K, Roth J. Potentials and pitfalls of DNA array analysis of the endothelial stress response. Biochim Biophys Acta 1746, 73-84 (2005).

Bantel H, Beikler T, Flemmig TF, Schulze-Osthoff K. Caspase activation is involved in chronic periodontitis. FEBS Lett 579, 5559-64 (2005).

Essmann F, Pohlmann S, Gillissen B, Daniel PT, Schulze-Osthoff K, Jänicke RU. Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. J Biol Chem 280, 37169-77 (2005).

Siegmund D, Wicovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H. Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Mol Cell Biol 25, 6363-79 (2005).

Haslinger-Löffler B, Kahl BC, Grundmeier M, Strangfeld K, Wagner B, Fischer U, Cheung AL, Peters G, Schulze-Osthoff K, Sinha B. Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. Cell Microbiol 7, 1087-97 (2005).

Schwerk C, Schulze-Osthoff K. Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death. Oncogene 24, 7002-11 (2005).

Scholz C, Richter A, Lehmann M, Schulze-Osthoff K, Dörken B, Daniel PT. Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway. Oncogene 24, 7031-42 (2005).

Schwerk C, Schulze-Osthoff K. Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 19, 1-13 (2005).

Seidel N, Volkmann X, Länger F, Flemming P, Manns MP, Schulze-Osthoff K, Bantel H. The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology 42, 113-20 (2005).

Fischer U, Schulze-Osthoff K. New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev 57, 187-215 (2005).

Engels IH, Totzke G, Fischer U, Schulze-Osthoff K, Jänicke RU.Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner. Mol Cell Biol 25, 2808-18 (2005).

Scholz C, Wieder T, Stärck L, Essmann F, Schulze-Osthoff K, Dörken B, Daniel PT. Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway. Oncogene 24, 1904-13 (2005).

Fischer U, Schulze-Osthoff K. Apoptosis-based therapies and drug targets. Cell Death Differ Suppl 1, 942-61 (2005).

Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M. Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation ofNF-kappa B. Invest Dermatol 124, 38-45 (2005).

Sohn D, Schulze-Osthoff K, Jänicke RU. Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem 280, 5267-73 (2005).

Fischer U, Steffens S, Frank S, Rainov NG, Schulze-Osthoff K, Kramm CM. Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene 24, 1231-43 (2005).

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2004

Bantel H, Lügering C, Heidemann J, Volkmann X, Poremba C, Strassburg C, Manns MP, Schulze-Osthoff K.
Detection of caspase activation in the sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 40, 1078-1087 (2004).

Bornstein SR, Zacharowski P, Barthel A, Tran N, Papewalis C, Novotny GE, Ehrhart-Bornstein M, Schulze-Osthoff K, Scherbaum WA, Tarnow J, Zacharowski K. Impaired adrenal stress response in Toll-like receptor 2 deficient mice. Proc Natl Acad Sci USA, in press (2004).

Buddenkotte J, Stroh C, Engels IH, Moormann C, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M. Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular adhesion molecule-1 in primary human keratinocytes via activation of NF- κB. J Invest Dermatol, in press (2004).

Essmann F, Engels IH, Totzke G, Schulze-Osthoff K, Jänicke RU. Caffeine-mediated radiosensitizatin of MCF-7 breast carcinoma cells proceeds independently of p53 and cell cycle control, but requires caspase-3.
Cancer Res 64, 7065-7072 (2004).

Fischer U, Steffens S, Frank S, Rainov NG, Schulze-Osthoff K, Kramm CM. Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene, in press (2004).

Müller A, Hasenjäger A, Belka C, Schulze-Osthoff K, Dörken B, Daniel PT. Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8 independent manner by activation of the mitochondrial cell death pathway. Oncogene, in press (2004).

Müller FU, Bantel H, Loser K, Kleideiter U, Neumann J, Engels IH, Scheld HH, Schulze-Osthoff K, Schmitz W. Adenovirus-mediated gene transfer of the transcription factor AP-2 alpha triggers apoptosis in cardiac myocytes. Cell Death Differ 11, 485-493 (2004).

Pandiyan P, Gärtner D, Soezeri S, Radbruch A, Schulze-Osthoff K, Brunner-Weinzierl MC. CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death. J Exp Med 199, 831-842 (2004).

Schmelz K, Tamm I, Wieder T, Essmann F, Geilen C, Schulze-Osthoff K, Dörken B, Daniel PT. Tumor necrosis factor-α sensitizes myeloid cells to chemotherapeutic drugs by a caspase-8 and NF-κB independent mechanism. Oncogene 23, 6743-6759 (2004).

Scholz C, Essmann F, Stärck L, Wieder T, Schulze-Osthoff K, Dörken B, Daniel PT. Arsenic trioxide induces caspase-independent cell death through a mitochondrial death pathway. Oncogene, in press (2004).

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2003


Fischer U, Jänicke RU, Schulze-Osthoff K. Many cuts ro ruin: a comprehensive update of caspase substrates.
Cell Death Differ. 10, 76-100 (2003.

van Haefen CT, Wieder T, Essmann F, Schulze-Osthoff K, Dörken B, Daniel PT. Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspase-3/caspase-8-driven mitochondrial amplification loop.
Oncogene 22, 2236-2247 (2003).

Bantel H, Schulze-Osthoff K. Apoptosis in hepatitis C virus infection. Cell Death Differ. 10, 48-58 (2003).

Berg CP, Rothbart A, Lauber K, Engels IH, Belka C, Gregor M, Jänicke RU, Schulze-Osthoff K, Wesselborg S. Tributyltin induces ultra-rapid caspase activation independent of apoptosome formation in human platelets. Oncogene 22, 775-780 (2003).

Schlosser S, Schuler F, Berg M, Lauber CP, Schulze-Osthoff K, Schmahl FW and Wesselborg S. Ribavirin and interferon-alpha-enhance CD95-mediated caspase activity in human hepatoma cells. Antimicrob. Agents Chemother. 47, 1912-1921 (2003).

Schwerk C, Schulze-Osthoff K. Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem. Pharmacol. 66, 1453-1458 (2003).

Stroh C, Samraj AK, Held J, Schulze-Osthoff K. Intracellular protein delivery of IκBalpha of JNK signaling diminishes early but not late cellular stress-induced apoptosis. Int. J. Cancer 107, 520-527 (2003).

Totzke G, Schulze-Osthoff K, Jänicke RU. COX-2 inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition. Oncogene 22, 6077-6086 (2003).

Lauber K, Bohn E, Krober SM, Xia Y, Blumenthal SG, Lindemann R, Marini K, Wiedig C, Zobywalski A, Baksh S, Xu Y, Autenrieth IB, Schulze-Osthoff K, Belka C, Stuhler G and Wesselborg S. Apoptotic cells induce migration of phagocytes via caspase-3 mediated release of a lipid attraction signal. Cell 113, 717-730 (2003).

Müller FU, Bantel H, Loser K, Kleideiter U, Neumann J, Engels IH, Schulze-Osthoff K, Scheld H-H, Schmitz W. Adenovirus-mediated gene transfer of the transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Cell Death Differ., in press (2003).

Daniel PT, Schulze-Osthoff K, Belka C, Güner D. Guardians of cell death: the Bcl-2 family proteins. Essays biochem. 39, 73-88 (2003).

Haslinger B, Strangfeld K, Peters G, Schulze-Osthoff K , Sinha B. Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumor necrosis factor-alpha and the mitrochondrial death pathway. Cell. Microbiol. 5, 729-741 (2003).

Essmann F, Bantel H, Sinha B, Totzke G, Schulze-Osthoff K , Jänicke RU. Staphylococcus aureus alpha-toxin induced cell death: predominant necrosis despite apoptotic caspase activation. Cell Death Differ. 10, 1260-1272 (2003).

Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT. Induction of cell death by the BH3-only Bcl-2 homolog Bik/Nbκ is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J. 22, 3580-3590 (2003).

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2002

Chlichli K, Los M, Schulze-Osthoff K, Gazzolo L, Schirrmacher V, Khazaie K. Redox events in HTLV-1 Tax-induced apoptotic T-cell death. Antioxid. Redox. Res. 4, 471-477 (2002).

Los M, Mozoluk M, Ferrari D, Stepczynska A, Stroh C, Zdenko H, Wang ZQ, Schulze-Osthoff K . Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol. Biol. Cell 13, 978-988 (2002).

Shpacovitch VM, Brzoska T, Buddenkotte J, Stroh C, Sommerhoff CP, Ansel JC, Schulze-Osthoff K, Bunnett NW, Luger TA, Steinhoff M. Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor κB in human dermal microvascular endothelial cells. J. Invest. Dermatol. 118, 380-385 (2002).

Brehm BR, Wolf SC, Freudenberg J, Friedmann F, Heinle H, Schulze-Osthoff K. Modulation of the beta-adrenergic receptor sysstem of vascular smooth mucle cells in vitro and in vivo by chronically elevated endothelin-1 levels. Biochem. Pharmacol. 63, 1361-1369 (2002).

Stroh C, Cassens U, Samraj AK, Sibrowski W, Schulze-Osthoff K, Los M. The role of caspases in cryoinjury: caspase inhibition strongly improves the recovery of cryopreserved hematopoietic and other cells. FASEB J. 16, 1651-1653 (2002).

Bitzer M, Armeanu S, Prinz F, Ungerechts G, Wybranietz W, Spiegel M, Bernlöhr C, Cecconi F, Gregor M, Schulze-Osthoff K, Lauer UM. Caspase-8 and Apaf-1 independent caspase-9 activation in Sendai virus-infected cells. J. Biol. Chem. 277, 29817-29824 (2002).

Bantel H, Schmitz ML, Gregor M, Schulze-Osthoff K. Critical role of NF-κB and stress-activated protein kinases in steroid unresponsiveness of inflammatory bowel disease. FASEB J. 16, 1832-1834 (2002).

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2001

Brehm BR, Bock C, Pfeiffer S, Wesselborg S, Schulze-Osthoff K. The topoisomerase inhibitor topotecan prevents proliferation of human coronary smooth muscle cells without inducing apoptosis. Biochem. Pharmacol. 61, 119-127 (2001).

Brehm BR, Bertsch R, Klaussner M, Pfeiffer S, Schüler S, Wesselborg S, Schulze-Osthoff K, Wolf S.C. Effects of nebivolol on proliferation, migration and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovascular Res. 49, 430-439 (2001).

Belka C, Marini P, Schmidt B, Rudner J, Durand E, Faltin H, Bamberg M, Schulze-Osthoff K, Budach W. Combined effects of ionizing radiation and TRAIL on human lymphoma cells. Oncogene 20, 2190-2196 (2001).

Los M, Stroh C, Jänicke RU, Engels IE, Schulze-Osthoff K. Caspases: more than just killers? Immunol. Today 22, 31-34 (2001).

Wieder T, Essmann F, Prokop A, Schulze-Osthoff K, Beyaert R, Dörken B, Daniel PT. Activation of caspase-8 during drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor/ligand interaction and occurs downstream of caspase-3. Blood 97, 1378-1387 (2001).

Friedrich K, Wieder T, van Haefen C, Jänicke RU, Schulze-Osthoff K, Dörken B, Daniel PT. Retroviral gene transfer of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cells with acquired drug resistance. Oncogene 20, 2749-2760 (2001).

Ferrari D, Stroh C, Wesseslborg S, Di Virgilio F, Schulze-Osthoff K , Extracellular ATP activates transcription factor NFAT in mouse microglial cells. Drug. Dev. Res. 52, 213-219 (2001).

Stepczynska A, Lauber K, Engels IH, Janssen O, Kabelitz D, Wesselborg S, Schulze-Osthoff K . Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activations. Oncogene 20, 1193-1202 (2001).

Schmidt M, Lügering N, Lügering A, Pauels HG, Schulze-Osthoff K, Domschke W, Kucharzik T. Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis. J. Immunol. 166, 1344-1351 (2001).

Daniel PT, Wieder T, Sturm I, Schulze-Osthoff K . The kiss of death: promisses and failures of death receptor and ligands in cancer therapy. Leukemia 15, 1022-1032 (2001).

Bantel H, Ruck P, Gregor M, Schulze-Osthoff K. Detection of elevated caspase activation and early apoptosis in liver diseases. Eur. J. Cell Biol. 80, 230-239 (2001).

Jänicke RU, Engels IH, Dunkern T, Kaina B, Schulze-Osthoff K, Porter AG. Cancer drugs and gamma-irradiation induce different caspase-3 activation pathways upstream of mitochondria. Oncogene 20, 5043-5053 (2001).

Luetjens CM, Kögel D, Reimertz C, Dussmann H, Renz A, Schulze-Osthoff K, Nieminen A-L, Poppe M, Prehn JHM. Multiple kinetics of mitochondrial cytochrome c release in apoptosis. Mol. Pharmacol. 60, 1008-1019 (2001).

Berg CP, Engels IE, Rothbart A, Lauber K, Schlosser SF, Gregor M, Schulze-Osthoff K, Wesselborg S. Human mature red blood express caspase-3 and caspase-8 but are devoid of mitochondrial regulators of apoptosis. Cell Death Differ. 8, 1097-1206 (2001).

Renz A, Berdel WE, Kreuter M, Belka C, Schulze-Osthoff K, Los M. Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo. Blood 98, 1542-1547 (2001).

Lauber K, Schlosser SF, Appel H, Gregor M, Schulze-Osthoff K, Wesselborg S. The adapter protein Apaf-1 is proteolytically processed during apoptosis. J. Biol. Chem. 276, 29772-29778 (2001).

Bantel H, Lügering A, Poremba C, Lügering N, Domschke W, Schulze-Osthoff K. Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection. Hepatology 34, 758-767 (2001).

Totzke G, Vetter H, Schulze-Osthoff K, Ko Y. p53 downregulation in myelodysplastic syndrome: a quantitative analysis by competitive RT-PCR. Leukemia 15, 1663-1164 (2001).

Roth J, Goebeler M, Schulze-Osthoff K, Ludwig S, Kilian K, Sorg C, Harms E, Koch HG. Homocysteine inhibits TNF-alpha but not IFN-gamma mediated activation of endothelium via modulation of NF-kB activity. Biochem. Biophys. Acta 1540, 154-165 (2001).

Rudner J, Lepple-Wienhues A, Budach W, Berschauer J, Friedrich B, Wesselborg S, Schulze-Osthoff K, Belka C. Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor induced apoptosis. J. Cell Science 114, 4161-4172 (2001).

Wieder T, Prokop A, Bagci B, Eßmann F, Bernicke D, Schulze-Osthoff K, Dörken B, Schmalz HG, Daniel PT, Henze G. Piceatannol, an analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in BJAB cells and primary leukemic lymphoblasts. Leukemia 15, 1735-1742 (2001).

Burek C, Roth J, Koch HG, Harzer K, Los M, Schulze-Osthoff K. The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceraqmidase-deficient Farber disease cells. Oncogene 20, 6493-6502 (2001).

Renz A, Burek C, Mier W, Mozoluk M, Schulze-Osthoff K, Los M. Cytochrome c is rapidly extruded from apoptotic cells and detectable in serum of anticancer-drug treated tumor patients. Adv. Exp. Med. Biol. 495, 331-334 (2001).

Held J, Schulze-Osthoff K . Potential and caveats of TRAIL in cancer therapy. Drug Resist. Updates 4, 243-252 (2001).

Bantel H, Sinha B, Domschke W, Peters G, Schulze-Osthoff K and Jänicke RU. Alpha-toxin is the mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling. J. Cell Biol. 155, 637-647 (2001).

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2000

Wollert KC, Heineke J, Westermann J, Zierhut W, Laurent D, Bauer MKA, Schulze-Osthoff K, Drexler H. Left ventricular expression of the Fas receptor is related to diastolic wall stress in volume-overload hypertrophy: impact on cardiomyocyte apoptosis. Circulation 101, 1172-1178 (2000).

Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K. Differntial role of caspase-8 and BID activation in radiation- and CD95-induced apoptosis. Oncogene 19, 1181-1190 (2000).

Schmidt M, Lügering N, Pauels HG, Schulze-Osthoff K, Domschke W, Kucharzik T. IL-10 induced apoptosis in human monocytes involving the CD95 receptor/ligand pathway. Eur. J. Immunol. 30, 1769-1777 (2000).

Bantel H, Ruck P, Schulze-Osthoff K, In situ monitoring of caspase activation and apoptosis in hepatobiliary diseases. Cell Death Differ. 7, 504-505 (2000).

Pinton P, Ferrari D, Schulze-Osthoff K, Di Virgilio F, Pozzan T, Rizzuto R. Reduced loading of intracellular Ca2+ influx in Bcl-2 overexpressing cells. J. Cell Biol. 148, 857-862 (2000).

Stier S, Totzke T, Grünewald E, Neuhaus T, Fronhoffs S, Sachinidis A, Vetter H, Schulze-Osthoff K, Ko Y. Identification of syntenin and other TNF-inducible genes in human umbilical arterial endothelial cells by suppression subtractive hybridization. FEBS Lett. 467, 299-304 (2000).

Bantel H, Domschke W, Kaskas B, Gregor M, Schulze-Osthoff K. Abnormal activation of transcription factor NF-κBi involved in steroid resistance of chronic inflammatory bowel disease. Am. J. Gastroenterol. 95, 1845-1846 (2000).

Los M, Walczak H, Schulze-Osthoff K, Reed JC. Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis. Methods Mol. Biol. 121, 155-162 (2000).

Los M, Neubüser D, Mozoluk M, Poutska A, Coy JF, Schulze-Osthoff K. Molecular characterization of DNase X, a novel apoptotic endonuclease expressed in muscle cells. Biochemistry 39, 7365-7373 (2000).

Jüsten HP, Grünewald E, Totzke G, Gouni-Berthold I, Sachinidis A, Wessinghage D, Vetter H, Schulze-
Osthoff K, Ko Y. Differential gene expression in synovium of rheumatoid arthritis and osteoarthritis. Mol. Cell. Biol. Res. Comm. 3, 165-172 (2000).

Bantel H, Domschke W, Schulze-Osthoff K. Molecular mechanisms of glucocorticoid resistance. Gastroenterology 119, 1178-1179 (2000).

Engels IH, Stepczynska A, Stroh C, Berg C, Schwenzer R, Wajant H, Jänicke RU, Porter AG, Belka C, Gegor M, Wesselborg S, Schulze-Osthoff K. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 165, 4563-4573 (2000).

Hehner S, Breitkreuz R, Shubinsky G, Unsoeld H, Schulze-Osthoff K, Schmitz ML, Dröge W. Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool. J. Immunol. 165, 4319-4328 (2000).

Schulze-Osthoff K, Stroh C. Induced proximity model attracts NF-κB researchers. Cell Death Differ. 7, 1025-1026 (2000).

Bantel H, Berg C, Vieth M, Stolte M, Kruis W, Schulze-Osthoff K. Mesalazine therapy of ulcerative colitis inhibits NF-κB activation in situ. Am. J. Gastroenterol. 95, 3452-3457 (2000).

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1999

Bitzer M, Prinz F, Bauer M, Spiegel M, Neubert WJ, Gregor M, Schulze-Osthoff K, Lauer U. Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32). J. Virol. 73, 702-708 (1999).

Ferrari D, Los M, Vandenabeele P, Wesselborg S, Schulze-Osthoff K. Caspases are involved in signaling events leading to DNA fragmentation but not cell lysis during purinoreceptor-mediated cell death. FEBS Lett. 447, 71-75 (1999).

Wesselborg S, Engels I, Rossman E, Los M, Schulze-Osthoff K. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction. Blood 93, 3053-3063 (1999).

Bantel H, Engels I, Voelker W, Schulze-Osthoff K, Wesselborg S. Mistletoe lectin activates caspases independently of CD95 receptor/ligand interaction and potentiates anticancer drug-induced apoptosis. Cancer Res. 59, 2083-2090 (1999).

Ferrari D, Stroh C, Schulze-Osthoff K . P2X7/P2Z purinoreceptor-mediated activation of transcription factor NF-AT in microglial cells. J. Biol. Chem. 274, 13205-13210 (1999).

Belka C, Marini P, Lepple-Wienhues A, Budach W, Lang F, Schulze-Osthoff K, Gulbins E, Bamberg M. The tyrosine kinase Lck is required for caspase-8 activation and apoptosis in response to ionizing radiation. Oncogene 18, 4983-4992 (1999).

Belka C, Heinrich V, Marini P, Faltin H, Schulze-Osthoff K, Bamberg M, Budach W. Ionizing irradiation i nduces activation of caspase-8 in highly apoptosis sensitive lymphoma cells. Radiation Res. 75, 1257-1264 (1999).

Los M, Wesselborg S, Schulze-Osthoff K. The role of caspases in development, immunity and apoptotic signal transduction: lessons from knock-out mice. Immunity 10, 629-639 (1999).

Fiebich BL, Hofer TJ, Lieb K, Huell M, Butcher RD, Schulze-Osthoff K , Bauer J. The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and α1-antichymotrypsin synthesis in astrocytes by preventing degradation of IκB-α. Neuropharmacology 38, 1325-1333 (1999).

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1998

Lieb K, Schaller H, Kaltschmidt C, Gyufko K, Merola M, Bauer J, Schulze-Osthoff K, Fiebich B. Substance P and histamine induce IL-6 expression in human astrocytoma cells by a mechanism requiring NF-IL6 but not NF-κB p65 (RelA). J. Neurochem. 70, 1577-1583 (1998).

Hehner SP, Heinrich M, Bork PM, Vogt M, Ratter F, Lehrmann V, Schulze-Osthoff K, Dröge W, Schmitz ML. Sesquiterpene lactones specifically inhibit a common step of NF-κB activation by preventing the degradation of IκB-α and IκB-β. J. Biol. Chem. 273, 1288-1297 (1998).

Belka C, Marini P, Budach W, Schulze-Osthoff K, Lang F, Gulbins E, Bamberg M. Radiation-induced apotosis in human lymphocytes and lymphoma cells critically relies on upregulation of CD95 (Fas/APO-1) ligand. Radiation Res. 149, 588-595 (1998).

Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur. J. Biochem. 254, 439-459 (1998).

Bauer MKA, Vogt M, Los M, Siegel J, Wesselborg S, Schulze-Osthoff K. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression in T lymphocytes. J. Biol. Chem. 273, 8048-8055 (1998).

Luttmann W, Opfer A, Dauer E, Foerster M, Matthys H, Eibel H, Schulze-Osthoff K, Kroegel C, Virchow J-C. Differential regulation of CD95 (Fas/APO-1) expression on human blood eosinophils. Eur. J. Immunol. 28, 2057-2065 (1998).

Vogt M, Bauer MKA, Ferrari D, Schulze-Osthoff K. Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells. FEBS Lett. 429, 67-72 (1998).

Los M, Khazaie K, Schulze-Osthoff K, Baeuerle A, Schirrmacher V, Chlichlia K. HTLV-1 Tax-mediated T-cell apoptosis follows an enhanced intracellular prooxidant state. J. Immunol. 161, 3050-3055 (1998).

Ferrari D, Stepzynska A, Los M, Wesselborg S, Schulze-Osthoff K. Differential regulation and ATP requirement of caspase-8 and -3 activation during CD95- and anticancer drug-induced apoptosis. J. Exp. Med. 188, 979-984 (1998).

Stroh C, Schulze-Osthoff K. Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ. 5, 997-1000 (1998).

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1997

Los M, Herr I, Friesen C, Fulda S, Schulze-Osthoff K , Debatin KM. Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases) in drug-induced cell death. Blood 90, 3118-329 (1997).

Bauer MKA, Lieb K, Schulze-Osthoff K, Bauer J, Gebicke-Haerter PJ, Fiebich BI. Expression and regulation of cyclooxygenase-2 in rat microglia. Eur. J. Biochem. 243, 726-731 (1997).

Bauer MKA, Wesselborg S, Schulze-Osthoff K . The C. elegans protein Ced-4 contains a sequence motif with similarity to the mammalian "death effector domain". FEBS Lett. 402, 256-258 (1997).

Wesselborg S, Bauer M., Schulze-Osthoff K. Activation of transcription factor NF-κB and p38 MAP kinase is mediated by distinct and separate stress effector pathways. J. Biol. Chem. 272, 12422-12429 (1997).

Schulze-Osthoff K, Ferrari D, Riehemann K, Wesselborg S. Regulation of NF- B activation by MAP kinase cascades. Immunobiol. 197, 35-49 (1997).

Lieb K, Fiebich BL, Berger M, Bauer J, Schulze-Osthoff K. The neuropeptide substance P activates transcription factor NF-κB and κB-dependent gene expression in human astrocytoma cells. J. Immunol. 159, 4952-4958 (1997).

Wang Z-Q, Stingl C, Morrison C, Jantsch M, Los M, Schulze-Osthoff K, Wagner EW. ADPRT/PARP is important for genomic stability but is dispensable in apoptosis. Genes & Development 11, 2347-2358 (1997).

Ferrari D, Wesselborg S, Bauer MKA, Schulze-Osthoff K . Extracellular ATP activates transcription factor NF- κB through the P2Z purinoreceptor by selectively targeting NF-κB p65 (RelA). J. Cell Biol. 139, 1635-1643 (1997).

Schulze-Osthoff K, Baeuerle PA. Regulation of gene expression by oxidative stress. Adv. Mol. Cell Biol. 25, 15-44 (1997).

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1996

Makropoulos V, Schulze-Osthoff K. Selenium-mediated inhibition of transcription factor NF-κB and HIV-1 LTR promoter activity. Arch. Toxicol. 70, 277-283 (!996).

Schenk H, Vogt M, Dröge W, Schulze-Osthoff K. Thioredoxin as a potent costimulus of cytokine expression. J. Immunol. 156, 765-771 (1996).

Schulze-Osthoff K, Bauer M, Vogt M, Los M. Involvement of ICE-related and other proteases in Fas-mediated apoptosis. Cell Death Differ. 3, 177-184 (1996).

Ratter F, Germer M, Fischbach T, Schulze-Osthoff K , Peter ME, Dröge W, Krammer PH, Lehmann V. S-Adenosylhomocysteine as a physiological mediator of APO-1-mediated apoptosis. Intern. Immunol. 8, 139-1147 (1996).

Grimm S, Bauer M, Baeuerle PA, Schulze-Osthoff K . Bcl-2 attenuates the activity of NF-κB which is induced upon apoptosis. J. Cell Biol. 134, 13-23 (1996).

Pahl H, Krauß B, Schulze-Osthoff K, Decker T, Traenckner EBM, Myers C, Parks T, Vogt M, Warring P, Mühlbacher A, Czernilofsky A-P, Baeuerle PA. The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κB. J. Exp. Med. 183, 1829-1840 (1996).

Mehlen P, Schulze-Osthoff K , Arrigo A-P. Small stress proteins as novel regulators of apoptosis: hsp27 blocks Fas/APO-1 and staurosporine-induced cell death. J. Biol. Chem . 271, 16510-16514 (1996).


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1995

Los M, Dröge W, Baeuerle PA, Schulze-Osthoff K. Hydrogen peroxide as a potent activator of T-lymphocyte functions. Eur. J. Immunol. 25, 159-165 (1995).

Westendorp M, Shatrov V, Schulze-Osthoff K , Frank R, Kraft M, Los M, Krammer PH, Dröge W, Lehmann V. HIV-1 Tat potentiates TNF-induced NF-κB activation and cytotoxicity by altering the cellular redox state. EMBO J. 14, 546-554 (1995).

Los M, van de Craen M, Penning CL, Schnek H, Westendorp M, Baeuerle PÅ, Dröge W, Krammer PH, Fiers W,
Schulze-Osthoff K. Requirement of an ICE/Ced-3 protease for Fas/APO-1 mediated apoptosis. Nature 371, 81-83 (1995).

Los M, Schenk H, Hexel K, Baeuerle PA, Dröge W, Schulze-Osthoff K. IL-2 gene expression and NF-κB activation through CD28 requires reactive oxygen production by 5-lipoxygenase. EMBO J. 14, 3731-3740 (1995).

Schulze-Osthoff K, Los M, Baeuerle PA. Redox signalling by transcription factors NF-κB and AP-1 in the immune system. Biochem. Pharmacol. 50, 735-741 (1995).

Goebeler M, Roth J, Bröcker E-B, Sorg C, Schulze-Osthoff K. Activation of nuclear factor-κB and gene expression in human endothelial cells by the common haptens nickel and cobalt. J. Immunol. 155, 2549-2467 (1995).

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1994


Schenk H, Klein M, Erdbrügger W, Dröge W, Schulze-Osthoff K. Distinct effects of thioredoxin and other antioxidants on the activation of NF-κB and AP-1. Proc. Natl. Acad. Sci USA 91, 1672-1676 (1994).

Bergmann S, Shatrov V, Ratter F, Schiemann S, Schulze-Osthoff K, Lehmann V. Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter nuclear factor-κB activation in L929 cells. J. Immunol. 153, 1736-1741 (1994).

Schulze-Osthoff K, Walczak H, Dröge W, Krammer PH. Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol. 127, 15-20 (1994).

Dröge W, Schulze-Osthoff K, Mihm S, Galter D, Schenk H, Eck H-P, Roth S, Gmünder H. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J. 14, 1131-1138 (1994).

Schulze-Osthoff K, Krammer PH, Dröge W. Divergent signaling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J. 13, 4587-4596 (1994).

Schulze-Osthoff K. The Fas/APO-1 receptor and its deadly ligand. Trends Cell Biol. 4, 421-426 (1994).

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