IFIB – Interfakultäres Institut für Biochemie

Key publications

Wimmers F, Pulendran B. Emerging technologies for systems vaccinology – multi-omics integration and single-cell (epi)genomic profiling. Curr Opin Immunol 2020; 65: 57-64. Link

Wimmers F, Donato M*, Kuo A*, Ashuach T*, Gupta S, Li C, Dvorak M, Foecke MH, Chang SE, Hagan T, De Jong SE, Maecker HT, van der Most R, Cheung P, Cortese M, Bosinger SE, Davis M, Rouphael N, Subramaniam S, Yosef N, Utz PJ, Khatri P, Pulendran B. The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination. Cell 2021; 184(15): 3915-35.e21. Link

Arunachalam PS*, Wimmers F* (equally contributing), Mok CKP*, Perera RAPM*, Scott M, Hagan T, Sigal N, Feng Y, Bristow L, Tak-Yin Tsang O, Wagh D, Coller J, Pellegrini KL, Kazmin D, Alaaeddine G, Leung WS, Chan JMC, Chik TSH, Choi CYC, Huerta C, Paine McCullough M, Lv H, Anderson E, Edupuganti S, Upadhyay AA, Bosinger SE, Maecker HT, Khatri P, Rouphael N, Peiris M, Pulendran B. Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans. Science 2020; 369(6508): 1210-20. Link

Wimmers F, Subedi N, van Buuringen N, Heister D, Vivié J, Beeren-Reinieren I, Woestenenk R, Dolstra H, Piruska A, Jacobs JFM, van Oudenaarden A, Figdor CG*, Huck WTS*, de Vries IJM*, Tel J. Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells. Nature Com 2018; 9(1): 3317. Link

Wimmers F, Aarntzen EH, Duiveman-deBoer T, Figdor CG, Jacobs JF*, Tel J*, de Vries IJM. Long-lasting multifunctional CD8(+) T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination. Oncoimmunology 2015; 5(1): e1067745. Link

List of all publications