Interfakultäres Institut für Mikrobiologie und Infektionsmedizin



Eberl, C et al., Reproducible Colonization of Germ-Free Mice with the Oligo-Mouse-Microbiota in Different Animal Facilities, Front Microbiol, 2020


Maerz, JK et al., Bacterial Immunogenicity is Critical for the Induction of Regulatory B Cells in Supressing Inflammatory Immune Responses, Front Immonuol, 2019

Steimle, A et al., Weak agonistic LPS restores intestinal immune homeostasis, Mol Ther, 2019

Steimle, A et al., Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains, PLoS Biol, 2019

Lange et al., A Gelleria mellonella oral administration model to study commensal-induced innate immune responses, J Vis Exp, 2019


Lange et al., Galleria mellonella: a novel invertebrate model to distinguish intestinal symbionts from pathobionts, Front Immunol, 2018

Lange et al., Genome Sequence of Galleria mellonella (Greater Wax Moth), Genome Announc, 2018.

Korkmaz et al., Proteome and phosphoproteome analysis of commensally induced dendritic cell maturation states, J Proteomics, 2017.

Parusel, R et al., An important question: Which LPS do you use?, Virulence, 2017.

Maerz, JK et al., Outer membrane vesicles blebbing contributes to B. vulgatus mpk-mediated immune response silencing, Gut microbes, 2017.

Peng, Z et al., Phosphotransferase systems in Enterococcus faecalis OG1RF enahnce anti-stress capacity in vitro and in vivo, Res Microbiol., 2017.

Schmid, M et al., Successful treatment of pouchitis with Vedolizumab, but not fecal microbiota transfer (FMT), after proctocolectomy in ulcerative colitis, Int J Colorectal Dis, 2017.

Frick, JS et al., Microbiome and chronic inflammatory diseases, J Mol Med, 2017.


Steimle, A. et al., The challenge of specific cathepsin S acitivity detection, J Neurol Neuromed, 2016.

Semrau, A., et al., Non-invasive detection and successful treatment of a Helicobacter pylori infection in a captive rhesus macaque. Lab Anim, 2016.

Steimle, A., et al., Symbiotic gut commensal bacteria act as host cathepsin S activity regulators. J Autoimmun, 2016.

Lange, A., et al., Extensive Mobilome-Driven Genome Diversification in Mouse Gut-Associated Bacteroides vulgatus mpk. Genome Biol Evol, 2016. 8(4): p. 1197-207.

Steimle, A., I.B. Autenrieth, and J.S. Frick, Structure and function: Lipid A modifications in commensals and pathogens. Int J Med Microbiol, 2016. 306(5): p. 290-301.

Steimle, A. and J.S. Frick, Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice. J Immunol Res, 2016. 2016: p. 1958650.

Frick, J.S. and D. Haller, Intestinal microbiota: From sequencing to function. Int J Med Microbiol, 2016. 306(5): p. 255-6.

Steimle, A., et al., A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells. J Immunol Methods, 2016. 432: p. 87-94.

Stammler, D., et al., Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1beta via a Caspase-1-Independent Mechanism. 2015. 195(11): p. 5421-31.

Matz-Rensing, K., et al., Outbreak of Tuberculosis in a Colony of Rhesus Monkeys (Macaca mulatta) after Possible Indirect Contact with a Human TB Patient. J Immunol, 2015. 153(2-3): p. 81-91.

Vogel, S., et al., Platelet-derived HMGB1 is a critical mediator of thrombosis. J Clin Invest, 2015. 125(12): p. 4638-54.

Wittmann, A., et al., TLR signaling-induced CD103-expressing cells protect against intestinal inflammation. Inflamm Bowel Dis, 2015. 21(3): p. 507-19.

Hector, A., et al., Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection. Am J Respir Crit Care Med, 2015. 191(8): p. 914-23.


Gronbach, K., et al., Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice. Gastroenterology, 2014. 146(3): p. 765-75.

Schaffler, H., et al., NOD2 stimulation by Staphylococcus aureus-derived peptidoglycan is boosted by Toll-like receptor 2 costimulation with lipoproteins in dendritic cells. Infect Immun, 2014. 82(11): p. 4681-8.

Schaffler, H., et al., Two patients with intestinal failure requiring home parenteral nutrition, a NOD2 mutation and tuberculous lymphadenitis. BMC Gastroenterol, 2014. 14: p. 43.

Volz, T., et al., Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells. J Invest Dermatol, 2014. 134(1): p. 96-104.

Felkel, M., et al., Evaluation of Mycobacterium tuberculosis drug susceptibility in clinical specimens from Nigeria using genotype MTBDRplus and MTBDRsl assays. Eur J Microbiol Immunol (Bp), 2013. 3(4): p. 252-7.

Klimosch, S.N., et al., Functional TLR5 genetic variants affect human colorectal cancer survival. Cancer Res, 2013. 73(24): p. 7232-42.

Wittmann, A., I.B. Autenrieth, and J.S. Frick, Plasmacytoid dendritic cells are crucial in Bifidobacterium adolescentis-mediated inhibition of Yersinia enterocolitica infection. PLoS One, 2013. 8(8): p. e71338.

Eller, C., et al., Presence of beta-lactamases in extended-spectrum-cephalosporin-resistant Salmonella enterica of 30 different serovars in Germany 2005-11. J Antimicrob Chemother, 2013. 68(9): p. 1978-81.

Hildebrand, D.G., et al., IkappaBzeta is a transcriptional key regulator of CCL2/MCP-1. J Immunol, 2013. 190(9): p. 4812-20.

Bugl, S., et al., Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood, 2013. 121(5): p. 723-33.


Gerlach, A.M., et al., Role of CD40 ligation in dendritic cell semimaturation. BMC Immunol, 2012. 13: p. 22.

Marschal, M., et al., Evaluation of 3 different rapid automated systems for diagnosis of urinary tract infections. Diagn Microbiol Infect Dis, 2012. 72(2): p. 125-30.

Jacobi, C.A., et al., Quorum sensing in the probiotic bacterium Escherichia coli Nissle 1917 (Mutaflor) - evidence that furanosyl borate diester (AI-2) is influencing the cytokine expression in the DSS colitis mouse model. Gut Pathog, 2012. 4(1): p. 8.

Zimmer, J., et al., A vegan or vegetarian diet substantially alters the human colonic faecal microbiota. Eur J Clin Nutr, 2012. 66(1): p. 53-60.

Schwille-Kiuntke, J., et al., Postinfectious irritable bowel syndrome: follow-up of a patient cohort of confirmed cases of bacterial infection with Salmonella or Campylobacter. Neurogastroenterol Motil, 2011. 23(11): p. e479-88.

Schwille-Kiuntke, J., et al., Post-infectious irritable bowel syndrome--a review of the literature. Z Gastroenterol, 2011. 49(8): p. 997-1003.

Eisner, F., et al., Immunonutrition with long-chain fatty acids prevents activation of macrophages in the gut wall. J Gastrointest Surg, 2011. 15(5): p. 853-9.

Doycheva, D., et al., The use of positron emission tomography/CT in the diagnosis of tuberculosis-associated uveitis. Br J Ophthalmol, 2011. 95(9): p. 1290-4.


Gronbach, K., et al., Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the host. Infect Immun, 2010. 78(7): p. 3036-46.

Schwiertz, A., et al., Microbiota in pediatric inflammatory bowel disease. J Pediatr, 2010. 157(2): p. 240-244.e1.

Frick, J.S., F. Grunebach, and I.B. Autenrieth, Immunomodulation by semi-mature dendritic cells: a novel role of Toll-like receptors and interleukin-6. Int J Med Microbiol, 2010. 300(1): p. 19-24.

Enck, P., et al., The effects of maturation on the colonic microflora in infancy and childhood. Gastroenterol Res Pract, 2009. 2009: p. 752401.

Enck, P., et al., The effects of ageing on the colonic bacterial microflora in adults. Z Gastroenterol, 2009. 47(7): p. 653-8.

Frick, J.S., et al., Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol, 2009. 182(8): p. 4957-64.


Muller, M., et al., Intestinal colonization of IL-2 deficient mice with non-colitogenic B. vulgatus prevents DC maturation and T-cell polarization. PLoS One, 2008. 3(6): p. e2376.

Bareiss, P.M., et al., Organotypical tissue cultures from adult murine colon as an in vitro model of intestinal mucosa. Histochem Cell Biol, 2008. 129(6): p. 795-804.

Geisel, J., et al., IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells. J Immunol, 2007. 179(9): p. 5811-8.

Kuhlicke, J., et al., Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS One, 2007. 2(12): p. e1364.

Benedix, F., et al., Early disseminated borreliosis with multiple erythema migrans and elevated liver enzymes: case report and literature review. Acta Derm Venereol, 2007. 87(5): p. 418-21.

Frick, J.S., et al., Identification of commensal bacterial strains that modulate Yersinia enterocolitica and dextran sodium sulfate-induced inflammatory responses: implications for the development of probiotics. Infect Immun, 2007. 75(7): p. 3490-7.

Frick, J.S., et al., Lactobacillus fermentum attenuates the proinflammatory effect of Yersinia enterocolitica on human epithelial cells. Inflamm Bowel Dis, 2007. 13(1): p. 83-90.


Frick, J.S., et al., Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: an important role for IL-6. Eur J Immunol, 2006. 36(6): p. 1537-47.

Calder, P.C., et al., Early nutrition and immunity - progress and perspectives. Br J Nutr, 2006. 96(4): p. 774-90.

Bohn, E., et al., Host gene expression in the colon of gnotobiotic interleukin-2-deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: common patterns and bacteria strain specific signatures. Inflamm Bowel Dis, 2006. 12(9): p. 853-62.

Waidmann, M., et al., Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice. Gastroenterology, 2003. 125(1): p. 162-77.