The worldwide increase in antimicrobial resistant bacterial pathogens coupled with declining discoveries of novel antibiotics is a serious threat to medicine and patients worldwide. Next generation sequencing technologies, bioinformatics and gnotobiotic models, however, led to new understanding of the human microbiome, its role in health and disease, particularly infectious diseases, and offer new opportunities for medical microbiology in the 21th century.
We are studying the molecular mechanisms and pathogenesis of mucosal bacterial infections, particularly in the gastrointestinal tract, in order to develop novel therapies and prevention strategies. Our approaches encompass genomics of bacterial pathogens, clinical epidemiology, experimental preclinical models of infectious and inflammatory diseases, as well as discovery and testing of novel targets and compounds to develop new antimicrobials.
Studies in medicine (Ulm, Dundee), resident in medical microbiology and hygiene (Ulm, Würzburg), postdoc and research group leader (Würzburg, Lausanne). Professor for medical microbiology and hygiene, Max von Pettenkofer Institute, Ludwig Maximilians University, Munich. Since 2000 professor for medical microbiology, chair of the Institute for Medical Microbiology and Hygiene, University Hospital of Tübingen. Since 2006 dean of the Medical Faculty, University of Tübingen. Spokesperson DZIF, partner site Tübingen, German Centre of Infection Research.
- Tacconelli E, Autenrieth IB, Peschel A. 2017. Fighting the enemy within. Science. 355:689-690.
- Autenrieth IB. 2017. The microbiome in health and disease: a new role of microbes in molecular medicine. J Mol Med 95:1-3
- Willmann M, El-Hadidi M, Huson DH, Schütz M, Weidenmaier C, Autenrieth IB, Peter S. 2015. Antibiotic selection pressure determination through sequence-based metagenomics. Antimicrob Agents Chemother. 59(12):7335-45
- Baur S, Rautenberg M, Faulstich M, Grau T, Severin Y, Unger C, Hoffmann WH, Rudel T, Autenrieth IB, Weidenmaier C. 2014. A nasal epithelial receptor for Staphylococcus aureus WTA governs adhesion to epithelial cells and modulates nasal colonization. PLoS Pathog. 10:e1004089
- Gronbach K, Flade I, Holst O, Lindner B, Ruscheweyh HJ, Wittmann A, Menz S, Schwiertz A, Adam P, Stecher B, Josenhans C, Suerbaum S, Gruber AD, Kulik A, Huson DH, Autenrieth IB, Frick JS. 2013. Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice. Gastroenterology. 146:765-775
- Autenrieth SE, Warnke P, Wabnitz GH, Lucero Estrada C, Pasquevich KA, Drechsler D, Günter M, Hochweller K, Novakovic A, Beer-Hammer S, Samstag Y, Hämmerling GJ, Garbi N, Autenrieth IB. 2012. Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis; PLoS Pathog. 8:e1002552.
- Müller JE, Papic D, Ulrich T, Grin I, Schütz M, Oberhettinger P, Tommassen J, Linke D, Dimmer KS, Autenrieth IB, Rapaport D. 2011. Mitochondria can recognize and assemble fragments of a beta-barrel structure. Mol Biol Cell. 22:1638-1647
- Renz H, von Mutius E, Brandtzaeg P, Cookson WO, Autenrieth IB, Haller D. 2011. Gene-environment interactions in chronic inflammatory disease. Nat Immunol. 12:273-277
- Autenrieth SE, Linzer T-R, Hiller C, Keller B, Warnke P, Köberle M, Bohn E, Biedermann T, Bühring H-J, Hammerling GJ, Rammensee HG, Autenrieth IB. 2010. Immune evasion by Yersinia enterocolitica: differential targeting of dendritic cell subpopulations in vivo. PLoS Pathog. 24:e1001212
- Köberle M, Klein-Günther A. Schütz M, Fritz M, Berchtold S, Tolosa E, Autenrieth IB, Bohn E. 2009. Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model. PLoS Pathog. 5:e1000551