Interfakultäres Institut für Mikrobiologie und Infektionsmedizin

List of Publications:


54. Unsleber S, Borisova M, Mayer C (2017) Enzymatic synthesis and semi-preparative isolation of N-acetylmuramic acid 6-phosphate, Carbohydrate Research, In press, available online 6 April 2017, pii/S0008621517300721.

53. Borisova M, Gisin J, Mayer C. (2017) The N-Acetylmuramic Acid 6-Phosphate Phosphatase MupP Completes the Pseudomonas Peptidoglycan Recycling Pathway Leading to Intrinsic Fosfomycin Resistance. mBio. 8. pii: e00092-17. doi: 10.1128/mBio.00092-17.

52. Morales AD, Liu Y, Hartman AM, Borisova M, de Sousa Borges A, de Kok N, Beilharz K, Veening JW, Mayer C, Hirsch AK, Scheffers DJ. (2017) Pentapeptide-rich peptidoglycan at the Bacillus subtilis cell-division site. Mol Microbiol. 104:319-333. doi: 10.1111/mmi.13629.


51. Mayer G, Schüller A, Matzner D, Lünse C, Wittmann V, Schumacher C, Unsleber S, Brötz-Oesterhelt H, Mayer C, Bierbaum G. (2016) Activation of the glmS ribozyme confers bacterial growth inhibition. Chembiochem. doi: 10.1002/cbic.201600491. [Epub ahead of print]

50. Borisova M, Gaupp R, Duckworth A, Schneider A, Dalügge D, Mühleck M, Deubel D, Unsleber S, Yu W, Muth G, Bischoff M, Götz F, Mayer C (2016) Peptidoglycan recycling in Gram-positive bacteria is crucial to survival in stationary phase. mBio doi: 10.1128/mBio.00923-16.

49. Jorge AM, Schneider J, Unsleber S, Göhring N, Mayer C, Peschel A (2016) Utilization of glycerophosphodiesters by Staphylococcus aureus. Mol. Microbiol. doi: 10.1111/mmi.13552.

48. Ruscitto A, Hottmann I, Stafford GP, Schäffer C, *Mayer C, *Sharma A (2016) Identification of a novel N-acetylmuramic acid transporter in Tannerella forsythia. J. Bacteriol. 198:3119-3125, *share corresponding authorship,

47. Studer P, Borisova M, Schneider A, Ayala JA, Mayer C, Schuppler M, Loessner MJ, Briers Y (2016) The Absence of a Mature Cell Wall Sacculus in Stable Listeria monocytogenes L-Form Cells Is Independent of Peptidoglycan Synthesis. PLoS One 11(5):e0154925. doi: 10.1371/journal.pone.0154925,


46. Kästle B, Geiger T, Gratani FL, Reisinger R, Goerke C, Borisova M, Mayer C, Wolz C (2015) rRNA regulation during growth and under stringent conditions in Staphylococcus aureus. Environ. Microbiol. 17:4394-4405. doi: 10.1111/1462-2920.12867,

45. Jeske O, Schüler M, Schumann P, Schneider A, Boedeker C, Jogler M, Bollschweiler D, Rohde M, Mayer C, Engelhardt H, Spring S and Jogler C (2015) Planctomycetes do possess peptidoglycan. Nat. Communications 6, 7116, doi: 10.1038/ncomms8116,

44. #Renner-Schneck M, #Hinderberger I, Gisin J, Exner T, *Mayer C, *Stehle T (2015) Crystal structure of the N-acetylmuramic acid α-1-phosphate (MurNAc-α1P) uridylyltransferase MurU, a minimal sugar-nucleotidyltransferase and potential drug target enzyme in Gram-negative pathogens. J. Biol. Chem. 290, 10804-13, #contributed equally, *share corresponding authorship,

43. Bertsche U, Mayer C, Götz F, *Gust AA. (2015) Peptidoglycan perception: sensing bacteria by their common envelope structure, Int. J. Med. Microbiol. 305, 217-223,


42. Borisova M, Gisin J, Mayer C (2014) Blocking peptidoglycan recycling in Pseudomonas aeruginosa attenuates intrinsic resistance to fosfomycin. Microb. Drug. Res. 20, 231-237,

41. Denger K, Weiss M, Felux A-K, Schneider A, Mayer C, Spiteller D, Huhn T, Cook AM, Schleheck D (2014) Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle. Nature 507(7490), 114-117,


40. Gisin J, Schneider A, Nägele B, Borisova M, Mayer C (2013) A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nature Chem. Biol. 9, 491-493,

39. Bertsche U, Yang SJ, Kuehner D, Wanner S, Mishra NN, Roth T, Nega M, Schneider A, Mayer C, Grau T, Bayer AS, Weidenmaier C (2013) Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. PLoS One 8(6): e67398,


38. Mayer C (2012) Bacterial cell wall recycling. In eLS. Encyclopedia of life science, John Wiley & Sons Ltd, Chichester, URL:,


37. Reith J, Mayer C (2011) Peptidoglycan turnover and recycling in Gram-positive bacteria. Appl. Microbiol. Biotechnol., 92, 1-11,

36. Reith J, Mayer C (2011) Characterization of a glucosamine/glucosaminide
N-acetyltransferase of Clostridium acetobutylicum. J. Bacteriol., 193, 5393-99,

35. Reith J, Berking A, Mayer C (2011) Characterization of an N-acetylmuramic acid/N-acetylglucosamine kinase of Clostridium acetobutylicum. J. Bacteriol., 193, 5386-92,


34. Litzinger S, Fischer S, Polzer P, Diederichs K, Welte W, Mayer C. (2010) Structural and kinetic analysis of Bacillus subtilis b-N-acetylglucosaminidase reveals a unique Asp-His dyad mechanism. J. Biol. Chem., 285, 35675-84,

33. Mayer C. (2010) Enzymologie des bakteriellen Zellwandrecyclings. (German). BIOspektrum, 5, 593.

32. Litzinger S, Duckworth A, Nitzsche K, Risinger C, Wittmann V, Mayer C. (2010) Muropeptide rescue in Bacillus subtilis involves sequential hydrolysis by β-N-acetylglucosaminidase and N-acetyl-l-alanine amidase. J. Bacteriol., 192, 3132-3143,

31. Litzinger S, Mayer C. (2010) Chapter 1: The murein sacculus. In H. König, H. Claus, A. Varma (eds.), Prokaryotic cell wall compounds – structure and biochemistry, Springer, Berlin, Heidelberg, 3-54,

before 2010

30. Mayer C (2008) Enzymology and physiology of the bacterial cell wall recycling and amino sugar metabolism. Habilitation thesis, University of Konstanz.

29. Hadi T, Dahl U, Mayer C, Tanner M (2008) Mechanistic studies on N-acetyl-muramic acid 6-phosphate hydrolase (MurQ): An etherase involved in peptidoglycan recycling. Biochemistry, 47, 11547-11558.

28. Jaeger T, Mayer C (2008) The transcriptional factors MurR and catabolite activator protein regulate N-acetylmuramic acid metabolism in Escherichia coli.
J. Bacteriol., 190, 6598-6608.

27. Jaeger T, Mayer C (2008) N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases). Cell. Mol. Life Sci., 65, 928-939.

26. Draing C, Sigel S, Deininger S, Traub S, Munke R, Mayer C, Hareng L, Hartung T, von Aulock S, Hermann C (2008) Cytokine induction by Gram-positive bacteria. Immunobiology, 213, 285-296.

25. Qu J, Mayer C, Behrens S, Holst O, Kleinschmidt JH (2007) The trimeric periplasmic chaperon Skp of E. coli froms 1:1 complexes with outer membrane proteins via hydrophobic and electrostatic interactions. J. Mol. Biol., 374, 91-105.

24. Mayer C, Vocadlo D, Mah M, Rupitz K, Stoll D, Warren RAJ, Withers SG (2006) Characterisation of a b-N-acetylhexosaminidase and a b-N-acetyl-glucosaminidase/b-glucosidase from Cellulomonas fimi. FEBSJ 273, 2929-2941.

23. Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT (2006) MurQ etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall. J. Bacteriol., 188, 1660-1662.

22. Mayer C (2005) Wie Bakterien ihre Verpackung wiederverwerten: Mureinabbau und Recycling. BIOspektrum 5, 616-619.

21. Jaeger T, Arsic M, Mayer C (2005) Scission of the lactyl ether bond of N-acetyl muramic acid by Escherichia coli "etherase". J. Biol. Chem., 280, 30100-30106.

20. Mayer C, Boos W (2005) Chapter 3.4.1 Hexose/hexitol and pentose/pentitol metabolism. In R. Curtiss III (Editor in Chief), EcoSal – Escherichia coli and Salmonella: Cellular and Molecular Biology. [Online.], ASM Press, Washington, D.C.

19. Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C (2004) Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid. J. Bacteriol., 186, 2385-2392.

18. Rast DM, Baumgartner D, Mayer C, Hollenstein GO (2003) Cell wall-associated enzymes in fungi. Phytochemistry 64, 339-366.

17. Tolborg JF, Petersen L, Jensen KJ, Mayer C, Jakeman DL, Warren RA, Withers SG (2002) Solid-phase oligosaccharide and glycopeptide synthesis using glycosynthases. J. Org. Chem., 67, 4243-4249.

16. Zechel DL, Reid SP, Nashiru O, Mayer C, Stoll D, Jakeman DL, Warren RA, Withers SG (2001) Enzymatic synthesis of carbon-fluorine bonds. J. Am. Chem. Soc., 123, 4350-4351.

15. Mayer C, Jakeman DL, Mah M, Karjala G, Gal L, Warren RA, Withers SG. (2001) Directed evolution of new glycosynthases from Agrobacterium b-glucosidase: a general screen to detect enzymes for oligosaccharide synthesis. Chem. Biol., 8, 437-443.

14. Mayer C, Zechel D, Warren RAJ, Withers SG (2000) E358S mutant of Agrobacterium sp. b-glucosidase is a greatly improved glycosynthase. FEBS Letters, 466, 40-44.

13. Mayer C, Vocadlo D, Withers SG (2000) b-N-Acetylhexosaminidases: two enzyme families, two mechanisms. Advances in Chitin Science (Peter, M.G, Muzzarelli, R.A.A., Domard, A., eds.), Vol. 4, European Chitin Society.

12. Zechel DL, Mayer C, Nashiru O, Warren RAJ, Withers SG (2000) Turbo-glycosynthases: Enhanced glycosylation activity obtained by substituting serine at the nucleophile position in retaining glycosidases. Biochemistry, 39, 1555.

11. Vocadlo DJ, Mayer C, Withers SG (2000) Mechanisms of retaining b-hexosaminidases: functionally related enzymes, differing catalytic mechanisms. Biochemistry, 39, 1554.

10. Mayer C, Vocadlo D, Withers SG (2000) b-N-Acetylhexosaminidases: two enzyme families, two mechanisms. Advances in Chitin Science (Peter, M.G, Muzzarelli, R.A.A., Domard, A., eds.), Vol. 4, European Chitin Society.

9. Vocadlo D, Mayer C, He S, Withers SG (2000) Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-b-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-a-L-idopyranosyl fluoride. Biochemistry, 31, 117-126.

8. Mayer C, Gal L, Warren RAJ, Withers, SG (1999) New glycosynthases: Screening of an enzyme library generated by combined region-directed mutagenesis/DNA-shuffling. FASEB Journal, 13, A1444.

7. Horsch M, Mayer C, Sennhauser U, Rast DM (1997) b-N-Acetylhexosaminidase: A target for the design of antifungal agents. Pharmacology Therapy, 76, 187-218.

6. Mayer C, Rast DM (1997) High-pH anion-exchange chromatography analysis of hydrolysis and transglycosylation catalyzed by chitinolytic enzymes.
In Chitin Handbook (Muzzarelli, R.A.A. and Peter M.G.,eds.), pp. 345-351, European Chitin Society, Grottammare, Italy.

5. Mayer C (1997) Eine mechanistische Analyse von Enzymen der Chitinlyse bei Pilzen. Ph.D. Thesis, University of Zürich, Juris Druck & Verlag, Dietikon (German).

4. Horsch M, Mayer C, Rast DM (1996) Stereochemical requirements of chitin synthase for ligand binding at the allosteric site for N-acetylglucosamine. Eur. J. Biochem. 237, 476-482.

3. Mayer C, Ruffner HP, Rast DM (1995) Assessment of the mode of action of chitinases with anion exchange chromatography/pulsed amperometric detection. In Advances in Chitin Science (Domard, A., Jeuniaux, Ch., Muzzarelli, R. and Roberts, G., eds.), Vol. 1, pp. 108-113, Jacques André Publisher, Lyon, France.

2. Sennhauser U, Mayer C, Rast, D.M. (1995) b-N-acetylhexosaminidases - a test system for new antimicrobials. In Advances in Chitin Science (Domard, A., Jeuniaux, Ch., Muzzarelli, R. and Roberts, G., eds.), Vol.1, pp. 114, Jacques André Publisher, Lyon, France.

1. Mayer C, Horsch M, Linder C, Rast DM (1993) Purification and substrate specificity of a b-N-acetylhexosaminidase from growing hyphae. In R.A.A. Muzzarelli (ed.) Proc. Int. Symp. on Chitin Enzymology, pp. 485, Eur. Chitin Soc., Ancona, Italy.