Feil group - signal transduction, transgenic models

We study signal transduction in transgenic cell and mouse models by an approach that we call "in vivo biochemistry". To this end, we use state-of-the-art transgenic mouse technology and try to "watch" biochemical processes in real time in living cells, tissues and mice. Specifically, we are interested in the role of the signalling molecule cGMP in health and disease, with a current focus on cell growth and plasticity in the mammalian cardiovascular and nervous system. The projects involve analyses at the whole organism, cellular and molecular level.

Research topics

  • Cardiovascular and neuronal cGMP signaling in health and disease
  • Visualization of cGMP and other signaling molecules with optical imaging (live cell and intravital imaging)
  • Genetic inducible cell fate mapping and cell tracking in animal models of diseases
  • Conditional gene targeting

DFG FOR 2060

The Feil group is a member of the DFG Research Unit FOR 2060
"cGMP Signalling in Cell Growth and Survival"

Read about the International FOR 2060 Meeting "Hot Topics in Signal Transduction & cGMP Research" in Tübingen, October 8-10, 2018

Jobs

We have new openings for PhD and postdoc positions. For more info, please see our advertisements (short version or long version). Application deadline is 31 October 2018.

Do you want to perform an internship or your Bachelor/Master thesis in our lab? Please contact Robert Feil (mail)!

News

  • We are happy to announce that the DFG will fund a Research Training Group Tübingen-Boston on "cGMP: From Bedside to Bench". More information in English or German.
  • Antilock brake system in arteries protects against heart attack (Press Release)
     
  • Congratulations to Susanne Feil! She attracted considerable funding from the EU/BMBF for an international project on atherosclerosis research. For more information, see news article in English or German. (english news article; deutsche Version auf attempto online)
     
  • Michael Paolillo was awarded the prize for the best presentation at the IFIB PhD Retreat. Congratulations, Michael!
     
  • Robert and Susanne Feil, together with Bernd Pichler (Werner Siemens Imaging Center), were awarded with the Eberle Innovation Prize 2017 for the development of a method for non-invasive visualisation of specific cell populations in mice using positron emission tomography (PET). Congratulations, Robert and Susanne! (Press Release)
     
  • Congratulations to Michael Paolillo on his Travel Award from the Elisabeth und Franz Knoop-Stiftung. Michael will use his award money for a collaboration between Tübingen University and the University of California San Diego.
     
  • Cell marking opens up a window into the body (Press Release)
     
  • Robert Feil received a Teaching Award from the students of Human Medicine. He was ranked among the TOP 25 lecturers during summer term 2016 and winter term 2016/2017.
     
  • Markus Wolters has received a grant of the University of Tübingen Program for the Promotion of Junior Researchers for his project "Comparative real-time analysis of cGMP signals linked to degeneration and regeneration of the eye and ear". Congratulations, Markus! Link to News Article
     
  • We are pleased to announce that Susanne Feil has received a DFG grant to initiate an international collaboration with Monash University, Melbourne, Australia. The project is entitled "Translational aspects of cardiovascular cGMP signaling".
     
  • Congratulations to Susanne Feil and Martin Thunemann! They won a poster prize at the 2nd German Pharm-Tox Summit (March 6-9 2017, Heidelberg, Germany) for their poster entitled "Transgenic mice for noninvasive visualization of specific cell populations in health, disease, and in response to pharmacotherapy".
     
  • Robert Feil received a Teaching Award from the students of Human Medicine. He was ranked among the TOP 25 lecturers during summer term 2015 and winter term 2015/2016.
     
  • Virility Drug May Boost Skin Cancer (Press Release)
     
  • We are pleased to announce that Martin Thunemann has received the "Preis für Biochemie an der Universität Tübingen 2015" (together with Bärbel Blaum, IFIB) for his work "Visualization of biochemical processes in mammals". Our sincere congratulations, Martin! This prize is awarded to excellent junior biochemists by the Elisabeth und Franz Knoop-Stiftung. Read Martin's project summary or Robert's laudatory speech.
     
  • Find more in the Feil lab's news archive!