Our research is focused on the study of dynamic membrane processes from a quantitative point of view. We have a special interest in the mitochondrial membrane alterations during apoptosis and the mechanism of action of the Bcl-2 proteins. To address these problems, we make use of our expertise in membrane biophysics, advanced microscopy and single molecule techniques.
- Identification and description of regulators of lymphocyte activation
- Molecular mechanisms of NF-kB activation in lymphocytes and lymphoma cells
- Assembly process of antigen receptors
- The role of the protease MALT1 in diseases
We work on intracellular RNA trafficking. Ribonucleic acid carries the cell's building instructions from the genome in the nucleus to the cytosol where proteins are synthesized according to these messages. Whether and where RNA is translated into protein is an important decision for the cell. We investigate mRNA localization and translation in yeast along with the life cycle and positioning of RNA-protein complexes, so called ribonucleoprotein particles (RNP), that are crucial for post-translational regulation.
- mRNA localisation and translational control in yeast
- Coordination of RNP and organelle transport
- Control of translation elongation
- Assembly and disassembly of transport ribonucleoprotein particles