Interfakultäres Institut für Mikrobiologie und Infektionsmedizin

AG Kretschmer

Forschungsschwerpunkte

Certain structurally conserved bacterial molecules, (Microbe-Associated Molecular Patterns, MAMPs) are directly recognized by dedicated host receptors to activate defense mechanisms. However, most of the known MAMPs are shared by commensals and pathogens and do not allow a discrimination between innocuous and aggressive bacteria. Using defined bacterial mutants we could demonstrate that staphylococcal PSM peptide leucocidins are chemoattractive to human phagocytes and are sensed by the human FPR2 receptor, which has hardly been implicated in innate immunity before. Hence, PSMs represent true pathogen-associated signals that attract leukocytes in relation to staphylococcal virulence. The role of FPR2 and of FPR2 agonists or antagonists in innate immunity are currently analyzed.

Werdegang

Dorothee Kretschmer studied Biology and obtained her Diploma (2006) and PhD degree (2010) in Microbiology in Tübingen. After holding a postdoctoral position in the lab of Andreas Peschel in Tübingen she establishes her junior group since 2011 focusing on Staphylococcus aureus host/pathogen interaction with emphasis on the role of pathogen recognition receptors in Gram-positive infections.

Arbeitsgruppe

Name/E-Mail Funktion
Dorothee Kretschmer Postdoc
Elisabeth Weiß Doktorandin
Katja Schlatterer Doktorandin
Cordula Gekeler TA
Vera Augsburger TA
   

Ausgewählte Publikationen

Funding

DFG - Transregional Collaborative Research Center TR-SFB 34 -Pathophysiology of Staphylococci