Interfakultäres Institut für Mikrobiologie und Infektionsmedizin

Curriculum vitae von Friedrich Götz

Bildung und Berufserfahrung

1968 - 1973 Studium der Biologie und Chemie an der Ludwig-Maximilians-Universität (LMU) München
1974 - 1978 Doktorand an der LMU München unter Prof. Dr. K. H. Schleifer in der Abteilung für Mikrobiologie
1978 Promotion
1985 Habilitation an der TU München über "Devolpment of a Host-Vector system in staphylococci"
1987 - 2015 Professor für Mikrobielle Genetik an der Universität Tübingen
2015 - Senior-Professor

Auszeichnungen / Ehrungen

1979/81 EMBO long term fellowship, Biomedical Center Uppsala
1989 DECHEMA award 1988 für die Entwicklung eines neuen Klonierungssystem in Staphylococcus carnosus
1991 DGHM Award 1990 für die wissenschaftliche Arbeit über die mikrobielle Genetik
2003 - 2009 Präsident und Vizepräsident der VAAM (Vereinigung für Allgemeine und Angewandte Mikrobiologie)
2011 - Mitglied der European Academy of Microbiology (EAM)

Projektmanagement, editoriale Arbeit und Beratung

2001 - 2010 Sprecher des Graduiertenkollegs 685 (DFG): Infection biology: human- and plant pathogenic bacteria and fungi
2006 - 2013 Koordinator der Tübinger Gruppe des Transregio SFB Greifswald Tübingen-Würzburg-Münster (TR34)

2000, 2004,

2008 - 2012

Mitglied des DFG Panel 204 "Microbiology, Virology, and Immunology"
1992 - 2000 Editor FEMS Microbiology Letters
1993 - 1999 Editor Applied and Environmental Microbiology
2003 - 2006 Editor "Molecular Microbiology"
2004 - Editor "Medical Microbiology and Immunology"
2011 Jodi Lindsay & Fritz Götz: Organisatoren der Gordon Research Conference "Staphylococcal Diseases" Il Ciocco, Italy
2011 Ralph Bertram & Fritz Götz: Organisatoren von "How dead is dead II" Tübingen

Aktuelle Forschungsthemen

Publikationen: > 360 peer reviewed Publikationen - h-Faktor 87

Zitierungsindices Alle Seit 2013

Zitierungen 26830 10186

h-index 87 63

i10-index 268 191 (Anzahl der Zitierungen mit wenigstens 10 Zitaten)

https://scholar.google.com/citations?hl=en&user=uq_ofGsAAAAJ&view_op=list_works

Ehemalige Doktoranden und/oder Postdocs in der Wissenschaft:

Prof. Raja Biswas, Center for Nanoscience and Molecular Medicine,
Amrita Institute of Medical Sciences and Research Centre, Kerala, India

Prof. Chih-Jung Chen, Department of Pediatric, Chang Gung Children’s Hospital,
Taoyuan, Taiwan

Prof. Jiří Doškař, Genetics and Molecular Biology, Brno University of Technology,
Czech Republic

Prof. Qiang Gao, College of Biotechnology, Tianjin University of Science
& Technology, Tianjin, China

PD Christine Heilmann, Medical Microbiology, University Münster, Germany

Prof. Wolfgang Liebl, Technical University München, Germany

Prof. Per-Eric Lindgren, Div. Microbiology and Infection, Linköping University,
Sweden

Dr. Michael Otto, Director, Pathogen Molecular Genetics Section, NIH, Washington
D.C. USA

Prof. Andreas Peschel, Infection Biology Department, University Tübingen,
Germany

Prof. Waldemar Vollmer, Bacterial Biochemistry, Newcastle University, UK

Ausgewählte Publikationen von 2015 – 2018

Deplanche, M., R.A. Filho, L. Alekseeva, E. Ladier, J. Jardin, G. Henry, V. Azevedo, A. Miyoshi, L. Beraud, F. Laurent, G. Lina, F. Vandenesch, J.P. Steghens, Y. Le Loir, M. Otto, F. Götz & N. Berkova, (2015) Phenol-soluble modulin alpha induce G2/M phase transition delay in eukaryotic HeLa cells. FASEB J pii:
fj.14-260513.

Ebner, P., A. Luqman, S. Reichert, K. Hauf, P. Popella, K. Forchhammer, M. Otto & F. Götz, (2017) Non-classical Protein Excretion Is Boosted by PSMalpha-Induced Cell Leakage. Cell Rep 20: 1278-1286.

Ebner, P., M. Prax, M. Nega, I. Koch, L. Dube, W. Yu, J. Rinker, P. Popella, M.Flötenmeyer & F. Götz, (2015) Excretion of cytoplasmic proteins (ECP) in Staphylococcus aureus. Mol Microbiol 97: 775-789.

Ebner, P., J. Rinker, M.T. Nguyen, P. Popella, M. Nega, A. Luqman, B. Schittek, M. Di Marco, S. Stevanovic & F. Götz, (2016) Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus. Infect Immun 84: 1672-1681.

Götz, F., W. Yu, L. Dube, M. Prax & P. Ebner, (2015) Excretion of cytosolic proteins (ECP) in bacteria. Int J Med Microbiol 305: 230-237.

Hanzelmann, D., H.S. Joo, M. Franz-Wachtel, T. Hertlein, S. Stevanovic, B. Macek, C. Wolz, F. Götz, M. Otto, D. Kretschmer & A. Peschel, (2016) Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants. Nat Commun 7: 12304.

Homma, T., A. Nuxoll, A.B. Gandt, P. Ebner, I. Engels, T. Schneider, F. Götz, K. Lewis & B.P. Conlon, (2016) Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis. Antimicrob Agents Chemother 60: 6510-6517.

Luqman, A., M. Nega, M.T. Nguyen, P. Ebner & F. Götz, (2018) SadA-Expressing Staphylococci in the Human Gut Show Increased Cell Adherence and Internalization. Cell Rep 22: 535-545.

Mayer, S., W. Steffen, J. Steuber & F. Götz, (2015) The Staphylococcus aureus NuoL-Like Protein MpsA Contributes to the Generation of Membrane Potential. J Bacteriol 197: 794-806.

Mechler, L., E.J. Bonetti, S. Reichert, M. Flötenmeyer, J. Schrenzel, R. Bertram, P. Francois & F. Götz, (2016) Daptomycin Tolerance in the Staphylococcus aureus pitA6 Mutant Is Due to Upregulation of the dlt Operon. Antimicrob Agents Chemother 60: 2684-2691.

Nega, M., L. Dube, M. Kull, A.K. Ziebandt, P. Ebner, D. Albrecht, B. Krismer, R. Rosenstein, M. Hecker & F. Götz, (2015) Secretome analysis revealed adaptive and non-adaptive responses of the Staphylococcus carnosus femB mutant. Proteomics 15: 1268-1279.

Nguyen, M.T., M. Deplanche, M. Nega, Y. Le Loir, L. Peisl, F. Götz & N. Berkova, (2016) Staphylococcus aureus Lpl Lipoproteins Delay G2/M Phase Transition in HeLa Cells. Front Cell Infect Microbiol 6: 201.

Nguyen, M.T. & F. Götz, (2016) Lipoproteins of Gram-Positive Bacteria: Key Players in the Immune Response and Virulence. Microbiol Mol Biol Rev 80: 891-903.

Nguyen, M.T., D. Hanzelmann, T. Hartner, A. Peschel & F. Götz, (2015a) Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response. Infect Immun 84: 205-215.

Nguyen, M.T., B. Kraft, W. Yu, D.D. Demicrioglu, T. Hertlein, M. Burian, M. Schmaler, K. Boller, I. Bekeredjian-Ding, K. Ohlsen, B. Schittek & F. Götz, (2015b) The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells. PLoS Pathog 11:e1004984.

Nguyen, M.T., A. Luqman, K. Bitschar, T. Hertlein, J. Dick, K. Ohlsen, B. Bröker, B. Schittek & F. Götz, (2017a) Staphylococcal (phospho)lipases promote biofilm formation and host cell invasion. Int J Med Microbiol.

Nguyen, M.T., J. Uebele, N. Kumari, H. Nakayama, L. Peter, O. Ticha, A.K. Woischnig, M. Schmaler, N. Khanna, N. Dohmae, B.L. Lee, I. Bekeredjian-Ding & F. Götz, (2017b) Lipid moieties on lipoproteins of commensal and noncommensal staphylococci induce differential immune responses. Nat Commun
8: 2246.

Popella, P., S. Krauss, P. Ebner, M. Nega, J. Deibert & F. Götz, (2016) VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity. Antimicrob Agents Chemother 60: 2391-2401.

Saising, J., M.T. Nguyen, T. Hartner, P. Ebner, A. Al Mamun Bhuyan, A. Berscheid, M. Muehlenkamp, S. Schakermann, N. Kumari, M.E. Maier, S.P. Voravuthikunchai, J. Bandow, F. Lang, H. Brötz-Oesterhelt & F. Götz, (2018) Rhodomyrtone (rom) is a membrane-active compound. Biochim Biophys Acta.

Shahmirzadi, S.V., M.T. Nguyen & F. Götz, (2016) Evaluation of Staphylococcus aureus Lipoproteins: Role in Nutritional Acquisition and Pathogenicity. Front Microbiol 7: 1404.

Uebele, J., C. Stein, M.T. Nguyen, A. Schneider, F. Kleinert, O. Ticha, G. Bierbaum, F. Götz & I. Bekeredjian-Ding, (2017) Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. PLoS Pathog 13: e1006387.