Pharmakologie, Toxikologie und Klinische Pharmazie

Publikationen

ATP-binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate KATP channels.

Sikimic J, McMillen TS, Bleile C, Dastvan F, Quast U, Krippeit-Drews P, Drews G, Bryan J.

J Biol Chem. 2018 Dec 26. pii: jbc.RA118.005236. doi: 10.1074/jbc.RA118.005236. [Epub ahead of print]

TGR5 Activation Promotes Stimulus-Secretion Coupling of Pancreatic Beta-Cells via a PKA-Dependent Pathway.

Maczewsky J, Kaiser J, Gresch A, Gerst F, Düfer M, Krippeit-Drews P, Drews G.

Diabetes. 2018 Nov 8. pii: db180315. doi: 10.2337/db18-0315. [Epub ahead of print]

ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic β-cells.

Bauer C, Kaiser J, Sikimic J, Krippeit-Drews P, Düfer M, Drews G.

Endocrine. 2018 Sep 18. doi: 10.1007/s12020-018-1731-0. [Epub ahead of print]

Energy depletion and not ROS formation is a crucial step of glucolipotoxicity (GLTx) in pancreatic beta cells.
Barroso Oquendo M, Layer N, Wagner R, Krippeit-Drews P, Drews G.
Pflugers Arch. 2018, 470:537-547.

Atrial Natriuretic Peptide Affects Stimulus-Secretion Coupling of Pancreatic β-Cells.
Undank S, Kaiser J, Sikimic J, Düfer M, Krippeit-Drews P, Drews G.
Diabetes. 2017, 66:2840-2848.

The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism.
Maczewsky J, Sikimic J, Bauer C, Krippeit-Drews P, Wolke C, Lendeckel U, Barthlen W, Drews G.
Endocrinology. 2017, 158:2145-2154.

The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo.
Sahr A, Wolke C, Maczewsky J, Krippeit-DrewsP, Tetzner A, Drews G, Venz S, Gürtler S, van den Brandt J, Berg S, Döring P, Dombrowski F, Walther T, Lendeckel U.
Endocrinology. 2016 157:4677-4690.

Evidence against a Ca2+-induced potentiation of dehydrogenase activity in pancreatic beta-cells.
Drews G, Bauer C, Edalat A, Düfer M, Krippeit-Drews P.
Pflügers Arch. 2015 467:2389-2397.

Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells.
Edalat A, Schulte-Mecklenbeck P, Bauer C, Undank S, Krippeit-Drews P, Drews G, Düfer M.
Diabetologia. 2015 58:1532-1541.

Human Islets Exhibit Electrical Activity on Microelectrode Arrays (MEA).
Schönecker S, Kraushaar U, Guenther E, Gerst F, Ullrich S, Häring HU, Königsrainer A, Barthlen W, Drews G, Krippeit-Drews P.
Exp Clin Endocrinol Diabetes. 2015 123:296-298.

Role of FXR in β-cells of lean and obese mice.
Schittenhelm B, Wagner R, Kähny V, Peter A, Krippeit-Drews P, Düfer M, Drews G.
Endocrinology. 2015 156:1263-1271.

Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays.
Schönecker S, Kraushaar U, Düfer M, Sahr A, Härdtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G.
Integrative biology : quantitative biosciences from nano to macro (Camb). 2014 6:540-544.

Glitazones exert multiple effects on β-cell stimulus-secretion coupling.
Düfer M, Noack K, Edalat A, Krippeit-Drews P, Drews G.
Molecular pharmacology. 2013 83:51-60.

The significance of the nuclear farnesoid X receptor (FXR) in β cell function.
Düfer M, Hörth K, Krippeit-Drews P, Drews G.
Islets. 2012 4:333-338. Review.

H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα.
Müller PM, Gnügge R, Dhayade S, Thunemann M, Krippeit-Drews P, Drews G, Feil R.
Free radical biology & medicine. 2012 53:1574-1583.

Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.
Düfer M, Hörth K, Wagner R, Schittenhelm B, Prowald S, Wagner TF, Oberwinkler J, Lukowski R, Gonzalez FJ, Krippeit-Drews P, Drews G.
Diabetes. 2012 61:1479-1489

Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays.
Pfeiffer T, Kraushaar U, Düfer M, Schönecker S, Haspel D, Günther E, Drews G, Krippeit-Drews
Pflügers Archiv : European journal of physiology. 2011 462:835-840.

Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells.
Düfer M, Noack K, Krippeit-Drews P, Drews G.
Islets. 2010 2:156-63.

BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells.
Düfer M, Neye Y, Hörth K, Krippeit-Drews P, Hennige A, Widmer H, McClafferty H, Shipston MJ, Häring HU, Ruth P, Drews G.
Diabetologia. 2011 54:423-432

Oxidative stress and beta-cell dysfunction.
Drews G, Krippeit-Drews P, Düfer M.
Pflugers Arch. 2010 460:703-718

Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse beta-cell
Martina Düfer, Katja Noack, Peter Krippeit-Drews and Gisela Drews
Islets 2010;2:1-9

Electrophysiology of islet cells.
Drews G, Krippeit-Drews P, Düfer M.
Advances in experimental medicine and biology. 2010;654:115-63

Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.
Gier B, Krippeit-Drews P, Sheiko T, Aguilar-Bryan L, Bryan J, Düfer M, Drews G.
The Journal of clinical investigation. 2009;119:3246-3256

Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.
Düfer M, Gier B, Wolpers D, Krippeit-Drews P, Ruth P, Drews G.
Diabetes. 2009;58:1835-1843.

Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells.
Düfer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G.
Pflugers Archiv : European journal of physiology. 2009;457:1351-1360.

An adenylate kinase is involved in KATP channel regulation of mouse pancreatic beta cells.
Schulze DU, Düfer M, Wieringa B, Krippeit-Drews P, Drews G.
Diabetologia. 2007;50:2126-2134.

The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells.
Dufer M, Haspel D, Krippeit-Drews P, Kelm M, Ranta F, Nitschke R, Ullrich S, Aguilar-Bryan L, Bryan J, Drews G.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2007;20:65-74.

ABCC8 and ABCC9: ABC transporters that regulate K+ channels.
Bryan J, Muñoz A, Zhang X, Düfer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L.
Pflugers Archiv : European journal of physiology. 2007 Feb;453:703-718.

HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents.
Neye Y, Düfer M, Drews G, Krippeit-Drews P.
The Journal of pharmacology and experimental therapeutics. 2006;316:106-112.

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.
Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Abdullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C,Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M, Ruth P.
Circulation. 2005;112:60-68.

Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.
Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G, Düfer M.
Diabetologia. 2005;48:913-921.

Direct interference of HIV protease inhibitors with pancreatic beta-cell function.
Düfer M, Neye Y, Krippeit-Drews P, Drews G.
Naunyn Schmiedebergs Arch Pharmacol. 2004;369:583-590.

Oscillations of membrane potential and cytosolic Ca2+ concentration in SUR1-/- beta cells.
Düfer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G.
Diabetologia. 2004;47:488-498.

Palmitate-induced Ca2+-signaling in pancreatic beta-cells.
Remizov O, Jakubov R, Düfer M, Krippeit Drews P, Drews G, Waring M, Brabant G, Wienbergen A, Rustenbeck I, Schöfl C.
Molecular and cellular endocrinology. 2003;212:1-9

Phosphocreatine as a determinant of KATP channel activity in pancreatic beta-cells.
Krippeit-Drews P, Bäcker M, Düfer M, Drews G.
Pflugers Archiv : European journal of physiology. 200 ;445:556-562.

Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate.
Düfer M, Krippeit-Drews P, Buntinas L, Siemen D, Drews G.
The Biochemical journal. 2002;368:817-825.

Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells.
Düfer M, Krippeit-Drews P, Drews G.
Pflugers Archiv : European journal of physiology. 2002;444:236-243.

Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells.
Düfer M, Krippeit-Drews P, Lembert N, Idahl LA, Drews G.
Molecular pharmacology. 2001;60:873-879

Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells.
Drews G, Krämer C, Düfer M, Krippeit-Drews P.
Biochem J. 2000;352:389-397

Dual effect of NO on KATP current of mouse pancreatic B-cells: stimulation by deenergizing mitochondria and inhibition by direct interaction with the channel.
Drews G, Krämer C, Krippeit-Drews P.
Biochimica et biophysica acta. 2000;1464:62-68

Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells.
Krippeit-Drews P, Düfer M, Drews G.
Biochem Biophys Res Commun. 2000;267:179-183

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