Pharmazeutische Biologie


94. A Buchmann, H Gross* (2020) Improved de-novo Draft Genome Sequence of the Nocavionin Producing Type Strain Nocardia terpenica IFM 0706T and comparative Genomics with the Closely Related Strain Nocardia terpenica IFM 0406. Microbiol. Resour. Announc., accepted
93. BT Odumosu, UN Augusta, C Cano-Prieto, A Buchmann, K Nieselt, H Gross* (2020). Draft Genome Sequence of Ochrobactrum sp. Strain MC-1LL, a Bacterial Strain with Antimicrobial Properties, Isolated from Marine Sediments in Nigeria. Microbiol. Resour. Announc.9, e00425-20.

N Kirchner, C Cano-Prieto, M van der Voort, JM Raaijmakers, H Gross* (2020) Draft Genome Sequence of Lipopeptide-Producing Strain Pseudomonas fluorescens DSM 11579 and Comparative Genomics with Pseudomonas sp. Strain SH-C52, a Closely Related Lipopeptide-Producing Strain. Microbiol. Resour. Announc., 9, e00304-20.

91. H Miess, A Frediansyah, M Göker, H Gross* (2020) Draft Genome Sequences of Six Type Strains of the Genus Massilia. Microbiol. Resour. Announc., 9, e00226-20.
90. S Schäfermann, C Hauk, E Wemakor, R Neci, G Mutombo, E Ngah Ndze, T Cletus, M Pattinora, F Nyaah, D Wistuba, I Helmle, C Häfele-Abah, H Gross, L Heide* (2020)
Substandard and falsified antibiotics and medicines against non-communicable diseases in western Cameroon and north-eastern Democratic Republic of Congo. Am. J. Trop. Med. Hyg., accepted.
89. J Chen, A Frediansyah, D Männle, J Straetener, H Brötz-Oesterhelt, N Ziemert, L Kaysser and H Gross* (2020) New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406. ChemBioChem, 21, 2205-2213. Available through open access:
88. S Mehnaz, A Bechthold and H Gross* (2020) Draft Genome Sequence of Pseudomonas chlororaphis subsp. aurantiaca ARS-38, a Bacterial Strain with Plant Growth Promotion Potential, Isolated from the Rhizosphere of Cotton in Pakistan. Microbiol. Resour. Announc., 9, e01398-19.
87. J Jiao, J Du, A Frediansyah, G Jahanshah and H Gross* (2020) Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli. J. Antibiot., 73, 28-34.
Selected as Bullet Point on the cover page: Trinickiabactin, an antibacterial lipopeptide siderophore with diazeniumdiolate moieties
86. T Schafhauser, L Lahn, N Kirchner, A Kulik, L Flor, A Lang, T Caradec, DP Fewer, K Sivonen, WJH van Berkel, P Jacques, T Weber, H Gross, KH van Pée, W Wohlleben* and J Ludwig-Müller* (2019) Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus. Proc. Natl. Acad. Sci. USA, 116, 26909-26917.
85. H Miess, P Arlt, AK Apel, T Weber, K Nieselt, F Hanssen, S Czemmel, S Nahnsen and H Gross* (2019) The Draft Whole-Genome Sequence of the Antibiotic Producer Empedobacter haloabium ATCC 31962 Provides Indications for Its Taxonomic Reclassification. Microbiol. Resour. Announc., 8, e01120-19.
84. N Aryal, S Aziz, P Rajbhandari and H Gross* (2019) Draft Genome Sequence of Nonomuraea sp. Strain C10, a Producer of Brartemicin, Isolated from a Mud Dauber Wasp Nest in Nepal. Microbiol. Resour. Announc., 8, e01109-19.
83. F Wiker, M Konnerth, I Helmle, A Kulik, L Kaysser, H Gross and B Gust* (2019) Identification of Novel α-Pyrones from Conexibacter woesei Serving as Sulfate Shuttles. ACS Chem. Biol., 14, 1972-1980.
82. M Alanjary, C Cano-Prieto, H Gross* and MH Medema* (2019) Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines. Nat. Prod. Rep., 36, 1249-1261.
81. A Baulig, I Helmle, M Bader, F Wolf, A Kulik, A Al-Dilaimi, D Wibberg, J Kalinowski, H Gross and L Kaysser* (2019) Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N–P-bond-forming kinase. Chem. Sci., 10, 4486-4490.

G Jahanshah, Q Yan, H Gerhardt, Z Pataj, M Lämmerhofer, I Pianet, M Josten, HG Sahl, MW Silby, JE Loper and H Gross* (2019) Discovery of the Cyclic Lipopeptide Gacamide A by Genome Mining and Repair of the Defective GacA Regulator in Pseudomonas fluorescens Pf0-1. J. Nat. Prod., 82, 301-308.

79. G Jahanshah, H Miess, T Busche, C Rückert, J Kalinowski, H Rokni-Zadeh and H Gross* (2019) Draft Genome Sequence of Micromonospora sp. Strain  MW-13, a Bacterical Strain with Antibacterial Properties and Plant Growth Promotion Potential, Isolated from the Rhizosphere of Wheat in Iran. Microbiol. Resour. Announc., 8, e01375-18.
78. A Buchmann, C Cano-Prieto, A Nafis, M Barakate, M Baz, L Hassani, N Ortlieb, THJ Niedermeyer and H Gross* (2019) Draft Genome Sequence of the Novonestmycin-Producing Strain Streptomyces sp. Z26, isolated from potato rhizosphere in Morocco. Microbiol. Resour. Announc., 8, e01514-18.



N Ortlieb, K Bretzel, A Kulik, J Haas, S Lüdeke, N Keilhofer, SD Schrey, H Gross and THJ Niedermeyer* (2018) Xanthocidin Derivatives from the Endophytic Streptomyces sp. AcE210 Provide Insight into the Xanthocidin Biosynthesis. ChemBioChem, 19, 2472-2480.


N Ortlieb, N Keilhofer, SD Schrey, H Gross and THJ Niedermeyer* (2018) Draft Genome Sequence of the Xanthocidin-Producing Strain Streptomyces sp. AcE210, Isolated from a Root Nodule of Alnus glutinosa (L.). Microbiol. Resour. Announc., 7, e01190-18. 


H Miess, G Jahanshah, H Brötz-Oesterhelt, M Willmann, S Peter and H Gross* (2018) Draft Genome Sequence of the Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolate TUEPA7472. Microbiol. Resour. Announc., 7, e01055-18.


M Eitel, D Schollmeyer, H Gross and P Koch* (2018) (2S,3S)-2-Azaniumyl-4-[(1S,4aS,4bS,6S,7S,8aS,10aS)- 6,7-dihydroxy-2,4b,8,8,10a-pentamethyl-

1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydrophenanthren-1-yl]-3-methoxybutanoate–methanol-water (1/1/1). IUCrData, 3, x181194.


S Aziz, Y Mast, W Wohlleben and H Gross* (2018) Draft Genome Sequence of the Pristinamycin-Producing Strain Streptomyces sp. SW4, Isolated from Soil in Nusa Kambangan, Indonesia. Microbiol. Resour. Announc., 7, e00912-18.


JB McAlpine,* SN Chen, A Kutateladze, JB MacMillan, G Appendino, A Barison, MA Beniddir, MW Biavatti, S Bluml, A Boufridi, MS Butler, RJ Capon, YH Choi, D Coppage, P Crews, MT Crimmins, M Csete, P Dewapriya, JM Egan, MJ Garson, G Genta-Jouve, WH Gerwick, H Gross, MK Harper, P Hermanto, JM Hook, L Hunter, D Jeannerat, NY Ji, TA Johnson, DGI Kingston, H Koshino, HW Lee, G Lewin, J Li, RG Linington, M Liu, KL McPhail, TF Molinski, BS Moore, JW Nam, RP Neupane, M Niemitz, JM Nuzillard, NH Oberlies, FMM Ocampos, G Pan, RJ Quinn, DS Reddy, JH Renault, J Rivera-Chavez, W Robien, CM Saunders, TJ Schmidt, C Seger, B Shen, C Steinbeck, H Stuppner, S Sturm, O Taglialatela-Scafati, DJ Tantillo, R Verpoorte, BG Wang, CM Williams, PG Williams, J Wist, JM Yue, C Zhang, Z Xu, C Simmler, DC Lankin, J Bisson and GF Pauli * (2018)

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Nat. Prod. Rep., 36, 35-107.


DT Linh, S Schwarz, H Gross, K Breitbach, F Hochgräfe, J Mostertz, K Eske-Pogodda, GE Wagner, I Steinmetz and C Kohler* (2018) GvmR - A Novel LysR-Type Regulator Involved in Virulence and Primary and Secondary Metabolism of Burkholderia pseudomallei. Frontiers in Microbiol., 9:935. doi: 10.3389/fmicb.2018.00935.


T Bahrami, S Zarvandi, R De Mot, H Gross, M Changi-Ashtiani and H Rokni-Zadeh* (2018) Draft Genome Sequence of Pseudomonas gingeri LMG 5327, the agent of ginger blotch in Agaricus bisporus. Genome Announc., 6(13), e00196-18.


J Paterson and H Gross* (2018) Draft Genome Sequence and Annotation of the phytopathogenic Ralstonia pickettii (Previously Burkholderia glumae) Strain ICMP-8657. Genome Announc., 6(10), e00128-18.


J Jiao, J Paterson, T Busche, C Rückert, J Kalinowski, D Harwani and H Gross* (2018) Draft Genome Sequence of Streptomyces sp. Strain DH-12, a Soilborne Isolate from the Thar Desert with Broad-Spectrum Antibacterial Activity. Genome Announc., 6(9), e00108-18.


PN Schwarz, A Buchmann, L Roller, A Kulik, H Gross, W Wohlleben and E Stegmann* (2018) The Immunosuppressant Brasilicardin: Determination of the Biosynthetic Gene Cluster in the Heterologous Host Amycolatopsis japonicum. Biotechnol. J., 13, 1700527.




F Leipoldt, J Santos-Aberturas, DP Stegmann, F Wolf, A Kulik, R Lacret, D Popadic, D Keinhörster, N Kirchner, P Bekiesch, H Gross, AW Truman* and L Kaysser* (2017) Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors. Nature Comm. 8, 1965.


JS Bauer, S Fillinger, K Förstner, A Herbig, AC Jones, K Flinspach, C Sharma, H Gross, K Nieselt and AK Apel* (2017) dRNA-seq Transcriptional Profiling of the FK506 Biosynthetic Gene Cluster in Streptomyces tsukubaensis NRRL18488 and General Analysis of the Transcriptome. RNA Biol. 14(11), 1617-1626.


F Wolf, JS Bauer, TM Bendel, A Kulik, J Kalinowski, H Gross and L Kaysser* (2017) Biosynthesis of the β-lactone proteasome inhibitors belactosins and cystargolides. Angew. Chem. Int. Ed., 56, 6665-6668.


J Paterson, G Jahanshah, Y Li, Q Wang, S Mehnaz and H Gross* (2017) The Contribution of Genome Mining Strategies to the Understanding of Active Principles of PGPR Strains. FEMS Microbiol. Ecol., 93, fiw249.




JS Bauer, N Hauck, L Christof, S Mehnaz, B Gust and H Gross* (2016) The Systematic Investigation of the Quorum Sensing System of the Biocontrol Strain Pseudomonas chlororaphis subsp. aurantiaca PB-St-2 Unveils aurI to Be a Biosynthetic Origin for 3-Oxo-Homoserine Lactones. PLoS ONE 11(11), e0167002.


A Buchmann, M Eitel, P Koch, PN Schwarz, E Stegmann, W Wohlleben, M Wolanski, M Krawiec, J Zakrzewska-Cerwinska, C Mendez, A Botas, LE Núnez, F Morís, J Cortes and H Gross* (2016) High-Quality Draft Genome Sequence of the Actinobacterium Nocardia terpenica IFM 0406, Producer of the Immunosuppressant Brasilicardins, Using Illumina and PacBio Technologies. Genome Announc., 4(6), e01391-16.


H Miess, S van Trappen, I Cleenwerck, P De Vos, and H Gross* (2016) Reclassification of Pseudomonas sp. PB-6250T as Lysobacter firmicutimachus sp. nov. Int. J. Syst. Evol. Microbiol., 66, 4162-4166.


A Deveau,* H Gross, B Palin, S Mehnaz, M Schnepf, P Leblond, PC Dorrestein, B Aigle (2016) Role of secondary metabolites in the interaction between Pseudomonas fluorescens and soil microorganisms under iron limited conditions. FEMS Microbiol. Ecol., 92(8), fiw107.


MGK Ghequire,* T Swings, J Michiels, H Gross, R De Mot (2016) Draft Genome Sequence of Pseudomonas putida BW11M1, a Banana Rhizosphere Isolate with a Diversified Antimicrobial Armamentarium. Genome Announc. 4(2): e00251-16.


T Schafhauser,* N Kirchner, A Kulik, MME Huijbers, L Flor, T Caradec, DP Fewer, H Gross, P Jacques, L Jahn, J Jokela, V Leclère, J Ludwig-Müller, K Sivonen, WJH van Berkel, T Weber, W Wohlleben* and KH van Pée (2016) The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicusPenicillium islandicum´). Environ. Microbiol., 18(11), 3728-3741.


T Zhang, E Holder, P Franco, M Lämmerhofer, A Sievers-Engler, H Gerhardt, H Gross, and W Lindner* (2016) Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary option to HILIC and to Reversed-Phase Chromatography. LC-GC Europe 29, 112-128.


H Gerhardt, A Sievers-Engler, G. Jahanshah, Z Pataj, F. Ianni, H Gross, W Lindner, and M Lämmerhofer* (2016) Methods for the comprehensive structural elucidation of constitution and stereochemistry of lipopeptides. J. Chromatogr. A, 1428, 280-291.




JS Bauer, MGK Ghequire, M Nett, M Josten, HG Sahl, R De Mot,*and H Gross* (2015) Biosynthetic Origin of the Antibiotic Pseudopyronines A and B in Pseudomonas putida BW11M1. ChemBioChem 16, 2491-2497.


MH Medema,* R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, I de Bruijn YH Chooi, J Claesen, RC Coates, P Cruz-Morales, S Duddela, S Düsterhus, DJ Edwards, DP Fewer, N Garg, C Geiger, JP Gomez-Escribano, A Greule, M Hadjithomas, AS Haines, EJN Helfrich, ML Hillwig, K Ishida, AC Jones, CS Jones, K Jungmann, C Kegler, HU Kim, P Kötter, D Krug, J Masschelein, AV Melnik, SM Mantovani, EA Monroe, M Moore, N Moss, H-W Nützmann, G Pan, A Pati, D Petras, FJ Reen, F Rosconi, Z Rui, Z Tian, NJ Tobias, Y Tsunematsu, P Wiemann, E Wyckhoff, X Yan, G Yim, F Yu, Y Xie, B Aigle, AK Apel, CJ Balibar, EP Balskus, F Barona-Gómez, A Bechthold, HB Bode, R Boriss, SF Brady, AA Brakhage, P Caffrey, Y-Q Cheng, J Clardy, RJ Cox, R De Mot, S Donadio, MS Donia, WA van der Donk, PC Dorrestein, S Doyle, AJM Driessen, M Ehling-Schulz, K-D Entian, MA Fischbach, L Gerwick, WH Gerwick, H Gross, et al. (2015) Minimum Information about a Biosynthetic Gene cluster. Nature Chem. Biol., 11, 625-631.


M van der Voort, H Meijer, Y Schmidt, J Watrous, E Dekkers, R Mendes, PC Dorrestein, H Gross, and JM Raaijmakers* (2015) Genome mining and metabolic profiling of the rhizosphere bacterium Pseudomonas sp. SH-C52 for antimicrobial compounds. Frontiers in Microbiol., 6, 693.
This article was selected to be published also in a Frontiers eBook as part of a special research topic: Ciancio, A., Pieterse, C. M. J., Mercado-Blanco, J., eds. (2016). Harnessing Useful Rhizosphere Microorganisms for Pathogen and Pest Biocontrol, Lausanne: Frontiers Media, pp 269-309, doi: 10.3389/978-2-88945-059-6 (


C Zachow,* G Jahanshah, I de Bruijn, C Song, F Ianni, Z Pataj, H Gerhardt, I Pianet, M Lämmerhofer, G Berg, H Gross, and JM Raaijmakers (2015) The Novel Lipopeptide Poaeamide of the Endophyte Pseudomonas poae RE*1-1-14 is Involved in Pathogen Suppression and Root Colonization. Mol. Plant-Microbe Interact., 28 (7), 800-810.




P Zeyhle, JS Bauer, M Steimle, F Leipoldt, M Rösch, J Kalinowski, H Gross,* and L Heide* (2014) A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509. ChemBioChem, 15, 2385-2392.


M Spohn, N Kirchner, A Kulik, A Jochim, F Wolf, P Muenzer, O Borst, H Gross, W Wohlleben and E Stegmann* (2014) Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17. Antimicrob. Agents Chemother., 58, 6185-6196.


P Zeyhle, JS Bauer, J Kalinowski, K Shin-ya, H Gross and L Heide* (2014) Genome-Based Discovery of a Novel Membrane-Bound 1,6-Dihydroxyphenazine Prenyltransferase from a Marine Actinomycete. PLoS ONE, 9, e99122.


F Ianni, Z Pataj, H Gross, R Sardella, B Natalini, W Lindner and M Lämmerhofer* (2014) Direct enantioseparation of underivatized aliphatic 3-hydroxyalkanoic acids with a quinine-based zwitterionic chiral stationary phase. J. Chromatogr. A, 1363, 101-108.


S Schieferdecker, TE Exner, H Gross, M Roth and M Nett* (2014) New myxothiazols from the predatory bacterium Myxococcus fulvus. J. Antibiot., 67, 519-525.


N Kirchner, JS Bauer, H Miess and H Gross* (2014) Woher nehmen, wenn nicht stehlen? Strategien für die Entwicklung neuer Antibiotika. Deutsche Apotheker Zeitung, 5, 54-63.


N Kirchner, JS Bauer, H Miess and H Gross* (2014) Mangelware Antibiotika. Wie es zu der Entwicklungslücke kommen konnte. Deutsche Apotheker Zeitung, 5, 48-53.


T Schneider*, A Müller, H Miess and H Gross* (2014) Cyclic lipopeptides as antibacterial agents – Potent antibiotic activity mediated by intriguing mode of actions. Int. J. Med. Microbiol. 304, 37-43.


S Mehnaz*, JS Bauer, H Gross*, (2014) Complete Genome Sequence of the Sugar Cane Endophyte Pseudomonas aurantiaca PB-St2, a Disease-Suppressive Bacterium with Antifungal Activity toward the Plant Pathogen Colletotrichum falcatum. Genome Announc. 2(1): e01108-13.


Y Schmidt, M van der Voort, M Crüsemann, J Piel, M Josten, HG Sahl, H Miess, JM Raaijmakers,* and H Gross* (2014) Biosynthetic Origin of the Antibiotic Cyclocarbamate Brabantamide A (SB-253514) in Plant-Associated Pseudomonas. ChemBioChem 15, 259-266.


A Deveau*, H Gross, E Morin, T Karpinets, S Utturkar, S Mehnaz, F Martin, P Frey-Klett, J Labbé (2014) Genome Sequence of the Mycorrhizal Helper Bacterium Pseudomonas fluorescens BBc6R8. Genome Announc. 2(1):e01152-13.




P Schweiger*, H Gross, J Zeiser, and U Deppenmeier (2013) Asymmetric reduction of diketones by two Gluconobacter oxydans oxidoreductases. Appl. Microbiol. Biotechnol., 97, 3475-3484.


S Mehnaz*, RSZ Saleem, B Yameen, I Pianet, G Schnakenburg, H Pietraszkiewicz, F Valeriote, M Josten, HG Sahl, SG Franzblau, and H Gross* (2013) Lahorenoic Acids A-C, ortho-Dialkyl-Substituted Aromatic Acids from the Biocontrol Strain Pseudomonas aurantiaca PB-St2. J. Nat. Prod. 76, 135-141.


SL Hartney, S. Mazurier, MK Girard, S Mehnaz, EW Davis II, H Gross, P Lemanceau, JE Loper* (2013) Ferric-Pyoverdine Recognition by Fpv Outer Membrane Proteins of Pseudomonas protegens Pf-5. J. Bacteriol. 195, 765-776.




TAM Gulder,* H Hong, J Correa, E Egereva, J Wiese, JF Imhoff, and H Gross* (2012) Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus. Mar. Drugs, 10, 2912-2935.


K Graupner, K Scherlach, T Bretschneider, G Lackner, M Roth, H Gross, and C Hertweck* (2012) Imaging Mass Spectrometry and Genome Mining Reveal Highly Antifungal Virulence Factor of Mushroom Soft Rot Pathogen. Angew. Chem. Int. Ed., 51, 13173-13177.


A Lange, H Sun, J Pilger, UM Reinscheid*, and H Gross* (2012) Predicting the Structure of Cyclic Lipopeptides by Bioinformatics: Structure Revision of Arthrofactin. ChemBioChem, 13, 2671-2675.


J Watrous, P Roach, T Alexandrov, BS Heath, JY Yang, RD Kersten, M van der Voort, K Pogliano, H Gross, JM Raaijmakers, BS Moore, J Laskin, N Bandeira, PC Dorrestein* (2012) Mass spectral molecular networking of living microbial colonies. PNAS, 109, E1743-E1752.


A Müller, D Münch, Y Schmidt, K Reder-Christ, G Schiffer, G Bendas, H Gross, HG Sahl, T Schneider, H Brötz-Oesterhelt* (2012) The lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors. J. Biol. Chem., 287, 20270-20280.


K Reder-Christ, Y Schmidt, M Dörr, HG Sahl, M Josten, JM Raaijmakers, H Gross*, and G Bendas* (2012) Model membrane studies for characterization of different antibiotic activities of lipopeptides from Pseudomonas. BBA Biomembranes, 1818, 566-573.




S. Mehnaz and H Gross (2011) Pseudomonas aurantiaca PB-St2 – a bio-fungicide and a bio-fertilizer for the future in: Plant Growth-Promoting Rhizobacteria (PGPR) for sustainable agriculture, MS Reddy, and Qi Wang, eds. China Agricultural Science and Technology Press, Beijing, pp. 79-88 (ISBN: 978-7-5116-0611-2).


B Han*, H Gross, KL McPhail, D Goeger, CS Maier, and WH Gerwick (2011) Wewakamide A and Guineamide G, Cyclic Depsipeptides from the Marine Cyanobacteria Lyngbya semiplena and Lyngbya majuscula. J. Microbiol. Biotechnol., 21, 930-936.


B Han, UM Reinscheid, WH Gerwick, and H Gross* (2011) The structure elucidation of isomalyngamide K from the marine cyanobacterium Lyngbya majuscula by experimental and DFT computational methods. J. Mol. Struct. 989, 109-113.




IE Mohamed, S Kehraus, A Krick, GM König, G Kelter, A Maier, HH Fiebig, M Kalesse, NP Malek, and H Gross* (2010) Mode of Action of Epoxyphomalins A and B and Characterization of Related Metabolites from the Marine-Derived Fungus Paraconiothyrium sp. J. Nat. Prod. 73, 2053-2056.


H Greve, IE Mohamed, A Pontius, S Kehraus, H Gross and GM König* (2010) Fungal metabolites: structural diversity as incentive for anticancer drug development. Phytochem. Rev. 9, 537-545.


MB Tabot, G Schnakenburg and H Gross* (2010) Pregna-1,4,20-trien-3-one, a cytotoxic marine steroid from the marine soft coral Nephthea sp. Acta Cryst. E66:o2040-o2041.


M Kurz, AY Burch, B Seip, SE Lindow and H Gross* (2010) Genome-Driven investigation of compatible solute biosynthesis pathways of Pseudomonas syringae pv. syringae and their contribution to water stress tolerance. Appl. Environ. Microbiol. 76(16), 5452-5462.


H Gross, KL McPhail, DE Goeger, FA Valeriote and WH Gerwick* (2010) Two Cytotoxic Stereoisomers of Malyngamide C, 8-Epi-Malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the Marine Cyanobacterium Lyngbya majuscula. Phytochemistry 71, 1729-1735.


P Schweiger, H Gross and U Depppenmeier* (2010) Characterization of two aldo-keto reductases from Gluconobacter oxydans 621H capable of regio- and stereoselective α-ketocarbonyl reduction. Appl. Microbiol. Biotechnol. 87, 1415-1426.


J Moldenhauer, DCG Götz, CR Albert, SK Bischof, K Schneider, RD Süssmuth, M Engeser, H Gross, G Bringmann and J Piel* (2010) The Final Steps of Bacillaene Biosynthesis in Bacillus amyloliquefaciens FZB42: Direct Evidence for β,γ Dehydration by a trans-Acyltransferase Polyketide Synthase. Angew. Chem. Int. Ed. 49(8), 1465-1467.




IE Mohamed, H Gross*, A Pontius, S Kehraus, A Krick, G Kelter, A Maier, HH Fiebig and GM König (2009) Epoxyphomalin A and B, Prenylated Polyketides with Potent Cytotoxicity from the Marine-Derived Fungus Phoma sp. Org. Letters 11, 5014-5017.


H Gross* and JE Loper* (2009) Genomics of secondary metabolite production by Pseudomonas spp. Nat. Prod. Rep. 26, 1408-1446.


H Gross* (2009) Genomic mining - a concept for the discovery of new bioactive natural products. Curr. Opin. Drug Discov. Devel. 12(2), 207-219


H Gross*, AD Wright, U Reinscheid and GM König (2009) Three New Spongian Diterpenes from the Fijian Marine Sponge Spongia sp. Nat. Prod. Commun., 4 (3), 315-322.




JE Loper, D Bruck, M Pechy-Tarr, M Maurhofer, C Keel, and H Gross (2008) Genomic analysis of secondary metabolite production by Pseudomonas fluorescens Pf-5. Paper number 101 in: Biology of Plant-Microbe Interactions, Volume 6. M Lorito, SL Woo, and F Scala, eds. International Society for Molecular Plant-Microbe Interactions, St. Paul, MN.


JE Loper, MD Henkels, BT Shaffer, FA Valeriote and H Gross* (2008) Isolation and Identification of Rhizoxin Analogs from Pseudomonas fluorescens Pf-5 by Using a Genomic Mining Strategy. Appl. Environ. Microbiol. 74(10), 3085-3093.


A Schmitz, G Harbaum-Neuhaus and H Gross* (2008) Der Zaubersalbei, Deutsche Apotheker Zeitung 148. Jahrgang, 1566-1571.


P Schweiger, H Gross, S Wesener and U Deppenmeier* (2008) Vinyl ketone reduction by three disctinct Gluconobacter oxydans 621H enzymes. Appl. Microbiol. Biotechnol. 80, 995-1006.




JE Loper* and H Gross (2007) Genomic analysis of antifungal metabolite production by Pseudomonas fluorescens Pf-5. Eur. J. Plant Pathol. 119(3), 265-278.


H Gross* (2007) Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects. Appl. Microbiol. Biotechnol. 75, 267-277.


H Gross, VO Stockwell, MD Henkels, B Nowak-Thompson, JE Loper and WH Gerwick* (2007) The Genomisotopic Approach: A Systematic Method to Isolate Products of Orphan Biosynthetic Gene Clusters. Chem. Biol. 14, 53-63.
This article was highlighted by a preview (C Corre and GL Challis (2007) Heavy Tools for Genome Mining. Chem. Biol. 14, 7-9) and selected for the journal cover page.

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H Gross and GM König* (2006) Terpenoids from marine organisms: unique structures and their pharmacological potential. Phytochem. Rev. 5, 115-141.


H Gross, DE Goeger, P Hills, SL Mooberry, DL Ballantine, TF Murray, FA Valeriote and WH Gerwick* (2006) Lophocladines, Bioactive Alkaloids from the Red Alga Lophocladia sp. J. Nat. Prod. 69, 640-644.


B Han, H Gross, DE Goeger, SL Mooberry and WH Gerwick* (2006) Aurilides B and C, Cancer Cell Toxins from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscula. J. Nat. Prod. 69, 572-575.

2005 and older



B Han, KL McPhail, H Gross, DE Goeger, SL Mooberry and WH Gerwick* (2005) Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Tetrahedron 61, 11723-11729.


EH Andrianasolo, H Gross, D Goeger, M Musafija-Girt, K McPhail, RM Leal, SL Mooberry and WH Gerwick* (2005) Isolation of Swinholide A and Related Glycosylated Derivatives from Two Field Collections of Marine Cyanobacteria. Org. Letters 7(7), 1375-1378.


H Gross, J Reitner and GM König* (2004) Isolation and structure elucidation of azoricasterol, a new sterol of the deepwater sponge Macandrewia azorica. Naturwissenschaften 91, 441-446.


H Gross, AD Wright, W Beil and GM König* (2004) Two new bicyclic cembranolides from a new Sarcophyton species and determination of the absolute configuration of sarcoglaucol-16-one. Org. Biomol. Chem. 2, 1133-1138.


H Gross, S Kehraus, M Nett, GM König*, W Beil and AD Wright (2003) New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp. Org. Biomol. Chem. 1, 944-949.


H Gross, S Kehraus, GM König, G Woerheide and AD Wright* (2002) New and Biologically Active Imidazole Alkaloids from Two Sponges of the Genus Leucetta. J. Nat. Prod. 65, 1190-1193.