Publications
2020
Micro-UHPLC-MS/MS method for analysis of oxylipins in plasma and platelets
Malgorzata Cebo, Xiaoqing Fu, Meinrad Gawaz, Madhumita Chatterjee, Michael Lämmerhofer
J. Pharm. Biomed. Anal., (2020), 113426
https://doi.org/10.1016/j.jpba.2020.113426
Multiple Heart-Cutting Mixed-mode Chromatography-Reversed-phase 2D-Liquid Chromatography Method for Separation and Mass Spectrometric Characterization of Synthetic Oligonucleotides
Feiyang Li, Xiaoli Su, Stefanie Bäurer, Michael Laemmerhofer,
J. Chromatogr. A, (2020) 461338
https://doi.org/10.1016/j.chroma.2020.461338
Lipid atlas of keratinocytes and betulin effects on its lipidome profiled by comprehensive UHPLC-MS/MS with data independent acquisition using targeted data processing
Carlos Calderón, Lara Rubarth, Malgorzata Cebo, Irmgard Merfort, Michael Lämmerhofer
Proteomics, 20 (2020) 1900113.
https://doi.org/10.1002/pmic.201900113
Lipidomic profiling of non-mineralized dental plaque and biofilm by untargeted UHPLC-QTOF-MS/MS and SWATH acquisition
Bernhard Drotleff, Simon Roth, Kerstin Henkel, Jörg Schlotterbeck, Merja Neukamm, Michael Laemmerhofer
Analytical and Bioanalytical Chemistry, 412 (2020) 2303–2314.
https://doi.org/10.1007/s00216-019-02364-2
Fragment-based Design of Zwitterionic, Strong Cation- and Weak Anion-Exchange Type Mixed-mode Liquid Chromatography Ligands and their Chromatographic Exploration
Martina Ferri, Stefanie Bäurer, Andrea Carotti, Marc Wolter, Belal Alshaar, Johannes Theiner, Tohru Ikegami, Caroline West, Michael Lämmerhofer
J. Chromatogr. A, 1621 (2020), 461075.
https://doi.org/10.1016/j.chroma.2020.461075
Thiol-ene photo-click immobilization of a chiral chromatographic ligand on silica particles
Christian Geibel, Kristina Dittrich, Marc Wolter, Michael Lämmerhofer
J. Chromatogr. A, 1622 (2020) 461133
https://doi.org/10.1016/j.chroma.2020.461133
Enantioselective UHPLC-MS/MS method based on sub-2µm particle polysaccharide column for chiral separation of oxylipins and its application for the analysis of auto-oxidized fatty acids and platelet releasates
Malgorzata Cebo, Xiaoqing Fu, Meinrad Gawaz, Madhumita Chatterjee, Michael Lämmerhofer
J. Chromatogr. A, 1624 (2020) 461206
https://doi.org/10.1016/j.chroma.2020.461206
Separation of Carbohydrate Isomers and Anomers on Poly-N-(1H-tetrazole-5-yl)-methacrylamide-bonded Stationary Phase by Hydrophilic Interaction Chromatography as well as Determination of Anomer Interconversion Energy Barriers
Xiaoqing Fu, Malgorzata Cebo, Tohru Ikegami, Michael Lämmerhofer
J. Chromatogr. A, 1620 (2020), 460981
https://doi.org/10.1016/j.chroma.2020.460981
Cinchona-based zwitterionic stationary phases: Exploring retention and enantioseparation mechanisms in supercritical fluid chromatography with a fragmentation approach
Adrien Raimbault, Cam Mai Anh Ma, Martina Ferri, Stefanie Bäurer, Pascal Bonnet, Stéphane Bourg, Michael Lämmerhofer, Caroline West
J. Chromatogr. A, 1612 (2020), 460689.
https://doi.org/10.1016/j.chroma.2019.460689
Simultaneous targeted and untargeted UHPLC-ESI-MS/MS method with data-independent acquisition for quantification and profiling of (oxidized) fatty acids released upon platelet activation by thrombin
Malgorzata Cebo, Jörg Schlotterbeck, Meinrad Gawaz, Madhumita Chatterjee, Michael Lämmerhofer
Anal. Chim. Acta, 1094 (2020) 57-69.
https://doi.org/10.1016/j.aca.2019.10.005
Mixed-mode Chromatography Characteristics of Chiralpak ZWIX(+) and ZWIX(-) and Elucidation of their Chromatographic Orthogonality for LC×LC Application
Stefanie Bäurer, Martina Ferri, Andrea Carotti, Stefan Neubauer, Roccaldo Sardella, Michael Lämmerhofer
Anal. Chim. Acta, 1093 (2020) 168-179.
https://doi.org/10.1016/j.aca.2019.09.068
Retention Characteristics of Poly(N-(1H-tetrazole-5-yl)-methacrylamide)-bonded Stationary Phase in Hydrophilic Interaction Chromatography
Xiaoqing Fu, Malgorzata Cebo, Tohru Ikegami, Michael Lämmerhofer
J. Chromatogr. A, 1609 (2020), 460500.
2019
In-situ photopolymerized polyhedral oligomeric silsesquioxane-derived monolithic capillary columns with quinidine functionality for enantioseparation by nano-liquid chromatography
Siyao Liu, Xinyue Fu, Ronny Löffler, Michael Lämmerhofer
Electrophoresis, 40 (2019), 3132-3139.
https://doi.org/10.1002/elps.201900316
Racemization without deamidation: Effect of racemization conditions on 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate tagged amino acids
Jeannie Horak, Michael Lämmerhofer.
J. Chromatogr. A, 1604 (2019), 460492.
https://doi.org/10.1016/j.chroma.2019.460492
Comprehensive Lipidomics of Mouse Plasma using Class-Specific Surrogate Calibrants and SWATH Acquisition for Large-Scale Lipid Quantification in Untargeted Analysis
Bernhard Drotleff, Julia Illison, Jörg Schlotterbeck, Robert Lukowski, Michael Lämmerhofer
Anal. Chim. Acta, 1086 (2019), 90-102.
https://doi.org/10.1016/j.aca.2019.08.030
Guidelines for Selection of Internal Standard-based Normalization Strategies in Untargeted Lipidomic Profiling by LC-HR-MS/MS
Bernhard Drotleff, Michael Lämmerhofer
Anal. Chem., 2019, 91, 15, 9836-9843.
https://doi.org/10.1021/acs.analchem.9b01505
Evaluation of superficially porous particle based zwitterionic chiral ion exchangers against fully porous particle benchmarks for enantioselective ultra-high performance liquid chromatography
Christian Geibel, Kristina Dittrich, Ulrich Woiwode, Michal Kohout, Tong Zhang, Wolfgang Lindner, Michael Lämmerhofer
J. Chromatogr. A, 1603 (2019), 130-140.
https://doi.org/10.1016/j.chroma.2019.06.026
Derivatize, Racemize and Analyze - an Easy and Simple Procedure for Chiral Amino Acid Standard Preparation for Enantioselective Metabolomics
Jeannie Horak, Michael Lämmerhofer
Anal. Chem., 2019, 91, 12, 7679-7689.
https://doi.org/10.1021/acs.analchem.9b00666
Functionalized gold nanoparticles for sample preparation: A review
Siyao Liu, Michael Lämmerhofer
Electrophoresis, 40 (2019), 2438-2461.
https://doi.org/10.1002/elps.201900111
Chiral separation of underivatized and 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate derivatized amino acids using zwitterionic quinine and quinidine type ZWIX columns by liquid chromatography - high-resolution mass spectrometry
Jeannie Horak, Michael Lämmerhofer
J. Chromatogr. A, 1596 (2019), 69-78.
https://doi.org/10.1016/j.chroma.2019.02.060
Stable-bond reversed-phase/weak anion-exchange mixed-mode stationary phase obtained by simultaneous functionalization and crosslinking of a poly(3-mercaptopropyl)methylsiloxane-film on vinyl silica via thiol-ene double click reaction
Stefanie Bäurer, Aleksandra Zimmermann, Ulrich Woiwode, Orlando Sánchez-Muñoz, Markus Kramer, Jeannie Horak, Michael Lämmerhofer
J. Chromatogr. A, 1593 (2019) 110-118.
https://doi.org/10.1016/j.chroma.2019.01.078
In-situ photopolymerized C4-functionalized organosilicon monoliths for reversed-phase protein separation in nano-liquid chromatography.
Çiğdem Kip, Siyao Liu, Xinhue Fu, Ali Tuncel, Michael Lämmerhofer
Talanta, 198 (2019) 330-336.
https://doi.org/10.1016/j.talanta.2019.01.116
A combined Targeted/Untargeted LC-MS/MS-based Screening Approach for Mammalian Cell Lines Treated with Ionic Liquids: Toxicity Correlates with Metabolic Profile
Corinna Sanwald, Alexandra Robciuc, Suvi-Katriina Ruokonen, Susanne K. Wiedmer, Michael Lämmerhofer
Talanta, 197 (2019) 472-481.
https://doi.org/10.1016/j.talanta.2019.01.054
Discovery of the Cyclic Lipopeptide Gacamide A by Genome Mining and Repair of the defective GacA-Regulator in Pseudomonas fluorescens Pf0-1.
Gahzaleh Jahanshah, Heike Gerhardt, Zoltán Pataj, Michael Lämmerhofer, Isabelle Pianet, Markus Nett, Michaele Josten, Hans-Georg Sahl, Mark W. Silby, Joyce E. Loper, Harald Gross
J. Nat. Prod., 2019, 82, 2, 301-308.
https://doi.org/10.1021/acs.jnatprod.8b00747
Guidelines for tuning the macropore structure of monolithic columns for high-performance liquid chromatography
José Luís Dores-Sousa, Alejandro Fernández-Pumarega, Jelle De Vos, Michael Lämmerhofer, Gert Desmet, Sebastiaan Eeltink,
J. Sep. Sci., 42 (2019) 522-533.
https://doi.org/10.1002/jssc.201801092
Quantitative analysis of chemoresistance-inducing fatty acid in food supplements using UHPLC-ESI-MS/MS
Jörg Schlotterbeck, Malgorzata Cebo, Agnes Kolb, Michael Lämmerhofer
Anal. Bioanal. Chem., 411 (2019) 479-491.
https://doi.org/10.1007/s00216-018-1468-x
Comparison of simple monophasic versus classical biphasic extraction protocols for comprehensive UHPLC-MS/MS lipidomics analysis of Hela cells
Carlos Calderón, Corinna Sanwald, Jörg Schlotterbeck, Bernhard Drotleff, Michael Lämmerhofer
Anal. Chim. Acta, 1048 (2019) 66-74.
https://doi.org/10.1016/j.aca.2018.10.035
Protein A- and Protein G-Gold Nanoparticle Bioconjugates as Nano-Immunoaffinity Platform for human IgG Depletion in Plasma and Antibody Extraction from Cell Culture Supernatant
Siyao Liu, Elisabeth Haller, Jeannie Horak, Marlene Brandstetter, Thomas Heuser, Michael Lämmerhofer
Talanta, 194 (2019) 664-672.
https://doi.org/10.1016/j.talanta.2018.10.079
Simultaneous separation of water- and fat-soluble vitamins by selective comprehensive hilic × rplc (high-resolution sampling) and active solvent modulation
Stefanie Bäurer, Wenkai Guo, Stefan Polnick, Michael Lämmerhofer
Chromatographia, 82 (2019) 167-180.
https://doi.org/10.1007/s10337-018-3615-0
Comprehensive MS/MS profiling by UHPLC-ESI-QTOF-MS/MS using swath data-independent acquisition for the study of platelet lipidomes in coronary artery disease
Jörg Schlotterbeck, Madhumita Chatterjee, Meinrad Gawaz, Michael Lämmerhofer
Anal. Chim. Acta, 1046 (2019) 1-15.
2018
Free fatty acid profiling in marine algae extract by LC‐MS/MS and isolation as well as quantification of the ω‐3 fatty acid hexadeca‐4,7,10,13‐tetraenoic acid
Jörg Schlotterbeck, Agnes Kolb, Michael Lämmerhofer
J. Sep. Sci., 41 (2018) 4286-4295.
https://doi.org/10.1002/jssc.201800780
Comparison of small size fully porous particles and superficially porous particles of chiral anion-exchange type stationary phases in ultra-high performance liquid chromatography: Effect of particle and pore size on chromatographic efficiency and kinetic performance
Kristina Schmitt, Ulrich Woiwode, Michal Kohout, Tong Zhang, Wolfgang Lindner, Michael Lämmerhofer
J. Chromatogr. A, 1569 (2018) 149-159.
https://doi.org/10.1016/j.chroma.2018.07.056
Zwitterionic codeine-derived methacrylate monoliths for enantioselective capillary electrochromatography of chiral acids and chiral bases
Enrique Javier Carrasco-Correa, Martina Ferri, Ulrich Woiwode, Yubo Ma, José Manuel Herrero-Martínez, Guillermo Ramis-Ramos, Wolfgang Lindner, Michael Lämmerhofer
Electrophoresis, 39 (2018) 2558-2565.
https://doi.org/10.1002/elps.201800126
Imaging peptide and protein chirality via amino acid analysis by chiral × chiral two-dimensional correlation liquid chromatography
Ulrich Woiwode, Roland Johann Reischl, Stephan Buckenmaier, Wolfgang Lindner, and Michael Lämmerhofer
Anal. Chem., 2018, 90 (13), pp 7963–7971
https://doi.org/10.1021/acs.analchem.8b00676
Complementary enantioselectivity profiles of chiral cinchonan carbamate selectors with distinct carbamate residues and their implementation in enantioselective two-dimensional high-performance liquid chromatography of amino acids
Ulrich Woiwode, Martina Ferri, Norbert M Maier, Wolfgang Lindner, Michael Laemmerhofer
J. Chromatogr. A, 1558 (2018) 29-36.
https://doi.org/10.1016/j.chroma.2018.04.061
N-Propyl-N'-2-pyridylurea-modified silica as mixed-mode stationary phase with moderate weak anion exchange capacity and pH-dependent surface charge reversal
Stefanie Baeurer, Stefan Polnick, Orlando L Sanchez-Munoz, Markus Kramer, Michael Laemmerhofer
J. Chromatogr. A, 1560 (2018) 45-54.
https://doi.org/10.1016/j.chroma.2018.05.012
Enantioselective multiple heartcut two-dimensional ultra-high-performance liquid chromatography method with a Coreshell chiral stationary phase in the second dimension for analysis of all proteinogenic amino acids in a single run
Ulrich Woiwode, Stefan Neubauer, Wolfgang Lindner, Stephan Buckenmaier, Michael Lämmerhofer
J. Chromatogr. A, 1562 (2018) 69-77.
https://doi.org/10.1016/j.chroma.2018.05.062
Quantification of Steroid Hormones in Plasma Using a Surrogate Calibrant Approach and UHPLC-ESI-QTOF-MS/MS with SWATH-Acquisition Combined with Untargeted Profiling
B. Drotleff, M. Hallschmid, M. Lämmerhofer
Anal. Chim. Acta, 1022 (2018) 70-80.
https://doi.org/10.1016/j.aca.2018.03.040
Insulin and Estrogen Independently and Differentially Reduce Macronutrient Intake in Healthy Men
R. Krug, L. Mohwinkel, B. Drotleff, J. Born, M. Hallschmid
J. Clin. Endocrinol. Metab, 103 (2018) 1393-1401
https://doi.org/10.1210/jc.2017-01835
Chiral Separation of disease biomarkers with 2-hydroxycarboxylic acid structure
Carlos Calderon, Cristina Santi, Michael Lämmerhofer
J. Sep. Sci., 41 (2018) 1224-1231
https://doi.org/10.1002/jssc.201701243
Correlation between ionic liquid cytotoxicity and liposome-ionic liquid interactions.
Suvi-Katriina Ruokonen, Corinna Sanwald, Alexandra Robciuc, Sami Hietala, Antti H. Rantamäki, Joanna Witos, Alistair W. T. King, Michael Lämmerhofer, Susanne K. Wiedmer
Chem. Eur .J., 24 (2018) 2669 –2680
http://dx.doi.org/10.1002/chem.201704924.
Response Surface Methodology for the Determination of the Design Space of Enantiomeric Separations on Cinchona-based Zwitterionic Chiral Stationary Phases by High Performance Liquid chromatography.
Rasha Sayed Hanafi, Michael Lämmerhofer
J. Chromatogr. A, 1534 (2018) 55-63
https://doi.org/10.1016/j.chroma.2017.12.044
Optimization of surface modification process of crosslinked polythiol-coated chiral stationary phases synthesized by two-step thiol-ene click reaction
Kristina Schmitt, Michael Lämmerhofer
J. Sep. Sci., 41 (2018) 1338–1345
2017
Sub-minute Separations in Enantioselective Ultra High-Performance Liquid Chromatography with Superficially Porous Chiral Stationary Phases
Ulrich Woiwode, Stefan Neubauer, Mike Kaupert, Wolfgang Lindner, Michael Lämmerhofer
Chrom+Food FORUM, 09 (2017)
Accurate and Reliable Quantification of the Protein Surface Coverage on Protein-Functionalized Nanoparticles
Siyao Liu, Jeannie Horak, Markus Höldrich, Michael Lämmerhofer
Anal. Chim. Acta, 989 (2017) 29-37.
http://dx.doi.org/10.1016/j.aca.2017.08.004
Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine
Niklas M. Walter, Heike K. Wentsch, Mike Bührmann, Silke M. Bauer, Eva Döring, Svenja Mayer-Wrangowski, Adrian Sievers-Engler, Nicole Willemsen-Seegers, Guido Zaman, Rogier Buijsman, Michael Lämmerhofer, Daniel Rauh, and Stefan A. Laufer
J. Med. Chem., 60 (2017) 8027–8054.
http://dx.doi.org/10.1021/acs.jmedchem.7b00745
Trends in Enantioselective High-Performance Liquid Chromatography
Ulrich Woiwode, Stefan Neubauer, Mike Kaupert, Wolfgang Lindner, Michael Lämmerhofer
Special Issue on Recent Developments in HPLC and UHPLC (Ed. Deirdre Cabooter), Supplement to LCGC Europe / LCGC North America, June 01, 2017, Volume 30, Issue 6, 34-42.
http://www.chromatographyonline.com/trends-enantioselective-high-performance-liquid-chromatography
Preparation of Mach-Zehnder interferometric photonic biosensors by inkjet printing technology
Florian Strasser; Eva Melnik; Paul Muellner; Pilar Jiménez-Meneses; Magdalena Nechvile; Guenther Koppitsch; Peter Lieberzeit; Michael Laemmerhofer; Rudolf Heer; Rainer Hainberger
Proc. SPIE 10231, Optical Sensors 2017, 102312H (May 16, 2017)
http://dx.doi.org/10.1117/12.2267156
Trisubstituted imidazoles with a rigidized hinge binding motif act as single digit nM inhibitors of clinically relevant EGFR L858R/T790M and L858R/T790M/C797S mutants: An example of target hopping
Michael Juchum, Marcel Günther, Eva Doering, Adrian Sievers-Engler, Michael Lämmerhofer, Stefan A. Laufer
J. Med. Chem., 60 (2017) 4636-4656.
http://dx.doi.org/10.1021/acs.jmedchem.7b00178
Surface-anchored counterions on weak chiral anion-exchangers accelerate separations and improve their compatibility for mass-spectrometry-hyphenation
Ulrich Woiwode, Adrian Sievers-Engler, Aleksandra Zimmermann, Wolfgang Lindner, Orlando L. Sánchez-Muñoz, Michael Lämmerhofer
J. Chromatogr. A, 1503 (2017) 21-31.
http://dx.doi.org/10.1016/j.chroma.2017.04.054
Gold Nanoparticle-Based Immobilized Enzyme Reactors Straightforward and Accelerated Sample Preparation in Protein and Biopharmaceuticals Analysis
Siyao Liu, Markus Höldrich, Helmut Hinterwirth, Michael Lämmerhofer
Chrom+Food FORUM, 04 (2017) 12-15.
In-situ Functionalized Monolithic Polysiloxane-Polymethacrylate Composite Materials from Polythiol-Ene Double Click Reaction in Capillary Column Format for Enantioselective Nano-HPLC
Marc Wolter, Michael Lämmerhofer,
J. Chromatogr. A, 1497 (2017) 172-179.
http://dx.doi.org/10.1016/j.chroma.2017.03.070
Regulation of oxidized platelet lipidome: implications for coronary artery disease
Madhumita Chatterjee, Dominik Rath, Jörg Schlotterbeck, Johannes Rheinlaender, Britta Walker-Allgaier, Nada Alnaggar, Monika Zdanyte, Iris Müller, Oliver Borst, Tobias Geisler, Tilman E. Schäffer, Michael Lämmerhofer and Meinrad Gawaz
Eur Heart J., 38 (2017) 1993-2005.
http://dx.doi.org/10.1093/eurheartj/ehx146
Selective Targeting of G-Quadruplex Structures by a Benzothiazole-Based Binding Motif
Ina Buchholz, Beatrice Karg, Jonathan Dickerhoff, Adrian Sievers-Engler, Michael Lämmerhofer, Klaus Weisz
Chem. Eur. J., 23 (2017) 5814-5823.
http://dx.doi.org/10.1002/chem.201700298
Papain-functionalized Gold Nanoparticles as Heterogeneous Biocatalyst for Bioanalysis and Biopharmaceuticals Analysis
Siyao Liu, Markus Höldrich, Adrian Sievers-Engler, Jeannie Horak, Michael Lämmerhofer
Anal. Chim. Acta, 963 (2017) 33-43,
http://dx.doi.org/10.1016/j.aca.2017.02.009
Taylor Dispersion Analysis, Resonant Mass Measurement and Bioactivity of Pepsin-Coated Gold Nanoparticles
Markus Höldrich, Siyao Liu, Markus Epe, Michael Lämmerhofer
Talanta, 167 (2017) 67–74
http://dx.doi.org/10.1016/j.talanta.2017.02.010
Chiral Separation of Short Chain Aliphatic Hydroxycarboxylic Acids on Cinchonan Carbamate based Weak Chiral Anion Exchangers and Zwitterionic Chiral Ion Exchangers
Carlos Calderón, Michael Lämmerhofer
J. Chromatogr. A, 1487 (2017) 194–200
http://dx.doi.org/10.1016/j.chroma.2017.01.060
Tri‐ and Tetra‐substituted Pyridinylimidazoles as Covalent Inhibitors of c‐Jun N‐Terminal Kinase 3
Felix Muth, Ahmed El-Gokha, Francesco Ansideri, Michael Eitel, Eva Döring, Adrian Sievers-
Engler, Andreas Lange, Frank M. Boeckler, Michael Laemmerhofer, Pierre Koch, and Stefan A. Laufer
J. Med. Chem., 60 (2017) 594–607
2016
Surface Modification of Integrated Optical MZI Sensor Arrays Using Inkjet Printing Technology
Eva Melnik, Florian Strasser, Paul Muellner, Rudolf Heer, Giorgio C. Mutinati, Guenther Koppitsch, Peter Lieberzeit, Michael Laemmerhofer, Rainer Hainberger
Procedia Engineering, 168 (2016) 337–340.
http://dx.doi.org/10.1016/j.proeng.2016.11.113.
Insect adhesion secretions: Similarities and dissimilarities in hydrocarbon profiles of tarsi and corresponding tibiae
Heike Gerhardt, Oliver Betz, Klaus Albert, Michael Lämmerhofer
J. Chem. Ecol., 42(2016), 725-738
http://dx.doi.org/10.1007/s10886-016-0718-7
Local functionalization of CMOS-compatible Si3N4 Mach-Zehnder interferometers with printable functional polymers
Eva Melnik, Paul Muellner, Giorgio Mutinati, Guenther Koppitsch, Franz Schrank, Rainer Hainberger, Michael Laemmerhofer
Sensors und Actuators B, Chemical, 236 (2016) 1061–1068
DOI: 10.1016/j.snb.2016.05.121
Effect of Ionic Liquids on Zebrafish (Danio rerio) Viability, Behavior, and Histology; Correlation between Toxicity and Ionic Liquid Aggregation.
Suvi-Katriina Ruokonen, Corinna Sanwald, Maria Sundvik, Stefan Polnick, Kashmira Vyavaharkar, Filip Duša, Ashley J. Holding, Alistair W. T. King, Ilkka Kilpeläinen, Michael Lämmerhofer, Pertti Panula, and Susanne K. Wiedmer
Environmental Science & Technology, 50 (2016), 7116–7125
Gold nanoparticle-conjugated pepsin for efficient solution-like heterogeneous biocatalysis in analytical sample preparation protocols
Markus Höldrich, Adrian Sievers-Engler, Michael Lämmerhofer
Anal. Bioanal. Chem., 408 (2016), 5415–5427
DOI: 10.1007/s00216-016-9657-y
Chiral Separation of 2-Hydroxyglutaric Acid on Cinchonan Carbamate based Weak Chiral Anion Exchangers by High-Performance Liquid Chromatography-Charged Aerosol Detector
Carlos Calderon, Jeannie Horak, Michael Lämmerhofer
J. Chromatogr. A, 1467 (2016) 239-245
DOI: 10.1016/j.chroma.2016.05.042
Surface-crosslinked poly(3-mercaptopropyl)methylsiloxane-coatings on silica as new platform for low-bleed mass spectrometry-compatible functionalized stationary phases synthesized via thiol-ene click reaction
Aleksandra Zimmermann, Jeannie Horak, Adrian Sievers-Engler, Corinna Sanwald, Wolfgang Lindner, Markus Kramer, Michael Lämmerhofer
J. Chromatogr. A, 1436 (2016) 73–83
DOI: 10.1016/j.chrima.2016.01.058
Peptide analysis: Stereoselective ion exchangers as complementary option to HILIC and to RP chromatography
Tong Zhang, Emilie Holder, Pilar Franco, Michael Lämmerhofer, Adrian Sievers-Engler, Heike Gerhardt, Harald Gross, Wolfgang Lindner
LCGC, 29 (3) (2016) 112-128
Human IgG detection in serum on polymer based Mach-Zehnder interferometric biosensors
Eva Melnik, Roman Bruck, Paul Müllner, Thomas Schlederer , Rainer Hainberger, Michael Lämmerhofer
J. Biophotonics, 9 (2016) 218-223
Preparation of fluorescent labeled gentamicin as biological tracer and its characterization by liquid chromatography and high resolution mass spectrometry
U. Woiwode, A. Sievers-Engler, M. Lämmerhofer
J. Pharm. Biomed. Anal.,121, (2016) 307–315
DOI: 10.1016/j.jpba.2015.12.053
Methods for the comprehensive structural elucidation of constitution and stereochemistry of lipopeptides
Heike Gerhardt, Adrian Sievers-Engler, Ghazaleh Jahanshah, Zoltán Pataj, Federica Ianni, Harald Gross, Wolfgang Lindner, Michael Lämmerhofer
J. Chromatogr. A, 1428 (2016) 280–291
DOI: 10.1016/j.chroma.2015.05.065
Quinine-based zwitterionic chiral stationary phase as complementary tool for peptide analysis: Mobile phase effects on enantio- and stereoselectivity of underivatized oligopeptides
Federica Ianni, Roccaldo Sardella, Andrea Carotti, Benedetto Natalini, Wolfgang Lindner, Michael Lämmerhofer
Chirality, 28 (2016) 5–16
Mastering analytical challenges for the characterization of pentacyclic triterpene mono and diesters of Calendula officinalis flowers by non-aqueous C30 HPLC and hyphenation with APCI-QTOF-MS
Christoph Nicolaus, Adrian Sievers-Engler, Renato Murillo, Michele D’Ambrosio, Michael Lämmerhofer, Irmgard Merfort
J. Pharm. Biomed. Anal., 118 (2016) 195–205
2015
Structural and Biophysical Evaluation of the Applicability of Halogen Bonding in Molecular Design - Targeting the Gatekeeper MET146 of C-Jun N-terminal Kinase 3 (JNK3)
Andreas Lange, Marcel B. Günther, Felix Büttner, Markus O. Zimmermann, Johannes Heidrich, Susanne Hennig, Christoph Schall, Adrian Sievers-Engler, Francesco Ansideri, Pierre Koch, Michael Lämmerhofer, Thilo Stehle, Stefan A. Laufer, Frank M. Böckler
J. Am. Chem. Soc., 137 (2015) 14640-14652
Review: Developments in hyphenation of isoelectric focusing with mass spectrometry
Jens Hühner, Michael Lämmerhofer, Christian Neusüß
Electrophoresis, 36 (2015) 2670-2686
Molecular Recognition and Visual Detection of G-Quadruplexes by a Dicarbocyanine Dye
Beatrice Karg, Andrea Funke, Anna Ficht, Adrian Sievers-Engler, Michael Lämmerhofer, Klaus Weisz
Chemistry- A European Journal, 21 (2015) 13802-13811
Investigating insect adhesion secretions by gas chromatography – mass spectrometry
Klaus Albert, Heike Gerhardt, Michael Lämmerhofer
J Chromatograph Separat Techniq, (2015) S1
Surface charge fine tuning of reversed-phase/weak anion-exchange type mixed-mode stationary phases for milder elution conditions
Aleksandra Zimmermann, Jeannie Horak, Orlando L. Sánchez-Muñoz, Michael Lämmerhofer
J. Chromatogr. A, 1409 (2015) 189-200
DOI: 10.1016/j.chroma.2015.07.036
Digging into Biomarkers of Oxidative Stress: Hyphenated chromatography techniques enable the selection of representative biomarkers of oxidative stress – and help resolve the huge complexity of lipid oxidation products
Michael Lämmerhofer
The Analytical Scientist, July 20th, 2015| Issue #0715 (Article # 302).
Selective Sample Preparation by Carbonyl-Tagging and Nanoparticle-Based Enrichment for LC-MS/MS Analysis of Carbonylated Phospholipids as Biomarkers of Oxidative Stress
Michael Lämmerhofer, Elisabeth Haller, Wolfgang Lindner
ChromFood Forum, 06 (2015) 9-13
Staying power: Adhesives modeled on insect secretions
Heike Gerhardt and Michael Lämmerhofer
q&more 01.15, English version
Starke Haftkraft: Klebstoffe nach dem Vorbild von Insektensekreten
Heike Gerhardt, Michael Lämmerhofer
q&more 01.15, Deutsche Ausgabe
Phosphatidyl choline covalently linked to a methacrylate-based monolith as stationary phase for capillary liquid chromatography
Dana Moravcová, Enrique Javier Carrasco-Correa, Josef Planeta, Michael Lämmerhofer, Susanne K. Wiedmer
J. Chromatogr. A, 1402 (2015) 27–35
DOI: 10.1016/j.chroma.2015.05.004
The novel lipopeptide poaeamide of the endophyte Pseudomonas poae RE*1-1-14 is involved in pathogen suppression and root colonization
Christin Zachow, Ghazaleh Jahanshah, Irene de Bruijn, Chunxu Song, Federica Ianni, Zoltán Pataj, Heike Gerhardt, Isabelle Pianet, Michael Lämmerhofer, Gabriele Berg, Harald Gross, Jos M. Raaijmakers
Molecular Plant-Microbe Interactions, 28 (2015) 800-810
DOI: 10.1094/MPMI-12-14-0406-R
New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: Compounds with an iron chelating potential
Imke von Koschitzky, Heike Gerhardt, Michael Lämmerhofer, Michal Kohout, Matthias Gehringer, Stefan Laufer, Mario Pink, Simone Schmitz-Spahnke, Christina Strube, Annette Kaiser
Amino Acids, 47 (2015) 1155-1166
DOI: 10.1007/s00726-015-1943-z
Contact Solid-phase Microextraction with Uncoated Glass and Polydimethylsiloxane-coated Fibers versus Solvent Sampling for the Determination of Hydrocarbons in Adhesion Secretions of Madagascar Hissing Cockroaches Gromphadorrhina portentosa (Blattodea) by Gas Chromatography-Mass Spectrometry
Heike Gerhardt, Christian Schmitt, Oliver Betz, Klaus Albert, Michael Lämmerhofer
J. Chromatography A, 1388 (2015) 24-35
DOI: 10.1016/j.chroma.2015.02.027
Impact of amphiphilic biomass-dissolving ionic liquids on biological cells and liposomes
Suvi-Katriina Mikkola, Alexandra Robciuc, Jana Lokajova, Ashley Holding, Michael Lämmerhofer, Ilkka Kilpeläinen, Juha Holopainen, Alistair King, Susanne Wiedmer
Environmental Science & Technology, 49 (2015) 1870-1878
Quantification of riboflavin, flavin mononucleotide and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection
Jens Hühner, Álvaro Ingles-Prieto, Christian Neusüß, Michael Lämmerhofer, Harald Janovjak
Electrophoresis, 36 (2015) 518-525
Gold Nanoparticle – Antibody Bioconjugates for Specific Extraction and subsequent LC-MS/MS Analysis of Malondialdehyde-modified LDL as Biomarker for Atherosclerotic Risk Assessment
Elisabeth Haller, Wolfgang Lindner, Michael Lämmerhofer
Anal. Chim. Acta, 857 (2015) 53-63
DOI: 10.1016/j.aca.2014.12.024
Analysis of Chemical Profiles of Insect Adhesion Secretions by Gas Chromatography-Mass Spectrometry
Manuela Reitz, Heike Gerhardt, Christian Schmitt, Oliver Betz, Klaus Albert, Michael Lämmerhofer
Anal. Chim. Acta, 854 (2015) 47-60
2014
Mixed-mode (RP/WAX) stationäre Phasen – Verbesserung der Selektivität bei der Reinigung und Analyse synthetischer Oligonukleotide für die Gentherapie
Aleksandra Zimmermann, Jeannie Horak, Michael Lämmerhofer
chrom+food FORUM, 09 (2014) 57-59
Polymethacrylate monoliths with immobilized poly-3-mercaptopropyl methylsiloxane film for high-coverage surface functionalization by thiol-ene click reaction
Enrique J. Carrasco Correa, Guillermo Ramis Ramos, José Manuel Herrero-Martínez, Michael Lämmerhofer
J. Chromatogr. A, 1367 (2014) 132-130
DOI: 10.1016/j.chroma.2014.09.066
Chemical Recognition of Oxidation-Specific Epitopes in Low Density Lipoproteins by a Nanoparticle based Concept for Trapping, Enrichment and LC-MS/MS Analysis of Oxidative Stress Biomarkers
ElisabethHaller, Gerald Stübiger, Daniel Lafitte, Wolfgang Lindner, Michael Lämmerhofer
Anal. Chem., 86(19) (2014) 9954–9961
Liquid chromatographic enantiomer separation with special focus on zwitterionic chiral ion-exchangers
Michael Lämmerhofer
Anal. Bioanal. Chem., 406 (2014) 6095-6103
DOI: 10.1007/s00216-014-7930-5
Synthetic oligonucleotide separation by mixed-mode reversed-phase/weak anion-exchange liquid chromatography
Aleksandra Zimmermann, Roberto Greco, Isabel Walker, Jeannie Horak, Alberto Cavazzini, Michael Lämmerhofer
J. Chromatogr. A, 1354 (2014) 43-55
DOI: 10.1016/j.chroma.2014.05.048
Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium
James T. Njuguna, Imke von Koschitzky, Heike Gerhardt, Michael Lämmerhofer, Ali Choucry, Mario Pink, Simone Schmitz-Spahnke, Mohammed A. Bakheit, Christina Strube, Annette Kaiser
Bioorg. Med. Chem., 22 (2014) 4338–4346
DOI: 10.1016/j.bmc.2014.05.007
Mucin-based Stationary Phases as Tool for the Characterization of Drug - Mucus Interaction
Andrea F.G. Gargano, Michael Lämmerhofer, Hans Lönn, Peter Schoenmakers, Tomas Leek
J. Chromatogr. A., 1351 (2014) 70-81
DOI: 10.1016/j.chroma.2014.05.031
Ligand-Receptor Binding Increments in Enantioselective Liquid Chromatography
Adrian Sievers-Engler, Wolfgang Lindner, Michael Lämmerhofer
J. Chromatogr. A, 1363 (2014) 79-88
DOI: 10.1016/j.chroma.2014.04.077
Direct enantioseparation of underivatized aliphatic 3-hydroxyalkanoic acids with a quinine-based zwitterionic chiral stationary phase
Federica Ianni, Zoltán Pataj, Harald Gross, Roccaldo Sardella, Benedetto Natalini, Wolfgang Lindner, Michael Lämmerhofer
J. Chromatogr. A, 1363 (2014) 101-108
DOI: 10.1016/j.chroma.2014.03.060
Trendbericht: Analytische Chemie 2012/2013
Michael Lämmerhofer, Jürgen Popp, Suhang He, Werner Nau, Kerstin Leopold, Christine Kranz, Jürgen W. Einax, Boris Mizaikoff
Nachrichten aus der Chemie, 62(4) (2014) 407-414
Extract from gum resin of boswellia serrata decreases IA2-antibody in a patient with “Late onset Autoimmune Diabetes of the Adult” (LADA)
E. Schrott, S. Laufer, M. Lämmerhofer, H.P.T. Ammon
Phytomedicine, 21(6) (2014) 786
DOI: 10.1016/j.phymed.2014.02.004
Streptavidin binding as model to characterize thiol-ene chemistry based polyamine surfaces for reversible photonic protein biosensing
Eva Melnik, Paul Muellner, Ole Bethge, Emmerich Bertagnolli, Rainer Hainberger, Michael Lämmerhofer
Chem. Commun., 50(19) (2014) 2424-2427
Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by LC MS/MS
Mirjam C.K. Geditz, Wolfgang Lindner, Michael Lämmerhofer, Georg Heinkele, Reinhold Kerb, Michael Ramharter, Matthias Schwab, Ute Hofmann
J. Chromatogr. B, 968 (2014) 32-39
2013
Direct high-performance liquid chromatographic enantioseparation of free α-, β- and γ-aminophosphonic acids employing cinchona-based chiral zwitterionic ion exchangers
Andrea F. G. Gargano, Michal Kohout, Pavla Macíková, Michael Lämmerhofer, Wolfgang Lindner
Anal. Bioanal. Chem., 405 (2013) 8027-8038
DOI: 10.1007/s00216-013-6938-6
Chemoaffinity material for plasmid DNA analysis by HPLC with condition-dependent switching between isoform and topoisomer selectivity
M. Mahut, A. Gargano, H. Schuchnigg, W. Lindner, M. Lämmerhofer
Anal. Chem., (2013) 2913-2920
Metabolomics in Practice, Successful Strategies to Generate and Analyze Metabolic Data
Lämmerhofer, Michael / Weckwerth, Wolfram (eds.)
1. Auflage Januar 2013
ISBN 978-3-527-33089-8 Wiley-VCH, Weinheim
Quantifying Thiol Ligand Density of Self-Assembled Monolayers on Gold Nanoparticles by Inductively Coupled Plasma Mass Spectrometry
H. Hinterwirth, S. Kappel, T. Waitz, T. Prohaska, W. Lindner and M. Lämmerhofer
ACS Nano, 7 (2013),1129-1136
Comparative method evaluation for size and size-distribution analysis of gold nanoparticles
H. Hinterwirth, S. K. Wiedmer, M. Moilanen, A. Lehner, G. Allmaier, T. Waitz, W. Lindner, M. Lämmerhofer
J. Sep. Sci., 36 (2013) 2952–2961
Phosphopeptidomimetic substance libraries from multicomponent reaction: Enantioseparation on quinidine carbamate stationary phase
A.F.G. Gargano, W.Lindner, M. Lämmerhofer
J. Chromatogr. A, 1310 (2013) 56– 65
DOI: 10.1016/j.chroma.2013.08.019
Mixed-mode chromatography with zwitterionic phosphopeptidomimetic selectors from Ugi multicomponent reaction
A.F.G. Gargano, T. Leek, W.Lindner, M. Lämmerhofer
J. Chromatogr. A, 1317 (2013) 12-21
DOI: 10.1016/j.chroma.2013.07.095
Gold nanoparticle-conjugated anti-oxidized low-density lipoprotein antibodies for targeted lipidomics of oxidative stress biomarkers
H. Hinterwirth, G. Stübiger, W. Lindner, M. Lämmerhofer
Anal. Chem., 85 (2013) 8376-8384
Single step Ugi Multicomponent Reaction for the synthesis of phosphopeptidomimetics
A.F.G. Gargano, S. Buchinger, M. Kohout, W. Lindner, M. Lämmerhofer
J. Org. Chem., 78 (2013) 10077–10087
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
T. Hanke, F. Dehm, S. Liening, S.D. Popella, J. Maczewsky, M. Pillong, J. Kunze, C. Weinigel, D. Barz, A. Kaiser, M. Wurglics, M. Lämmerhofer, G. Schneider, L. Sautebin, M. Schubert-Zsilavecz, O. Werz
J. Med. Chem., 56 (2013) 9031–9044
Special Issue: Trends 2013 (in honor of Prof. Frantisek Svec)
M. Lämmerhofer (Editor)
J. Sep. Sci., 36 (2013) 17
Trends in Separation Science (editorial)
M. Lämmerhofer
J. Sep. Sci., 36 (2013)
Virtual Special Issue: HILIC and Mixed-modes
M. Lämmerhofer (Editor)
J. Sep. Sci.
2012
Bioconjugation of trypsin onto gold nanoparticles: effect of surface chemistry on bioactivity
H. Hinterwirth, W. Lindner, M. Lämmerhofer
Anal. Chim. Acta, 733 (2012), 90-97
DOI: 10.1016/j.aca.2012.04.036
Trendbericht: Analytische Chemie 2010/2011
Boris Mizaikoff, Michael Lämmerhofer, José A.C. Broekaert, Jürgen Popp, Bernhard Lendl, Kerstin Leopold, Frieder W. Scheller, Aysu Yarman, Soeren Schumacher, Nicolas Plumeré, Andreas Hennig, Werner Nau, Christine Kranz, Jürgen W. Einax
Nachrichten aus der Chemie, 60 (4) (2012), 406–420
DOI: 10.1002/nadc.201290145
Activation of a silent phenazine biosynthetic gene cluster reveals a novel natural product and a new resistance mechanism against phenazines
Orwah Saleh, Tobias Bonitz, Katrin Flinspach, Andreas Kulik, Nadja Burkard, Agnes Mühlenweg, Andreas Vente, Stefan Polnick, Michael Lämmerhofer, Bertolt Gust, Hans-Peter Fiedler and Lutz Heide
MedChemComm., 3 (2012), 1009-1019
Quantitative LC-MS/MS impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-Alanyl-L-Glutamine
S. Schiesel, M. Lämmerhofer, A. Leitner, W. Lindner
J. Chromatogr. A, 1259 (2012), 111-120
DOI: 10.1016/j.chroma.2012.01.020
Comprehensive impurity profiling of multi-component nutritional infusion solutions for amino acid supplementation by a multidimensional analysis assay using off-line RPLC x HILIC – ion-trap MS and charged aerosol detection with universal calibration
S. Schiesel, M. Lämmerhofer, W. Lindner
J. Chromatogr. A, 1259 (2012), 100-110
DOI: 10.1016/j.chroma.2012.01.009
Analysis of Phytosiderophore-Metal Complexes in soil related samples: CE-MS vs. LC-MS
Madeleine Dell’mour, Walter Schenkeveld, Eva Oburger, Lisa Fischer, Stephan Kraemer, Markus Puschenreiter, Michael Lämmerhofer, Gunda Koellensperger, Stephan Hann
Electrophoresis, 33 (2012), 726–733
Molecular recognition principles and stationary phase characteristics of topoisomer-selective chemoaffinity materials for chromatographic separation of circular plasmid DNA topoisomers
Marek Mahut, Wolfgang Lindner, Michael Lämmerhofer
J. Am. Chem. Soc., 134 (2012), 859–862
Plasmid DNA manufacturing: Topology-selective chromatography reveals plasmid supercoiling shifts during fermentation and allows large-scale production of topoisomers
M. Mahut, E. Haller, P. Ghazidezfuli, M. Leitner, P. Hinterdorfer, W. Lindner, M. Lämmerhofer
Angew. Chem. Int. Ed., 51 (2012), 267-270
for the International Edition: DOI: 10.1002/anie.201106495
for the German Edition: DOI: 10.1002/ange.201106495
Time-resolved chloroquine-induced relaxation of supercoiled plasmid DNA bionanoparticles
Mahut, Marek; Leitner, Michael; Ebner, Andreas; Laemmerhofer, Michael; Hinterdorfer, Peter; Lindner, Wolfgang
Anal. Bioanal. Chem., 402 (2012), 373-380
DOI: 10.1007/s00216-011-5213-y
Optimization Strategies accounting for the Additive in Preparative Chiral Liquid Chromatography
Patrik Forssen, Lena Edström, Michael Lämmerhofer, Jörgen Samuelsson, Anders Karlsson, Wolfgang Lindner, Torgny Fornstedt
J. Chromatogr. A., 1269 (2012), 279– 286
DOI: 10.1016/j.chroma.2012.05.052
Enantioseparation of Chiral Sulfonic Acids by Liquid Chromatography and Subcritical Fluid Chromatography
Reinhard Pell, Georg Schuster, Michael Lämmerhofer, Wolfgang Lindner
J. Sep. Sci., 35 (2012), 2521 -2528
Enantiomer and topoisomer separation of acidic compounds on anion-exchanger chiral stationary phases by HPLC and SFC
Pilar Franco, Tong Zhang, Andrea Gargano, Marek Mahut, Michael Lämmerhofer and Wolfgang Lindner
LC-GC Europe, 25 (2012), 600-610
Special Issue: Separation Science in Biotechnology
M. Lämmerhofer (Editor)
J. Sep. Sci., Volume 35, Issue 22 (2012)
Separation Science: Enabling Technology in Biotech (Editorial)
M. Lämmerhofer
J. Sep. Sci., 35 (2012)
Special Issue: Chiral Separation and Enantioselectivity
M. Lämmerhofer (Editor)
J. Chromatogr. A, 1269 (2012)
Chiral Separations and Enantioselectivity (Editorial)
M. Lämmerhofer
J. Chromatogr. A, 1269 (2012), 1-2
2011
Comparison of microparticulate and monolithic columns for RP-LC of tryptic digests of industrial enzymes in cleaning products
M. Beneito-Cambra, J.M. Herrero-Martínez, G. Ramis-Ramos, W. Lindner, M. Lämmerhofer
J. Chromatogr. A, 1218 (2011), 7275-7280
DOI: 10.1016/j.chroma.2011.08.055
Multi-step surface functionalization of polyimide based evanescent wave photonic biosensors and application for DNA hybridization by Mach-Zehnder Interferometer
Eva Melnik, Roman Bruck, Rainer Hainberger, Michael Lämmerhofer
Anal. Chim. Acta, 699 (2011), 206– 215
DOI: 10.1016/j.aca.2011.05.017
Integrated polymer-based Mach-Zehnder interferometer label-free streptavidin biosensor compatible with injection molding
R. Bruck, E. Melnik, P. Muellner, R. Hainberger, M. Lämmerhofer
Biosens. Bioelectron., 26 (2011), 3832-3837
DOI: 10.1016/j.bios.2011.02.042
Multi-modal applicability of a reversed-phase/weak-anion exchange material in reversed-phase, anion-exchange, ion-exclusion, hydrophilic interaction and hydrophobic interaction chromatography modes
M. Lämmerhofer*, R. Nogueira, W. Lindner
Anal. Bioanal. Chem., 400 (2011), 2517–2530
DOI: 10.1007/s00216-011-4755-3
Simultaneous separation and analysis of water- and fat-soluble vitamins on multi-modal reversed phase – weak anion exchange material by HPLC-UV
R. Dabre, N. Azada, A. Schwämmle, M. Lämmerhofer, W. Lindner
J. Sep. Sci., 34 (2011), 761-772
DOI: 10.1002/jssc.201000793