Pharmazeutische Chemie

Publications

2018

Guidelines for tuning the macropore structure of monolithic columns for high-performance liquid chromatography

José Luís Dores-Sousa, Alejandro Fernández-Pumarega, Jelle De Vos, Michael Lämmerhofer, Gert Desmet, Sebastiaan Eeltink,

J. Sep. Sci., 2018, submitted

https://doi.org/10.1002/jssc.201801092

Quantitative analysis of chemoresistance-inducing fatty acid in food supplements using UHPLC-ESI-MS/MS

Jörg Schlotterbeck, Malgorzata Cebo, Agnes Kolb, Michael Lämmerhofer

Anal, Bioanal. Chem., 2018, in print

https://doi.org/10.1007/s00216-018-1468-x

Comparison of simple monophasic versus classical biphasic extraction protocols for comprehensive UHPLC-MS/MS lipidomics analysis of Hela cells

Carlos Calderón, Corinna Sanwald, Jörg Schlotterbeck, Bernard Drotleff, Michael Lämmerhofer,

Anal. Chim. Acta, 2018, in print

https://doi.org/10.1016/j.aca.2018.10.035

Protein A- and Protein G-Gold Nanoparticle Bioconjugates as Nano-Immunoaffinity Platform for human IgG Depletion in Plasma and Antibody Extraction from Cell Culture Supernatant

Siyao Liu, Elisabeth Haller, Jeannie Horak, Marlene Brandstetter, Thomas Heuser, Michael Lämmerhofer

Talanta, 2018, in print

https://doi.org/10.1016/j.talanta.2018.10.079 

Simultaneous separation of water- and fat-soluble vitamins by selective comprehensive hilic × rplc (high-resolution sampling) and active solvent modulation

Stefanie Bäurer, Wenkai Guo, Stefan Polnick, Michael Lämmerhofer

Chromatographia, 2018, in print

https://doi.org/10.1007/s10337-018-3615-0

Comprehensive ms/ms profiling by uhplc-esi-qtof-ms/ms using swath data-independent acquisition for the study of platelet lipidomes in coronary artery disease

Jörg Schlotterbeck, Madhumita Chatterjee, Meinrad Gawaz, Michael Lämmerhofer

Anal. Chim. Acta, 2018, in print

https://doi.org/10.1016/j.aca.2018.08.060

Free fatty acid profiling in marine algae extract by LC‐MS/MS and isolation as well as quantification of the ω‐3 fatty acid hexadeca‐4,7,10,13‐tetraenoic acid

 Jörg Schlotterbeck, Agnes Kolb, Michael Lämmerhofer

J. Sep. Sci., 2018, in print

https://doi.org/10.1002/jssc.201800780

Comparison of small size fully porous particles and superficially porous particles of chiral anion-exchange type stationary phases in ultra-high performance liquid chromatography: Effect of particle and pore size on chromatographic efficiency and kinetic performance

Kristina Schmitt, Ulrich Woiwode, Michal Kohout, Tong Zhang, Wolfgang Lindner, Michael Lämmerhofer

J. Chromatogr. A, 1569 (2018) 149-159.

https://doi.org/10.1016/j.chroma.2018.07.056

Zwitterionic codeine-derived methacrylate monoliths for enantioselective capillary electrochromatography of chiral acids and chiral bases

Enrique Javier Carrasco-Correa, Martina Ferri, Ulrich Woiwode, Yubo Ma, José Manuel Herrero-Martínez, Guillermo Ramis-Ramos, Wolfgang Lindner, Michael Lämmerhofer

Electrophoresis, 39 (2018) 2558-2565.

https://doi.org/10.1002/elps.201800126

Imaging peptide and protein chirality via amino acid analysis by chiral × chiral two-dimensional correlation liquid chromatography

Ulrich Woiwode, Roland Johann Reischl, Stephan Buckenmaier, Wolfgang Lindner, and Michael Lämmerhofer

Anal. Chem., 2018, 90 (13), pp 7963–7971

https://doi.org/10.1021/acs.analchem.8b00676

Complementary enantioselectivity profiles of chiral cinchonan carbamate selectors with distinct carbamate residues and their implementation in enantioselective two-dimensional high-performance liquid chromatography of amino acids

Ulrich Woiwode, Martina Ferri, Norbert M Maier, Wolfgang Lindner, Michael Laemmerhofer

J. Chromatogr. A, 1558 (2018) 29-36.

https://doi.org/10.1016/j.chroma.2018.04.061

N-Propyl-N'-2-pyridylurea-modified silica as mixed-mode stationary phase with moderate weak anion exchange capacity and pH-dependent surface charge reversal

Stefanie Baeurer, Stefan Polnick, Orlando L Sanchez-Munoz, Markus Kramer, Michael Laemmerhofer

J. Chromatogr. A, 1560 (2018) 45-54.

https://doi.org/10.1016/j.chroma.2018.05.012

Enantioselective multiple heartcut two-dimensional ultra-high-performance liquid chromatography method with a Coreshell chiral stationary phase in the second dimension for analysis of all proteinogenic amino acids in a single run

Ulrich Woiwode, Stefan Neubauer, Wolfgang Lindner, Stephan Buckenmaier, Michael Lämmerhofer

J. Chromatogr. A, 1562 (2018) 69-77.

https://doi.org/10.1016/j.chroma.2018.05.062

Quantification of Steroid Hormones in Plasma Using a Surrogate Calibrant Approach and UHPLC-ESI-QTOF-MS/MS with SWATH-Acquisition Combined with Untargeted Profiling

B. Drotleff, M. Hallschmid, M. Lämmerhofer

Anal. Chim. Acta, 1022 (2018) 70-80.

https://doi.org/10.1016/j.aca.2018.03.040

Insulin and Estrogen Independently and Differentially Reduce Macronutrient Intake in Healthy Men

R. Krug, L. Mohwinkel, B. Drotleff, J. Born, M. Hallschmid

J. Clin. Endocrinol. Metab, 103 (2018) 1393-1401

https://doi.org/10.1210/jc.2017-01835

Chiral Separation of disease biomarkers with 2-hydroxycarboxylic acid structure

Carlos Calderon, Cristina Santi, Michael Lämmerhofer

J. Sep. Sci., 41 (2018) 1224-1231

https://doi.org/10.1002/jssc.201701243

Correlation between ionic liquid cytotoxicity and liposome-ionic liquid interactions.

Suvi-Katriina Ruokonen, Corinna Sanwald, Alexandra Robciuc, Sami Hietala, Antti H. Rantamäki, Joanna Witos, Alistair W. T. King, Michael Lämmerhofer, Susanne K. Wiedmer

Chem. Eur .J., 24 (2018) 2669 –2680

http://dx.doi.org/10.1002/chem.201704924.

Response Surface Methodology for the Determination of the Design Space of Enantiomeric Separations on Cinchona-based Zwitterionic Chiral Stationary Phases by High Performance Liquid chromatography.

Rasha Sayed Hanafi, Michael Lämmerhofer

J. Chromatogr. A, 1534 (2018) 55-63

https://doi.org/10.1016/j.chroma.2017.12.044

Optimization of surface modification process of crosslinked polythiol-coated chiral stationary phases synthesized by two-step thiol-ene click reaction

Kristina Schmitt, Michael Lämmerhofer

J. Sep. Sci., 41 (2018) 1338–1345

http://dx.doi.org/10.1002/jssc.201701425

2017

Sub-minute Separations in Enantioselective Ultra High-Performance Liquid Chromatography with Superficially Porous Chiral Stationary Phases

Ulrich Woiwode, Stefan Neubauer, Mike Kaupert, Wolfgang Lindner, Michael Lämmerhofer
Chrom+Food FORUM, 09 (2017)

Accurate and Reliable Quantification of the Protein Surface Coverage on Protein-Functionalized Nanoparticles

Siyao Liu, Jeannie Horak, Markus Höldrich, Michael Lämmerhofer

Anal. Chim. Acta, 989 (2017) 29-37.

http://dx.doi.org/10.1016/j.aca.2017.08.004

Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine

Niklas M. Walter, Heike K. Wentsch, Mike Bührmann, Silke M. Bauer, Eva Döring, Svenja Mayer-Wrangowski, Adrian Sievers-Engler, Nicole Willemsen-Seegers, Guido Zaman, Rogier Buijsman, Michael Lämmerhofer, Daniel Rauh, and Stefan A. Laufer

J. Med. Chem., 60 (2017) 8027–8054.
http://dx.doi.org/10.1021/acs.jmedchem.7b00745

Trends in Enantioselective High-Performance Liquid Chromatography

Ulrich Woiwode, Stefan Neubauer, Mike Kaupert, Wolfgang Lindner, Michael Lämmerhofer
Special Issue on Recent Developments in HPLC and UHPLC (Ed. Deirdre Cabooter), Supplement to LCGC Europe / LCGC North America, June 01, 2017, Volume 30, Issue 6, 34-42.

http://www.chromatographyonline.com/trends-enantioselective-high-performance-liquid-chromatography

Preparation of Mach-Zehnder interferometric photonic biosensors by inkjet printing technology

Florian Strasser; Eva Melnik; Paul Muellner; Pilar Jiménez-Meneses; Magdalena Nechvile; Guenther Koppitsch; Peter Lieberzeit; Michael Laemmerhofer; Rudolf Heer; Rainer Hainberger

Proc. SPIE 10231, Optical Sensors 2017, 102312H (May 16, 2017)

http://dx.doi.org/10.1117/12.2267156

Trisubstituted imidazoles with a rigidized hinge binding motif act as single digit nM inhibitors of clinically relevant EGFR L858R/T790M and L858R/T790M/C797S mutants: An example of target hopping

Michael Juchum, Marcel Günther, Eva Doering, Adrian Sievers-Engler, Michael Lämmerhofer, Stefan A. Laufer

J. Med. Chem., 60 (2017) 4636-4656.

http://dx.doi.org/10.1021/acs.jmedchem.7b00178

Surface-anchored counterions on weak chiral anion-exchangers accelerate separations and improve their compatibility for mass-spectrometry-hyphenation

Ulrich Woiwode, Adrian Sievers-Engler, Aleksandra Zimmermann, Wolfgang Lindner, Orlando L. Sánchez-Muñoz, Michael Lämmerhofer

J. Chromatogr. A, 1503 (2017) 21-31.

http://dx.doi.org/10.1016/j.chroma.2017.04.054

Gold Nanoparticle-Based Immobilized Enzyme Reactors Straightforward and Accelerated Sample Preparation in Protein and Biopharmaceuticals Analysis

Siyao Liu, Markus Höldrich, Helmut Hinterwirth, Michael Lämmerhofer

Chrom+Food FORUM, 04 (2017) 12-15.


In-situ Functionalized Monolithic Polysiloxane-Polymethacrylate Composite Materials from Polythiol-Ene Double Click Reaction in Capillary Column Format for Enantioselective Nano-HPLC

Marc Wolter, Michael Lämmerhofer,

J. Chromatogr. A, 1497 (2017) 172-179.

http://dx.doi.org/10.1016/j.chroma.2017.03.070

Regulation of oxidized platelet lipidome: implications for coronary artery disease

Madhumita Chatterjee, Dominik Rath, Jörg Schlotterbeck, Johannes Rheinlaender, Britta Walker-Allgaier, Nada Alnaggar, Monika Zdanyte, Iris Müller, Oliver Borst, Tobias Geisler, Tilman E. Schäffer, Michael Lämmerhofer and Meinrad Gawaz

Eur Heart J., 38 (2017) 1993-2005.

http://dx.doi.org/10.1093/eurheartj/ehx146


Selective Targeting of G-Quadruplex Structures by a Benzothiazole-Based Binding Motif

Ina Buchholz, Beatrice Karg, Jonathan Dickerhoff, Adrian Sievers-Engler, Michael Lämmerhofer, Klaus Weisz

Chem. Eur. J., 23 (2017) 5814-5823.

http://dx.doi.org/10.1002/chem.201700298

Papain-functionalized Gold Nanoparticles as Heterogeneous Biocatalyst for Bioanalysis and Biopharmaceuticals Analysis

Siyao Liu, Markus Höldrich, Adrian Sievers-Engler, Jeannie Horak, Michael Lämmerhofer

Anal. Chim. Acta, 963 (2017) 33-43,

http://dx.doi.org/10.1016/j.aca.2017.02.009


Taylor Dispersion Analysis, Resonant Mass Measurement and Bioactivity of Pepsin-Coated Gold Nanoparticles
Markus Höldrich, Siyao Liu, Markus Epe, Michael Lämmerhofer

Talanta, 167 (2017) 67–74

http://dx.doi.org/10.1016/j.talanta.2017.02.010


Chiral Separation of Short Chain Aliphatic Hydroxycarboxylic Acids on Cinchonan Carbamate based Weak Chiral Anion Exchangers and Zwitterionic Chiral Ion Exchangers
Carlos Calderón, Michael Lämmerhofer

J. Chromatogr. A, 1487 (2017) 194–200

http://dx.doi.org/10.1016/j.chroma.2017.01.060

Tri‐ and Tetra‐substituted Pyridinylimidazoles as Covalent Inhibitors of c‐Jun N‐Terminal Kinase 3
Felix Muth, Ahmed El-Gokha, Francesco Ansideri, Michael Eitel, Eva Döring, Adrian Sievers-
Engler, Andreas Lange, Frank M. Boeckler, Michael Laemmerhofer, Pierre Koch, and Stefan A. Laufer

J. Med. Chem., 60 (2017) 594–607

http://dx.doi.org/10.1021/acs.jmedchem.6b01180

2016

Surface Modification of Integrated Optical MZI Sensor Arrays Using Inkjet Printing Technology
Eva Melnik, Florian Strasser, Paul Muellner, Rudolf Heer, Giorgio C. Mutinati, Guenther Koppitsch, Peter Lieberzeit, Michael Laemmerhofer, Rainer Hainberger

Procedia Engineering, 168 (2016) 337–340.

http://dx.doi.org/10.1016/j.proeng.2016.11.113.

Insect adhesion secretions: Similarities and dissimilarities in hydrocarbon profiles of tarsi and corresponding tibiae

Heike Gerhardt, Oliver Betz, Klaus Albert, Michael Lämmerhofer

J. Chem. Ecol., 42(2016), 725-738

http://dx.doi.org/10.1007/s10886-016-0718-7

Local functionalization of CMOS-compatible Si3N4 Mach-Zehnder interferometers with printable functional polymers

Eva Melnik, Paul Muellner, Giorgio Mutinati, Guenther Koppitsch, Franz Schrank, Rainer Hainberger, Michael Laemmerhofer

Sensors und Actuators B, Chemical, 236 (2016) 1061–1068

DOI: 10.1016/j.snb.2016.05.121

Effect of Ionic Liquids on Zebrafish (Danio rerio) Viability, Behavior, and Histology; Correlation between Toxicity and Ionic Liquid Aggregation.

Suvi-Katriina Ruokonen, Corinna Sanwald, Maria Sundvik, Stefan Polnick, Kashmira Vyavaharkar, Filip Duša, Ashley J. Holding, Alistair W. T. King, Ilkka Kilpeläinen, Michael Lämmerhofer, Pertti Panula, and Susanne K. Wiedmer

Environmental Science & Technology, 50 (2016), 7116–7125

DOI: 10.1021/acs.est.5b06107

Gold nanoparticle-conjugated pepsin for efficient solution-like heterogeneous biocatalysis in analytical sample preparation protocols

Markus Höldrich, Adrian Sievers-Engler, Michael Lämmerhofer

Anal. Bioanal. Chem., 408 (2016), 5415–5427

DOI: 10.1007/s00216-016-9657-y

Chiral Separation of 2-Hydroxyglutaric Acid on Cinchonan Carbamate based Weak Chiral Anion Exchangers by High-Performance Liquid Chromatography-Charged Aerosol Detector

Carlos Calderon, Jeannie Horak, Michael Lämmerhofer

J. Chromatogr. A, 1467 (2016) 239-245

DOI: 10.1016/j.chroma.2016.05.042

Surface-crosslinked poly(3-mercaptopropyl)methylsiloxane-coatings on silica as new platform for low-bleed mass spectrometry-compatible functionalized stationary phases synthesized via thiol-ene click reaction

Aleksandra Zimmermann, Jeannie Horak, Adrian Sievers-Engler, Corinna Sanwald, Wolfgang Lindner, Markus Kramer, Michael Lämmerhofer

J. Chromatogr. A, 1436 (2016) 73–83

DOI: 10.1016/j.chrima.2016.01.058

Peptide analysis: Stereoselective ion exchangers as complementary option to HILIC and to RP chromatography

Tong Zhang, Emilie Holder, Pilar Franco, Michael Lämmerhofer, Adrian Sievers-Engler, Heike Gerhardt, Harald Gross, Wolfgang Lindner

LCGC, 29 (3) (2016) 112-128

http://www.chromatographyonline.com/peptide-analysis-zwitterionic-chiral-ion-exchangers-complementary-option-hilic-and-reversed-phase-ch

Human IgG detection in serum on polymer based Mach-Zehnder interferometric biosensors

Eva Melnik, Roman Bruck, Paul Müllner, Thomas Schlederer , Rainer Hainberger, Michael Lämmerhofer

J. Biophotonics, 9 (2016) 218-223

DOI: 10.1002/jbio.201500280

Preparation of fluorescent labeled gentamicin as biological tracer and its characterization by liquid chromatography and high resolution mass spectrometry

U. Woiwode, A. Sievers-Engler, M. Lämmerhofer

J. Pharm. Biomed. Anal.,121, (2016) 307–315

DOI: 10.1016/j.jpba.2015.12.053

Methods for the comprehensive structural elucidation of constitution and stereochemistry of lipopeptides

Heike Gerhardt, Adrian Sievers-Engler, Ghazaleh Jahanshah, Zoltán Pataj, Federica Ianni, Harald Gross, Wolfgang Lindner, Michael Lämmerhofer

J. Chromatogr. A, 1428 (2016) 280–291

DOI: 10.1016/j.chroma.2015.05.065

Quinine-based zwitterionic chiral stationary phase as complementary tool for peptide analysis: Mobile phase effects on enantio- and stereoselectivity of underivatized oligopeptides

Federica Ianni, Roccaldo Sardella, Andrea Carotti, Benedetto Natalini, Wolfgang Lindner, Michael Lämmerhofer

Chirality, 28 (2016) 5–16

DOI: 10.1002/chir.22541

Mastering analytical challenges for the characterization of pentacyclic triterpene mono and diesters of Calendula officinalis flowers by non-aqueous C30 HPLC and hyphenation with APCI-QTOF-MS

Christoph Nicolaus, Adrian Sievers-Engler, Renato Murillo, Michele D’Ambrosio, Michael Lämmerhofer, Irmgard Merfort

J. Pharm. Biomed. Anal., 118 (2016) 195–205

DOI: 10.1016/j.jpba.2015.10.025

2015

Structural and Biophysical Evaluation of the Applicability of Halogen Bonding in Molecular Design - Targeting the Gatekeeper MET146 of C-Jun N-terminal Kinase 3 (JNK3)

Andreas Lange, Marcel B. Günther, Felix Büttner, Markus O. Zimmermann, Johannes Heidrich, Susanne Hennig, Christoph Schall, Adrian Sievers-Engler, Francesco Ansideri, Pierre Koch, Michael Lämmerhofer, Thilo Stehle, Stefan A. Laufer, Frank M. Böckler

J. Am. Chem. Soc., 137 (2015) 14640-14652

DOI: 10.1021/jacs.5b07090

Review: Developments in hyphenation of isoelectric focusing with mass spectrometry
Jens Hühner, Michael Lämmerhofer, Christian Neusüß

Electrophoresis, 36 (2015) 2670-2686

DOI: 10.1002/elps.201500185


Molecular Recognition and Visual Detection of G-Quadruplexes by a Dicarbocyanine Dye
Beatrice Karg, Andrea Funke, Anna Ficht, Adrian Sievers-Engler, Michael Lämmerhofer, Klaus Weisz
Chemistry- A European Journal, 21 (2015) 13802-13811

DOI: 10.1002/chem.201502118

Investigating insect adhesion secretions by gas chromatography – mass spectrometry

Klaus Albert, Heike Gerhardt, Michael Lämmerhofer

J Chromatograph Separat Techniq, (2015) S1

DOI: 10.4172/2157-7064.S1-002

Surface charge fine tuning of reversed-phase/weak anion-exchange type mixed-mode stationary phases for milder elution conditions

Aleksandra Zimmermann, Jeannie Horak, Orlando L. Sánchez-Muñoz, Michael Lämmerhofer

J. Chromatogr. A, 1409 (2015) 189-200

DOI: 10.1016/j.chroma.2015.07.036

Digging into Biomarkers of Oxidative Stress: Hyphenated chromatography techniques enable the selection of representative biomarkers of oxidative stress – and help resolve the huge complexity of lipid oxidation products

Michael Lämmerhofer

The Analytical Scientist, July 20th, 2015| Issue #0715 (Article # 302).

Selective Sample Preparation by Carbonyl-Tagging and Nanoparticle-Based Enrichment for LC-MS/MS Analysis of Carbonylated Phospholipids as Biomarkers of Oxidative Stress
Michael Lämmerhofer, Elisabeth Haller, Wolfgang Lindner

ChromFood Forum, 06 (2015) 9-13

Staying power: Adhesives modeled on insect secretions
Heike Gerhardt and Michael Lämmerhofer
q&more 01.15, English version

www.q-more.com


Starke Haftkraft: Klebstoffe nach dem Vorbild von Insektensekreten
Heike Gerhardt, Michael Lämmerhofer

q&more 01.15, Deutsche Ausgabe

www.q-more.com

Phosphatidyl choline covalently linked to a methacrylate-based monolith as stationary phase for capillary liquid chromatography

Dana Moravcová, Enrique Javier Carrasco-Correa, Josef Planeta, Michael Lämmerhofer, Susanne K. Wiedmer

J. Chromatogr. A, 1402 (2015) 27–35

DOI: 10.1016/j.chroma.2015.05.004

The novel lipopeptide poaeamide of the endophyte Pseudomonas poae RE*1-1-14 is involved in pathogen suppression and root colonization

Christin Zachow, Ghazaleh Jahanshah, Irene de Bruijn, Chunxu Song, Federica Ianni, Zoltán Pataj, Heike Gerhardt, Isabelle Pianet, Michael Lämmerhofer, Gabriele Berg, Harald Gross, Jos M. Raaijmakers

Molecular Plant-Microbe Interactions, 28 (2015) 800-810

DOI: 10.1094/MPMI-12-14-0406-R

New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: Compounds with an iron chelating potential

Imke von Koschitzky, Heike Gerhardt, Michael Lämmerhofer, Michal Kohout, Matthias Gehringer, Stefan Laufer, Mario Pink, Simone Schmitz-Spahnke, Christina Strube, Annette Kaiser

Amino Acids, 47 (2015) 1155-1166

DOI: 10.1007/s00726-015-1943-z

Contact Solid-phase Microextraction with Uncoated Glass and Polydimethylsiloxane-coated Fibers versus Solvent Sampling for the Determination of Hydrocarbons in Adhesion Secretions of Madagascar Hissing Cockroaches Gromphadorrhina portentosa (Blattodea) by Gas Chromatography-Mass Spectrometry

Heike Gerhardt, Christian Schmitt, Oliver Betz, Klaus Albert, Michael Lämmerhofer

J. Chromatography A, 1388 (2015) 24-35

DOI: 10.1016/j.chroma.2015.02.027

Impact of amphiphilic biomass-dissolving ionic liquids on biological cells and liposomes

Suvi-Katriina Mikkola, Alexandra Robciuc, Jana Lokajova, Ashley Holding, Michael Lämmerhofer, Ilkka Kilpeläinen, Juha Holopainen, Alistair King, Susanne Wiedmer

Environmental Science & Technology, 49 (2015) 1870-1878

DOI: 10.1021/es505725g

Quantification of riboflavin, flavin mononucleotide and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection

Jens Hühner, Álvaro Ingles-Prieto, Christian Neusüß, Michael Lämmerhofer, Harald Janovjak

Electrophoresis, 36 (2015) 518-525

DOI: 10.1002/elps.201400451

Gold Nanoparticle – Antibody Bioconjugates for Specific Extraction and subsequent LC-MS/MS Analysis of Malondialdehyde-modified LDL as Biomarker for Atherosclerotic Risk Assessment

Elisabeth Haller, Wolfgang Lindner, Michael Lämmerhofer

Anal. Chim. Acta, 857 (2015) 53-63

DOI: 10.1016/j.aca.2014.12.024

Analysis of Chemical Profiles of Insect Adhesion Secretions by Gas Chromatography-Mass Spectrometry

Manuela Reitz, Heike Gerhardt, Christian Schmitt, Oliver Betz, Klaus Albert, Michael Lämmerhofer

Anal. Chim. Acta, 854 (2015) 47-60

DOI: 10.1016/j.aca.2014.10.056

2014

Mixed-mode (RP/WAX) stationäre Phasen – Verbesserung der Selektivität bei der Reinigung und Analyse synthetischer Oligonukleotide für die Gentherapie

Aleksandra Zimmermann, Jeannie Horak, Michael Lämmerhofer

chrom+food FORUM, 09 (2014) 57-59

Polymethacrylate monoliths with immobilized poly-3-mercaptopropyl methylsiloxane film for high-coverage surface functionalization by thiol-ene click reaction

Enrique J. Carrasco Correa, Guillermo Ramis Ramos, José Manuel Herrero-Martínez, Michael Lämmerhofer

J. Chromatogr. A, 1367 (2014) 132-130

DOI: 10.1016/j.chroma.2014.09.066

Chemical Recognition of Oxidation-Specific Epitopes in Low Density Lipoproteins by a Nanoparticle based Concept for Trapping, Enrichment and LC-MS/MS Analysis of Oxidative Stress Biomarkers

ElisabethHaller, Gerald Stübiger, Daniel Lafitte, Wolfgang Lindner, Michael Lämmerhofer

Anal. Chem., 86(19) (2014) 9954–9961

DOI: 10.1021/ac502855n

Liquid chromatographic enantiomer separation with special focus on zwitterionic chiral ion-exchangers

Michael Lämmerhofer

Anal. Bioanal. Chem., 406 (2014) 6095-6103

DOI: 10.1007/s00216-014-7930-5

Synthetic oligonucleotide separation by mixed-mode reversed-phase/weak anion-exchange liquid chromatography

Aleksandra Zimmermann, Roberto Greco, Isabel Walker, Jeannie Horak, Alberto Cavazzini, Michael Lämmerhofer

J. Chromatogr. A, 1354 (2014) 43-55

DOI: 10.1016/j.chroma.2014.05.048

Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium

James T. Njuguna, Imke von Koschitzky, Heike Gerhardt, Michael Lämmerhofer, Ali Choucry, Mario Pink, Simone Schmitz-Spahnke, Mohammed A. Bakheit, Christina Strube, Annette Kaiser

Bioorg. Med. Chem., 22 (2014) 4338–4346

DOI: 10.1016/j.bmc.2014.05.007

Mucin-based Stationary Phases as Tool for the Characterization of Drug - Mucus Interaction

Andrea F.G. Gargano, Michael Lämmerhofer, Hans Lönn, Peter Schoenmakers, Tomas Leek

J. Chromatogr. A., 1351 (2014) 70-81

DOI: 10.1016/j.chroma.2014.05.031

Ligand-Receptor Binding Increments in Enantioselective Liquid Chromatography

Adrian Sievers-Engler, Wolfgang Lindner, Michael Lämmerhofer

J. Chromatogr. A, 1363 (2014) 79-88

DOI: 10.1016/j.chroma.2014.04.077

Direct enantioseparation of underivatized aliphatic 3-hydroxyalkanoic acids with a quinine-based zwitterionic chiral stationary phase

Federica Ianni, Zoltán Pataj, Harald Gross, Roccaldo Sardella, Benedetto Natalini, Wolfgang Lindner, Michael Lämmerhofer

J. Chromatogr. A, 1363 (2014) 101-108

DOI: 10.1016/j.chroma.2014.03.060

Trendbericht: Analytische Chemie 2012/2013

Michael Lämmerhofer, Jürgen Popp, Suhang He, Werner Nau, Kerstin Leopold, Christine Kranz, Jürgen W. Einax, Boris Mizaikoff

Nachrichten aus der Chemie, 62(4) (2014) 407-414

DOI: 10.1002/nadc.201490115

Extract from gum resin of boswellia serrata decreases IA2-antibody in a patient with “Late onset Autoimmune Diabetes of the Adult” (LADA)

E. Schrott, S. Laufer, M. Lämmerhofer, H.P.T. Ammon

Phytomedicine, 21(6) (2014) 786

DOI: 10.1016/j.phymed.2014.02.004

Streptavidin binding as model to characterize thiol-ene chemistry based polyamine surfaces for reversible photonic protein biosensing

Eva Melnik, Paul Muellner, Ole Bethge, Emmerich Bertagnolli, Rainer Hainberger, Michael Lämmerhofer

Chem. Commun., 50(19) (2014) 2424-2427

DOI: 10.1039/c3cc48640k

Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by LC MS/MS

Mirjam C.K. Geditz, Wolfgang Lindner, Michael Lämmerhofer, Georg Heinkele, Reinhold Kerb, Michael Ramharter, Matthias Schwab, Ute Hofmann

J. Chromatogr. B, 968 (2014) 32-39

DOI: 10.1016/j.jchromb.2013.11.035

2013

Direct high-performance liquid chromatographic enantioseparation of free α-, β- and γ-aminophosphonic acids employing cinchona-based chiral zwitterionic ion exchangers

Andrea F. G. Gargano, Michal Kohout, Pavla Macíková, Michael Lämmerhofer, Wolfgang Lindner

Anal. Bioanal. Chem., 405 (2013) 8027-8038

DOI: 10.1007/s00216-013-6938-6

Chemoaffinity material for plasmid DNA analysis by HPLC with condition-dependent switching between isoform and topoisomer selectivity

M. Mahut, A. Gargano, H. Schuchnigg, W. Lindner, M. Lämmerhofer

Anal. Chem., (2013) 2913-2920

DOI: 10.1021/ac3034823

Metabolomics in Practice, Successful Strategies to Generate and Analyze Metabolic Data

Lämmerhofer, Michael / Weckwerth, Wolfram (eds.)

1. Auflage Januar 2013

ISBN 978-3-527-33089-8 Wiley-VCH, Weinheim

Quantifying Thiol Ligand Density of Self-Assembled Monolayers on Gold Nanoparticles by Inductively Coupled Plasma Mass Spectrometry

H. Hinterwirth, S. Kappel, T. Waitz, T. Prohaska, W. Lindner and M. Lämmerhofer

ACS Nano, 7 (2013),1129-1136

DOI: 10.1021/nn306024a

Comparative method evaluation for size and size-distribution analysis of gold nanoparticles

H. Hinterwirth, S. K. Wiedmer, M. Moilanen, A. Lehner, G. Allmaier, T. Waitz, W. Lindner, M. Lämmerhofer

J. Sep. Sci., 36 (2013) 2952–2961

DOI: 10.1002/jssc.201300460

Phosphopeptidomimetic substance libraries from multicomponent reaction: Enantioseparation on quinidine carbamate stationary phase

A.F.G. Gargano, W.Lindner, M. Lämmerhofer

J. Chromatogr. A, 1310 (2013) 56– 65

DOI: 10.1016/j.chroma.2013.08.019

Mixed-mode chromatography with zwitterionic phosphopeptidomimetic selectors from Ugi multicomponent reaction

A.F.G. Gargano, T. Leek, W.Lindner, M. Lämmerhofer

J. Chromatogr. A, 1317 (2013) 12-21

DOI: 10.1016/j.chroma.2013.07.095

Gold nanoparticle-conjugated anti-oxidized low-density lipoprotein antibodies for targeted lipidomics of oxidative stress biomarkers

H. Hinterwirth, G. Stübiger, W. Lindner, M. Lämmerhofer

Anal. Chem., 85 (2013) 8376-8384

DOI: 10.1021/ac401778f

Single step Ugi Multicomponent Reaction for the synthesis of phosphopeptidomimetics

A.F.G. Gargano, S. Buchinger, M. Kohout, W. Lindner, M. Lämmerhofer

J. Org. Chem., 78 (2013) 10077–10087

DOI: 10.1021/jo401372x

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.

T. Hanke, F. Dehm, S. Liening, S.D. Popella, J. Maczewsky, M. Pillong, J. Kunze, C. Weinigel, D. Barz, A. Kaiser, M. Wurglics, M. Lämmerhofer, G. Schneider, L. Sautebin, M. Schubert-Zsilavecz, O. Werz

J. Med. Chem., 56 (2013) 9031–9044

DOI: 10.1021/jm401557w

Special Issue: Trends 2013 (in honor of Prof. Frantisek Svec)

M. Lämmerhofer (Editor)

J. Sep. Sci., 36 (2013) 17

DOI: 10.1002/jssc.v36.17

Trends in Separation Science (editorial)

M. Lämmerhofer

J. Sep. Sci., 36 (2013)

DOI: 10.1002/jssc.201370164

Virtual Special Issue: HILIC and Mixed-modes

M. Lämmerhofer (Editor)

J. Sep. Sci.

ISSN: 1615-9314

2012

Bioconjugation of trypsin onto gold nanoparticles: effect of surface chemistry on bioactivity

H. Hinterwirth, W. Lindner, M. Lämmerhofer

Anal. Chim. Acta, 733 (2012), 90-97

DOI: 10.1016/j.aca.2012.04.036

Trendbericht: Analytische Chemie 2010/2011

Boris Mizaikoff, Michael Lämmerhofer, José A.C. Broekaert, Jürgen Popp, Bernhard Lendl, Kerstin Leopold, Frieder W. Scheller, Aysu Yarman, Soeren Schumacher, Nicolas Plumeré, Andreas Hennig, Werner Nau, Christine Kranz, Jürgen W. Einax

Nachrichten aus der Chemie, 60 (4) (2012), 406–420
DOI: 10.1002/nadc.201290145

Activation of a silent phenazine biosynthetic gene cluster reveals a novel natural product and a new resistance mechanism against phenazines

Orwah Saleh, Tobias Bonitz, Katrin Flinspach, Andreas Kulik, Nadja Burkard, Agnes Mühlenweg, Andreas Vente, Stefan Polnick, Michael Lämmerhofer, Bertolt Gust, Hans-Peter Fiedler and Lutz Heide

MedChemComm., 3 (2012), 1009-1019

DOI: 10.1039/c2md20045g

Quantitative LC-MS/MS impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-Alanyl-L-Glutamine

S. Schiesel, M. Lämmerhofer, A. Leitner, W. Lindner

J. Chromatogr. A, 1259 (2012), 111-120

DOI: 10.1016/j.chroma.2012.01.020

Comprehensive impurity profiling of multi-component nutritional infusion solutions for amino acid supplementation by a multidimensional analysis assay using off-line RPLC x HILIC – ion-trap MS and charged aerosol detection with universal calibration

S. Schiesel, M. Lämmerhofer, W. Lindner

J. Chromatogr. A, 1259 (2012), 100-110

DOI: 10.1016/j.chroma.2012.01.009

Analysis of Phytosiderophore-Metal Complexes in soil related samples: CE-MS vs. LC-MS

Madeleine Dell’mour, Walter Schenkeveld, Eva Oburger, Lisa Fischer, Stephan Kraemer, Markus Puschenreiter, Michael Lämmerhofer, Gunda Koellensperger, Stephan Hann

Electrophoresis, 33 (2012), 726–733

DOI: 10.1002/elps.201100466

Molecular recognition principles and stationary phase characteristics of topoisomer-selective chemoaffinity materials for chromatographic separation of circular plasmid DNA topoisomers

Marek Mahut, Wolfgang Lindner, Michael Lämmerhofer

J. Am. Chem. Soc., 134 (2012), 859–862

DOI: 10.1021/ja210241a

Plasmid DNA manufacturing: Topology-selective chromatography reveals plasmid supercoiling shifts during fermentation and allows large-scale production of topoisomers

M. Mahut, E. Haller, P. Ghazidezfuli, M. Leitner, P. Hinterdorfer, W. Lindner, M. Lämmerhofer

Angew. Chem. Int. Ed., 51 (2012), 267-270

for the International Edition: DOI: 10.1002/anie.201106495

for the German Edition: DOI: 10.1002/ange.201106495

Time-resolved chloroquine-induced relaxation of supercoiled plasmid DNA bionanoparticles

Mahut, Marek; Leitner, Michael; Ebner, Andreas; Laemmerhofer, Michael; Hinterdorfer, Peter; Lindner, Wolfgang

Anal. Bioanal. Chem., 402 (2012), 373-380

DOI: 10.1007/s00216-011-5213-y

Optimization Strategies accounting for the Additive in Preparative Chiral Liquid Chromatography

Patrik Forssen, Lena Edström, Michael Lämmerhofer, Jörgen Samuelsson, Anders Karlsson, Wolfgang Lindner, Torgny Fornstedt

J. Chromatogr. A., 1269 (2012), 279– 286

DOI: 10.1016/j.chroma.2012.05.052

Enantioseparation of Chiral Sulfonic Acids by Liquid Chromatography and Subcritical Fluid Chromatography

Reinhard Pell, Georg Schuster, Michael Lämmerhofer, Wolfgang Lindner

J. Sep. Sci., 35 (2012), 2521 -2528

DOI: 10.1002/jssc.201200448

Enantiomer and topoisomer separation of acidic compounds on anion-exchanger chiral stationary phases by HPLC and SFC

Pilar Franco, Tong Zhang, Andrea Gargano, Marek Mahut, Michael Lämmerhofer and Wolfgang Lindner

LC-GC Europe, 25 (2012), 600-610

Article

Special Issue: Separation Science in Biotechnology

M. Lämmerhofer (Editor)

J. Sep. Sci., Volume 35, Issue 22 (2012)

DOI: 10.1002/jssc.201270182

Separation Science: Enabling Technology in Biotech (Editorial)

M. Lämmerhofer

J. Sep. Sci., 35 (2012)

DOI: 10.1002/jssc.201270183

Special Issue: Chiral Separation and Enantioselectivity

M. Lämmerhofer (Editor)

J. Chromatogr. A, 1269 (2012)

J. Chromatogr. A, 1269

Chiral Separations and Enantioselectivity (Editorial)

M. Lämmerhofer

J. Chromatogr. A, 1269 (2012), 1-2

DOI: 10.1016/j.chroma.2012.10.009

2011

Comparison of microparticulate and monolithic columns for RP-LC of tryptic digests of industrial enzymes in cleaning products
M. Beneito-Cambra, J.M. Herrero-Martínez, G. Ramis-Ramos, W. Lindner, M. Lämmerhofer
J. Chromatogr. A, 1218 (2011), 7275-7280
DOI: 10.1016/j.chroma.2011.08.055

Multi-step surface functionalization of polyimide based evanescent wave photonic biosensors and application for DNA hybridization by Mach-Zehnder Interferometer
Eva Melnik, Roman Bruck, Rainer Hainberger, Michael Lämmerhofer
Anal. Chim. Acta, 699 (2011), 206– 215
DOI: 10.1016/j.aca.2011.05.017

Integrated polymer-based Mach-Zehnder interferometer label-free streptavidin biosensor compatible with injection molding
R. Bruck, E. Melnik, P. Muellner, R. Hainberger, M. Lämmerhofer
Biosens. Bioelectron., 26 (2011), 3832-3837
DOI: 10.1016/j.bios.2011.02.042

Multi-modal applicability of a reversed-phase/weak-anion exchange material in reversed-phase, anion-exchange, ion-exclusion, hydrophilic interaction and hydrophobic interaction chromatography modes
M. Lämmerhofer*, R. Nogueira, W. Lindner
Anal. Bioanal. Chem., 400 (2011), 2517–2530
DOI: 10.1007/s00216-011-4755-3

Simultaneous separation and analysis of water- and fat-soluble vitamins on multi-modal reversed phase – weak anion exchange material by HPLC-UV
R. Dabre, N. Azada, A. Schwämmle, M. Lämmerhofer, W. Lindner
J. Sep. Sci., 34 (2011), 761-772
DOI: 10.1002/jssc.201000793