Junior Group Leader Neuroepigenomics
Institute for Medical Genetics and Applied Genomics, University of Tübingen
Parkinson’s disease (PD), like related neurodegenerative disorders, occurs from a presumed but still largely enigmatic interplay of genetic predispositions, age-related processes, and environmental factors. Increasing evidence points to the epigenome at the nexus between genes and the environment playing a key role in that process. Drawing on genome-wide sequencing technologies, we investigate environment-driven modulations of the epigenome in animal models, cell lines, and human samples of PD to better understand the unfolding of the disease along the gene-environment axis.
Current Research Topics
- decipherPD: DEcipher the ComplexIty and Plasticity of epigenomic cHaracteristics under influence of Environmental factors in the pathomechanistic Regulation of Parkinson’s Disease