@article{Buechel2013c,
  author   = {B\"uchel, Finja and Saliger, Sandra and Dr\"ager, Andreas and Hoffmann, Stephanie and
    Wrzodek, Clemens and Zell, Andreas and Kahle, Philipp J.},
  title    = {{Parkinson's disease: dopaminergic nerve cell model is consistent with experimental
    finding of increased extracellular transport of $\alpha$-synuclein}},
  journal  = {BMC Neuroscience},
  year     = {2013},
  volume   = {14},
  number   = {136},
  month    = nov,
  abstract = {Background: Parkinson's disease is an age-related disease, whose
        pathogenesis is not completely known. Animal models exist for investigating
        the disease but not all results can be easily transferred to humans.
        Therefore, mathematical or probabilistic models for the human disease
        are to be constructed \emph{in-silico} in order to predict specific
        processes within a cell, such as the dopamine metabolism and transport
        processes in a neuron.

        Results: We present an SBML model of a whole dopaminergic nerve cell
        consisting of 139 reactions and 111 metabolites which includes, among
        others, the dopamine metabolism and transport, oxidative stress, aggregation
        of $\alpha$-synuclein ($\alpha$SYN), lysosomal and proteasomal degradation,
        and mitophagy. The predictive power of the model was investigated using flux
        balance analysis for the identification of steady model states. To this end,
        we performed six experiments: (i) investigation of the normal cell behavior,
        (ii) increase of O\textsubscript{2}, (iii) increase of ATP, (iv) influence
        of neurotoxins, (v) increase of $\alpha$SYN the cell and (vi) increase
        of dopamine synthesis. The SBML model is available in BioModels database
        with identifier MODEL1302200000.

        Conclusion: It is possible to simulate the normal behavior of an
        \emph{in-vivo} nerve cell with the developed model. We show that the model
        is sensitive for neurotoxins and oxidative stress. Further, an increased
        level of $\alhpa$SYN induces apoptosis and we observed an increased flux of
        $\alpha$SYN to the extracellular space.},
  doi      = {10.1186/1471-2202-14-136},
  issn     = {1471-2202},
  keywords = {Parkinson's disease, Dopaminergic nerve cell model, SBML model, Flux balance analysis},
  pdf      = {https://www.biomedcentral.com/content/pdf/1471-2202-14-136.pdf},
  url      = {https://www.biomedcentral.com/1471-2202/14/136}
}