@article{Renz2021b,
  author   = {Renz, Alina and Widerspick, Lina and Dr\"ager, Andreas},
  title    = {{First Genome-Scale Metabolic Model of \emph{Dolosigranulum pigrum} Confirms Multiple
    Auxotrophies}},
  journal  = {Metabolites},
  volume   = {11},
  year     = {2021},
  month    = apr,
  number   = {4},
  article-number = {232},
  url      = {https://www.mdpi.com/2218-1989/11/4/232},
  issn     = {2218-1989},
  abstract = {Dolosigranulum pigrum is a quite recently discovered Gram-positive coccus. It has
    gained increasing attention due to its negative correlation with Staphylococcus aureus, which
    is one of the most successful modern pathogens causing severe infections with tremendous
    morbidity and mortality due to its multiple resistances. As the possible mechanisms behind its
    inhibition of S. aureus remain unclear, a genome-scale metabolic model (GEM) is of enormous
    interest and high importance to better study its role in this fight. This article presents the
    first GEM of D. pigrum, which was curated using automated reconstruction tools and extensive
    manual curation steps to yield a high-quality GEM. It was evaluated and validated using all
    currently available experimental data of D. pigrum. With this model, already predicted
    auxotrophies and biosynthetic pathways could be verified. The model was used to define a minimal
    medium for further laboratory experiments and to predict various carbon sources' growth
    capacities. This model will pave the way to better understand D. pigrum's role in the fight
    against S. aureus.},
  doi      = {10.3390/metabo11040232}
}