@article{Roemer2016a,
  author    = {R\"omer, Michael and Eichner, Johannes and Dr\"ager, Andreas and Wrzodek, Clemens
    and Wrzodek, Finja and Zell, Andreas},
  title     = {{ZBIT Bioinformatics Toolbox: a Web-Platform for Systems Biology and Expression Data
    Analysis}},
  year      = {2016},
  month     = feb,
  number    = {2},
  volume    = {11},
  pages     = {e0149263},
  journal   = {PLoS ONE},
  publisher = {Public Library of Science},
  abstract  = {Bioinformatics analysis has become an integral part of research in biology. However,
    installation and use of scientific software can be difficult and often requires technical expert
    knowledge. Reasons are dependencies on certain operating systems or required third-party
    libraries, missing graphical user interfaces and documentation, or nonstandard input and output
    formats. In order to make bioinformatics software easily accessible to researchers, we here
    present a web-based platform. The Center for Bioinformatics Tuebingen (ZBIT) Bioinformatics
    Toolbox provides web-based access to a collection of bioinformatics tools developed for systems
    biology, protein sequence annotation, and expression data analysis. Currently, the collection
    encompasses software for conversion and processing of community standards SBML and BioPAX,
    transcription factor analysis, and analysis of microarray data from transcriptomics and
    proteomics studies. All tools are hosted on a customized Galaxy instance and run on a dedicated
    computation cluster. Users only need a web browser and an active internet connection in order to
    benefit from this service. The web platform is designed to facilitate the usage of the
    bioinformatics tools for researchers without advanced technical background. Users can combine
    tools for complex analyses or use predefined, customizable workflows. All results are stored
    persistently and reproducible. For each tool, we provide documentation, tutorials, and example
    data to maximize usability. The ZBIT Bioinformatics Toolbox is freely available at
    \url{https://webservices.cs.uni-tuebingen.de}.},
  doi       = {10.1371/journal.pone.0149263},
  keywords  = {Transcription factors, Bioinformatics, DNA-binding proteins, Genome analysis, Systems biology, Software tools, Carcinogens, User interfaces},
  url       = {https://doi.org/10.1371%2Fjournal.pone.0149263},
}