Publications

Articles

2019
27.	L. Kaysser* “Build to bind: biosynthetic strategies for the formation of small-molecule protease inhibitors.” Natural Product Reports (2019), doi:10.1039/C8NP00095F
26.	Baulig, I. Helmle, M. Bader, F. Wolf, A. Kulik, H. Gross and L. Kaysser*, “Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase.“ Chemical Science (2019), doi:10.1039/C9SC00641A
2018
25.	F. Wolf, F. Leipoldt, A. Kulik and L. Kaysser* "Characterization of the actinonin biosynthetic gene cluster.” ChemBioChem (2018), 19(11):1189-1195.
2017
24.	F. Leipoldt, J. Santos-Aberturas, D.P. Stegmann, F. Wolf, A. Kulik, R. Lacret, D. Popadić, D. Keinhörster, N. Kirchner, P. Bekiesch, H. Gross, A.W. Truman* and L. Kaysser* "Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors." Nature Communications (2017), 8(1):1965.
23.	F. Wolf, J.S. Bauer, T.M. Bendel, A. Kulik, J. Kalinowski, H. Gross and L. Kaysser* "Biosynthesis of the β-lactone proteasome inhibitors belactosins and cystargolides." Angewandte Chemie Internationale Edition (2017), 56 (23):6665-6668.
22.	L. Kaysser* “Genom-basierte Suche nach Protease-Inhibitoren aus bakteriellen Quellen.” Biospektrum (2017), 23 (1):41-45
2016
21.	J. Zettler, F. Zubeil, A. Kulik, S. Grond and L. Kaysser* “Epoxomicin and Eponemycin Biosynthesis Involves gem-Dimethylation and an AcylCoA Dehydrogenase-like Enzyme.” ChemBioChem (2016), 17(9):792-8.
2015
20.	F. Leipoldt, P. Zeyhle, A. Kulik, J. Kalinowski, L. Heide and L. Kaysser* ”Diversity of ABBA prenyltransferases in Streptomyces sp. CNQ-509: Promiscuous enzymes for the biosynthesis of meroterpenoid compounds.” PLoS ONE (2015), doi:10.1371/journal.pone.0143237
19.	M.H. Medema, R. Kottmann, P. Yilmaz, M. Cummings, .., L. Kaysser, .., F.O. Glöckner "Minimum Information about a Biosynthetic Gene cluster" Nature Chemical Biology (2015), 11(9):625–631.
18.	C. Rückert, F. Leipoldt, P. Zeyhle, W. Fenical, P.R. Jensen, J. Kalinowski, L. Heide and L. Kaysser ”Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry.” Journal of Biotechnology (2015), 216(20):140-141
2014

17.	R. Teufel, L. Kaysser, M.T. Villaume, S. Diethelm, M.K. Carbullido, P.S. Baran and B.S. Moore “One-pot Enzymatic Synthesis of Merochlorins A and B.” Angewandte Chemie Internationale Edition (2014), 53(41):11019-22. Highlighted in: Editor’s choice: HOT paper Angewandte Chemie Internationale Edition (2014) J. M. Finkelstein “RESEARCH HIGHLIGHTS Biosynthesis: All together now” Nature Chemical Biology (2014), 10(10):795.
16.	S. Diethelm, R. Teufel, L. Kaysser and B.S. Moore “A Multitasking Vanadium-Dependent Chloroperoxidase as an Inspiration for the Chemical Synthesis of the Merochlorins.” Angewandte Chemie Internationale Edition (2014), 53(41):11023-26. Highlighted in: M. Hartmann “RESEARCH HIGHLIGHTS Biochemistry: Marine enzyme can multi-task” Nature (2014), 513:8 J. M. Finkelstein “RESEARCH HIGHLIGHTS Biosynthesis: All together now” Nature Chemical Biology (2014), 10(10):795
15.	L. Kaysser “Resistent: Wie Antibiotika wirken und wie Bakterien sie wirkungslos machen.“ Deutsche Apotheker Zeitung (2014), 154(5):368-374.
14.	M. Schorn, J. Zettler, J.P. Noel, P. Dorrestein, B.S. Moore and L. Kaysser ”The genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.” ACS Chemical Biology (2014), 9(1):301-309.
2013
13.	X. Tang, K. Eitel, L. Kaysser, A. Kulik, S. Grond and B. Gust ”A two-step sulfation mechanism in antibiotic biosynthesis requires a type III polyketide synthase.” Nature Chemical Biology (2013), 9(10):610-15. Highlighted in: Steven G. van Lanen “Biosynthesis: A sulfonate relay revealed” Nature Chemical Biology (2013), 9(10):602-3 F1000Prime by Prof. Kate Caroll, Faculty of 1000, 03/10/2013.
2012
12.	L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J.G. Ruby, P. Skewes-Cox, P.R. Jensen, W. Fenical and B.S. Moore ”Merochlorins A−D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases.” Journal of the American Chemical Society (2012), 134(29):11988-91.
2011
11.	L. Kaysser, X. Tang, E. Wemakor, K. Sedding, S. Hennig, S. Siebenberg and B. Gust ”Identification of the Napsamycin Gene Cluster by Genome Mining.” ChemBioChem (2011), 12(3):477-87.
10.	Siebenberg S, Kaysser L, Wemakor E, Heide L, Gust B, Kammerer B. (2011) Identification and structural elucidation of new caprazamycins from Streptomyces sp. MK730-62F2 by liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Rapid Commun Mass Spectrom. 25(4):495-502.
2010
9.	K. Flinspach, L. Westrich, L. Kaysser, S. Siebenberg, J.P. Gomez-Escribano, M. Bibb B. Gust, and L. Heide “Heterologous expression of the biosynthetic gene clusters of coumermycin A₁, clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains.” Biopolymers (2010), 93(9):823-32.
8.	L. Kaysser, E. Wemakor, S. Siebenberg, J. Salas, J.K. Sohng, B. Kammerer and B. Gust “Caprazamycin Biosynthesis: Formation and Attachment of the Deoxysugar Moiety and Assembly of the Gene Cluster.” Applied and Environmental Microbiology (2010), 76(12):4008-18.
7.	L. Kaysser, K. Eitel, T. Tanino, S. Siebenberg, A. Matsuda, S. Ichikawa, and B. Gust “A New ASST-type Sulfotransferase Involved in Liponucleoside Antibiotic Biosynthesis in Streptomycetes.“ Journal of Biological Chemistry (2010), 285(17):12684-94.
6.	L. Kaysser, S. Siebenberg, B. Kammerer and B. Gust “Analysis of the Liposidomycin Gene Cluster Leads to the Identification of New Caprazamycin Derivatives.” ChemBioChem (2010), 11(2):191-96.
2009
5.	L. Kaysser, L. Lutsch, S. Siebenberg, E. Wemakor, B. Kammerer and B. Gust “Identification and Manipulation of the Caprazamycin Gene Cluster Leads to New Simplified Liponucleoside Antibiotics and Gives Insights into the Biosynthetic Pathway.” Journal of Biological Chemistry (2009), 284(22):14987-96.
4.	X. Zhao, L. Kaysser “Meeting report: the 13th International Biotechnology Symposium and Exhibition in Dalian, China.“ Biotechnology Journal (2009), 4(1):23-27.
2006
3.	S. Eiben, L. Kaysser, S. Maurer, K. Kühnel, V.B. Urlacher, R.D. Schmid “Preparative use of isolated CYP102 monooxygenases - a critical appraisal.“ Journal of Biotechnology (2006), 124(4):662-69.
2.	J.B. van Beilen, E.G. Funhoff, A. van Loon, A. Just, L. Kaysser, M. Bouza, R. Holtackers, M. Röthlisberger, Z. Li, B. Witholt, “Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases.“ Applied and Environmental Microbiology (2006), 72(1):59-65.
2005
1.	S. Maurer, K. Kühnel, L. Kaysser, S. Eiben, R.D. Schmid and V.B. Urlacher "Catalytic Hydroxylation in Biphasic Systems using CYP102A1 (P450 BM-3) Mutants." Advanced Synthesis and Catalysis (2005), 347:1090-98.

Patent Applications

2.	B. Gust, L. Kaysser, K. Eitel „Die Sulfotransferase Cpz4, ein Biokatalysator zur Herstellung sulfatisierter Liponukleosid-Antibiotika“. DE 10 2010 005 273.6, Deutsches Patent- und Markenamt (2010).
1.	B. Gust, L. Kaysser „Ein neues Caprazamycin Biosynthesegencluster“. DE 10 2009 014 432.3, Deutsches Patent- und Markenamt (2009).