Uni-Tübingen

Stellenangebote

14.08.2019

PhD position in Molecular Biology and Biophysics

Faculty of Science, Center for Plant Molecular Biology (ZMBP)

PhD position in Molecular Biology and Biophysics

General interest: Most biological processes involve changes in molecular and cell shapes, and such deformations, in essence, involve a mechanical component. But how a mechanical stress is perceived and how this signal is transduced into the cell to exert these effects is still poorly understood, and remains challenging questions in both the plant and animal community.
Among the structural components of plant cells (cell wall, cytoskeleton…), the plasma membrane has received very little attention. Our group at the ZMBP Tübingen investigates the role of membrane lipids at the nexus between plant morphogenesis and mechanics using Arabidopsis as a model. For more information, visit our website "Stanislas Lab ZMBP“.

PhD project: In order to understand at the molecular level, the role of the lipid composition of the PM for mechano-sensing, it is needed to simplify the system. This will allow to test a wide range of hypothesis and to clearly make a link between a mechanical stimulus and a molecular response.
The selected PhD candidate will have to develop a microfluidic device to induce and quantify of mechanical signals at the cell level.

References:

  • A phosphoinositide map at the shoot apical meristem in Arabidopsis thaliana, Stanislas T, Platre M, Liu M, Rambaud L, Jaillais Y, Hamant H, BMC Biology, 16:20 (2018)
  • In-vivo analysis of morphogenesis in plants Stanislas T, Hamant O, Traas J, Methods in Cell Biology, 139:203-223 (2017)
  • A PtdIns(4)P-driven electrostatic field controls cell membrane identity and signalling in plants. Simon ML, Platre MP, Marques Bueno MM, Armengot L, Stanislas T, Bayle V, Caillaud MC, Jaillais Y, Nature Plant, 20, 2, 16089 (2016)

Requirements/Qualifications: We are looking for highly motivated candidates with a master degree in biology, engineering sciences, nanotechnology, biophysics or equivalent. Specific skills in microfluidics is highly advantageous. Prior experience with confocal microscopy is a plus but not required. Good English communication skills as well as excellent teamwork abilities are expected.
The position is available immediately. Application will be accepted until the position is filled. Please send your application in English as a composite pdf-file (letter of motivation stating your research interests, CV, name and addresses of at least two referees) to Thomas.stanislasspam prevention@zmbp.uni-tuebingen.de.

The ZMBP is a world‐class center for Plant Biology research and is situated in a brand-new and well-equipped building in the University of Tübingen science campus. The University of Tübingen is an equal opportunity employer and particularly welcomes applications from qualified women and individuals with disabilities. Formal employment procedures will be carried out by the central administration of the University of Tübingen.

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