IFIB – Interfakultäres Institut für Biochemie

Dr. Della David

Dr. Della David obtained her Ph.D. in 2005 from the University of Zürich. After postdoctoral research at the University of Sydney and University of California, San Francisco, she was group leader at the German Center for Neurodegenerative Diseases (DZNE) in Tübingen between 2011 and 2019. Since October 2019, she relocated to the IFIB as independent group leader financed by the DFG.  

Publications (as senior author)

Extracellular proteostasis prevents aggregation during pathogenic attack.
Gallotta I, Sandhu A, Peters M, Haslbeck M, Jung R, Agilkaya S, Blersch JL, Rödelsperger C, Röseler W, Huang C, Sommer RJ, David DC. Nature. 2020 Aug;584(7821):410-414. doi: 10.1038/s41586-020-2461-z.

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans. Huang C, Wagner-Valladolid S, Stephens AD, Jung R, Poudel C, Sinnige T, Lechler MC, Schlörit N, Lu M, Laine RF, Michel CH, Vendruscolo M, Kaminski CF, Kaminski Schierle GS, David DC. Elife. 2019 May 3;8. pii: e43059. doi: 10.7554/eLife.43059.
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans. Groh N, Gallotta I, Lechler MC, Huang C, Jung R, David DC. J Vis Exp. 2017 Nov 26;(129). doi: 10.3791/56464.

Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation. Groh N, Bühler A, Huang C, Li KW, van Nierop P, Smit AB, Fändrich M, Baumann F, David DC. Front Aging Neurosci. 2017 May 17;9:138. doi: 10.3389/fnagi.2017.00138. 

Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging. Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC. Cell Rep. 2017 Jan 10;18(2):454-467. doi: 10.1016/j.celrep.2016.12.033.

Aging and the aggregating proteome. David DC. Front Genet. 2012 Nov 20;3:247. doi: 10.3389/fgene.2012.00247.