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Über den Exzellenzcluster CMFI

Mikrobielle Gemeinschaften, sogenannte Mikrobiome, besiedeln die Oberflächen des menschlichen Körpers. Neben Bakterien, die die menschliche Gesundheit positiv beeinflussen, finden sich im Mikrobiom auch potenziell tödliche Krankheitserreger. Gegen diese Erreger wurden in den vergangenen Jahrzehnten oft Breitbandantibiotika eingesetzt. Inzwischen ist klar, dass dadurch nicht nur die Entstehung von Antibiotikaresistenzen gefördert, sondern in vielen Fällen auch das Mikrobiom als Ganzes geschädigt wird. Die Forschenden des Exzellenzclusters „Kontrolle von Mikroorganismen zur Bekämpfung von Infektionen“ wollen zur Kontrolle von Infektionen nun eine neue Strategie entwickeln.

Ihr Ziel ist es, neue zielgerichtete Wirkstoffe zu entwickeln, die sich positiv auf Mikrobiome auswirken. So ist bekannt, dass nützliche Bakterien ihre gefährlichen Artgenossen in Schach halten können. Um die zugrundeliegenden Mechanismen zu verstehen und nutzbar zu machen, sollen im Rahmen des Exzellenzclusters Forscherinnen und Forscher aus molekularen, bioinformatischen und klinischen Disziplinen zusammenarbeiten. Sprecher des Clusters sind Professor Andreas Peschel und Professorin Heike Brötz-Oesterhelt vom Interfakultären Institut für Mikrobiologie und Infektionsmedizin der Universität Tübingen sowie Professorin Ruth Ley, Direktorin des Max-Planck-Instituts für Biologie. Beteiligt sind zudem das Universitätsklinikum Tübingen und das Deutsche Zentrum für Infektionsforschung (DZIF).

Veranstaltungen


Aktuelle Stellenausschreibungen

PhD Position on the Molecular Basis of Microbe-Virus Interactions

PhD Position on the Molecular Basis of Microbe-Virus Interactions

The Independent Research Group for “Molecular Basis of Microbial Community Interactions” within the Cluster of Excellence “Controlling Microbes to Fight Infections” (CMFI) is looking for a PhD student. The group is led by Dr. Bastian Molitor and is hosted in the Environmental Biotechnology Group as part of the Center for Applied Geosciences at the University of Tübingen (http://envbiotech.de/) with an international, interdisciplinary, and dynamic team of environmental/biological engineers, microbiologists, biotechnologists, and molecular biologists.

Activities and responsibilities

We are looking to fill a PhD position to work on different aspects of microbial community interactions. The project aims at understanding the physiology of a methanogen within the human microbiome and the interactions between methanogenic archaea and their viruses on a molecular level. The project will contain the work with anaerobic hydrogenotrophic methanogens in liquid and on solid media, the operation of chemostat bioreactor systems to collect samples for -omics investigations, and a computational aspect on genome-scale metabolic modeling to analyze the generated data. The direction and emphasis of the different aspects of the position can be defined by the background and interests of the successful applicant to a certain extent.

Qualification profile

Qualified candidates have a Master’s degree in (micro)biology, biochemistry, biotechnology, or related fields. Successful candidates are expected to be involved in supervising bachelor and master students. Very good English language skills are necessary. German language skills are helpful but not a requirement. Other requirements include the ability to do work independently and in a team, excellent management and communication skills, and a high motivation. Candidates will have the opportunity to present their results in international journals and conferences.

We offer

The position is intended to be filled as soon as possible. The contract is for 3 years and the employment will be arranged by the administration of the University of Tübingen (salary TVL E13, 65%). The University of Tübingen is seeking to increase the proportion of women in science and teaching, and therefore is asking qualified women to apply. Disabled persons will be preferred in case of equal qualification.
Applications (in English), combined as one pdf document, including cover letter, CV, transcripts and diplomas, and contact addresses of two referees should be sent by email to bastian.molitorspam prevention@uni-tuebingen.de.

Deadline

Applications will be accepted until the application deadline of June 30, 2022.

 

Dr. Bastian Molitor
Environmental Biotechnology, Geo and Environmental Science Center, University of Tübingen.

 

PhD Student (EN)

PhD student position to perform techno-economic and life-cycle assessments for a power-to-protein process

The research group of Environmental Biotechnology in the Center for Applied Geosciences at the University of Tübingen (http://envbiotech.de/) is looking for an excellent PhD student to support our international, interdisciplinary, and dynamic team of environmental/biological/systems engineers, microbiologists, biotechnologists, and molecular biologists. The research in the Environmental Biotechnology group focuses on the recovery of carbon from diverse waste streams, and this includes single-cell protein production from carbon dioxide and hydrogen and oxygen gases, which we refer to as power-to-protein.

Qualified candidates would ideally have a Master’s degree in systems engineering, chemical/environmental engineering, process modeling, biotechnology, or related fields. The candidate should be able to perform techno-economic and life-cycle assessments on our biotechnological approach. The candidate should have hands-on experience with systems analysis or GIS techniques for value-chain optimization and resource mapping. This project will involve close collaborations within our group, but also with research groups from German or Danish institutions, including bioprocess engineers and researchers within the biotechnology field.

The project will focus on a biotechnological approach to radically change the way our societies produce protein for human consumption. Current agricultural practices to produce protein must be altered to save our planet. The current agricultural practices simply use too much land, water, and fossil fuels to feed a future 10 billion people. In this power-to-protein system, hydrogen and oxygen from electrolysis (water splitting) with renewable energy are combined with carbon dioxide in a 2-step bioprocess to produce protein. In the first step, hydrogen and carbon dioxide gases are converted into acetate with anaerobic bacteria, and in the second step, the dilute acetate is converted with oxygen gas into yeast biomass with approximately 45-65% protein. The growth nutrients, such as ammonium, will come from the safe recycling of wastes from humans. The main activity of the candidates will be to: 1) use process modeling to further scale and optimize this power-to-protein technology based on data from an ongoing bench-scale and a pilot-scale project; and 2) apply techno-economic and life-cycle modeling methods to evaluate power-to-protein technology for its economic and sustainable merits.

The successful candidate is expected to be involved in managing the project, which includes the supervision of bachelor and master students. Furthermore, she/he will closely interact with collaboration partners. Therefore, very good English language skills are necessary. Other requirements include the ability to work independently and in teams, have excellent management and communication skills, and be self-motivated. The candidate will have the opportunity to present her/his results in international journals and conferences.

The position is intended to be filled as soon as possible. The contract is for 3 years and the employment will be arranged by the administration of the University of Tübingen (salary TVL E13, 65%). The adjustment takes place via the ZV.

The University of Tübingen is seeking to increase the proportion of women in science and teaching, and therefore we are especially asking qualified women to apply. Disabled persons will be preferred in case of equal qualification.

Applications (in English), as one pdf document, including cover letter, CV, an overview of techniques and methods used in the past, transcripts, and diplomas, and contact address of at least two referees should be sent by email to application-envbiotechspam prevention@ifg.uni-tuebingen.de . Applications will be accepted until the position is filled.

 

Prof. Lars Angenent

Environmental Biotechnology Group, Center for Applied Geosciences, University of Tübingen.

 

Postdoctoral Researcher (EN)

The Cluster of Excellence “Controlling Microbes to Fight Infections” (CMFI) at the University of Tübingen, aims to understand and control microbial communities to fight infections. Our consortium uses highly multidisciplinary approaches at the interface of microbiology, microbial ecology, mass spectrometry-based metabolomics, and proteomics as well as chemical biology.
www.controlling-microbes.com

For a collaborative research project within the research cluster, we are looking for a:

Postdoctoral Researcher (f/m/d)

to strengthen our team and to work on the development of a synthetic microbial community that mimics the human microbiome to study metabolic exchange between microorganisms and the host.

The position will initially be offered for two years with salary according to TV-L, E13 (100%).
Besides an inclusive environment, supportive mentoring and guidance for your individual career development, we provide detailed scientific training and access to state-of- the-art equipment as well as an open science environment. Beyond scientific publications, this will include conference visits, organization and attendance of workshops and close collaborations with other research groups, including possible research visits at other universities.

As part of the CMFI Cluster of Excellence, you will be working in an excellent research environment with plenty of potential collaboration partners, a high amount of independence, and possibilities to develop and apply for funding for your own research ideas.
The focus of the position will be on research (no formal teaching duties); however, there will be the possibility to participate in college level teaching and mentoring of bachelor and master students.

At the time of employment, the candidate should have a PhD degree in microbiology/microbial ecology, biochemistry, biotechnology, or related fields. We expect that the candidate will be interested in highly interdisciplinary microbiome research; has an independent, responsible, and committed work attitude and is fluent in (scientific) English. We expect strong knowledge in microbiology and microbial ecology as well as a strong interest to develop and apply synthetic microbial community models in combination with bioanalytical techniques such as next generation sequencing and mass spectrometry-based metabolomics and proteomics.

Please send your application as a single PDF (including a brief statement on your research interests and experience; your CV; list of publications; contact information for two academic references; university transcripts to:
hannes.linkspam prevention@uni-tuebingen.de and daniel.petrasspam prevention@uni-tuebingen.de

The University of Tübingen is an Equal Opportunity Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will be considered for employment without regards to gender, race, color, national origin, sexual orientation, religion, disability, or age.

The review of applications will begin June 15th 2022 and will continue until the position is filled.

More infos: www.linkmetabolism.com and www.functional-metabolomics.com

Postdoctoral Researcher (EN)

The Functional Metabolomics Lab, part of the Cluster of Excellence “Controlling Microbes to Fight Infections” (CMFI) at the University of Tübingen, aims to understand and control microbial communities in order to contribute to the fight against infections. The group uses a multidisciplinary approach at the interface of natural product research, mass spectrometry-based metabolomics, and proteomics as well as chemical biology (www.functional-metabolomics.com).

For a project in the Collaborative Research Center CellMap (https://trr261.de), we are looking for a:

Postdoctoral Researcher (f/m/d)

to work on the application of native mass spectrometry and metabolomics approaches to study ClpP protease regulation mechanisms and the screening for new inhibitors.

For the position, we offer salary according to TV-L, E13 (100%). Besides inclusive environment, supportive mentoring and guidance for your individual career development, we provide detailed scientific training and access to state-of- the-art equipment and open science communication. Beyond scientific publications, this will include conference visits, organization and attendance of workshops and close collaborations with other research groups, including possible research visits at other universities.

As part of the CMFI Cluster of Excellence in Tübingen, you will be working in an excellent research environment with plenty of potential collaboration partners, a high amount of autonomy, and possibilities to develop and apply for funding for your own research ideas. The main focus of the position will be on research (no formal teaching duties); however, there will be the possibility to participate in college level teaching and mentoring of bachelor and master students.

At the time of employment, the candidate should have a PhD degree in analytical chemistry, biochemistry, biotechnology, or a related field. We expect that the candidate will be interested in highly interdisciplinary research; has an independent, responsible, and committed work attitude and is fluent in (scientific) English.

We expect strong knowledge of and interest to further develop bioanalytical techniques, in particular high-resolution mass spectrometry-based approaches.

Ideally, the candidate will bring experience in native mass spectrometry and protein biochemistry methods, such as heterologous protein expression and protein purification

Applications and inquiries should be sent to daniel.petrasspam prevention@uni-tuebingen.de.

Please send your application as a single PDF file that includes: a brief statement on your research interests and experience; your CV (including a list of publications); contact information for two academic references; and university transcripts.

The University of Tübingen is an Equal Opportunity Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will be considered for employment without regards to gender, race, color, national origin, sexual orientation, religion, disability, or age.

PhD Student (EN)

 

 

The Functional Metabolomics Lab, part of the Cluster of Excellence “Controlling Microbes to Fight Infections” (CMFI) at the University of Tübingen, aims to understand and control microbial communities in order to contribute to the fight against infections. The group uses a multidisciplinary approach at the interface of natural product research, mass spectrometry-based metabolomics, and proteomics as well as chemical biology (www.functional-metabolomics.com).

The lab's science mission is to develop and apply mass spectrometry-based tools to systematically determine the role of small molecules in complex microbial communities and to mine them for novel bioactive compounds. For the development and application of native mass spectrometry and bioactivity guided metabolomics methods we are looking for a:

PhD Student (f/m/d)

The project will focus on the method development and application of native MS, HPLC fractionation, and bioactivity-guided approaches in combination with non-targeted metabolomics for the screening of culture extracts and environmental samples.

For the position, we offer salary according to TV-L, E13 (65%). Besides supportive mentoring and guidance for your individual career development, we provide detailed scientific training on state-of-the-art equipment and open, community-focused science communication. Beyond scientific publications, this will include conference visits, organization and attendance of workshops and possible research visits to other universities and field sites.

As part of the Cluster of Excellence CMFI in Tübingen you will be located in an excellent research environment with plenty of potential collaboration partners, a high amount of autonomy, and possibilities to develop your own research ideas.

At the time of employment, the candidate should have a masters or equivalent degree in chemistry, biochemistry, biotechnology, or a related field. We expect that the candidate is interested in highly interdisciplinary research, has an independent, responsible and committed work attitude, and is fluent in (scientific) English.

We expect good knowledge of bioanalytical techniques, in particular mass spectrometry as well as biochemistry and/or microbiology.

Ideally, the candidate will bring basic statistical and computational skills (e.g., scripting in Python, R, or MATLAB) and an interest to learn computational methods for mass spectrometry data analysis.

Applications or questions about the position should be sent to daniel.petrasspam prevention@uni-tuebingen.de.

Please send your application as a single PDF file that includes: a brief statement on your interests and experience; your CV; contact information for two academic references; and university transcripts.

The University of Tübingen is an Equal Opportunity Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will be considered for employment without regard to gender, race, color, national origin, sexual orientation, religion, disability, or age.

The review of applications will begin in August 2021 and will continue until the position is filled.

 

Postdoctoral Researcher (EN)

 

The Functional Metabolomics Lab, part of the Cluster of Excellence “Controlling Microbes to Fight Infections” (CMFI) at the University of Tübingen, aims to understand and control microbial communities in order to contribute to the fight against infections. The group uses a multidisciplinary approach at the interface of natural product research, mass spectrometry-based metabolomics, and proteomics as well as chemical biology (www.functional-metabolomics.com).

The lab's science mission is to develop and apply mass spectrometry-based tools to systematically determine the role of small molecules in complex microbial communities and to mine them for novel bioactive compounds. To build up the mass spectrometry pipeline, we are looking for a:

Postdoctoral Researcher (f/m/d)

to work on method development and application of tandem MS and native MS approaches for the analysis of culture extracts and environmental samples, as well as the bioinformatic data analysis.

For the position, we offer salary according to TV-L, E13 (100%). Besides supportive mentoring and guidance for your individual career development, we provide detailed training and access to state-of- the-art equipment and open, community-focused science communication. Beyond scientific publications, this will include conference visits, organization and attendance of workshops and possible research visits to other universities and field sites.

As part of the Cluster of Excellence CMFI in Tübingen, you will be working in an excellent research environment with plenty of potential collaboration partners, a high amount of autonomy, and possibilities to develop and apply for funding for your own research ideas. The main focus of the position will be on research (no formal teaching duties); however, there will be the possibility to participate in college level teaching and mentoring of bachelor and master students.

At the time of employment, the candidate should have a PhD degree in analytical chemistry, biochemistry, biotechnology, or a related field. We expect that the candidate will be interested in highly interdisciplinary research; has an independent, responsible, and committed work attitude and is  fluent in (scientific) English.

We expect strong knowledge of and interest to develop bioanalytical techniques, in particular high- resolution mass spectrometry-based approaches (such as metabolomics, proteomics, or structure elucidation).

Ideally, the candidate will bring fundamental statistical and computational skills (e.g., scripting in Python, R, or MATLAB) and an interest to broaden their use of computational methods for mass spectrometry data analysis.

Applications and inquiries should be sent to daniel.petrasspam prevention@uni-tuebingen.de.

Please send your application as a single PDF file that includes: a brief statement on your interests and experience; your CV (including a list of publications); contact information for two academic references; and university transcripts.

The University of Tübingen is an Equal Opportunity Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will be considered for employment without regard to gender, race, color, national origin, sexual orientation, religion, disability, or age.

The review of applications will begin in August 2021 and will continue until the position is filled.

Postdoctoral researchers in Mathematical and Computational Population Genetics (EN)

 

The newly founded independent junior research group „Mathematical and Computational Population Genetics“, headed by Franz Baumdicker at the University of Tübingen has an opening for

Postdoctoral researchers (f/m/d)

The group develops and applies mathematical models and bioinformatic tools with a special focus on microbial evolution. We are interested in a variety of evolutionary scenarios including CRISPR Cas Evolution, Pan-Genome Evolution, Horizontal Gene Transfer, Fluctuationg Selection, and Cooperation in Bacteria.

The postdoc should be interested to operate at the intersection of Mathematical Population Genetics / Computational Biology / Bioinformatics using mathematical population genetics, phylogenetics, statistical analysis, machine learning algorithms, and large scale simulations to derive new mathematical results, develop open source software and apply them to (microbial) genome data.

For scientific questions please contact: franz.baumdicker@uni-tuebingen.de.

 

Candidate profiles we would love to see:

  • PhD degree in (Bio-)Mathematics, Statistics, Bioinformatics, Computational Biology or a related field
  • Interest in interdisciplinary research
  • Strong mathematical preparation and interest and/or good computational skills (e.g. in Python, R)
  • Independent, responsible and committed work
  • Fluency in (scientific) English

 

What we offer:

  • Salary according to TV-L, E13 (100%)
  • The group is part of two Excellence Clusters (Controlling Microbes to Fight Infections & Machine Learning) in Tübingen, which offers an excellent research environment with plenty of potential collaboration partners.
  • Flexible starting date and the possibility to start the project remotely in the initial phase
  • Focus on research (no formal teaching duties)
  • Intense personal and scientific mentoring in an open and supportive environment
  • Integration into a young and agile research group
  • Responsibility to conduct your own research projects with a high amount of autonomy
  • The opportunity to visit and organize conferences, workshops and research visits to other universities and summer schools.
  • Possibilities to develop your own research ideas and mentor Ph.D. students

 

The University of Tübingen is an Equal Opportunity Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will be considered for employment without regard to gender, race, color, national origin, sexual orientation, religion, disability, or age. Researchers from outside Germany are particularly encouraged to apply.

Applications and inquiries should be sent to franz.baumdickerspam prevention@uni-tuebingen.de.

Please send your application as a single PDF file and include a brief statement on your interests and experience, CV (including a possible list of publications and the contact info of two academic references), and university transcripts.

The review of applications will begin in June 2022 and continue until the positions are filled.

PhD students in Mathematical and Computational Population Genetics (EN)

 

The newly founded independent junior research group „Mathematical and Computational Population Genetics“ headed by Franz Baumdicker at the University of Tübingen has an opening for

PhD students (f/m/d)

The group develops and applies mathematical models and bioinformatic tools with a special focus on microbial evolution.

The PhD students will work at the intersection of Mathematical Population Genetics / Computational Biology / Bioinformatics using population genetics, phylogenetics, statistical analysis, machine learning algorithms, and large scale simulations to derive new theoretical results, develop open source software and apply them to (microbial) genome data.

We are interested in a variety of evolutionary scenarios including CRISPR-Cas Evolution and Dynamics, Pan-Genome Evolution, Horizontal Gene Transfer, Fluctuationg Selection, and Cooperation in Bacteria.

For scientific questions please contact: franz.baumdicker@uni-tuebingen.de.


Candidate profiles we would love to see:

  • Master's degree in (Bio-)Mathematics, Statistics, Bioinformatics, Computational Biology or a related field
  • Interest in interdisciplinary research
  • Strong mathematical preparation and interest and/or good computational skills (e.g. in Python, R)
  • Independent, responsible and committed work
  • Fluency in (scientific) English


What we offer:

  • Salary according to TV-L, E13 (65%)
  • Dissertation at the Faculty of Natural Sciences working with two advisors
  • The group is part of two Excellence Clusters (Controlling Microbes to Fight Infections & Machine Learning) in Tübingen, which offers an excellent research environment with plenty of potential collaboration partners.
  • Possibly integration into the DFG priority programme SPP2141, where appropriate
  • Focus on research (no formal teaching duties)
  • Intense personal and scientific mentoring in an open and supportive environment
  • Integration into a young and agile research group
  • The opportunity to visit conferences, workshops, other research groups and summer schools.
  • Responsibility to conduct your own research projects with a high amount of autonomy
  • Possibilities to develop your own research ideas in a young and agile team


The University of Tübingen is an Equal Opportunity Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will be considered for employment without regard to gender, race, color, national origin, sexual orientation, religion, disability, or age. Researchers from outside Germany are particularly encouraged to apply.

Applications and inquiries should be sent to franz.baumdickerspam prevention@uni-tuebingen.de.

Please send your application as a single PDF file and include- brief statement on the applicant's interests and experience, CV (including a possible list of publications and the contact info of two academic references), and university transcripts.

The review of applications will begin in June 2022 and continue until the positions are filled.