Publications
2017
1. Castaneda Vega S, Weinl C, Calaminus C, Wang L, Harant M, Ehrlichmann W, Thiele D, Kohlhofer U, Reischl G, Hempel JM, Ernemann U, Quintanilla Martinez L, Nordheim A, Pichler BJ. (2017) Characterization of a novel murine model for spontaneous hemorrhagic stroke using in vivo PET and MR multiparametric imaging. Neuroimage 155: 245-6
2. Hermanns C, Hampl V, Holzer K, Aigner A, Penkava J, Frank N, Martin DE, Maier KC, Waldburger N, Roessler S, Goppelt-Struebe M, Akrap I, Thavamani A, Singer S, Nordheim A, Gudermann T, Muehlich S (2017) The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma. Oncogene 36: 3464-6
3. Fitzgerald JC, Zimprich A, Carvajal Berrio DA, Schindler KM, Maurer B, Schulte C, Bus C,Hauser A-K, Kübler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wüst R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Krüger R (2017) Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson’s disease. Brain 140: 2444–59
4. Bakula D, Mueller AJ, Proikas-Cezanne T (2017) WIPI β-propellers function as scaffolds for STK11/LKB1-AMPK and AMPK-related kinase signaling in autophagy. Autophagy, doi: 10.1080/15548627.2017.1382784.
5. Bakula D, Müller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T (2017) WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. Nat Commun. 8:15637
2016
1. Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters PJ, Wallace W, Alberti S, Nordheim A, Jenkins G. (2016) Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression. J Biol Chem. 291(18): 9540-53
2. Akrap I, Thavamani A, Nordheim A. (2016) Vps4A-mediated tumor suppression upon exosome modulation? Ann Transl Med. 4(9): 18
3. Takacs Z, Proikas-Cezanne T. (2016) Primary cilia mechanosensing triggers autophagy-regulated cell volume control. Nat Cell Biol. 18(6):591-2
4. Walter C, Clemens LE, Müller AJ, Fallier-Becker P, Proikas-Cezanne T, Riess O, Metzger S, Nguyen HP (2016) Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology 108:24-38.
5. Casas C, Codogno P, Pinti M, Batoko H, Morán M, Proikas-Cezanne T, Reggiori F, Sirko A, Soengas MS, Velasco G, Lafont F, Lane J, Faure M, Cossarizza A (2016) TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledg. Autophagy 12(3):614-7.
6. Klionsky DJ, ......et al........Proikas-Cezanne T, ...et al. ... (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222.
2015
1. Weinl C, Castaneda Vega S, Riehle H, Stritt C, Calaminus C, Wolburg H, Mauel S, Breithaupt A, Gruber AD, Wasylyk B, Olson EN, Adams RH, Pichler BJ, Nordheim A (2015) Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke Proc Natl Acad Sci U S A. 112: 9914-9
2. Cavignac Y, Lieber D, Laib Sampaio K, Madlung J, Lamkemeyer T, Jahn G, Nordheim A, Sinzger C (2015) The Cellular Proteins Grb2 and DDX3 Are Increased upon Human Cytomegalovirus Infection and Act in a Proviral Fashion, PLoS One 10: e0131614
3. Anastasiadou S, Liebenehm S, Sinske D, Meyer zu Reckendorf C, Moepps B, Nordheim A, Knöll B (2015) Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model, Glia 63: 958-76
4. Ohrnberger S, Thavamani A, Braeuning A, Lipka DB, Kirilov M, Geffers R, Autenrieth SE, Römer M, Zell A, Bonin M, Schwarz M, Schütz G, Schirmacher P, Plass C, Longerich T, Nordheim A (2015) Dysregulated serum response factor triggers formation of hepatocellular carcinoma, Hepatology 61: 979-89
5. Grimmel M, Backhaus C, Proikas-Cezanne T (2015) WIPI-Mediated Autophagy and Longevity, Cells 4: 202-17
6. Müller AJ, Proikas-Cezanne T (2015) Function of human WIPI proteins in autophagosomal rejuvenation of endomembranes?FEBS Lett. 589: 1546-51
7. Proikas-Cezanne T, Takacs Z, Dönnes P, Kohlbacher O (2015) WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome. J Cell Sci. 128: 207-17
8. Thost AK, Dönnes P, Kohlbacher O, Proikas-Cezanne T (2015) Fluorescence-based imaging of autophagy progression by human WIPI protein detection, Methods 75: 69-78.
9. Nordheim A, Knippers R (Hsg.) (2015) Lehrbuch: Molekulare Genetik, Thieme Verlag, Stuttgart; Autoren: Dröge P, Knippers R, Meister G, Nordheim A, Schiebel E, Vingron M, Walter J.
10. Denisova E, Heidenreich B, Nagore E, Rachakonda PS, Hosen I, Akrap I, Traves V, García-Casado Z, López-Guerrero JA, Requena C, Sanmartin O, Serra-Guillén C, Llombart B, Guillén C, Ferrando J, Gimeno E, Nordheim A, Hemminki K, Kumar R. (2015) Frequent DPH3 promoter mutations in skin cancers, Oncotarget. Sep 21. [Epub ahead of print]
2014
9. Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A. (2014) <span style="font-family: arial, helvetica, clean, sans-serif; font-size: 1.108em; color: rgb(100, 42, 143);">Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.</span>, PLoS One 9: e107048.
2013
1. Wuestefeld, T., Pesic, M., Rudalska, R., Dauch, D., Longerich, T., Kang, T. W., Yevsa, T., Heinzmann, F., Hoenicke, L., Hohmeyer, A., Potapova, A., Rittelmeier, I., Jarek, M., Geffers, R., Scharfe, M., Klawonn, F., Schirmacher, P., Malek, N. P., Ott, M., Nordheim, A., Vogel, A., Manns, M. P., and L. Zender (2013) A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration, Cell 153, 389-401.
2. Weinl, C., Riehle, H., Park, D., Stritt, C., Beck, S., Huber, G., Wolburg, H., Olson, E. N., Seeliger, M. W., Adams, R. H., and A. Nordheim (2013) Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae, The Journal of Clinical Investigation 123, 2193-2206.
3. Nemazanyy, I., Blaauw, B., Paolini, C., Caillaud, C., Protasi, F., Mueller, A., Proikas-Cezanne, T., Russell, R. C., Guan, K. L., Nishino, I., Sandri, M., Pende, M., and G. Panasyuk (2013) Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease, EMBO Molecular Medicine 5, 870-890.
4. Rieter, E., Vinke, F., Bakula, D., Cebollero, E., Ungermann, C., Proikas-Cezanne, T., and F. Reggiori (2013) Atg18 function in autophagy is regulated by specific sites within its beta-propeller, Journal of Cell Science 126, 593-604.
5. Seeber, A., Hauer, M., and S.M. Gasser (2013) Nucleosome remodelers in double-strand break repair, Curr. Op. Genet. & Dev. 23, 1-11.
6. Stern, S., Haverkamp, S. Sinske, D., Tedeschi, A., Naumann, U., Di Giovanni, S., Kochanek, S., Nordheim, A., and B. Knöll (2013) The transcription factor serum response factor (SRF) stimulates axon regeneration through cytoplasmic localization and cofilin interaction, J. Neuroscience 33, 18836-18848.
7. Bakula, D., Takacs, Z., and T. Proikas-Cezanne (2013) WIPI beta-propellers in autophagy-related diseases and longevity, Biochem Soc Trans. 41, 962-7.
8. Engedal, N., Torgersen, ML., Guldvik, IJ., Barfeld, SJ., Bakula, D., Sætre, F., Hagen, LK., Patterson, JB., Proikas-Cezanne, T., Seglen, PO., Simonsen, A., and Millis, IG., (2013) Modulation of intracellular calcium homeostasis blocks autophagosome formation, Autophagy 9, 1475-90.
2012
1. Beck, H., Flynn, K., Lindenberg, K.S., Schwarz, H., Bradke, F., Di Giovanni, S., and B. Knoll (2012) Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics. Proc Natl Acad Sci U S A 109:E2523-2532.
2. Franz-Wachtel, M., Eisler, S.A., Krug, K., Wahl, S., Carpy, A., Nordheim, A., Pfizenmaier, K., Hausser, A., and B. Macek (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 10, 160-170.
3. Gaugel, A., Bakula, D., Hoffmann, A., and T. Proikas-Cezanne (2012) Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 beta-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition. J Mol Signal 7, 16.
4. Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., ......Proikas-Cezanne, T. ............et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544.
5. Mauthe, M., Yu, W., Krut, O., Kronke, M., Gotz, F., Robenek, H., and Proikas-Cezanne, T. 2012. WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation. Int J Cell Biol 2012:179207.
6. Rieter, E., Vinke, F., Bakula, D., Cebollero, E., Ungermann, C., Proikas-Cezanne, T., and Reggiori, F. 2012. Atg18 function in autophagy is regulated by specific sites within its beta-propeller. J Cell Sci.
7. Sessler, N., Krug, K., Nordheim, A., Mordmuller, B., and Macek, B. 2012. Analysis of the Plasmodium falciparum proteasome using Blue Native PAGE and label-free quantitative mass spectrometry. Amino Acids 43:1119-1129.
8. Stern, S., Sinske, D., and Knoll, B. 2012. Serum response factor modulates neuron survival during peripheral axon injury. J Neuroinflammation 9:78.
9. van der Vos, K.E., Eliasson, P., Proikas-Cezanne, T., Vervoort, S.J., van Boxtel, R., Putker, M., van Zutphen, I.J., Mauthe, M., Zellmer, S., Pals, C., Verhagen, L.P., Groot Koerkamp, M.J., Braat, A.K., Dansen, T.B., Holstege, F.C., Gebhardt, R., Burgering, B.M., and Coffer, P.J. 2012. Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol 14:829-837.
2011
1. Knoll, B. 2011. Serum response factor mediated gene activity in physiological and pathological processes of neuronal motility. Front Mol Neurosci 4:49.
2. Mauthe, M., Jacob, A., Freiberger, S., Hentschel, K., Stierhof, Y.D., Codogno, P., and Proikas-Cezanne, T. 2011. Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation. Autophagy 7:1448-1461.
3. Meier, C., Anastasiadou, S., and Knoll, B. 2011. Ephrin-A5 suppresses neurotrophin evoked neuronal motility, ERK activation and gene expression. PLoS One 6:e26089.
4. Nahnsen, S., Bertsch, A., Rahnenfuhrer, J., Nordheim, A., and Kohlbacher, O. 2011. Probabilistic consensus scoring improves tandem mass spectrometry peptide identification. J Proteome Res 10:3332-3343.
5. Niessner, H., Beck, D., Sinnberg, T., Lasithiotakis, K., Maczey, E., Gogel, J., Venturelli, S., Berger, A., Mauthe, M., Toulany, M., et al. 2011. The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells. J Invest Dermatol 131:468-479.
6. Pfisterer, S.G., Mauthe, M., Codogno, P., and Proikas-Cezanne, T. 2011. Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy. Mol Pharmacol 80:1066-1075.
7. Proikas-Cezanne, T., and Codogno, P. 2011. A new fluorescence-based assay for autophagy. Chem Biol 18:940-941.
8. Proikas-Cezanne, T., and Codogno, P. 2011. Beclin 1 or not Beclin 1. Autophagy 7:671-672.
9. Proikas-Cezanne, T., and Robenek, H. 2011. Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes. J Cell Mol Med 15:2007-2010.
10. Sandstrom, J., Heiduschka, P., Beck, S.C., Philippar, U., Seeliger, M.W., Schraermeyer, U., and Nordheim, A. 2011. Degeneration of the mouse retina upon dysregulated activity of serum response factor. Mol Vision 17:1110-1127.
11. Tiffert, Y., Franz-Wachtel, M., Fladerer, C., Nordheim, A., Reuther, J., Wohlleben, W., and Mast, Y. 2011. Proteomic analysis of the GlnR-mediated response to nitrogen limitation in Streptomyces coelicolor M145. Appl Microbiol Biotechnol 89:1149-1159
12. Codogno, P., Mehrpour, M., Proikas-Cezanne, T. Canonical and non-canonical autophagy: variations on a common theme of self-eating? Nat Rev Mol Cell Biol. 13:7-12
2010
1. Bertsch, A., Jung, S., Zerck, A., Pfeifer, N., Nahnsen, S., Henneges, C., Nordheim, A., and Kohlbacher, O. 2010. Optimal de novo design of MRM experiments for rapid assay development in targeted proteomics. J Proteome Res 9:2696-2704.
2. Borchert, N., Dieterich, C., Krug, K., Schutz, W., Jung, S., Nordheim, A., Sommer, R.J., and Macek, B. 2010. Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models. Genome Res 20:837-846.
3. Burbulla, L.F., Schelling, C., Kato, H., Rapaport, D., Woitalla, D., Schiesling, C., Schulte, C., Sharma, M., Illig, T., Bauer, P., et al. 2010. Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis. Hum Mol Genet 19:4437-4452.
4. Costello, P., Nicolas, R., Willoughby, J., Wasylyk, B., Nordheim, A., and Treisman, R. 2010. Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development. J Immunol 185:1082-1092.
5. Harting, K., and Knoll, B. 2010. SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology. Eur J Cell Biol 89:262-269.
6. Jung, S., Fladerer, C., Braendle, F., Madlung, J., Spring, O., and Nordheim, A. 2010. Identification of a novel Plasmopara halstedii elicitor protein combining de novo peptide sequencing algorithms and RACE-PCR. Proteome Sci 8:24.
7. Knoll, B. 2010. Actin-mediated gene expression in neurons: the MRTF-SRF connection. Biol Chem 391:591-597.
8. Liu, Y., von Behrens, I., Muthreich, N., Schutz, W., Nordheim, A., and Hochholdinger, F. 2010. Regulation of the pericycle proteome in maize (Zea mays L.) primary roots by RUM1 which is required for lateral root initiation. Eur J Cell Biol 89:236-241.
9. Muthreich, N., Schutzenmeister, A., Schutz, W., Madlung, J., Krug, K., Nordheim, A., Piepho, H.P., and Hochholdinger, F. 2010. Regulation of the maize (Zea mays L.) embryo proteome by RTCS which controls seminal root initiation. Eur J Cell Biol 89:242-249.
10. Olson, E.N., and Nordheim, A. 2010. Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol 11:353-365.
11. Parkitna, J.R., Bilbao, A., Rieker, C., Engblom, D., Piechota, M., Nordheim, A., Spanagel, R., and Schutz, G. 2010. Loss of the serum response factor in the dopamine system leads to hyperactivity. FASEB J 24:2427-2435.
12. Pasztor, L., Ziebandt, A.K., Nega, M., Schlag, M., Haase, S., Franz-Wachtel, M., Madlung, J., Nordheim, A., Heinrichs, D.E., and Gotz, F. 2010. Staphylococcal major autolysin (Atl) is involved in excretion of cytoplasmic proteins. J Biol Chem 285:36794-36803.
13. Saleem, M., Lamkemeyer, T., Schutzenmeister, A., Madlung, J., Sakai, H., Piepho, H.P., Nordheim, A., and Hochholdinger, F. 2010. Specification of cortical parenchyma and stele of maize primary roots by asymmetric levels of auxin, cytokinin, and cytokinin-regulated proteins. Plant Physiol 152:4-18.
14. Stritt, C., and Knoll, B. 2010. Serum response factor regulates hippocampal lamination and dendrite development and is connected with reelin signaling. Mol Cell Biol 30:1828-1837.
15. Werth, D., Grassi, G., Konjer, N., Dapas, B., Farra, R., Giansante, C., Kandolf, R., Guarnieri, G., Nordheim, A., and Heidenreich, O. 2010. Proliferation of human primary vascular smooth muscle cells depends on serum response factor. Eur J Cell Biol 89:216-224.
16. Niessner, H., Beck, D., Sinnberg, T., Lasithiotakis, K., Maczey, E., Gogel, J., Venturelli, S., Berger, A., Mauthe, M., Toulany, M., et al. 2011. The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells. J Invest Dermatol 131:468-479.
17. Gao, P., Bauvy, C., Souquere, S., Tonelli, G., Liu, L., Zhu, Y., Qiao, Z., Bakula, D., Proikas-Cezanne, T., Pierron, G., et al. 2010. The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem 285:25570-25581.
18. Geeraert, C., Ratier, A., Pfisterer, S.G., Perdiz, D., Cantaloube, I., Rouault, A., Pattingre, S., Proikas-Cezanne, T., Codogno, P., and Pous, C. 2010. Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem 285:24184-24194.
19. Krebiehl, G., Ruckerbauer, S., Burbulla, L. F., Kieper, N., Maurer, B., Waak, J., Wolburg, H., Gizatullina, Z., Gellerich, F. N., Woitalla, D., Riess, O., Kahle, P.J., Proikas-Cezanne, T., Kruger, R. 2010. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 5:e9367.
20. Grotemeier, A., Alers, S., Pfisterer, S.G., Paasch, F., Daubrawa, M., Dieterle, A., Viollet, B., Wesselborg, S., Proikas-Cezanne, T., and Stork, B. 2010. AMPK-independent induction of autophagy by cytosolic Ca2+ increase. Cell Signal 22:914-925.