Pharmakologie, Toxikologie und Klinische Pharmazie

Experimentelle Pharmakologie

Institut für Pharmazie
Auf der Morgenstelle 8
D-72076 Tübingen


Übersichtsartikel und Buchbeiträge/Bücher

[11] Wagner TR, Burgstaller S, Frecot DI, Lukowski R, Rothbauer U: 30 Jahre Nanobodies: Neues von kleinen Helfern mit großem Potenzial, Biospektrum. 2/2023.
[10] Burgstaller S, Bischof H, Matt L, Lukowski R: Assessing K+ ions and K+ channel functions in cancer cell metabolism using fluorescent biosensors, Free Radic. Biol. Med. 2022; doi: 10.1016/j.freeradbiomed.2022.01.026.
[9] Stojkov D, Gigon L, Peng S, Lukowski R, Ruth P, Karaulov A,  Rizvanov A, Barlev NA, Yousefi S, Simon HU: Physiological and pathophysiological roles of metabolic pathways for NET formation and other neutrophil functions, Front. Immunology. 2022; doi: 10.3389/fimmu.2022.826515.
[8] Lukowski R, Cruz Santos M, Kuret A, Ruth P: cGMP and mitochondrial K+ channels - Compartmentalized but closely connected in cardioprotection, British Journal of Pharmacology. 2022; doi:10.1111/bph.15536.
[7] Ganser K, Klumpp L, Bischof H, Lukowski R, Eckert F, Huber SM: Potassium Channels in Cancer, Handbook of Experimental Pharmacology. 2021; doi: 10.1007/164_2021_465. 
[6] Adler J, Kuret A, Längst N, Lukowski R: Targets of cGMP/cGKI in cardiac myocytes, Journal of Cardiovascular Pharmacology. 2020; doi: 10.1097/FJC.0000000000000817
[5] Mohr CJ, Steudel FA, Gross D, Ruth P,  Lo WY, Hoppe R, Schroth W, Brauch H, Huber S, Lukowski R: Cancer-associated Intermediate Conductance Ca2+-activated K+ Channel KCa3.1, Cancers (Basel). 2019; doi: 10.3390/cancers11010109




Lukowski R, Krieg T, Rybalkin S, Beavo J, Hofmann F: Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust and beyond, Trends in Pharmacological Sciences. 2014;8:404-413.




Krieg T, Lukowski R (Editoren): Guanylate Cyclase and Cyclic GMP, Methods and Protocols. Humana Press. ISBN 978-1-62703-458-6.




Hofmann F, Bernhard D, Lukowski R, Weinmeister P. cGMP regulated protein kinases (cgk). Handbook of Experimental Pharmacology, 2009:137-162. BOOK CHAPTER.




Lukowski R, Weber S, Weinmeister P, Feil S, Feil R: Cre/loxP-vermittelte konditionale Mutagenese des cGMP-Signalwegs in der Maus, Biospektrum. 3/2005.



Pham T, Hussein T, Calis D, Bischof H, Skrabak D, Cruz Santos M, Maier S, Spähn D, Kalina D, Simonsig S, Ehinger R, Groschup B, Knipper M, Plesnila N, Ruth P, Lukowski R*, Matt L*: BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation, Cell Mol Life Sci. 2023; doi: 10.1007/s00018-023-05016-y. *equal contribution

[66] Skrabak D, Bischof H, Pham T, Ruth P, Ehinger R, Matt L, Lukowski R: Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing. Commun Biol. 2023; doi: 10.1038/s42003-023-05387-9
[65] Manke MC, Roslan A, Walker B, Münzer P, Kollotzek F, Peng B, Mencl S, Coman C, Szepanowski RD, Schulze H, Lieberman AP, Lang F, Gawaz M, Kleinschnitz C, Lukowski R, Ahrends R, Bobe R, Borst O: Niemann-Pick C1 protein regulates platelet membrane-associated Ca2+ signalling in thrombo-occlusive diseases in mice. J Thromb Haemost. 2023; doi: 10.1016/j.jtha.2023.03.038
[64] Calis D, Hess M, Marchetta P, Singer W, Nelissen E, Prickaerts J, Sandner P, Lukowski R, Ruth P, Knipper M and Rüttiger L: Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling, Front. Mol. Neurosci. 2023; doi: 10.3389/fnmol.2023.1017761
[63] Bachmann M, Rossa A, Varanita T, Fioretti B, Biasutto L, Milenkovic S, Checchetto V, Peruzzo R, Ahmad SA, Patel SH, Lukowski R, Edwards MJ, Ceccarelli M, Gulbins E, Zoratti M, Mattarei A, Szabo I: Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo, Cell Death & Disease. 2022; doi: 10.1038/s41419-022-05463-8.
[62] Gross D, Bischof H, Maier S, Sporbeck K, Birkenfeld AL, Malli R, Ruth P, Proikas-Cezanne T, Lukowski R: IKCa channels control­ breast cancer metabolism including AMPK-driven autophagy, Cell Death & Disease. 2022; doi: 10.1038/s41419-022-05329-z.

Burgstaller S, Wagner TR, Bischof H, Bueckle S, Padamsey A, Frecot D, Kaiser PD, Skrabak D, Malli R, Lukowski R*, Rothbauer U*: Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors, iScience. 2022; doi: 10.1016/j.isci.2022.104907.

*equal contribution

[60] Zhou F, Metzner K, Engel P, Balzulat A, Sisignanao M, Ruth P, Lukowski R, Schmidtko A, Lu R: Slack potassium channels modulate TRPA1-mediated nociception in sensory neurons, Cells. 2022; doi: 10.3390/cells11101693.

Längst N, Adler J, Kuret A, Peter A, Ruth P, Boldt K, Lukowski R: Cysteine-rich LIM-only protein 4 (CRP4) promotes atherogenesis in the ApoE-/- mouse model, Cells. 2022; doi: 10.3390/cells11081364.


Marchetta P, Eckert P, Lukowski R, Ruth P, Singer W, Rüttiger L, Knipper M: Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea, iScience. 2022; doi: 10.1016/j.isci.2022.103981. 

[57] Flauaus C, Engel P, Zhou F, Petersen J, Ruth P, Lukowski R, Schmidtko A, Lu R: Slick potassium channels control pain and itch in distinct populations of sensory and spinal neurons in mice, Anesthesiology. 2022; doi: 10.1097/ALN.0000000000004163.

Bork NI, Kuret A, Cruz Santos M, Molina CE, Reiter B, Reichenspurner H, Friebe A, Skryabin BV, Rozhdestvensky TS, Kuhn M, Lukowski R, Nikolaev VO: Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia, Redox Biol. 2021; doi: 10.1016/j.redox.2021.102179.


Burgstaller S, Bischof H, Rauter T, Schmidt T, Schindl R, Patz S, Groschup B,Filser S, van den Boom L, Sasse P, Lukowski R, Plesnila N, F. Graier W, and Malli R: Immobilization of recombinant fluorescent biosensors permits imaging of extracellular ion signals, ACS Sensors. 2021; doi: 10.1021/acssensors.1c01369.

[54] Matt L, Pham T, Skrabak D, Hoffmann F, Eckert P, Yin J, Gisevius M, Ehinger R, Bausch A, Ueffing M, Boldt K, Ruth P, Lukowski R: The Na+-activated K+ channel Slack contributes to synaptic development and plasticity, Cell Mol Life Sci. 2021; doi: 10.1007/s00018-021-03953-0.
[53] Längst N, Adler J, Schweigert O, Kleusberg F, Cruz Santos M, Knauer A, Sausbier M, Zeller T, Ruth P, Lukowski R: Cyclic GMP-dependent regulation of vascular tone and blood pressure involves cysteine-rich LIM-only protein 4 (CRP4), Int. J. Mol. Sci. 2021; doi: 10.3390/ijms22189925.

Burgstaller S, Bischof H, Lukowski R, Graier WF, Malli R: Investigating the K+-Sensitivity of Cellular Metabolism by Extracellular Flux Analysis, STAR Protocols. 2021; doi: 10.1016/j.xpro.2021.100843.


Bischof H, Burgstaller S, Graier WF, Lukowski R, Malli R: Unveiling the K+-sensitivity of Cell Metabolism Using Genetically-encoded, FRET-Based K+, Glucose, and ATP Biosensors, STAR Protocols. 2021; doi: 10.1016/j.xpro.2021.100843.


Schweigert O, Adler J, Längst N, Aïssi D, Escobar JD, Tong T, Müller C, Trégouët DA, Lukowski R*, Zeller T*: CRIP1 expression in monocytes related to hypertension, Clin Science. 2021; doi: 10.1042/CS20201372. *equal contribution


Ehinger R, Kuret A, Matt L, Frank N, Wild K, Kabagema-Bilan C, Bischof H, Malli R, Ruth P,  Bausch AE, Lukowski R: Slack K+ channels attenuate NMDA-induced excitotoxic brain damage and neuronal cell death, Faseb J. 2021; doi: 10.1096/fj.202002308RR. 

[48] Bischof H, Burgstaller S, Springer A, Matt L, Rauter T, Bachkönig OA,  Schmidt T, Groschner K, Schindl R, Madl T, Plesnila N, Lukowski R, Graier WF, Malli R: Potassium ions promote hexokinase-II dependent glycolysis, iScience. 2021; doi: 10.1016/j.isci.2021.102468.

Lu R, Metzner K, Zhou F, Flauaus C, Balzulat A, Engel P, Petersen J, Ehinger R, Bausch A, Ruth P, Lukowski R, Schmidtko A: Functional coupling of Slack channels and P2X3 receptors in mouse sensory neurons contributes to neuropathic pain processing, Int. J. Mol. Sci. 2021; doi: 10.3390/ijms22010405.

[46] Beyer T, Klose F, Kuret A, Hoffmann F, Lukowski R, Ueffing M, Boldt K: 

Tissue- and isoform-specific protein complex analysis with natively processed bait proteins, J Proteomics. 2021; doi: 10.1016/j.jprot.2020.103947.


Mohr CJ, Schroth W, Mürdter TE, Gross D, Maier S, Stegen B, Dragoi A, Steudel FA, Stehling S, Hoppe R, Madden S, Ruth P, Huber SM, Brauch H, Lukowski R: BK channel subunits promote breast cancer development and modulate endocrine treatment response in pre-clinical models, British Journal of Pharmacology. 2020; doi: 10.1111/bph.15147.


Quraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P,  Kaczmarek LK: Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (K(Na)1.1) Na(+)-activated K(+) channels, Sci Rep. 2020; doi: 10.1038/s41598-020-60028-z.

[43] Mohr CJ, Groß D, Sezgin E, Steudel FA, Ruth P, Huber SM, Lukowski R: KCa3.1 channels confer radioresistance to breast cancer cells, Cancers (Basel). 2019; doi: 10.3390/cancers11091285.
[42] Drotleff B, Illison J, Schlotterbeck J, Lukowski R, Lämmerhofer, M: Comprehensive Lipidomics of Mouse Plasma using Class-Specific Surrogate Calibrants and SWATH Acquisition for Large-Scale Lipid Quantification in Untargeted Analysis, Analytica Chimica Acta. 2019; doi: 10.1016/j.aca.2019.08.030.

Kersting D, Fasbender S, Pilch R, Kurth J, Franken A, Ludescher M, Naskou J, Hallenberger A, von Gall C, Mohr CJ, Lukowski R, Raba K, Jaschinski S, Esposito I, Fischer JC, Fehm T, Niederacher D, Neubauer H, Heinzel T: From in vitro to ex vivo: Subcellular localization and uptake of graphene quantum dots into solid tumors, Nanotechnology. 2019; doi: 10.1088/1361-6528/ab2cb4.




Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong  X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P: Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy, J Clin Invest. 2018; doi: 10.1172/JCI96098.


Bausch AE, Ehinger R, Straubinger J, Zerfass P, Nann Y, Lukowski R: Loss of sodium-activated potassium channel Slack and FMRP differentially affect social behavior in mice, Neuroscience. 2018; doi: 10.1016/j.neuroscience.2018.05.040.


Cheron G, Márquez-Ruiz J, Cheron J, Prigogine C, Ammann C, Lukowski R, Ruth P, Dan B: Purkinje cell BK channel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD, Sci Rep. 2018; doi: 10.1038/s41598-018-22654-6.


Frankenreiter S, Groneberg D, Kuret A, Krieg T, Ruth P, Friebe A, Lukowski R: Cardioprotection by ischemic postconditioning and cGMP-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase, Cardiovascular Res. 2018; doi: 10.1093/cvr/cvy039.




Frankenreiter S, Bednarczyk P, Kniess A, Bork N, Straubinger J, Koprowski P, Wrzosek A, Mohr E, Logan A, Murphy MP, Gawaz M, Krieg T, Szewczyk A, Nikolaev VO, Ruth P, Lukowski R: cGMP-elevating compounds and ischemic conditioning provide cardioprotection against ischemia and reperfusion injury via cardiomyocyte-specific BK channels, Circulation. 2017;2337-2355.


Lu R, Flauaus C, Kennel L, Petersen J, Drees O, Kallenborn-Gerhardt W, Ruth P, Lukowski R, Schmidtko A: KCa3.1 channels modulate the processing of noxious chemical stimuli in mice, Neuropharmacology. 2017; doi: 10.1016/j.neuropharm.2017.08.021.


Evely KM, Pryce K, Bausch A, Lukowski R, Ruth P, Haj-Dahmane S, Bhattacharjee A: Slack KNa Channels Influence Dorsal Horn Synapses and Nociceptive Behavior, Molecular Pain. 2017; doi: 10.1177/1744806917714342.


Steudel FA, Mohr CJ, Stegen B, Nguyen HY, Barnert A, Steinle M, Beer-Hammer S, Koch P, Lo WY, Schroth W, Hoppe R, Brauch H, Ruth P, Huber SM, Lukowski R: SK4 channels modulate Ca2+-signalling and cell cycle progression in murine breast cancer, Mol Oncol. 2017; doi: 10.1002/1878-0261.12087.


Straubinger J, Boldt K, Kuret A, Deng L, Krattenmacher D, Bork N, Desch M, Feil R, Feil S, Nemer M, Ueffing M, Ruth P, Just S, Lukowski R: Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein negative mouse hearts, FASEB J. 2017; 1620-1638.




Illison J, Tian L, McClafferty H, Werno M, Chamberlain LH, Leiss V, Sassmann A, Offermanns S, Ruth P, Shipston MJ, Lukowski R: Obesogenic and diabetogenic effects of high-calorie nutrition require adipocyte BK channels, Diabetes. 2016;3621-3635.


Fleming R, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK: Stimulation of Slack K+ channels alters mass at the plasma membrane by triggering disassociation of a phosphatase-regulatory complex, Cell reports. 2016;2281-2288.


Edalat L, Stegen B, Klumpp L, Haehl E, Schilbach K, Lukowski R, Kühnle M, Bernhardt G, Buschauer A, Zips D, Ruth P. Huber SM: BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells, Oncotarget. 2016;7:14259-78.


Angermeier E, Domes K, Lukowski R, Schlossmann J, Rathkolb B, Hrabě de Angelis M, Hofmann F: Iron deficiency anemia in cyclic GMP kinase knockout mice, Haematologica. 2016;101 e48-51.




Straubinger J, Schöttle V, Bork N, Subramanian H, Dünnes S, Russwurm M, Gawaz M, Friebe A, Nemer M, Nikolaev VO, Lukowski R: Sildenafil does not prevent cardiomyocyte AT1R signaling induced heart hypertrophy and fibrosis, Journal of Pharmacology and Experimental Therapeutics. 2015;354 406-416.


Zhou XB, Feng XF, Sun Q, Lukowski R, Qiu Y, Spiger K, Li Z, Ruth P, Korth M, Skolnik EY, Borggrefe M, Dobrev D, Wieland T: Nucleoside Diphosphate Kinase B Activated Intermediate-Conductance Potassium Channels Are Critical for Neointima Formation in Mouse Carotid Arteries, Arteriosclerosis, thrombosis, and vascular biology. 2015;35 1852-1861.


Bausch AE, Dieter R, Nann Y, Meyerdierks N, Hausmann M, Kaczmarek LK, Ruth P, Lukowski R: The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice, Learning & memory. 2015;22:323-35.


Brennenstuhl C, Tanimoto N, Burkard M, Wagner R, Bolz S, Trifunovic D, Kabagema-Bilan C, Paquet-Durand F, Beck SC, Huber G, Seeliger MW, Ruth P, Wissinger B, Lukowski R: Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory, The Journal of biological chemistry. 2015;17:10242-55.


Lu R, Bausch AE, Kallenborn-Gerhardt W, Stoetzer C, Debruin N, Ruth P, Geisslinger G, Leffler A, Lukowski R*, Schmidtko A*: Slack channels expressed in sensory neurons control neuropathic pain in mice, The Journal of Neuroscience. 2015;35:1125–1135. *Equal contribution.




Leiss V, Illison J, Domes K, Hofmann F, Lukowski R: Expression of cGMP-dependent protein kinase type I in mature white adipocytes, Biochemical and Biophysical Research Communications. 2014;452:151-156.


Patrucco E, Domes K, Sbroggio M, Blaich A, Schlossmann J, Desch M, Rybalkin S, Beavo J, Lukowski R, Hofmann F: The roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis, Proceedings of the National Academy of Sciences of the United States of America. 2014;111(35):12925-9.


Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R: Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis, Circulation research. 2014;115:662-667.


Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R: KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury, PLOS ONE. 2014;9:e103402.


Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A. Bkca channels expressed in sensory neurons modulate inflammatory pain in mice, Pain. 2014;155:556-565.


Grobner S, Lukowski R, Autenrieth IB, Ruth P. Lipopolysaccharide induces cell volume increase and migration of dendritic cells, Microbiology and immunology. 2014;58:61-67.




Zhang L*, Lukowski R*, Gaertner F, Lorenz M, Legate KR, Domes K, Angermeier E, Hofmann F, Massberg S. Thrombocytosis as a response to high interleukin-6 levels in cgmp-dependent protein kinase i mutant mice,  Arteriosclerosis, thrombosis, and vascular biology. 2013;33:1820-1828. *Equal contribution.


Methner C, Lukowski R, Grube K, Loga F, Smith RA, Murphy MP, Hofmann F, Krieg T. Protection through postconditioning or a mitochondria-targeted s-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G, Basic research in cardiology. 2013;108:337.




Zhou X, Wulfsen I, Korth M, McClafferty H, Lukowski R, Shipston MJ, Ruth P, Dobrev D, Wieland T. Palmitoylation and membrane association of the stress axis regulated insert (strex) controls bk channel regulation by protein kinase C, The Journal of biological chemistry. 2012;287:32161-32171.


Kohl S, Coppieters F, Meire F, Schaich S, Roosing S, Brennenstuhl C, Bolz S, van Genderen MM, Riemslag FC, Lukowski R, den Hollander AI, Cremers FP, De Baere E, Hoyng CB, Wissinger B. A nonsense mutation in pde6h causes autosomal-recessive incomplete achromatopsia, American journal of human genetics. 2012;91:527-532.


Dufer M, Horth K, Wagner R, Schittenhelm B, Prowald S, Wagner TF, Oberwinkler J, Lukowski R, Gonzalez FJ, Krippeit-Drews P, Drews G. Bile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid x receptor activation and k(atp) channel inhibition, Diabetes. 2012;61:1479-1489.


Singh AK, Spiessberger B, Zheng W, Xiao F, Lukowski R, Wegener JW, Weinmeister P, Saur D, Klein S, Schemann M, Krueger D, Seidler U, Hofmann F. Neuronal cgmp kinase i is essential for stimulation of duodenal bicarbonate secretion by luminal acid, FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2012;26:1745-1754.




Liang Z, Chen L, McClafferty H, Lukowski R, MacGregor D, King JT, Rizzi S, Sausbier M, McCobb DP, Knaus HG, Ruth P, Shipston MJ. Control of hypothalamic-pituitary-adrenal stress axis activity by the intermediate conductance calcium-activated potassium channel, SK4, The Journal of physiology. 2011;589:5965-5986.


Ertl C, Lukowski R, Sigl K, Schlossmann J, Hofmann F, Wegener JW. Kinetics of relaxation by cgmp/cgki signaling in fundus smooth muscle, European journal of pharmacology. 2011;670:266-271.


Steinle M, Palme D, Misovic M, Rudner J, Dittmann K, Lukowski R, Ruth P, Huber SM. Ionizing radiation induces migration of glioblastoma cells by activating bk k(+) channels, Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology. 2011;101:122-126.


Leiss V, Friebe A, Welling A, Hofmann F, Lukowski R. Cyclic gmp kinase i modulates glucagon release from pancreatic alpha-cells, Diabetes. 2011;60:148-156.




Lukowski R, Rybalkin SD, Loga F, Leiss V, Beavo JA, Hofmann F. Cardiac hypertrophy is not amplified by deletion of cgmp-dependent protein kinase i in cardiomyocytes, Proceedings of the National Academy of Sciences of the United States of America. 2010;107:5646-5651.


Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, Jochim A, Spiessberger B, Hocherl K, Feil R, Feil S, Lukowski R, Wegener JW, Hofmann F, Schlossmann J. Irag determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation, Cardiovascular research. 2010;86:496-505.




Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L, Hofmann F, Feil R. Cyclic guanosine monophosphate-dependent protein kinase i promotes adhesion of primary vascular smooth muscle cells, Molecular biology of the cell. 2008;19:4434-4441.


Lukowski R, Weinmeister P, Bernhard D, Feil S, Gotthardt M, Herz J, Massberg S, Zernecke A, Weber C, Hofmann F, Feil R. Role of smooth muscle cgmp/cgki signaling in murine vascular restenosis, Arteriosclerosis, thrombosis, and vascular biology. 2008;28:1244-1250.




Weber S, Bernhard D, Lukowski R, Weinmeister P, Worner R, Wegener JW, Valtcheva N, Feil S, Schlossmann J, Hofmann F, Feil R. Rescue of cgmp kinase i knockout mice by smooth muscle specific expression of either isozyme, Circulation research. 2007;101:1096-1103.


Worner R, Lukowski R, Hofmann F, Wegener JW. Cgmp signals mainly through camp kinase in permeabilized murine aorta. American journal of physiology, Heart and circulatory physiology. 2007;292:H237-244.


[18] Lukowski R, Feil R: Recent developments in cGMP research: From mechanisms to medicines and back, British Journal of Pharmacology. 2022; doi: 10.1111/bph.1582. Online ahead of print.

Lukowski R: Faculty Opinions Recommendation of [Valkovic AL et al., Int J Mol Sci 2022 23(3:)]. In Faculty Opinions, 18 Jul 2022;


Lukowski R, Booz GW. Deciphering the dynamics and therapeutic potential of the cardiac cGMP cascade: An update on where we are and what we need to know. J Cardiovasc Pharmacol. 2020 Feb 25. doi: 10.1097/FJC.0000000000000814.

[15] Lukowski R: F1000Prime Recommendation of [Dudem S et al., Proc Natl Acad Sci USA 2020 117(4):2194-2200]. In F1000Prime, 05 Mar 2020; 10.3410/f.737212019.793571753.
[14] Lukowski R: F1000Prime Recommendation of [Ros O et al., Cell Rep 2019 27(13):4003-4012.e6]. In F1000Prime, 11 Jul 2019; 10.3410/f.736050128.793562141.




Lukowski R: F1000Prime Recommendation of [Smith CO et al., FASEB J 2018 :fj201800139R]. In F1000Prime, 19 Jun 2018; DOI: 10.3410/f.733380453.793546973.


Lukowski R: F1000Prime Recommendation of [Bischof H et al., Nat Commun 2017 , 8(1):1422]. In F1000Prime, 27 Apr 2018; DOI: 10.3410/f.732095612.793544942.




Lukowski R: F1000Prime Recommendation of [Emdin CA et al., Circulation 2017:CIRCULATIONAHA.117.028021]. In F1000Prime, 11 Oct 2017; DOI: 10.3410/f.731776868.793537485.




Booz G and Lukowski R: F1000Prime Recommendation of [Lee DI et al., Nature 2015, 519(7544):472-6]. In F1000Prime, 13 Apr 2015; DOI: 10.3410/f.725402305.793505584.


Booz G and Lukowski R: F1000Prime Recommendation of [Degen CV et al., PLoS ONE 2015, 10(3):e0118664]. In F1000Prime, 18 Mar 2015; DOI: 10.3410/f.725381999.793504893.




Booz G and Lukowski R: F1000Prime Recommendation of [Gnad T et al., Nature 2014]. In F1000Prime, 30 Oct 2014; DOI: 10.3410/f.722007546.793501067.


Booz G and Lukowski R: F1000Prime Recommendation of [Stubbert D et al., Hypertension 2014]. In F1000Prime, 23 Oct 2014; DOI: 10.3410/f.718893960.793500871.


Booz G and Lukowski R: F1000Prime Recommendation of [Castaldi A et al., Circ Res 2014, 115(2):273-83]. In F1000Prime, 12 Aug 2014; DOI: 10.3410/f.718379172.793498299.


Booz G and Lukowski R: F1000Prime Recommendation of [Guo DC et al., Am J Hum Genet 2013, 93(2):398-404]. In F1000Prime, 05 Jun 2014; DOI: 10.3410/f.718058458.793495901.


Booz G and Lukowski R: F1000Prime Recommendation of [Thunemann M et al., Circ Res 2013, 113(4):365-71]. In F1000Prime, 03 Jun 2014; DOI: 10.3410/f.718426439.793495769.


Booz G and Lukowski R: F1000Prime Recommendation of [Ghofrani HA et al., N Engl J Med 2013, 369(4):330-40]. In F1000Prime, 03 Jun 2014; DOI: 10.3410/f.718047146.793495773.




Schmidt H and Lukowski R: F1000Prime Recommendation of [Ghebremariam YT et al., Circulation 2013]. In F1000Prime, 15 Aug 2013; DOI: 10.3410/f.718059599.793481605.




Lukowski R, Rybalkin SD, Beavo JA, Hofmann F: Reply to Kass and Takimoto: Cardiac hypertrophy without cGKI and PDE5 in cardiac myocytes Proceedings of the National Academy of Sciences of the United States of America. 107:E99.