Publications

Opportunities and challenges of RiPP-based therapeutics,

I. P.-M. Pfeiffer,# M.-P. Schröder,# S. Mordhorst,*

Nat. Prod. Rep., 2024, Advance Article
https://doi.org/10.1039/D3NP00057E

Biomimetic S-Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes,

L. Gericke, D. Mhaindarkar, L. C. Karst, S. Jahn, M. Kuge, M. K. F. Mohr, J. Gagsteiger, N. V. Cornelissen, X. Wen, S. Mordhorst, H. J. Jessen, A. Rentmeister, F. P. Seebeck, G.
Layer, C. Loenarz, J. N. Andexer,
ChemBioChem 2023, 24, e20230013.
https://doi.org/10.1002/cbic.202300133

Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase,
S. Mordhorst,# T. Badmann,# N. M. Bösch, B. I. Morinaka, H. Rauch, J. Piel, M. Groll, A. L. Vagstad,
ACS Chem. Biol. 2023, 18, 3, 528–536.
https://doi.org/10.1021/acschembio.2c00879

Emulating nonribosomal peptides with ribosomal biosynthetic strategies,
S. Mordhorst,# F. Ruijne,# A. L. Vagstad, O. P. Kuipers, J. Piel,

RSC Chem. Biol. 2023, 4, 7–36 (review article).
https://doi.org/10.1039/D2CB00169A

A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks, 

D. Popadic, D. Mhaindarkar, M. H. N. Dang Thai, H. C. Hailes, S. Mordhorst, J. N. Andexer,

RSC Chem. Biol. 2021, 2, 883-891.

https://doi.org/10.1039/D1CB00033K
This research article received the RSC Outstanding Paper Award 2021.

Posttranslationally Acting Arginases Provide a Ribosomal Route to Nonproteinogenic Ornithine Residues in Diverse Peptide Sequences,

S. Mordhorst, B. I. Morinaka, A. L. Vagstad, J. Piel,
Angew. Chem. Int. Ed. 2020, 59, 21442-21447, (Angew. Chem. 2020, 132, 21626-21631).

https://doi.org/10.1002/anie.202008990

This research article has been highlighted as VIP (Very Important Paper) in Biosynthesis.

Round, round we go – strategies for enzymatic cofactor regeneration,
S. Mordhorst, J. N. Andexer,
Nat. Prod. Rep. 2020, 37, 1316-1333 (review article).

https://doi.org/10.1039/D0NP00004C

Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5’- Polyphosphates,

S. Mordhorst,# J. Singh,# M. K. F. Mohr, R. Hinkelmann, M. Keppler, H. J. Jessen, J. N. Andexer,

ChemBioChem 2019, 20, 1019-1022.

https://doi.org/10.1002/cbic.201800704

Chorismatases – the family is growing,
M. J. Grüninger, P. C. F. Buchholz, S. Mordhorst, P. Strack, M. Müller, F. Hubrich, J. Pleiss, J. N. Andexer,
Org. Biomol. Chem. 2019, 17, 2092-2098.

https://doi.org/10.1039/C8OB03038C

Substrate Recognition and Mechanism Revealed by Ligand-Bound Polyphosphate Kinase 2 Structures,
A. E. Parnell,# S. Mordhorst,# F. Kemper, M. Giurrandino, N. Schwarzer, A. Hofer, H. J. Jessen, S. Gerhardt, O. Einsle, P. C. F. Oyston, J. N. Andexer, P. L. Roach,
Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 3350-3355.

https://doi.org/10.1073/pnas.1710741115

A Flexible Polyphosphate-Driven Regeneration System for Coenzyme A Dependent Catalysis,
S. Mordhorst, A. Maurer, D. Popadic, J. Brech, J. N. Andexer,
ChemCatChem 2017, 9, 4164-4168.
https://doi.org/10.1002/cctc.201700848

Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System,
S. Mordhorst, J. Siegrist, M. Müller, M. Richter, J. N. Andexer,
Angew. Chem. Int. Ed. 2017, 56, 4037-4041, (Angew. Chem. 2017, 129, 4095-4099).
https://doi.org/10.1002/anie.201611038
This research article has been highlighted as Hot Paper in Biocatalysis.

Asymmetric C-Alkylation by the S-Adenosylmethionine-Dependent Methyltransferase SgvM,
C. Sommer-Kamann, A. Fries, S. Mordhorst, J. N. Andexer, M. Müller,
Angew. Chem. Int. Ed. 2017, 56, 4033-4036, (Angew. Chem. 2017, 129, 4091-4094).

https://doi.org/10.1002/anie.201609375

Functional and structural characterisation of a bacterial O-methyltransferase and factors determ

ining regioselectivity,
J. Siegrist, J. Netzer, S. Mordhorst, L. Karst, S. Gerhardt, O. Einsle, M. Richter, J. N. Andexer, FEBS Lett. 2017, 591, 312-321.

https://doi.org/10.1002/1873-3468.12530

Regiocomplementary O-Methylation of Catechols by Using Three-Enzyme Cascades, J. Siegrist, S. Aschwanden,
S. Mordhorst, L. Thöny-Meyer, M. Richter, J. N. Andexer, ChemBioChem 2015, 16, 2576-2579, featured as back cover.

https://doi.org/10.1002/cbic.201500410

The research article is being featured on the back cover.

Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases,
F. Hubrich, S. Mordhorst, J. N. Andexer, Bioorg. Med. Chem. Lett. 2013, 23, 1477-1481.
https://doi.org/10.1016/j.bmcl.2012.12.059