Pharmazeutische Biologie


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Opportunities and challenges of RiPP-based therapeutics,

I. P.-M. Pfeiffer,# M.-P. Schröder,# S. Mordhorst,*

Nat. Prod. Rep., 2024, Advance Article


Biomimetic S-Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes,

L. Gericke, D. Mhaindarkar, L. C. Karst, S. Jahn, M. Kuge, M. K. F. Mohr, J. Gagsteiger, N. V. Cornelissen, X. Wen, S. Mordhorst, H. J. Jessen, A. Rentmeister, F. P. Seebeck, G.
Layer, C. Loenarz, J. N. Andexer,
ChemBioChem 2023, 24, e20230013.


Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase,
S. Mordhorst,# T. Badmann,# N. M. Bösch, B. I. Morinaka, H. Rauch, J. Piel, M. Groll, A. L. Vagstad,
ACS Chem. Biol. 2023, 18, 3, 528–536.


Emulating nonribosomal peptides with ribosomal biosynthetic strategies,
S. Mordhorst,# F. Ruijne,# A. L. Vagstad, O. P. Kuipers, J. Piel,

RSC Chem. Biol. 2023, 4, 7–36 (review article).


A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks, 

D. Popadic, D. Mhaindarkar, M. H. N. Dang Thai, H. C. Hailes, S. Mordhorst, J. N. Andexer,

RSC Chem. Biol. 2021, 2, 883-891.
This research article received the RSC Outstanding Paper Award 2021.


Posttranslationally Acting Arginases Provide a Ribosomal Route to Nonproteinogenic Ornithine Residues in Diverse Peptide Sequences,

S. Mordhorst, B. I. Morinaka, A. L. Vagstad, J. Piel,
Angew. Chem. Int. Ed. 2020, 59, 21442-21447, (Angew. Chem. 2020, 132, 21626-21631).

This research article has been highlighted as VIP (Very Important Paper) in Biosynthesis.


Round, round we go – strategies for enzymatic cofactor regeneration,
S. Mordhorst, J. N. Andexer,
Nat. Prod. Rep. 2020, 37, 1316-1333 (review article).


Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5’- Polyphosphates,

S. Mordhorst,# J. Singh,# M. K. F. Mohr, R. Hinkelmann, M. Keppler, H. J. Jessen, J. N. Andexer,

ChemBioChem 2019, 20, 1019-1022.


Chorismatases – the family is growing,
M. J. Grüninger, P. C. F. Buchholz, S. Mordhorst, P. Strack, M. Müller, F. Hubrich, J. Pleiss, J. N. Andexer,
Org. Biomol. Chem. 2019, 17, 2092-2098.


Substrate Recognition and Mechanism Revealed by Ligand-Bound Polyphosphate Kinase 2 Structures,
A. E. Parnell,# S. Mordhorst,# F. Kemper, M. Giurrandino, N. Schwarzer, A. Hofer, H. J. Jessen, S. Gerhardt, O. Einsle, P. C. F. Oyston, J. N. Andexer, P. L. Roach,
Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 3350-3355.


A Flexible Polyphosphate-Driven Regeneration System for Coenzyme A Dependent Catalysis,
S. Mordhorst, A. Maurer, D. Popadic, J. Brech, J. N. Andexer,
ChemCatChem 2017, 9, 4164-4168.


Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System,
S. Mordhorst, J. Siegrist, M. Müller, M. Richter, J. N. Andexer,
Angew. Chem. Int. Ed. 2017, 56, 4037-4041, (Angew. Chem. 2017, 129, 4095-4099).
This research article has been highlighted as Hot Paper in Biocatalysis.


Asymmetric C-Alkylation by the S-Adenosylmethionine-Dependent Methyltransferase SgvM,
C. Sommer-Kamann, A. Fries, S. Mordhorst, J. N. Andexer, M. Müller,
Angew. Chem. Int. Ed. 2017, 56, 4033-4036, (Angew. Chem. 2017, 129, 4091-4094).


Functional and structural characterisation of a bacterial O-methyltransferase and factors determ

ining regioselectivity,
J. Siegrist, J. Netzer, S. Mordhorst, L. Karst, S. Gerhardt, O. Einsle, M. Richter, J. N. Andexer, FEBS Lett. 2017, 591, 312-321.


Regiocomplementary O-Methylation of Catechols by Using Three-Enzyme Cascades, J. Siegrist, S. Aschwanden,
S. Mordhorst, L. Thöny-Meyer, M. Richter, J. N. Andexer, ChemBioChem 2015, 16, 2576-2579, featured as back cover.

The research article is being featured on the back cover.


Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases,
F. Hubrich, S. Mordhorst, J. N. Andexer, Bioorg. Med. Chem. Lett. 2013, 23, 1477-1481.

# equal author contribution