Pharmaceutical Biology


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D. Popadic, D. Mhaindarkar, M. H. N. Dang Thai, H. C. Hailes, S. Mordhorst, J. N. Andexer, A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks,  RSC Chem. Biol. 2021, 2, 883-891.

11. S. Mordhorst, B. I. Morinaka, A. L. Vagstad, J. Piel, Posttranslationally Acting Arginases Provide a Ribosomal Route to Nonproteinogenic Ornithine Residues in Diverse Peptide Sequences, Angew. Chem. Int. Ed. 2020, 59, 21442-21447, (Angew. Chem. 2020, 132, 21626-21631).

S. Mordhorst, J. N. Andexer, Round, round we go – strategies for enzymatic cofactor regeneration, Nat. Prod. Rep. 2020, 37, 1316-1333 (review article).


S. Mordhorst,* J. Singh,* M. K. F. Mohr, R. Hinkelmann, M. Keppler, H. J. Jessen, J. N. Andexer, Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5’- Polyphosphates, ChemBioChem 2019, 20, 1019-1022.



M. J. Grüninger, P. C. F. Buchholz, S. Mordhorst, P. Strack, M. Müller, F. Hubrich, J. Pleiss, J. N. Andexer, Chorismatases – the family is growing, Org. Biomol. Chem. 2019, 17, 2092-2098.


A. E. Parnell,* S. Mordhorst,* F. Kemper, M. Giurrandino, N. Schwarzer, A. Hofer, H. J. Jessen, S. Gerhardt, O. Einsle, P. C. F. Oyston, J. N. Andexer, P. L. Roach, Substrate Recognition and Mechanism Revealed by Ligand-Bound Polyphosphate Kinase 2 Structures, Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 3350-3355.


S. Mordhorst, A. Maurer, D. Popadic, J. Brech, J. N. Andexer, A Flexible Polyphosphate-Driven Regeneration System for Coenzyme A Dependent Catalysis, ChemCatChem 2017, 9, 4164-4168.


S. Mordhorst, J. Siegrist, M. Müller, M. Richter, J. N. Andexer, Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System, Angew. Chem. Int. Ed. 2017, 56, 4037-4041, (Angew. Chem. 2017, 129, 4095-4099).


C. Sommer-Kamann, A. Fries, S. Mordhorst, J. N. Andexer, M. Müller, Asymmetric C-Alkylation by the S-Adenosylmethionine-Dependent Methyltransferase SgvM, Angew. Chem. Int. Ed. 2017, 56, 4033-4036, (Angew. Chem. 2017, 129, 4091-4094).


J. Siegrist, J. Netzer, S. Mordhorst, L. Karst, S. Gerhardt, O. Einsle, M. Richter, J. N. Andexer, Functional and structural characterisation of a bacterial O-methyltransferase and factors determining regioselectivity, FEBS Lett. 2017, 591, 312-321.

2. J. Siegrist, S. Aschwanden, S. Mordhorst, L. Thöny-Meyer, M. Richter, J. N. Andexer, Regiocomplementary O-Methylation of Catechols by Using Three-Enzyme Cascades, ChemBioChem 2015, 16, 2576-2579, featured as back cover.

F. Hubrich, S. Mordhorst, J. N. Andexer, Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases, Bioorg. Med. Chem. Lett. 2013, 23, 1477-1481.

* equal author contribution