Pharmaceutical Biology

Publications

visit also my profile at ORCID

2023  
15.

Biomimetic S-Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes,
L. Gericke, D. Mhaindarkar, L. C. Karst, S. Jahn, M. Kuge, M. K. F. Mohr, J. Gagsteiger,
N. V. Cornelissen, X. Wen, S. Mordhorst, H. J. Jessen, A. Rentmeister, F. P. Seebeck, G.
Layer, C. Loenarz, J. N. Andexer,
ChemBioChem 2023, 24, e20230013.
https://doi.org/10.1002/cbic.202300133

14.

Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase,
S. Mordhorst,# T. Badmann,# N. M. Bösch, B. I. Morinaka, H. Rauch, J. Piel, M. Groll, A. L. Vagstad,
ACS Chem. Biol. 2023, 18, 3, 528–536.
https://doi.org/10.1021/acschembio.2c00879

13.

Emulating nonribosomal peptides with ribosomal biosynthetic strategies,
S. Mordhorst,# F. Ruijne,# A. L. Vagstad, O. P. Kuipers, J. Piel,

RSC Chem. Biol. 2023, 4, 7–36 (review article).
https://doi.org/10.1039/D2CB00169A

2021  
12.

A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks, 

D. Popadic, D. Mhaindarkar, M. H. N. Dang Thai, H. C. Hailes, S. Mordhorst, J. N. Andexer,

RSC Chem. Biol. 2021, 2, 883-891.

https://doi.org/10.1039/D1CB00033K
This research article received the RSC Outstanding Paper Award 2021.

2020  
11.

Posttranslationally Acting Arginases Provide a Ribosomal Route to Nonproteinogenic Ornithine Residues in Diverse Peptide Sequences,

S. Mordhorst, B. I. Morinaka, A. L. Vagstad, J. Piel,
Angew. Chem. Int. Ed. 2020, 59, 21442-21447, (Angew. Chem. 2020, 132, 21626-21631).

https://doi.org/10.1002/anie.202008990

This research article has been highlighted as VIP (Very Important Paper) in Biosynthesis.

10.

Round, round we go – strategies for enzymatic cofactor regeneration,
S. Mordhorst, J. N. Andexer,
Nat. Prod. Rep. 2020, 37, 1316-1333 (review article).

https://doi.org/10.1039/D0NP00004C

2019  
9.

S. Mordhorst,# J. Singh,# M. K. F. Mohr, R. Hinkelmann, M. Keppler, H. J. Jessen, J. N. Andexer, Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5’- Polyphosphates, ChemBioChem 2019, 20, 1019-1022.

https://doi.org/10.1002/cbic.201800704

8.

Chorismatases – the family is growing,
M. J. Grüninger, P. C. F. Buchholz, S. Mordhorst, P. Strack, M. Müller, F. Hubrich, J. Pleiss, J. N. Andexer,
Org. Biomol. Chem. 2019, 17, 2092-2098.

https://doi.org/10.1039/C8OB03038C

2018  
7.

Substrate Recognition and Mechanism Revealed by Ligand-Bound Polyphosphate Kinase 2 Structures,
A. E. Parnell,# S. Mordhorst,# F. Kemper, M. Giurrandino, N. Schwarzer, A. Hofer, H. J. Jessen, S. Gerhardt, O. Einsle, P. C. F. Oyston, J. N. Andexer, P. L. Roach,
Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 3350-3355.

https://doi.org/10.1073/pnas.1710741115

2017  
6.

A Flexible Polyphosphate-Driven Regeneration System for Coenzyme A Dependent Catalysis,
S. Mordhorst, A. Maurer, D. Popadic, J. Brech, J. N. Andexer,
ChemCatChem 2017, 9, 4164-4168.
https://doi.org/10.1002/cctc.201700848

5.

Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System,
S. Mordhorst, J. Siegrist, M. Müller, M. Richter, J. N. Andexer,
Angew. Chem. Int. Ed. 2017, 56, 4037-4041, (Angew. Chem. 2017, 129, 4095-4099).
https://doi.org/10.1002/anie.201611038
This research article has been highlighted as Hot Paper in Biocatalysis.

4.

Asymmetric C-Alkylation by the S-Adenosylmethionine-Dependent Methyltransferase SgvM,
C. Sommer-Kamann, A. Fries, S. Mordhorst, J. N. Andexer, M. Müller,
Angew. Chem. Int. Ed. 2017, 56, 4033-4036, (Angew. Chem. 2017, 129, 4091-4094).

https://doi.org/10.1002/anie.201609375

3.

Functional and structural characterisation of a bacterial O-methyltransferase and factors determ

ining regioselectivity,
J. Siegrist, J. Netzer, S. Mordhorst, L. Karst, S. Gerhardt, O. Einsle, M. Richter, J. N. Andexer, FEBS Lett. 2017, 591, 312-321.

https://doi.org/10.1002/1873-3468.12530

2.

Regiocomplementary O-Methylation of Catechols by Using Three-Enzyme Cascades, J. Siegrist, S. Aschwanden,
S. Mordhorst, L. Thöny-Meyer, M. Richter, J. N. Andexer, ChemBioChem 2015, 16, 2576-2579, featured as back cover.

https://doi.org/10.1002/cbic.201500410

The research article is being featured on the back cover.

2013  
1.

Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases,
F. Hubrich, S. Mordhorst, J. N. Andexer, Bioorg. Med. Chem. Lett. 2013, 23, 1477-1481.
https://doi.org/10.1016/j.bmcl.2012.12.059

# equal author contribution