Pharmazeutische Biologie


127. SJ Jaag, Y Valadbeigi, T Causon*, H Gross and Michael Lämmerhofer* (2024) Three-Minute Enantioselective Amino Acid Analysis by Ultra-High-Performance Liquid Chromatography Drift Tube Ion Mobility-Mass Spectrometry Using a Chiral Core–Shell Tandem Column Approach. Anal. Chem., 96, 2666-2675. Available through open access:
126. E Bach*, J Chen, CF Figueiredo Angolini, JS Bauer, H Gross and LM Pereira Passaglia (2024) Genome-guided purification of high amounts of the siderophore ornibactin and detection of potentially novel burkholdine derivatives produced by Burkholderia catarinensis 89T. J. Appl. Microbiol., 135, lxae040.
125. P Beller, P Fink, F Wolf, D Männle, I Helmle, W Kuttenlochner, D Unterfrauner, A Engelbrecht, ND Staudt, A Kulik, M Groll, H Gross and L Kaysser* (2024) Characterization of the cystargolide biosynthetic gene cluster and functional analysis of the methyltransferase CysG. J. Biol. Chem., 300, 105507.
124. H Saad*, T Majer, K Bhattarai, S Lampe, DT Nguyen, M Kramer, J Straetener, H Brötz-Oesterhelt, DA Mitchell and H Gross* (2023) Bioinformatics-guided discovery of biaryl-linked lasso peptides. Chem. Sci., 14,13176-13183.

Y Yang*, CE Steidele, C Rössner, B Löffelhardt, D Kolb, T Leisen, W Zhang, C Ludwig, G Felix, MF Seidl, A Becker, T Nürnberger, M Hahn, B Gust, H Gross, R Hückelhoven and AA Gust* (2023)
Convergent evolution of plant pattern recognition receptors sensing cysteine-rich patterns from three microbial kingdoms. Nature Comm., 14, 3621. Available through open access:

122. A Frediansyah, H Miess, I Cleenwerck and H Gross* (2023) Genome Sequences of the Two Telluria Type Strains, Telluria chitinolytica ACM 3522T and Telluria mixta DSM 29330T. Microbiol. Resour. Announc., 12, e00787-21. Available through open access:
121. S Elsabbagh, M Landau, H Gross, A Schultz and JE Schultz* (2023) Heme b inhibits class III adenylyl cyclases. Cell. Signal., 103, 110568.

NM Hegazi, TA Mohamed, HH Saad, MA Al-Hammady, TA Hussien, MEF Hegazy, and H Gross* (2022) Molecular Network Guided Cataloging of the Secondary Metabolome of Selected Egyptian Red Sea Soft Corals. Mar. Drugs 20, 630. Available through open access:

119. T Mayer, K Bhattarai, J Straetener, J Pohlmann, P Cahill, MO Zimmermann, MP Hübner, M Kaiser, J Svenson, M Schindler, H Brötz-Oesterhelt, FM Boeckler and H Gross* (2022) Discovery of Ircinianin Lactones B and C – Two New Cyclic Sesterterpenes from the Marine Sponge Ircinia wistarii. Mar. Drugs 20, 532. Available through open access:

LM Wingen, C Braun, M Rausch, H Gross, T Schneider and D Menche* (2022) Versatile synthesis of pathogen specific bacterial cell wall building blocks. RSC Adv., 12, 15046.

117. RD Castillo Arteagea, LM Garrido, B. Pedre, I Helmle, H Gross, B Gust and G Padilla* (2022) Mycothiol Peroxidase Activity as a Part of the Self-Resistance Mechanisms against the Antitumor Antibiotic Cosmomycin D. Microbiol. Spectr., e00493-22.
Available through open access:
116. N Aryal, J Chen, K Bhattarai, O Hennrich, I Handayani, M Kramer, J Straetener, T Wommer, A Berscheid, S Peter, N Reiling, H Brötz-Oesterhelt, C Geibel, M Lämmerhofer, Y Mast and H Gross* (2022) High Plasticity of the Amicetin Biosynthetic Pathway in Streptomyces sp. SHP 22-7 Led to the Discovery of Streptcytosine P and Cytosaminomycins F and G and Facilitated the Production of 12F-Plicacetin. J. Nat. Prod., 85, 530-539.
115. E Bach*, LM Pereira Passaglia, J Jiao and H Gross (2022) Burkholderia in the genomic era: from taxonomy to the discovery of new antimicrobial secondary metabolites. Crit. Rev. Microbiol., 48, 121-160.
114. FE Oni*, Q Esmaeel, JT Onyeka, R Adeleke, C Jacquard, C Clement, H Gross, EA Barka and M Höfte (2022). Pseudomonas Lipopeptide-Mediated Biocontrol: Chemotaxonomy and Biological Activity. Molecules 27, 372. Available through open access:

C Geibel, L Zhang, K Serafimov, H Gross and M Lämmerhofer* (2022) Towards enantioselective ultrahigh performance liquid chromatography-mass spectrometry-based metabolomics of branched-chain fatty acids and anteiso-fatty acids under reversed-phase conditions using sub-2-µm amylose- and cellulose-derived chiral stationary phases. Chirality, 34, 484-497. Available through open access:

112. P Arlt, H Hashizume, M Igarashi and H Gross* (2021) Genome Sequence of Lysobacter sp. Strain BMK333-48F3, the Producer Strain of Potent Lipopeptide Antibiotics of the Tripropeptin Family. Microbiol. Resour. Announc., 10, e00969-21. Available through open access:
111. L Assad, K Matjošaitis and H Gross* (2021) Genome Sequence of Escherichia coli Stbl4, a versatile genetic tool for heterologous expression. Microbiol. Resour. Announc., 10, e00823-21. Available through open access:
110. A Nawaz, F Mubeen, ZU Qamar, MU Marghoob, S Aziz and H Gross* (2021) Draft Genome Sequence of the Halophilic Strain Citrobacter braakii AN-PRR1, Isolated from Rhizospheric Soil of Rice (Oryza sativa L.) from Pakistan. Microbiol. Resour. Announc., 10, e00787-21. Available through open access:
109. R Karongo, M Ge, J Horak*, H Gross, M Kohout, W Lindner and M Lämmerhofer* (2021) Rapid enantioselective amino acid analysis by ultra-high performance liquid chromatography-mass spectrometry combining 6-aminoquinolyl- N-hydroxysuccinimidyl carbamate derivatization with core-shell quinine carbamate anion exchanger separation. J. Chromatogr. Open, 1, 100004. Available through open access:
108. I Handayani, H Saad, S Ratnakomala, P Lisdiyanti, W Kusharyoto, J Krause, A Kulik, W Wohlleben, S Aziz, H Gross, A Gavriilidou, N Ziemert and Y Mast* (2021) Mining Indonesian microbial biodiversity for novel natural compounds by a combined genome mining and molecular networking approach. Marine Drugs, 19, 316. Available through open access:
107. A Engelbrecht, H Saad, H Gross and L Kaysser* (2021) Natural Products from Nocardia and their Role in Pathogenicity. Microb. Physiol., 31, 217-232. Available through open access:
106. H Saad, S Aziz, M Gehringer, M Kramer, J Straetener, A Berscheid, H Brötz-Oesterhelt and H Gross* (2021) Nocathioamides, uncovered by a Tunable Metabologenomic Approach, define a Novel Class of Chimeric Lanthipeptides. Angew. Chem. Int. Ed., 60, 16472–16479. Available through open access:
105. M Eitel, DS Zinad, D Schollmeyer, H Gross and P Koch* (2021) Selective Mono-de-O-acetylation of the Per-O-acetylated Brasilicardin Carbohydrate Side Chain. Carbohydr. Res., 504, 108312.
104. A Botas, M Eitel, PN Schwarz, A Buchmann, P Costales, LE Núñez, J Cortés, F Morís, M Krawiec M Wolanski, B Gust, M Rodriguez, WN Fischer, B Jandeleit, J Zakrzewska-Czerwińska, W Wohlleben, E Stegmann*, P Koch*, C Méndez* and H Gross* (2021) Genetic engineering in combination with semisynthesis leads to a new route for gram‐scale production of the immunosuppressive natural product brasilicardin A. Angew. Chem. Int. Ed., 60, 13536–13541. Available through open access:
103. R Karongo, J Jiao, H Gross and M Lämmerhofer* (2021) Direct enantioselective gradient reversed-phase ultra-high performance liquid chromatography-tandem mass spectrometry method for 3-hydroxy alkanoic acids in lipopeptides on an immobilized 1.6 μm amylose-based chiral stationary phase. J. Sep. Sci., 44, 1875-1883. Available through open access:
102. N Aryal, S Aziz, P Rajbhandari and H Gross* (2021) Draft Genome Sequence of Pseudonocardia sp. C8, Isolated from a Mud Dauber Wasp Nest in Nepal. Microbiol. Resour. Announc., 10, e00007-21. Available through open access:

AA Aksenov, G Aleti, JA Moghaddam, AT Aron, S Aziz, A Bauermeister, KD Bauman, M Baunach, C Beemelmanns, JM Beman, MV Berlanga-Clavero, AA Blacutt, HB Bode, A Boullie, A Brejnrod, TS Bugni, A Calteau, L Cao, VJ Carrión, R Castelo-Branco, S Chanana, AB Chase, MG Chevrette, LV Costa-Lotufo, JM Crawford, CR Currie, B Cuypers, T Dang, T de Rond, AM Demko, E Dittmann, C Du, C Drozd, JC Dujardin, RJ Dutton, A Edlund, DP Fewer, N Garg, JM Gauglitz, EC Gentry, L Gerwick, E Glukhov, H Gross, M Gugger, DG Guillén Matus, EJN Helfrich, BF Hempel, JS Hur, M Iorio, PR Jensen, KB Kang, L Kaysser, NL Kelleher, CS Kim, KH Kim, I Koester, GM König, T Leao, SR Lee, YY Lee, X Li, JC Little, KN Maloney, D Männle, C Martin H, AC McAvoy, WW Metcalf, H Mohimani, C Molina-Santiago, BS Moore, MW Mullowney, M Muskat, LF Nothias, EC O’Neill, EI Parkinson, D Petras, J Piel, EC Pierce, K Pires, R Reher, D Romero, MC Roper, M Rust, H Saad, C Saenz, LM Sanchez, SJ Sørensen, M Sosio, RD Süssmuth, D Sweeney, K Tahlan, RJ Thomson, NJ Tobias, AE Trindade-Silva, GP van Wezel, M Wang, KC Weldon, F Zhang, N Ziemert, KR Duncan, M Crüsemann, S Rogers, PC Dorrestein,* MH Medema* and JJJ van der Hooft* (2021) A community resource for paired genomic and metabolomic data mining. Nature Chem. Biol., 17, 363-368. Available through open access:


A Théatre, C Cano-Prieto, M Bartolini, Y Laurin, M Deleu, J Niehren, T Fida, S Gerbinet, M Alanjary, MH Medema, A Léonard, L Lins, AL Arabolaza, H Gramajo, H Gross and P Jacques* (2021) The surfactin-like lipopeptides from Bacillus spp.: natural biodiversity and synthetic biology for a broader application range. Front. Bioeng. Biotechnol., 9, 623701. Available through open access:

99. N Kirchner, C Cano-Prieto, AC Schulz-Fincke, M Gütschow, N Ortlieb, J Moschny, THJ Niedermeyer, J Horak, M Lämmerhofer, M van der Voort, JM Raaijmakers and H Gross* (2021) Discovery of Thanafactin A, a Linear, Proline-Containing Octalipopeptide from Pseudomonas sp. SH-C52, Motivated by Genome Mining. J. Nat. Prod., 84, 101-109.
98. M Wolański,* M Krawiec, PN Schwarz, E Stegmann, W Wohlleben, A Buchmann, H Gross, M Eitel, P Koch, A Botas, C Méndez, LE Núñez, F Morís, J Cortés and J Zakrzewska-Czerwińska (2021) A novel LysR-type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin. Eng. Life Sci. 21, 4-18. Available through open access:
97. S Muzaffar, N Riaz,* M Saleem, W Shahid, M Ashraf,* B Bashir A Kaleem, M al-Rashida, B Baral, K Bhattarai and H Gross (2021) Probing phenylcarbamoylazinane-1,2,4-triazole amides derivatives as lipoxygenase inhibitors along with cytotoxic, ADME and molecular docking studies. Bioorg. Chem., 107, 104525.
96. A Frediansyah, J Straetener, H Brötz-Oesterhelt and H Gross* (2021) Massiliamide, a cyclic tetrapeptide with potent tyrosinase inhibitory properties from the Gram-negative bacterium Massilia albidiflava DSM 17472T. J. Antibiot., 74, 269-272. Available through open access:
95. T Majer, D Schollmeyer, P Koch and H Gross* (2020) (2S,3′S,3a′R,5′R,7a′R)-5′-((E)-5-(furan-3-yl)-2-methylpent-1-en-1-yl)-3-hydroxy-3′,4,7′-trimethyl-1′,2′,3′,3a′,5′,7a′-hexahydro-5H-spiro[furan-2,4′-inden]-5-one. IUCrData, 5, x201578. Available through open access:
94. A Buchmann and H Gross* (2020) Improved de-novo Draft Genome Sequence of the Nocavionin-Producing Type Strain Nocardia terpenica IFM 0706 and comparative Genomics with the Closely Related Strain Nocardia terpenica IFM 0406. Microbiol. Resour. Announc., 9, e00689-20. Available through open access:
93. BT Odumosu, UN Augusta, C Cano-Prieto, A Buchmann, K Nieselt and H Gross* (2020). Draft Genome Sequence of Ochrobactrum sp. Strain MC-1LL, a Bacterial Strain with Antimicrobial Properties, Isolated from Marine Sediments in Nigeria. Microbiol. Resour. Announc.9, e00425-20. Available through open access:

N Kirchner, C Cano-Prieto, M van der Voort, JM Raaijmakers and H Gross* (2020) Draft Genome Sequence of Lipopeptide-Producing Strain Pseudomonas fluorescens DSM 11579 and Comparative Genomics with Pseudomonas sp. Strain SH-C52, a Closely Related Lipopeptide-Producing Strain. Microbiol. Resour. Announc., 9, e00304-20. Available through open access:


H Miess, A Frediansyah, M Göker and H Gross* (2020) Draft Genome Sequences of Six Type Strains of the Genus Massilia. Microbiol. Resour. Announc., 9, e00226-20. Available through open access:

90. S Schäfermann, C Hauk, E Wemakor, R Neci, G Mutombo, E Ngah Ndze, T Cletus, M Pattinora, F Nyaah, D Wistuba, I Helmle, C Häfele-Abah, H Gross and L Heide* (2020) Substandard and falsified antibiotics and medicines against non-communicable diseases in western Cameroon and north-eastern Democratic Republic of Congo. Am. J. Trop. Med. Hyg., 103, 894-908.

Available through open access:

89. J Chen, A Frediansyah, D Männle, J Straetener, H Brötz-Oesterhelt, N Ziemert, L Kaysser and H Gross* (2020) New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406. ChemBioChem, 21, 2205-2213. Available through open access:

S Mehnaz, A Bechthold and H Gross* (2020) Draft Genome Sequence of Pseudomonas chlororaphis subsp. aurantiaca ARS-38, a Bacterial Strain with Plant Growth Promotion Potential, Isolated from the Rhizosphere of Cotton in Pakistan. Microbiol. Resour. Announc., 9, e01398-19. Available through open access:


J Jiao, J Du, A Frediansyah, G Jahanshah and H Gross* (2020) Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli. J. Antibiot., 73, 28-34.
Selected as Bullet Point on the cover page: Trinickiabactin, an antibacterial lipopeptide siderophore with diazeniumdiolate moieties


T Schafhauser, L Lahn, N Kirchner, A Kulik, L Flor, A Lang, T Caradec, DP Fewer, K Sivonen, WJH van Berkel, P Jacques, T Weber, H Gross, KH van Pée, W Wohlleben* and J Ludwig-Müller* (2019) Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus. Proc. Natl. Acad. Sci. USA, 116, 26909-26917.


H Miess, P Arlt, AK Apel, T Weber, K Nieselt, F Hanssen, S Czemmel, S Nahnsen and H Gross* (2019) The Draft Whole-Genome Sequence of the Antibiotic Producer Empedobacter haloabium ATCC 31962 Provides Indications for Its Taxonomic Reclassification. Microbiol. Resour. Announc., 8, e01120-19. Available through open access:

84. N Aryal, S Aziz, P Rajbhandari and H Gross* (2019) Draft Genome Sequence of Nonomuraea sp. Strain C10, a Producer of Brartemicin, Isolated from a Mud Dauber Wasp Nest in Nepal. Microbiol. Resour. Announc., 8, e01109-19. Available through open access:

F Wiker, M Konnerth, I Helmle, A Kulik, L Kaysser, H Gross and B Gust* (2019) Identification of Novel α-Pyrones from Conexibacter woesei Serving as Sulfate Shuttles. ACS Chem. Biol., 14, 1972-1980.

82. M Alanjary, C Cano-Prieto, H Gross* and MH Medema* (2019) Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines. Nat. Prod. Rep., 36, 1249-1261. Available through open access:
81. A Baulig, I Helmle, M Bader, F Wolf, A Kulik, A Al-Dilaimi, D Wibberg, J Kalinowski, H Gross and L Kaysser* (2019) Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N–P-bond-forming kinase. Chem. Sci., 10, 4486-4490.

G Jahanshah, Q Yan, H Gerhardt, Z Pataj, M Lämmerhofer, I Pianet, M Josten, HG Sahl, MW Silby, JE Loper and H Gross* (2019) Discovery of the Cyclic Lipopeptide Gacamide A by Genome Mining and Repair of the Defective GacA Regulator in Pseudomonas fluorescens Pf0-1. J. Nat. Prod., 82, 301-308.

79. G Jahanshah, H Miess, T Busche, C Rückert, J Kalinowski, H Rokni-Zadeh and H Gross* (2019) Draft Genome Sequence of Micromonospora sp. Strain  MW-13, a Bacterical Strain with Antibacterial Properties and Plant Growth Promotion Potential, Isolated from the Rhizosphere of Wheat in Iran. Microbiol. Resour. Announc., 8, e01375-18. Available through open access:
78. A Buchmann, C Cano-Prieto, A Nafis, M Barakate, M Baz, L Hassani, N Ortlieb, THJ Niedermeyer and H Gross* (2019) Draft Genome Sequence of the Novonestmycin-Producing Strain Streptomyces sp. Z26, isolated from potato rhizosphere in Morocco. Microbiol. Resour. Announc., 8, e01514-18. Available through open access:



N Ortlieb, K Bretzel, A Kulik, J Haas, S Lüdeke, N Keilhofer, SD Schrey, H Gross and THJ Niedermeyer* (2018) Xanthocidin Derivatives from the Endophytic Streptomyces sp. AcE210 Provide Insight into the Xanthocidin Biosynthesis. ChemBioChem, 19, 2472-2480.


N Ortlieb, N Keilhofer, SD Schrey, H Gross and THJ Niedermeyer* (2018) Draft Genome Sequence of the Xanthocidin-Producing Strain Streptomyces sp. AcE210, Isolated from a Root Nodule of Alnus glutinosa (L.). Microbiol. Resour. Announc., 7, e01190-18. Available through open access:


H Miess, G Jahanshah, H Brötz-Oesterhelt, M Willmann, S Peter and H Gross* (2018) Draft Genome Sequence of the Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolate TUEPA7472. Microbiol. Resour. Announc., 7, e01055-18. Available through open access:


M Eitel, D Schollmeyer, H Gross and P Koch* (2018) (2S,3S)-2-Azaniumyl-4-[(1S,4aS,4bS,6S,7S,8aS,10aS)- 6,7-dihydroxy-2,4b,8,8,10a-pentamethyl-

1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydrophenanthren-1-yl]-3-methoxybutanoate–methanol-water (1/1/1). IUCrData, 3, x181194. Available through open access:


S Aziz, Y Mast, W Wohlleben and H Gross* (2018) Draft Genome Sequence of the Pristinamycin-Producing Strain Streptomyces sp. SW4, Isolated from Soil in Nusa Kambangan, Indonesia. Microbiol. Resour. Announc., 7, e00912-18.  Available through open access:


JB McAlpine,* SN Chen, A Kutateladze, JB MacMillan, G Appendino, A Barison, MA Beniddir, MW Biavatti, S Bluml, A Boufridi, MS Butler, RJ Capon, YH Choi, D Coppage, P Crews, MT Crimmins, M Csete, P Dewapriya, JM Egan, MJ Garson, G Genta-Jouve, WH Gerwick, H Gross, MK Harper, P Hermanto, JM Hook, L Hunter, D Jeannerat, NY Ji, TA Johnson, DGI Kingston, H Koshino, HW Lee, G Lewin, J Li, RG Linington, M Liu, KL McPhail, TF Molinski, BS Moore, JW Nam, RP Neupane, M Niemitz, JM Nuzillard, NH Oberlies, FMM Ocampos, G Pan, RJ Quinn, DS Reddy, JH Renault, J Rivera-Chavez, W Robien, CM Saunders, TJ Schmidt, C Seger, B Shen, C Steinbeck, H Stuppner, S Sturm, O Taglialatela-Scafati, DJ Tantillo, R Verpoorte, BG Wang, CM Williams, PG Williams, J Wist, JM Yue, C Zhang, Z Xu, C Simmler, DC Lankin, J Bisson and GF Pauli * (2018)

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Nat. Prod. Rep., 36, 35-107. Available through open access:!divAbstract


DT Linh, S Schwarz, H Gross, K Breitbach, F Hochgräfe, J Mostertz, K Eske-Pogodda, GE Wagner, I Steinmetz and C Kohler* (2018) GvmR - A Novel LysR-Type Regulator Involved in Virulence and Primary and Secondary Metabolism of Burkholderia pseudomallei. Frontiers in Microbiol., 9:935. doi: 10.3389/fmicb.2018.00935. Available through open access:


T Bahrami, S Zarvandi, R De Mot, H Gross, M Changi-Ashtiani and H Rokni-Zadeh* (2018) Draft Genome Sequence of Pseudomonas gingeri LMG 5327, the agent of ginger blotch in Agaricus bisporus. Genome Announc., 6(13), e00196-18. Available through open access:


J Paterson and H Gross* (2018) Draft Genome Sequence and Annotation of the phytopathogenic Ralstonia pickettii (Previously Burkholderia glumae) Strain ICMP-8657. Genome Announc., 6(10), e00128-18. Available through open access:


J Jiao, J Paterson, T Busche, C Rückert, J Kalinowski, D Harwani and H Gross* (2018) Draft Genome Sequence of Streptomyces sp. Strain DH-12, a Soilborne Isolate from the Thar Desert with Broad-Spectrum Antibacterial Activity. Genome Announc., 6(9), e00108-18. Available through open access:


PN Schwarz, A Buchmann, L Roller, A Kulik, H Gross, W Wohlleben and E Stegmann* (2018) The Immunosuppressant Brasilicardin: Determination of the Biosynthetic Gene Cluster in the Heterologous Host Amycolatopsis japonicum. Biotechnol. J., 13, 1700527.




F Leipoldt, J Santos-Aberturas, DP Stegmann, F Wolf, A Kulik, R Lacret, D Popadic, D Keinhörster, N Kirchner, P Bekiesch, H Gross, AW Truman* and L Kaysser* (2017) Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors. Nature Comm. 8, 1965.


JS Bauer, S Fillinger, K Förstner, A Herbig, AC Jones, K Flinspach, C Sharma, H Gross, K Nieselt and AK Apel* (2017) dRNA-seq Transcriptional Profiling of the FK506 Biosynthetic Gene Cluster in Streptomyces tsukubaensis NRRL18488 and General Analysis of the Transcriptome. RNA Biol. 14(11), 1617-1626.


F Wolf, JS Bauer, TM Bendel, A Kulik, J Kalinowski, H Gross and L Kaysser* (2017) Biosynthesis of the β-lactone proteasome inhibitors belactosins and cystargolides. Angew. Chem. Int. Ed., 56, 6665-6668.


J Paterson, G Jahanshah, Y Li, Q Wang, S Mehnaz and H Gross* (2017) The Contribution of Genome Mining Strategies to the Understanding of Active Principles of PGPR Strains. FEMS Microbiol. Ecol., 93, fiw249.




JS Bauer, N Hauck, L Christof, S Mehnaz, B Gust and H Gross* (2016) The Systematic Investigation of the Quorum Sensing System of the Biocontrol Strain Pseudomonas chlororaphis subsp. aurantiaca PB-St-2 Unveils aurI to Be a Biosynthetic Origin for 3-Oxo-Homoserine Lactones. PLoS ONE 11(11), e0167002. Available through open access:



A Buchmann, M Eitel, P Koch, PN Schwarz, E Stegmann, W Wohlleben, M Wolanski, M Krawiec, J Zakrzewska-Cerwinska, C Mendez, A Botas, LE Núnez, F Morís, J Cortes and H Gross* (2016) High-Quality Draft Genome Sequence of the Actinobacterium Nocardia terpenica IFM 0406, Producer of the Immunosuppressant Brasilicardins, Using Illumina and PacBio Technologies. Genome Announc., 4(6), e01391-16. Available through open access:



H Miess, S van Trappen, I Cleenwerck, P De Vos, and H Gross* (2016) Reclassification of Pseudomonas sp. PB-6250T as Lysobacter firmicutimachus sp. nov. Int. J. Syst. Evol. Microbiol., 66, 4162-4166.


A Deveau,* H Gross, B Palin, S Mehnaz, M Schnepf, P Leblond, PC Dorrestein, B Aigle (2016) Role of secondary metabolites in the interaction between Pseudomonas fluorescens and soil microorganisms under iron limited conditions. FEMS Microbiol. Ecol., 92(8), fiw107.


MGK Ghequire,* T Swings, J Michiels, H Gross, R De Mot (2016) Draft Genome Sequence of Pseudomonas putida BW11M1, a Banana Rhizosphere Isolate with a Diversified Antimicrobial Armamentarium. Genome Announc. 4(2): e00251-16. Available through open access:


T Schafhauser,* N Kirchner, A Kulik, MME Huijbers, L Flor, T Caradec, DP Fewer, H Gross, P Jacques, L Jahn, J Jokela, V Leclère, J Ludwig-Müller, K Sivonen, WJH van Berkel, T Weber, W Wohlleben* and KH van Pée (2016) The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicusPenicillium islandicum´). Environ. Microbiol., 18(11), 3728-3741.


T Zhang, E Holder, P Franco, M Lämmerhofer, A Sievers-Engler, H Gerhardt, H Gross, and W Lindner* (2016) Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary option to HILIC and to Reversed-Phase Chromatography. LC-GC Europe 29, 112-128.


H Gerhardt, A Sievers-Engler, G. Jahanshah, Z Pataj, F. Ianni, H Gross, W Lindner, and M Lämmerhofer* (2016) Methods for the comprehensive structural elucidation of constitution and stereochemistry of lipopeptides. J. Chromatogr. A, 1428, 280-291.




JS Bauer, MGK Ghequire, M Nett, M Josten, HG Sahl, R De Mot,*and H Gross* (2015) Biosynthetic Origin of the Antibiotic Pseudopyronines A and B in Pseudomonas putida BW11M1. ChemBioChem 16, 2491-2497.


MH Medema,* R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, I de Bruijn YH Chooi, J Claesen, RC Coates, P Cruz-Morales, S Duddela, S Düsterhus, DJ Edwards, DP Fewer, N Garg, C Geiger, JP Gomez-Escribano, A Greule, M Hadjithomas, AS Haines, EJN Helfrich, ML Hillwig, K Ishida, AC Jones, CS Jones, K Jungmann, C Kegler, HU Kim, P Kötter, D Krug, J Masschelein, AV Melnik, SM Mantovani, EA Monroe, M Moore, N Moss, H-W Nützmann, G Pan, A Pati, D Petras, FJ Reen, F Rosconi, Z Rui, Z Tian, NJ Tobias, Y Tsunematsu, P Wiemann, E Wyckhoff, X Yan, G Yim, F Yu, Y Xie, B Aigle, AK Apel, CJ Balibar, EP Balskus, F Barona-Gómez, A Bechthold, HB Bode, R Boriss, SF Brady, AA Brakhage, P Caffrey, Y-Q Cheng, J Clardy, RJ Cox, R De Mot, S Donadio, MS Donia, WA van der Donk, PC Dorrestein, S Doyle, AJM Driessen, M Ehling-Schulz, K-D Entian, MA Fischbach, L Gerwick, WH Gerwick, H Gross, et al. (2015) Minimum Information about a Biosynthetic Gene cluster. Nature Chem. Biol., 11, 625-631.


M van der Voort, H Meijer, Y Schmidt, J Watrous, E Dekkers, R Mendes, PC Dorrestein, H Gross, and JM Raaijmakers* (2015) Genome mining and metabolic profiling of the rhizosphere bacterium Pseudomonas sp. SH-C52 for antimicrobial compounds. Frontiers in Microbiol., 6, 693.
This article was selected to be published also in a Frontiers eBook as part of a special research topic: Ciancio, A., Pieterse, C. M. J., Mercado-Blanco, J., eds. (2016). Harnessing Useful Rhizosphere Microorganisms for Pathogen and Pest Biocontrol, Lausanne: Frontiers Media, pp 269-309, doi: 10.3389/978-2-88945-059-6 (


C Zachow,* G Jahanshah, I de Bruijn, C Song, F Ianni, Z Pataj, H Gerhardt, I Pianet, M Lämmerhofer, G Berg, H Gross, and JM Raaijmakers (2015) The Novel Lipopeptide Poaeamide of the Endophyte Pseudomonas poae RE*1-1-14 is Involved in Pathogen Suppression and Root Colonization. Mol. Plant-Microbe Interact., 28 (7), 800-810.




P Zeyhle, JS Bauer, M Steimle, F Leipoldt, M Rösch, J Kalinowski, H Gross,* and L Heide* (2014) A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp. CNQ-509. ChemBioChem, 15, 2385-2392.


M Spohn, N Kirchner, A Kulik, A Jochim, F Wolf, P Muenzer, O Borst, H Gross, W Wohlleben and E Stegmann* (2014) Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17. Antimicrob. Agents Chemother., 58, 6185-6196.


P Zeyhle, JS Bauer, J Kalinowski, K Shin-ya, H Gross and L Heide* (2014) Genome-Based Discovery of a Novel Membrane-Bound 1,6-Dihydroxyphenazine Prenyltransferase from a Marine Actinomycete. PLoS ONE, 9, e99122.


F Ianni, Z Pataj, H Gross, R Sardella, B Natalini, W Lindner and M Lämmerhofer* (2014) Direct enantioseparation of underivatized aliphatic 3-hydroxyalkanoic acids with a quinine-based zwitterionic chiral stationary phase. J. Chromatogr. A, 1363, 101-108.


S Schieferdecker, TE Exner, H Gross, M Roth and M Nett* (2014) New myxothiazols from the predatory bacterium Myxococcus fulvus. J. Antibiot., 67, 519-525.


N Kirchner, JS Bauer, H Miess and H Gross* (2014) Woher nehmen, wenn nicht stehlen? Strategien für die Entwicklung neuer Antibiotika. Deutsche Apotheker Zeitung, 5, 54-63.


N Kirchner, JS Bauer, H Miess and H Gross* (2014) Mangelware Antibiotika. Wie es zu der Entwicklungslücke kommen konnte. Deutsche Apotheker Zeitung, 5, 48-53.


T Schneider*, A Müller, H Miess and H Gross* (2014) Cyclic lipopeptides as antibacterial agents – Potent antibiotic activity mediated by intriguing mode of actions. Int. J. Med. Microbiol. 304, 37-43.


S Mehnaz*, JS Bauer, H Gross*, (2014) Complete Genome Sequence of the Sugar Cane Endophyte Pseudomonas aurantiaca PB-St2, a Disease-Suppressive Bacterium with Antifungal Activity toward the Plant Pathogen Colletotrichum falcatum. Genome Announc. 2(1): e01108-13.


Y Schmidt, M van der Voort, M Crüsemann, J Piel, M Josten, HG Sahl, H Miess, JM Raaijmakers,* and H Gross* (2014) Biosynthetic Origin of the Antibiotic Cyclocarbamate Brabantamide A (SB-253514) in Plant-Associated Pseudomonas. ChemBioChem 15, 259-266.


A Deveau*, H Gross, E Morin, T Karpinets, S Utturkar, S Mehnaz, F Martin, P Frey-Klett, J Labbé (2014) Genome Sequence of the Mycorrhizal Helper Bacterium Pseudomonas fluorescens BBc6R8. Genome Announc. 2(1):e01152-13.




P Schweiger*, H Gross, J Zeiser, and U Deppenmeier (2013) Asymmetric reduction of diketones by two Gluconobacter oxydans oxidoreductases. Appl. Microbiol. Biotechnol., 97, 3475-3484.


S Mehnaz*, RSZ Saleem, B Yameen, I Pianet, G Schnakenburg, H Pietraszkiewicz, F Valeriote, M Josten, HG Sahl, SG Franzblau, and H Gross* (2013) Lahorenoic Acids A-C, ortho-Dialkyl-Substituted Aromatic Acids from the Biocontrol Strain Pseudomonas aurantiaca PB-St2. J. Nat. Prod. 76, 135-141.


SL Hartney, S. Mazurier, MK Girard, S Mehnaz, EW Davis II, H Gross, P Lemanceau, JE Loper* (2013) Ferric-Pyoverdine Recognition by Fpv Outer Membrane Proteins of Pseudomonas protegens Pf-5. J. Bacteriol. 195, 765-776.




TAM Gulder,* H Hong, J Correa, E Egereva, J Wiese, JF Imhoff, and H Gross* (2012) Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus. Mar. Drugs, 10, 2912-2935. Available through open access:



K Graupner, K Scherlach, T Bretschneider, G Lackner, M Roth, H Gross, and C Hertweck* (2012) Imaging Mass Spectrometry and Genome Mining Reveal Highly Antifungal Virulence Factor of Mushroom Soft Rot Pathogen. Angew. Chem. Int. Ed., 51, 13173-13177.


A Lange, H Sun, J Pilger, UM Reinscheid*, and H Gross* (2012) Predicting the Structure of Cyclic Lipopeptides by Bioinformatics: Structure Revision of Arthrofactin. ChemBioChem, 13, 2671-2675.


J Watrous, P Roach, T Alexandrov, BS Heath, JY Yang, RD Kersten, M van der Voort, K Pogliano, H Gross, JM Raaijmakers, BS Moore, J Laskin, N Bandeira, PC Dorrestein* (2012) Mass spectral molecular networking of living microbial colonies. PNAS, 109, E1743-E1752.


A Müller, D Münch, Y Schmidt, K Reder-Christ, G Schiffer, G Bendas, H Gross, HG Sahl, T Schneider, H Brötz-Oesterhelt* (2012) The lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors. J. Biol. Chem., 287, 20270-20280.


K Reder-Christ, Y Schmidt, M Dörr, HG Sahl, M Josten, JM Raaijmakers, H Gross*, and G Bendas* (2012) Model membrane studies for characterization of different antibiotic activities of lipopeptides from Pseudomonas. BBA Biomembranes, 1818, 566-573.




S. Mehnaz and H Gross (2011) Pseudomonas aurantiaca PB-St2 – a bio-fungicide and a bio-fertilizer for the future in: Plant Growth-Promoting Rhizobacteria (PGPR) for sustainable agriculture, MS Reddy, and Qi Wang, eds. China Agricultural Science and Technology Press, Beijing, pp. 79-88 (ISBN: 978-7-5116-0611-2).


B Han*, H Gross, KL McPhail, D Goeger, CS Maier, and WH Gerwick (2011) Wewakamide A and Guineamide G, Cyclic Depsipeptides from the Marine Cyanobacteria Lyngbya semiplena and Lyngbya majuscula. J. Microbiol. Biotechnol., 21, 930-936.


B Han, UM Reinscheid, WH Gerwick, and H Gross* (2011) The structure elucidation of isomalyngamide K from the marine cyanobacterium Lyngbya majuscula by experimental and DFT computational methods. J. Mol. Struct. 989, 109-113.




IE Mohamed, S Kehraus, A Krick, GM König, G Kelter, A Maier, HH Fiebig, M Kalesse, NP Malek, and H Gross* (2010) Mode of Action of Epoxyphomalins A and B and Characterization of Related Metabolites from the Marine-Derived Fungus Paraconiothyrium sp. J. Nat. Prod. 73, 2053-2056.


H Greve, IE Mohamed, A Pontius, S Kehraus, H Gross and GM König* (2010) Fungal metabolites: structural diversity as incentive for anticancer drug development. Phytochem. Rev. 9, 537-545.


MB Tabot, G Schnakenburg and H Gross* (2010) Pregna-1,4,20-trien-3-one, a cytotoxic marine steroid from the marine soft coral Nephthea sp. Acta Cryst. E66:o2040-o2041.


M Kurz, AY Burch, B Seip, SE Lindow and H Gross* (2010) Genome-Driven investigation of compatible solute biosynthesis pathways of Pseudomonas syringae pv. syringae and their contribution to water stress tolerance. Appl. Environ. Microbiol. 76(16), 5452-5462.


H Gross, KL McPhail, DE Goeger, FA Valeriote and WH Gerwick* (2010) Two Cytotoxic Stereoisomers of Malyngamide C, 8-Epi-Malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the Marine Cyanobacterium Lyngbya majuscula. Phytochemistry 71, 1729-1735.


P Schweiger, H Gross and U Depppenmeier* (2010) Characterization of two aldo-keto reductases from Gluconobacter oxydans 621H capable of regio- and stereoselective α-ketocarbonyl reduction. Appl. Microbiol. Biotechnol. 87, 1415-1426.


J Moldenhauer, DCG Götz, CR Albert, SK Bischof, K Schneider, RD Süssmuth, M Engeser, H Gross, G Bringmann and J Piel* (2010) The Final Steps of Bacillaene Biosynthesis in Bacillus amyloliquefaciens FZB42: Direct Evidence for β,γ Dehydration by a trans-Acyltransferase Polyketide Synthase. Angew. Chem. Int. Ed. 49(8), 1465-1467.




IE Mohamed, H Gross*, A Pontius, S Kehraus, A Krick, G Kelter, A Maier, HH Fiebig and GM König (2009) Epoxyphomalin A and B, Prenylated Polyketides with Potent Cytotoxicity from the Marine-Derived Fungus Phoma sp. Org. Letters 11, 5014-5017.


H Gross* and JE Loper* (2009) Genomics of secondary metabolite production by Pseudomonas spp. Nat. Prod. Rep. 26, 1408-1446.


H Gross* (2009) Genomic mining - a concept for the discovery of new bioactive natural products. Curr. Opin. Drug Discov. Devel. 12(2), 207-219


H Gross*, AD Wright, U Reinscheid and GM König (2009) Three New Spongian Diterpenes from the Fijian Marine Sponge Spongia sp. Nat. Prod. Commun., 4 (3), 315-322.




JE Loper, D Bruck, M Pechy-Tarr, M Maurhofer, C Keel, and H Gross (2008) Genomic analysis of secondary metabolite production by Pseudomonas fluorescens Pf-5. Paper number 101 in: Biology of Plant-Microbe Interactions, Volume 6. M Lorito, SL Woo, and F Scala, eds. International Society for Molecular Plant-Microbe Interactions, St. Paul, MN.


JE Loper, MD Henkels, BT Shaffer, FA Valeriote and H Gross* (2008) Isolation and Identification of Rhizoxin Analogs from Pseudomonas fluorescens Pf-5 by Using a Genomic Mining Strategy. Appl. Environ. Microbiol. 74(10), 3085-3093.


A Schmitz, G Harbaum-Neuhaus and H Gross* (2008) Der Zaubersalbei, Deutsche Apotheker Zeitung 148. Jahrgang, 1566-1571.


P Schweiger, H Gross, S Wesener and U Deppenmeier* (2008) Vinyl ketone reduction by three disctinct Gluconobacter oxydans 621H enzymes. Appl. Microbiol. Biotechnol. 80, 995-1006.




JE Loper* and H Gross (2007) Genomic analysis of antifungal metabolite production by Pseudomonas fluorescens Pf-5. Eur. J. Plant Pathol. 119(3), 265-278.


H Gross* (2007) Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects. Appl. Microbiol. Biotechnol. 75, 267-277.


H Gross, VO Stockwell, MD Henkels, B Nowak-Thompson, JE Loper and WH Gerwick* (2007) The Genomisotopic Approach: A Systematic Method to Isolate Products of Orphan Biosynthetic Gene Clusters. Chem. Biol. 14, 53-63.
This article was highlighted by a preview (C Corre and GL Challis (2007) Heavy Tools for Genome Mining. Chem. Biol. 14, 7-9) and selected for the journal cover page.

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H Gross and GM König* (2006) Terpenoids from marine organisms: unique structures and their pharmacological potential. Phytochem. Rev. 5, 115-141.


H Gross, DE Goeger, P Hills, SL Mooberry, DL Ballantine, TF Murray, FA Valeriote and WH Gerwick* (2006) Lophocladines, Bioactive Alkaloids from the Red Alga Lophocladia sp. J. Nat. Prod. 69, 640-644.


B Han, H Gross, DE Goeger, SL Mooberry and WH Gerwick* (2006) Aurilides B and C, Cancer Cell Toxins from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscula. J. Nat. Prod. 69, 572-575.

2005 and older



B Han, KL McPhail, H Gross, DE Goeger, SL Mooberry and WH Gerwick* (2005) Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Tetrahedron 61, 11723-11729.


EH Andrianasolo, H Gross, D Goeger, M Musafija-Girt, K McPhail, RM Leal, SL Mooberry and WH Gerwick* (2005) Isolation of Swinholide A and Related Glycosylated Derivatives from Two Field Collections of Marine Cyanobacteria. Org. Letters 7(7), 1375-1378.


H Gross, J Reitner and GM König* (2004) Isolation and structure elucidation of azoricasterol, a new sterol of the deepwater sponge Macandrewia azorica. Naturwissenschaften 91, 441-446.


H Gross, AD Wright, W Beil and GM König* (2004) Two new bicyclic cembranolides from a new Sarcophyton species and determination of the absolute configuration of sarcoglaucol-16-one. Org. Biomol. Chem. 2, 1133-1138.


H Gross, S Kehraus, M Nett, GM König*, W Beil and AD Wright (2003) New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp. Org. Biomol. Chem. 1, 944-949.


H Gross, S Kehraus, GM König, G Woerheide and AD Wright* (2002) New and Biologically Active Imidazole Alkaloids from Two Sponges of the Genus Leucetta. J. Nat. Prod. 65, 1190-1193.