Publications

2015-now:

• B. Vollmer, N. Steblau, N. Ladwig, C. Mayer, B. Macek, L. Mitousis, S. Sigle, A. Walter, W. Wohlleben, G. Muth. (2019). Role of the Streptomyces spore wall synthesizing complex SSSC in differentiation of Streptomyces coelicolor A3(2). Int J Med Microbiol. 309(6):151327. doi: 10.1016/j.ijmm.2019.07.001. Epub 2019 Jul 11.

• L. Thoma, B. Vollmer, F. Oesterhelt, G. Muth. (2019). Live-cell imaging of Streptomyces conjugation. Int J Med Microbiol. 309(5):338-343. doi: 10.1016/j.ijmm.2019.05.006. Epub 2019 May 31      

• E. Amado, G. Muth, I. Arechaga, E. Cabezón. (2019). The FtsK-like motor TraB is a DNA-dependent ATPase that forms higher-order assemblies. J Biol Chem. 294(13):5050-5059. doi: 10.1074/jbc.RA119.007459. Epub 2019 Feb 5.

• G. Muth. (2018). The pSG5-based thermosensitive vector family for genome editing and gene expression in actinomycetes. Appl Microbiol Biotechnol.102(21):9067-9080. doi: 10.1007/s00253-018-9334-5. Epub 2018 Sep 6.

• E. Grohmann, W. Keller, G. Muth. (2017). Mechanisms of Conjugative Transfer and Type IV Secretion-Mediated Effector Transport in Gram-Positive Bacteria. Curr Top Microbiol Immunol. 413:115-141. doi: 10.1007/978-3-319-75241-9_5.        

• S. Sigle, N. Steblau, W. Wohlleben and G. Muth. (2016). Polydiglycosylphosphate Transferase PdtA (SCO2578) of Streptomyces coelicolor A3(2) Is Crucial for Proper Sporulation and Apical Tip Extension under Stress Conditions. Appl Environ Microbiol. 82(18):5661-72. doi: 10.1128/AEM.01425-16.

• S. Sigle, N. Steblau, W. Wohlleben and G. Muth. (2016). A toolbox to measure changes in the cell wall glycopolymer composition during differentiation of Streptomyces coelicolor A3(2). J Microbiol Methods. 128:52-7. doi: 10.1016/j.mimet.2016.07.002.

• L. Thoma, B. Vollmer and G. Muth, (2016). Fluorescence microscopy of Streptomyces conjugation reveals DNA-transfer at the lateral walls and the spreading of the plasmid in the recipient mycelium. Environ Microbiol. 18(2):598-608. doi: 10.1111/1462-2920.13027.

• L. Thoma, G. Muth (2016). Conjugative DNA-transfer in Streptomyces, a mycelial organism. Plasmid. 28. pii: S0147-619X(16)30065-8. doi: 10.1016/j.plasmid.2016.09.004

• M. Borisova, R. Gaupp, A. Duckworth, A. Schneider, D. Dalügge, M. Mühleck, D. Deubel, S. Unsleber, W. Yu, G. Muth, M. Bischoff, F. Götz and Mayer C. (2016). Peptidoglycan Recycling in Gram-Positive Bacteria Is Crucial for Survival in Stationary Phase. MBio. 7(5). pii: e00923-16. doi: 10.1128/mBio.00923-16.

• L. Thoma and G. Muth, (2015). The conjugative DNA-transfer apparatus of Streptomyces. Int. J Med. Microbiol., 305:224-229.

• L. Thoma, H. Dobrowinski, C. Finger, L. Guezguez, D. Linke, E. Sepulveda and G. Muth. (2015). A multi-protein DNA-translocation complex directs intramycelial plasmid spreading during Streptomyces conjugation. mBio, 6(3):e02559-14. doi: 10.1128/mBio.02559-14.

• N. Ladwig, M. Franz-Wachtel, F. Hezel, B. Soufi, B. Macek, W. Wohlleben, and G Muth. (2015). Control of Morphological Differentiation of Streptomyces coelicolor A3(2) by Phosphorylation of MreC and PBP2. PLoS One. 10:e0125425. doi: 10.1371/journal.pone.0125425.

• S. Sigle, N. Ladwig, W. Wohlleben and G. Muth. (2015). The developmental life cycle of Streptomyces. Int. J. Med. Microbiol., 305:183-9.

Before 2014

• L. Thoma, E. Sepulveda, A. Latus and G. Muth, (2014) The stability region of the Streptomyces lividans plasmid pIJ101 encodes a DNA-binding protein recognizing a highly conserved short palindromic sequence motif. Front Microbiol. 5:499. doi: 10.3389/fmicb.2014.00499. eCollection 2014.

• L. Thoma and G. Muth, (2012) Conjugative DNA transfer in Streptomyces by TraB: is one protein enough? FEMS Microbiol. Lett. 337:81-88.

• W. Wohlleben, Y. Mast, G. Muth, M. Röttgen, E. Stegmann, and T. Weber. (2012). Synthetic biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production. FEBS Lett. 586:2171-2176.

• E. Salehghamari, J. Hamedi, E. Elahi, Z. Sepehrizadeh, M. Sadeghi, and G Muth. (2012). Prediction of the pho regulon in Streptomyces clavuligerus DSM 738. New Microbiol. 35(4):447-457.

• E.-M. Kleinschnitz, A. Latus, S. Sigle, I. Maldener, W. Wohlleben, and Muth G. (2011) Genetic analysis of SCO2997, encoding a TagF homologue, indicates a role for wall teichoic acids in sporulation of Streptomyces coelicolor A3(2). J Bacteriol. 193:6080-6085.

• E.-M. Kleinschnitz, A. Heichlinger, K. Schirner, J. Winkler, A. Latus, I. Maldener, W. Wohlleben, and G. Muth (2011) Proteins encoded by the mre gene cluster in Streptomyces coelicolor A3(2) co-operate in spore wall synthesis. Mol. Microbiol, 79:1367-79.

• A. Heichlinger, M. Ammelburg, E.-M. Kleinschnitz, A. Latus, I. Maldener, K. Flärdh, W. Wohlleben, and G. Muth (2011) The MreB-like Mbl protein of S. coelicolor A3(2) depends on MreB for proper localization and contributes to spore wall synthesis. J. Bacteriol., 193:1533-42

• J. Vogelmann, W. Wohlleben, and G. Muth (2011) Mobile genetic elements in Streptomyces. In Streptomyces. In “Streptomyces: Molecular Biology and Biotechnology” (ed. P. Dyson) Caister Academic Press ISBN: 978-1-904455-77-6

• J. Vogelmann, M. Ammelburg, C. Finger, J. Guezguez, D. Linke, M. Flötenmeyer, Y. Stierhof, W. Wohlleben, and G. Muth (2011). Conjugal plasmid transfer by a chromosome segregation mechanism, EMBO J. 30:2246-54 (Faculty 1000 selected).

• E. Sepulveda, J. Vogelmann, and G. Muth (2011) A septal chromosome segregator protein evolved into a conjugative DNA-translocator protein. Mobile Genetics Elements 1:1-5

• M. Chevillotte, R. Menges, G. Muth, W. Wohlleben, and E. Stegmann. (2008) A quick and reliable method for monitoring gene expression in actinomycetes J. Biotechnol. 135, 262-265.

• R. Menges, G. Muth, W. Wohlleben, and E. Stegmann (2007). The ABC transporter Tba of Amycolatopsis balhimycina is required for efficient export of the glycopeptide antibiotic balhimycin. Appl Microbiol Biotechnol. 77, 125-134.

• Y. Tiffert, B. Götz, J. Reuther, W. Wohlleben, and G. Muth (2007) Conjugative DNA transfer in Streptomyces: SpdB2 involved in the intramycelial spreading of plasmid pSVH1 is an oligomeric integral membrane protein that binds to DNA. Microbiology, 153:2976-2983

• J. Reuther, W. Wohlleben and G. Muth (2006) Modular architecture of the conjugative plasmid pSVH1 from Streptomyces venezuelae. Plasmid 55: 201-209

• J. Reuther, C. Gekeler, Y. Tiffert, W. Wohlleben and G. Muth (2006) Unique conjugation mechanism in mycelial streptomycetes: A DNA- binding ATPase translocates unprocessed plasmid DNA at the hyphal tip. Mol Microbiol. 61:436-464

• P. Mazza, E.E. Noens, K. Schirner, N. Grantcharova, A.M. Mommas, H.K. Koerten, G. Muth, K. Flärdh, G. van Wezel, and W. Wohlleben (2006) MreB of Streptomyces coelicolor is not essential for vegetative growth but is required for the integrity of aerial hyphae and spores. Mol Microbiol. 60:838-852.

• M. Pátek, G. Muth, W. Wohlleben (2003) Function of Corynebacterium glutamicum promoters in Escherichia coli, Streptomyces lividans, and Bacillus subtilis. J. Biotechnol. 104:325-3

• E. Grohmann, G. Muth and M. Espinosa (2003) Conjugative Plasmid Transfer in Gram-Positive Bacteria. Microbiol Mol Biol Rev. 67:277-301.

• S. Vierling, T. Weber, W. Wohlleben and G. Muth. (2001). Evidence that an additional mutation is required to tolerate insertional inactivation of the Streptomyces lividans recA gene. J. Bacteriol. 183:4374-81

• S. Vierling, T. Weber, W. Wohlleben and G. Muth. (2000). Transcriptional and mutational analyses of the S. lividans recX gene and its interference with RecA activity. J. Bacteriol. 182:4005-4011

• K. Poralla, G. Muth, and T. Härtner (2000) Hopanoids are formed during transition from substrate to aerial hyphae in Streptomyces coelicolor A3(2). FEMS Microbiol. Lett. 189:93-95

• E. L. Zechner, F. de la Cruz, R. Eisenbrandt, A. M. Grahn, G. Koraimann, E. Lanka, G. Muth, W. Pansegrau, C. M. Thomas, B. M. Wilkins, M. Zatyka (2000) Conjugative-DNA Transfer Processes. in: "The Horizontal Gene Pool" (Ed. C. M. Thomas) Harwood Academic Publishers, pp 87-174

• G. Muth, D.-F. Brolle and W. Wohlleben (1998) Genetics of Streptomyces. in: Manual of Industrial Microbiology and Biotechnology (Eds. J. E. Davies et al.,) ASM-Press, Washington.

• R.-M. Maas, J. Götz, W. Wohlleben and G. Muth. (1998) The conjugative plasmid pSG5 from Streptomyces ghanaensis DSM2932 differs in its transfer functions from other Streptomyces rolling circle type plasmids. Microbiol. 144:2809-2817

• G. Muth, D. Frese, A. Kleber and W. Wohlleben. (1997). Mutational analysis of the Streptomyces lividans recA gene suggests that only mutants with residual activity are viable. Mol. Gene. Genet. 255:420-428

• G. Muth, M. Farr, V. Hartmann and W. Wohlleben (1995) Streptomyces ghanaensis plasmid pSG5: nucleotide sequence analysis of the selftransmissible minimal replicon and characterization of the replication mode. Plasmid 33: 113-126

• B.-U. von Specht, B. Knapp, G. Muth, M. Bröker, K.-D. Hungerer, K.-D. Diehl, K. Massarat, A. Seemann and H. Domdey. (1995). Protection of immunocompromised mice against lethal infection with Pseudomonas aeruginosa by active or passive immunization with recombinant P. aeruginosa outer membrane protein F and outer membrane protein I fusion proteins. Infect. Immun. 63:1855-1862

• B.-U. von Specht, H. Domdey, F. Schöde, B. Blum, C. Lücking, B. Knapp, G. Muth, K.-D. Hungerer and M. Bröker. (1994). Outer membrane proteins of Pseudomonas aeruginosa as vaccine candidates. Behring Inst. Mitt. 95:85-96

• M. Roth, C. Hoffmeier, R. Geuther, G. Muth und W. Wohlleben (1994) Segregational stability of pSG5-derived vector plasmids in continuos cultures of Streptomyces lividans 66. Biotechnol. Lett. 16:1225-1230

• W. Wohlleben, V. Hartmann, D. Hillemann, K. Krey, G. Muth, B. Nussbaumer, S. Pelzer (1994) Transfer and establishment of DNA in Streptomyces (a brief review). Acta Microbiol Immunol Hung. 41:381-9

• W. Wohlleben, G. Muth and J. Kalinowski (1993) Genetic Engineering of Gram‑positive Bacteria.in: "Biotechnology", Vol. 2: Genetic Fundamentals and Genetic Engineering (H.‑J. Rehm, G. Reed, A. Pühler, P. Stadler, Eds.), pp. 455‑505, Verlag Chemie, Weinheim

• W. Wohlleben and G. Muth (1993) Streptomyces plasmid vectors. in: "Plasmids: A Practical Approach" (Ed. K.G. Hardy), pp. 147-175, Oxford University Press, Oxford

• W. Wohlleben, G. Muth and J. Kalinowski (1993) Genetic Engineering of Gram‑positive Bacteria. in: "Genetic Engineering of Microorganisms" (A. Pühler, Ed.), pp. 83-133, Verlag Chemie, Weinheim

• M. Finke, G. Muth, T. Reichhelm, M. Thoma, M. Duchene, K.-D. Hungerer, H. Domdey and B.-U. von Specht. (1991). Protection of immunosuppressed mice against infection with Pseudomonas aeruginosa by recombinant P. aeruginosa lipoprotein I and lipoprotein I-specific monoclonal antibodies. Infect. Immun. 59:1251-1254

• G. Muth, B. Nußbaumer, W. Wohlleben and A. Pühler (1989) A vector system with temperature-sensitive replication for gene disruption and mutational cloning in streptomycetes. Mol. Gen. Genet. 219, 341-348

• G. Muth, W. Wohlleben and A. Pühler (1988) The minimal replicon of the Streptomyces ghanaensis plasmid pSG5 identified by subcloning and Tn5 mutagenesis. Mol. Gen. Genet. 211, 424-429